The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABIOMED INC COM 003654100 116,416 654,428 SH   SOLE 0 654,428 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 78,339 2,176,677 SH   SOLE 0 2,176,677 0 0
AIMMUNE THERAPEUTICS INC COM 00900T107 72,698 3,471,740 SH   SOLE 0 3,471,740 0 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 35,110 1,861,630 SH   SOLE 0 1,861,630 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 387 73,500 SH   SOLE 0 73,500 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 93,822 957,950 SH   SOLE 0 957,950 0 0
ALIGN TECHNOLOGY INC COM 016255101 26,687 147,505 SH   SOLE 0 147,505 0 0
ALIMERA SCIENCES INC COM 016259103 1,707 3,013,793 SH   SOLE   3,013,793 0 0
AMAG PHARMACEUTICALS INC COM 00163U106 35,561 3,078,874 SH   SOLE 0 3,078,874 0 0
AMICUS THERAPEUTICS INC COM 03152W109 57,447 7,162,920 SH   SOLE 0 7,162,920 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 148,921 2,209,504 SH   SOLE 0 2,209,504 0 0
CELGENE CORP COM 151020104 2,173 21,883 SH   SOLE 0 21,883 0 0
CLOVIS ONCOLOGY INC COM 189464100 18,553 4,720,744 SH   SOLE 0 4,720,744 0 0
CYTOKINETICS INC COM 23282W605 1,408 123,686 SH   SOLE 0 123,686 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 4,765 331,813 SH   SOLE 0 331,813 0 0
EPIZYME INC COM 29428V104 65,548 6,354,659 SH   SOLE 0 6,354,659 0 0
GILEAD SCIENCES INC COM 375558103 2,491 39,300 SH   SOLE 0 39,300 0 0
IDERA PHARMACEUTICALS INC COM 45168K405 223 77,044 SH   SOLE 0 77,044 0 0
IMMUNOMEDICS INC COM 452907108 82,004 6,184,320 SH   SOLE 0 6,184,320 0 0
INSMED INC COM 457669307 127,707 7,239,649 SH   SOLE 0 7,239,649 0 0
KALEIDO BIOSCIENCES INC COM 483347100 5,934 787,999 SH   SOLE 0 787,999 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 46,581 4,842,150 SH   SOLE 0 4,842,150 0 0
MARINUS PHARMACEUTICALS INC COM 56854Q101 193 125,321 SH   SOLE 0 125,321 0 0
MELINTA THERAPEUTICS INC COM 58549G209 39 10,137 SH   SOLE 0 10,137 0 0
MINERVA NEUROSCIENCES INC COM 603380106 281 36,319 SH   SOLE 0 36,319 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 22,772 1,757,122 SH   SOLE 0 1,757,122 0 0
PROTHENA CORP PLC COM G72800108 7,875 1,004,449 SH   SOLE 0 1,004,449 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 15,132 1,405,680 SH   SOLE 0 1,405,680 0 0
RIGEL PHARMACEUTICALS INC COM 766559603 6,708 3,587,351 SH   SOLE 0 3,587,351 0 0
SAGE THERAPEUTICS INC COM 78667J108 95,523 680,894 SH   SOLE 0 680,894 0 0
SOPHIRIS BIO INC COM 83578Q209 144 247,000 SH   SOLE 0 247,000 0 0
STAAR SURGICAL CO COM 852312305 100,302 3,890,693 SH   SOLE 0 3,890,693 0 0
SUNESIS PHARMACEUTICALS INC COM 867328700 837 1,162,473 SH   SOLE 0 1,162,473 0 0
UNITED THERAPEUTICS CORP COM 91307C102 113,596 1,424,401 SH   SOLE 0 1,424,401 0 0
VANDA PHARMACEUTICALS INC COM 921659108 60,838 4,581,176 SH   SOLE 0 4,581,176 0 0
WRIGHT MEDICAL GROUP NV COM N96617118 51,456 2,494,255 SH   SOLE 0 2,494,255 0 0
ZOGENIX INC COM 98978L204 1,181 29,500 SH   SOLE 0 29,500 0 0