The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CL A COM 88025U109 5,040 100,000 SH   DFND 2 100,000 0 0
ABBOTT LABS COM 002824100 91,879 1,098,114 SH   DFND 2 1,098,114 0 0
ABIOMED INC COM 003654100 23,665 133,031 SH   DFND 2 133,031 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 3,253 90,400 SH   DFND 2 90,400 0 0
ACCELERON PHARMA INC COM 00434H108 1,019 25,800 SH   DFND 2 25,800 0 0
ADAMAS PHARMACEUTICALS INC COM 00548A106 593 116,000 SH   DFND 2 116,000 0 0
ADOBE INC COM 00724F101 414 1,500 SH   DFND 2 1,500 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 2,284 29,800 SH   DFND 2 29,800 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 797 24,600 SH   DFND 2 24,600 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 114,921 3,546,954 SH   DFND 1,2 3,546,954 0 0
AKCEA THERAPEUTICS INC COM 00972L107 10,172 660,963 SH   DFND 2 660,963 0 0
AKCEA THERAPEUTICS INC COM 00972L107 37,689 2,448,948 SH   DFND 1,2 2,448,948 0 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 32,561 1,726,458 SH   DFND 2 1,726,458 0 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 52,167 2,766,008 SH   DFND 1,2 2,766,008 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 5,103 52,100 SH   DFND 2 52,100 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 128,735 1,314,428 SH   DFND 1,2 1,314,428 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 113 150 SH Call DFND 2 150 0 0
ALIGN TECHNOLOGY INC COM 016255101 61,238 338,483 SH   DFND 2 338,483 0 0
ALLERGAN PLC SHS G0177J108 5,183 30,800 SH   DFND 2 30,800 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 22,838 283,983 SH   DFND 2 283,983 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 135,193 1,681,089 SH   DFND 1,2 1,681,089 0 0
AMEDISYS INC COM 023436108 23,013 175,658 SH   DFND 2 175,658 0 0
AMERICAN EXPRESS CO COM 025816109 426 3,600 SH   DFND 2 3,600 0 0
AMGEN INC COM 031162100 11,166 57,700 SH   DFND 2 57,700 0 0
ANALOG DEVICES INC COM 032654105 458 4,100 SH   DFND 2 4,100 0 0
ANSYS INC COM 03662Q105 399 1,802 SH   DFND 2 1,802 0 0
ANTHEM INC COM 036752103 73,496 306,106 SH   DFND 2 306,106 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 1,076 23,517 SH   DFND 2 23,517 0 0
ARGENX SE SPONSORED ADR 04016X101 2,098 18,500 SH   DFND 2 18,500 0 0
ARGENX SE SPONSORED ADR 04016X101 108,262 954,739 SH   DFND 1,2 954,739 0 0
ARVINAS INC COM 04335A105 17,378 806,403 SH   DFND 1,2 806,403 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 1,310 13,600 SH   DFND 2 13,600 0 0
ASPEN TECHNOLOGY INC COM 045327103 369 3,000 SH   DFND 2 3,000 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 281 10,000 SH   DFND 2 10,000 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 39,877 1,419,604 SH   DFND 1,2 1,419,604 0 0
AUTOLIV INC COM 052800109 536 6,800 SH   DFND 2 6,800 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 430 34,600 SH   DFND 2 34,600 0 0
AVANTOR INC COM 05352A100 2,895 196,951 SH   DFND 2 196,951 0 0
BAXTER INTL INC COM 071813109 31,102 355,568 SH   DFND 2 355,568 0 0
BECTON DICKINSON & CO COM 075887109 50,801 200,827 SH   DFND 2 200,827 0 0
BEIGENE LTD SPONSORED ADR 07725L102 8,979 72,100 SH   DFND 2 72,100 0 0
BENEFITFOCUS INC COM 08180D106 2,154 90,463 SH   DFND 2 90,463 0 0
BIOGEN INC COM 09062X103 7,532 32,350 SH   DFND 2 32,350 0 0
BIO RAD LABS INC CL A 090572207 2,246 6,750 SH   DFND 2 6,750 0 0
BLACKBAUD INC COM 09227Q100 371 4,107 SH   DFND 2 4,107 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 1,161 15,800 SH   DFND 2 15,800 0 0
BOOKING HLDGS INC COM 09857L108 393 200 SH   DFND 2 200 0 0
BOSTON SCIENTIFIC CORP COM 101137107 57,779 1,419,988 SH   DFND 2 1,419,988 0 0
BRISTOL MYERS SQUIBB CO COM 110122108 47,516 937,009 SH   DFND 2 937,009 0 0
BROADRIDGE FINL SOLUTIONS IN COM 11133T103 423 3,400 SH   DFND 2 3,400 0 0
BROWN FORMAN CORP CL B 115637209 477 7,600 SH   DFND 2 7,600 0 0
CAREDX INC COM 14167L103 16,339 722,655 SH   DFND 2 722,655 0 0
CATALENT INC COM 148806102 1,787 37,500 SH   DFND 2 37,500 0 0
CELGENE CORP COM 151020104 1,053 10,600 SH   DFND 2 10,600 0 0
CELGENE CORP COM 151020104 106,748 1,075,000 SH   DFND 1,2 1,075,000 0 0
CENTENE CORP DEL COM 15135B101 29,975 692,914 SH   DFND 2 692,914 0 0
CERNER CORP COM 156782104 423 6,200 SH   DFND 2 6,200 0 0
CHANGE HEALTHCARE INC COM 15912K100 10,436 863,922 SH   DFND 2 863,922 0 0
CHARLES RIV LABS INTL INC COM 159864107 1,099 8,300 SH   DFND 2 8,300 0 0
CHINA BIOLOGIC PRODS HLDGS I COM G21515104 515 4,500 SH   DFND 2 4,500 0 0
CIDARA THERAPEUTICS INC COM 171757107 4,579 2,295,272 SH   DFND 1,2 2,295,272 0 0
CIGNA CORP NEW COM 125523100 36,322 239,294 SH   DFND 2 239,294 0 0
CLOROX CO DEL COM 189054109 425 2,800 SH   DFND 2 2,800 0 0
COHERUS BIOSCIENCES INC COM 19249H103 4,081 201,435 SH   DFND 2 201,435 0 0
COLGATE PALMOLIVE CO COM 194162103 448 6,100 SH   DFND 2 6,100 0 0
COOPER COS INC COM NEW 216648402 9,495 31,969 SH   DFND 2 31,969 0 0
COVETRUS INC COM 22304C100 18 1,520 SH   DFND 2 1,520 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 1,094 26,700 SH   DFND 2 26,700 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 33,221 810,462 SH   DFND 1,2 810,462 0 0
CTRIP COM INTL LTD SPONSORED ADS 22943F100 384 13,100 SH   DFND 2 13,100 0 0
CVS HEALTH CORP COM 126650100 6,666 105,688 SH   DFND 2 105,688 0 0
DANAHER CORPORATION COM 235851102 53,694 371,763 SH   DFND 2 371,763 0 0
DENTSPLY SIRONA INC COM 24906P109 7,027 131,818 SH   DFND 2 131,818 0 0
DEXCOM INC COM 252131107 25,205 168,887 SH   DFND 2 168,887 0 0
DIREXION SHS ETF TR DAILY S&P BIOTEC 25460E539 1,393 55,000 SH   DFND 2 55,000 0 0
DOMINOS PIZZA INC COM 25754A201 465 1,900 SH   DFND 2 1,900 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 42,758 194,432 SH   DFND 2 194,432 0 0
ELECTRONIC ARTS INC COM 285512109 470 4,800 SH   DFND 2 4,800 0 0
ENTEGRIS INC COM 29362U104 485 10,300 SH   DFND 2 10,300 0 0
ESPERION THERAPEUTICS INC NEW COM 29664W105 21,574 588,497 SH   DFND 2 588,497 0 0
ESPERION THERAPEUTICS INC NEW COM 29664W105 133,918 3,652,964 SH   DFND 1,2 3,652,964 0 0
EVOLENT HEALTH INC CL A 30050B101 21,750 3,025,022 SH   DFND 2 3,025,022 0 0
EXELIXIS INC COM 30161Q104 18,104 1,023,700 SH   DFND 2 1,023,700 0 0
EXELIXIS INC COM 30161Q104 50,137 2,835,000 SH   DFND 1,2 2,835,000 0 0
FASTENAL CO COM 311900104 630 19,299 SH   DFND 2 19,299 0 0
FATE THERAPEUTICS INC COM 31189P102 933 60,100 SH   DFND 2 60,100 0 0
FITBIT INC CL A 33812L102 10,134 2,659,944 SH   DFND 2 2,659,944 0 0
G1 THERAPEUTICS INC COM 3621LQ109 16,445 721,925 SH   DFND 1,2 721,925 0 0
GENMARK DIAGNOSTICS INC COM 372309104 13,740 2,267,252 SH   DFND 2 2,267,252 0 0
GILEAD SCIENCES INC COM 375558103 7,073 111,600 SH   DFND 2 111,600 0 0
GILEAD SCIENCES INC COM 375558103 27,887 440,000 SH   DFND 1,2 440,000 0 0
GLAUKOS CORP COM 377322102 25,138 402,148 SH   DFND 2 402,148 0 0
GLOBUS MED INC CL A 379577208 15,217 297,666 SH   DFND 2 297,666 0 0
GRACO INC COM 384109104 447 9,700 SH   DFND 2 9,700 0 0
GUARDANT HEALTH INC COM 40131M109 6,049 94,761 SH   DFND 2 94,761 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 1,202 10,453 SH   DFND 2 10,453 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 796 51,300 SH   DFND 2 51,300 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 123,507 7,963,056 SH   DFND 1,2 7,963,056 0 0
HCA HEALTHCARE INC COM 40412C101 25,455 211,382 SH   DFND 2 211,382 0 0
HEALTH CATALYST INC COM 42225T107 5,069 160,216 SH   DFND 2 160,216 0 0
HENRY SCHEIN INC COM 806407102 4,037 63,575 SH   DFND 2 63,575 0 0
HILL ROM HLDGS INC COM 431475102 20,916 198,762 SH   DFND 2 198,762 0 0
HMS HLDGS CORP COM 40425J101 14,199 411,972 SH   DFND 2 411,972 0 0
HOLOGIC INC COM 436440101 7,836 155,208 SH   DFND 2 155,208 0 0
HOMOLOGY MEDICINES INC COM 438083107 29,179 1,612,122 SH   DFND 1,2 1,612,122 0 0
HORIZON THERAPEUTICS PUB LTD SHS G46188101 8,803 323,300 SH   DFND 2 323,300 0 0
HUAZHU GROUP LTD SPONSORED ADS 44332N106 446 13,500 SH   DFND 2 13,500 0 0
HUMANA INC COM 444859102 62,044 242,673 SH   DFND 2 242,673 0 0
HUTCHISON CHINA MEDITECH LTD SPONSORED ADR 44842L103 13,788 788,198 SH   DFND 2 788,198 0 0
IDEXX LABS INC COM 45168D104 9,282 34,134 SH   DFND 2 34,134 0 0
ILLUMINA INC COM 452327109 63,075 207,332 SH   DFND 2 207,332 0 0
INCYTE CORP COM 45337C102 8,626 116,200 SH   DFND 2 116,200 0 0
INCYTE CORP COM 45337C102 265,743 3,580,000 SH   DFND 1,2 3,580,000 0 0
INOGEN INC COM 45780L104 5,429 113,323 SH   DFND 2 113,323 0 0
INSMED INC COM PAR $.01 457669307 21,018 1,191,480 SH   DFND 2 1,191,480 0 0
INSPIRE MED SYS INC COM 457730109 14,856 243,457 SH   DFND 2 243,457 0 0
INSULET CORP COM 45784P101 14,719 89,245 SH   DFND 2 89,245 0 0
INTEGRA LIFESCIENCES HLDGS C COM NEW 457985208 12,828 213,557 SH   DFND 2 213,557 0 0
INTERACTIVE BROKERS GROUP IN COM CL A 45841N107 506 9,400 SH   DFND 2 9,400 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 345 5,200 SH   DFND 2 5,200 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 46,251 696,976 SH   DFND 1,2 696,976 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 443 4,800 SH   DFND 2 4,800 0 0
INTERSECT ENT INC COM 46071F103 7,801 458,588 SH   DFND 2 458,588 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 19,340 2,588,990 SH   DFND 1,2 2,588,990 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 94,836 175,645 SH   DFND 2 175,645 0 0
IONIS PHARMACEUTICALS INC COM 462222100 19,588 326,959 SH   DFND 2 326,959 0 0
IONIS PHARMACEUTICALS INC COM 462222100 478,978 7,994,955 SH   DFND 1,2 7,994,955 0 0
IPG PHOTONICS CORP COM 44980X109 475 3,500 SH   DFND 2 3,500 0 0
IRHYTHM TECHNOLOGIES INC COM 450056106 13,667 184,419 SH   DFND 2 184,419 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 42,315 330,227 SH   DFND 2 330,227 0 0
JD COM INC SPON ADR CL A 47215P106 415 14,700 SH   DFND 2 14,700 0 0
JOHNSON & JOHNSON COM 478160104 1,294 10,000 SH   DFND 2 10,000 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 4,036 1,230,523 SH   DFND 1,2 1,230,523 0 0
KIRBY CORP COM 497266106 485 5,900 SH   DFND 2 5,900 0 0
KOSMOS ENERGY LTD COM 500688106 374 60,000 SH   DFND 2 60,000 0 0
KURA ONCOLOGY INC COM 50127T109 2,523 166,300 SH   DFND 2 166,300 0 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409 936 5,573 SH   DFND 2 5,573 0 0
LAUDER ESTEE COS INC CL A 518439104 447 2,248 SH   DFND 2 2,248 0 0
LINDE PLC SHS G5494J103 358 1,848 SH   DFND 2 1,848 0 0
LIVANOVA PLC SHS G5509L101 20,020 271,314 SH   DFND 2 271,314 0 0
LIVE NATION ENTERTAINMENT IN COM 538034109 411 6,200 SH   DFND 2 6,200 0 0
LIVONGO HEALTH INC COM 539183103 754 43,220 SH   DFND 2 43,220 0 0
M & T BK CORP COM 55261F104 474 3,000 SH   DFND 2 3,000 0 0
MACROGENICS INC COM 556099109 13,161 1,031,405 SH   DFND 2 1,031,405 0 0
MACROGENICS INC COM 556099109 52,241 4,094,159 SH   DFND 1,2 4,094,159 0 0
MARKEL CORP COM 570535104 473 400 SH   DFND 2 400 0 0
MARKETAXESS HLDGS INC COM 57060D108 433 1,322 SH   DFND 2 1,322 0 0
MASIMO CORP COM 574795100 10,176 68,392 SH   DFND 2 68,392 0 0
MATERIALISE NV SPONSORED ADS 57667T100 4,449 240,770 SH   DFND 2 240,770 0 0
MCCORMICK & CO INC COM NON VTG 579780206 438 2,800 SH   DFND 2 2,800 0 0
MCKESSON CORP COM 58155Q103 810 5,924 SH   DFND 2 5,924 0 0
MEDICINES CO COM 584688105 1,445 28,900 SH   DFND 2 28,900 0 0
MEDTRONIC PLC SHS G5960L103 87,726 807,638 SH   DFND 2 807,638 0 0
METTLER TOLEDO INTERNATIONAL COM 592688105 493 700 SH   DFND 2 700 0 0
MICROCHIP TECHNOLOGY INC COM 595017104 465 5,000 SH   DFND 2 5,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 1,239 15,900 SH   DFND 2 15,900 0 0
MODERNA INC COM 60770K107 419 26,300 SH   DFND 2 26,300 0 0
MODERNA INC COM 60770K107 76,699 4,817,781 SH   DFND 1,2 4,817,781 0 0
MOLINA HEALTHCARE INC COM 60855R100 9,352 85,239 SH   DFND 2 85,239 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 648 50,000 SH   DFND 2 50,000 0 0
MOODYS CORP COM 615369105 410 2,000 SH   DFND 2 2,000 0 0
MSCI INC COM 55354G100 389 1,786 SH   DFND 2 1,786 0 0
MYLAN N V SHS EURO N59465109 5,799 293,200 SH   DFND 2 293,200 0 0
MYOKARDIA INC COM 62857M105 1,439 27,600 SH   DFND 2 27,600 0 0
MYOKARDIA INC COM 62857M105 65,965 1,264,913 SH   DFND 1,2 1,264,913 0 0
MYOVANT SCIENCES LTD COM G637AM102 25,039 4,815,109 SH   DFND 1,2 4,815,109 0 0
NEKTAR THERAPEUTICS COM 640268108 11,880 652,210 SH   DFND 2 652,210 0 0
NEKTAR THERAPEUTICS COM 640268108 45,914 2,520,676 SH   DFND 1,2 2,520,676 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 7,695 85,400 SH   DFND 2 85,400 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 289,530 3,213,074 SH   DFND 1,2 3,213,074 0 0
NEURONETICS INC COM 64131A105 2,709 325,961 SH   DFND 2 325,961 0 0
NEVRO CORP COM 64157F103 12,475 145,111 SH   DFND 2 145,111 0 0
OMNICELL INC COM 68213N109 12,405 171,646 SH   DFND 2 171,646 0 0
OXFORD IMMUNOTEC GLOBAL PLC ORD SHS G6855A103 10,609 637,972 SH   DFND 2 637,972 0 0
PACIFIC BIOSIENCES CALIF IN COM 69404D108 12,249 2,373,787 SH   DFND 2 2,373,787 0 0
PAYCHEX INC COM 704326107 447 5,400 SH   DFND 2 5,400 0 0
PENUMBRA INC COM 70975L107 3,369 25,048 SH   DFND 2 25,048 0 0
PFIZER INC COM 717081103 1,437 40,000 SH   DFND 2 40,000 0 0
PHREESIA INC COM 71944F106 5,350 220,690 SH   DFND 2 220,690 0 0
POLYONE CORP COM 73179P106 444 13,600 SH   DFND 2 13,600 0 0
POOL CORPORATION COM 73278L105 444 2,200 SH   DFND 2 2,200 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 1,172 43,700 SH   DFND 2 43,700 0 0
PTC THERAPEUTICS INC COM 69366J200 2,746 81,200 SH   DFND 2 81,200 0 0
QIAGEN NV SHS NEW N72482123 21,066 638,943 SH   DFND 2 638,943 0 0
QUANTERIX CORP COM 74766Q101 8,918 406,101 SH   DFND 2 406,101 0 0
QUIDEL CORP COM 74838J101 9,817 160,016 SH   DFND 2 160,016 0 0
QUOTIENT LTD SHS G73268107 5,811 747,894 SH   DFND 2 747,894 0 0
RADIUS HEALTH INC COM NEW 750469207 2,451 95,200 SH   DFND 2 95,200 0 0
RADIUS HEALTH INC COM NEW 750469207 174,628 6,781,685 SH   DFND 1,2 6,781,685 0 0
REGENXBIO INC COM 75901B107 1,200 33,700 SH   DFND 2 33,700 0 0
RESMED INC COM 761152107 7,381 54,630 SH   DFND 2 54,630 0 0
S&P GLOBAL INC COM 78409V104 416 1,700 SH   DFND 2 1,700 0 0
SAGE THERAPEUTICS INC COM 78667J108 3,283 23,400 SH   DFND 2 23,400 0 0
SAGE THERAPEUTICS INC COM 78667J108 179,586 1,280,104 SH   DFND 1,2 1,280,104 0 0
SANGAMO THERAPEUTICS INC COM 800677106 33,033 3,650,000 SH   DFND 1,2 3,650,000 0 0
SCHOLAR ROCK HOLDING CORP COM 80706P103 19,664 2,197,100 SH   DFND 1,2 2,197,100 0 0
SEATTLE GENETICS INC COM 812578102 6,943 81,300 SH   DFND 2 81,300 0 0
SENSATA TECHNOLOGIES HLDNG P SHS G8060N102 496 9,900 SH   DFND 2 9,900 0 0
SHOCKWAVE MED INC COM 82489T104 3,034 101,358 SH   DFND 2 101,358 0 0
SILK RAOD MEDICAL INC COM 82710M100 4,292 131,954 SH   DFND 2 131,954 0 0
SKYWORKS SOLUTIONS INC COM 83088M102 452 5,700 SH   DFND 2 5,700 0 0
SMILEDIRECTCLUB INC CL A COM 83192H106 4,858 350,000 SH   DFND 2 350,000 0 0
SOCIEDAD QUIMICA MINERA DE C SPON ADR SER B 833635105 501 18,200 SH   DFND 2 18,200 0 0
STARBUCKS CORP COM 855244109 383 4,334 SH   DFND 2 4,334 0 0
STEMLINE THERAPEUTICS INC COM 85858C107 328 31,500 SH   DFND 2 31,500 0 0
STRYKER CORP COM 863667101 40,726 188,284 SH   DFND 2 188,284 0 0
SUPERNUS PHARMACEUTICALS INC COM 868459108 11,448 416,600 SH   DFND 2 416,600 0 0
SYNEOS HEALTH INC CL A 87166B102 3,299 62,000 SH   DFND 2 62,000 0 0
TABULA RASA HEALTHCARE INC COM 873379101 11,081 201,693 SH   DFND 2 201,693 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 11,486 194,736 SH   DFND 2 194,736 0 0
TELADOC HEALTH INC COM 87918A105 77,137 1,139,057 SH   DFND 2 1,139,057 0 0
TELEFLEX INC COM 879369106 20,084 59,114 SH   DFND 2 59,114 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 1,028 150,000 SH   DFND 2 150,000 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 16,671 57,236 SH   DFND 2 57,236 0 0
TRIMBLE INC COM 896239100 454 11,700 SH   DFND 2 11,700 0 0
TYLER TECHNOLOGIES INC COM 902252105 400 1,525 SH   DFND 2 1,525 0 0
UNIQURE NV SHS N90064101 1,216 30,900 SH   DFND 2 30,900 0 0
UNITEDHEALTH GROUP INC COM 91324P102 51,877 238,712 SH   DFND 2 238,712 0 0
VARIAN MED SYS INC COM 92220P105 488 4,100 SH   DFND 2 4,100 0 0
VEEVA SYS INC CL A COM 922475108 7,769 50,884 SH   DFND 2 50,884 0 0
VEONEER INCORPORATED COM 92336X109 445 29,700 SH   DFND 2 29,700 0 0
VERISIGN INC COM 92343E102 396 2,100 SH   DFND 2 2,100 0 0
VERISK ANALYTICS INC COM 92345Y106 394 2,489 SH   DFND 2 2,489 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 25,267 149,139 SH   DFND 2 149,139 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 216,858 1,280,000 SH   DFND 1,2 1,280,000 0 0
VOCERA COMMUNICATONS INC COM 92857F107 6,142 249,173 SH   DFND 2 249,173 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 420 24,400 SH   DFND 2 24,400 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 46,128 2,680,283 SH   DFND 1,2 2,680,283 0 0
WABTEC CORP COM 929740108 460 6,400 SH   DFND 2 6,400 0 0
WATSCO INC COM 942622200 474 2,800 SH   DFND 2 2,800 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 31,880 1,552,858 SH   DFND 1,2 1,552,858 0 0
WRIGHT MED GROUP NV ORD SHS N96617118 16,593 804,291 SH   DFND 2 804,291 0 0
XILINX INC COM 983919101 403 4,200 SH   DFND 2 4,200 0 0
ZAI LAB LTD ADR 98887Q104 971 30,000 SH   DFND 2 30,000 0 0
ZIMMER BIOMET HLDGS INC COM 98956P102 19,818 144,373 SH   DFND 2 144,373 0 0
ZOGENIX INC COM NEW 98978L204 921 23,000 SH   DFND 2 23,000 0 0