The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Abbott Laboratories Common 002824100 40,984 471,835 SH   SOLE   471,835 0 0
AbbVie Inc. Common 00287Y109 30,185 340,916 SH   SOLE   340,916 0 0
ABIOMED, Inc. Common 003654100 5,581 32,716 SH   SOLE   32,716 0 0
AC Immune SA Shares H00263105 1,464 171,813 SH   SOLE   171,813 0 0
Acadia Healthcare Company, Inc. Common 00404A109 4,525 136,200 SH   SOLE   136,200 0 0
ACADIA Pharmaceuticals Inc. Common 004225108 9,338 218,283 SH   SOLE   218,283 0 0
Acceleron Pharma Inc. Common 00434H108 4,576 86,313 SH   SOLE   86,313 0 0
Adaptimmune Therapeutics plc Sponsored ADR 00653A107 92 77,061 SH   SOLE   77,061 0 0
Aerie Pharmaceuticals, Inc. Common 00771V108 1,612 66,688 SH   SOLE   66,688 0 0
Aerpio Pharmaceuticals, Inc. Common 00810B105 161 257,554 SH   SOLE   257,554 0 0
Agilent Technologies, Inc. Common 00846U101 2,331 27,325 SH   SOLE   27,325 0 0
Agios Pharmaceuticals, Inc. Common 00847X104 10,333 216,408 SH   SOLE   216,408 0 0
Alcon Inc. Ordinary Shares H01301128 3,132 55,369 SH   SOLE   55,369 0 0
Alexion Pharmaceuticals, Inc. Common 015351109 47,133 435,814 SH   SOLE   435,814 0 0
Align Technology, Inc. Common 016255101 6,244 22,378 SH   SOLE   22,378 0 0
Alkermes Public Limited Company Shares G01767105 4,040 198,048 SH   SOLE   198,048 0 0
Allakos Inc. Common 01671P100 6,808 71,396 SH   SOLE   71,396 0 0
Allergan Public Limited Company Shares G0177J108 30,507 159,581 SH   SOLE   159,581 0 0
Allogene Therapeutics, Inc. Common 019770106 2,086 80,280 SH   SOLE   80,280 0 0
Alnylam Pharmaceuticals, Inc. Common 02043Q107 16,561 143,795 SH   SOLE   143,795 0 0
Amarin Corporation plc Sponsored ADR 023111206 8,750 408,120 SH   SOLE   408,120 0 0
AmerisourceBergen Corporation Common 03073E105 9,839 115,723 SH   SOLE   115,723 0 0
Amgen Inc. Common 031162100 148,843 617,427 SH   SOLE   617,427 0 0
Amicus Therapeutics, Inc. Common 03152W109 3,594 368,960 SH   SOLE   368,960 0 0
AnaptysBio, Inc. Common 032724106 1,922 118,261 SH   SOLE   118,261 0 0
Anthem, Inc. Common 036752103 30,817 102,032 SH   SOLE   102,032 0 0
Apellis Pharmaceuticals, Inc. Common 03753U106 4,011 130,999 SH   SOLE   130,999 0 0
ARCA biopharma, Inc. Common 00211Y506 206 36,068 SH   SOLE   36,068 0 0
Ardelyx, Inc. Common 039697107 4,561 607,698 SH   SOLE   607,698 0 0
Arena Pharmaceuticals, Inc. Common 040047607 1,272 28,002 SH   SOLE   28,002 0 0
argenx SE Sponsored ADR 04016X101 7,220 44,977 SH   SOLE   44,977 0 0
ArQule, Inc. Common 04269E107 4,399 220,409 SH   SOLE   220,409 0 0
Arrowhead Pharmaceuticals, Inc. Common 04280A100 6,685 105,398 SH   SOLE   105,398 0 0
Ascendis Pharma A/S Sponsored ADR 04351P101 9,645 69,332 SH   SOLE   69,332 0 0
AstraZeneca PLC Sponsored ADR 046353108 13,766 276,098 SH   SOLE   276,098 0 0
Atreca, Inc. Class A Common 04965G109 8,120 524,896 SH   SOLE   524,896 0 0
Aurinia Pharmaceuticals Inc. Common 05156V102 1,839 90,788 SH   SOLE   90,788 0 0
Avadel Pharmaceuticals Public Limited Company Sponsored ADR 05337M104 6,150 814,588 SH   SOLE   814,588 0 0
AVROBIO, Inc. Common 05455M100 1,507 74,874 SH   SOLE   74,874 0 0
Axonics Modulation Technologies, Inc. Common 05465P101 779 28,100 SH   SOLE   28,100 0 0
Bausch Health Companies Inc. Common 071734107 4,153 138,812 SH   SOLE   138,812 0 0
Baxter International Inc. Common 071813109 10,869 129,983 SH   SOLE   129,983 0 0
Becton, Dickinson and Company Common 075887109 18,020 66,257 SH   SOLE   66,257 0 0
BeiGene, Ltd. Sponsored ADR 07725L102 13,441 81,089 SH   SOLE   81,089 0 0
Bellicum Pharmaceuticals, Inc. Common 079481107 77 60,000 SH   SOLE   60,000 0 0
Bio-Techne Corporation Common 09073M104 10,995 50,091 SH   SOLE   50,091 0 0
Biogen Inc. Common 09062X103 84,605 285,126 SH   SOLE   285,126 0 0
Biohaven Pharmaceutical Holding Company Ltd. Common G11196105 1,586 29,125 SH   SOLE   29,125 0 0
BioMarin Pharmaceutical Inc. Common 09061G101 23,383 276,560 SH   SOLE   276,560 0 0
bluebird bio, Inc. Common 09609G100 8,397 95,687 SH   SOLE   95,687 0 0
Blueprint Medicines Corporation Common 09627Y109 9,367 116,925 SH   SOLE   116,925 0 0
Boston Scientific Corporation Common 101137107 25,520 564,345 SH   SOLE   564,345 0 0
BridgeBio Pharma, Inc. Common 10806X102 1,375 39,228 SH   SOLE   39,228 0 0
Bristol-Myers Squibb Company Common 110122108 49,738 774,862 SH   SOLE   774,862 0 0
Bristol-Myers Squibb Company Right 110122157 4,436 1,473,710 SH   SOLE   1,473,710 0 0
Celldex Therapeutics, Inc. Common 15117B202 16 7,053 SH   SOLE   7,053 0 0
Cellectis Sponsored ADR 15117K103 1,886 110,147 SH   SOLE   110,147 0 0
Centene Corporation Common 15135B101 9,401 149,526 SH   SOLE   149,526 0 0
Charles River Laboratories International, Inc. Common 159864107 3,203 20,967 SH   SOLE   20,967 0 0
Cidara Therapeutics, Inc. Common 171757107 610 158,784 SH   SOLE   158,784 0 0
Cigna Corporation Common 125523100 38,967 190,555 SH   SOLE   190,555 0 0
Clearside Biomedical, Inc. Common 185063104 479 165,330 SH   SOLE   165,330 0 0
Coherus Biosciences, Inc. Common 19249H103 2,253 125,146 SH   SOLE   125,146 0 0
Community Health Systems, Inc. Common 203668108 591 203,935 SH   SOLE   203,935 0 0
Community Healthcare Trust Incorporated Common 20369C106 639 14,900 SH   SOLE   14,900 0 0
CRISPR Therapeutics AG Namen AKT H17182108 4,642 76,222 SH   SOLE   76,222 0 0
CVS Health Corporation Common 126650100 36,995 497,986 SH   SOLE   497,986 0 0
CymaBay Therapeutics, Inc. Common 23257D103 173 88,102 SH   SOLE   88,102 0 0
Danaher Corporation Common 235851102 25,397 165,476 SH   SOLE   165,476 0 0
Deciphera Pharmaceuticals, Inc. Common 24344T101 3,820 61,370 SH   SOLE   61,370 0 0
DENTSPLY SIRONA Inc. Common 24906P109 6,776 119,736 SH   SOLE   119,736 0 0
Dermira, Inc. Common 24983L104 1,352 89,200 SH   SOLE   89,200 0 0
Diversified Healthcare Trust Common 25525P107 3,019 357,720 SH   SOLE   357,720 0 0
Editas Medicine, Inc. Common 28106W103 4,380 147,939 SH   SOLE   147,939 0 0
Edwards Lifesciences Corporation Common 28176E108 16,227 69,557 SH   SOLE   69,557 0 0
Eidos Therapeutics, Inc. Common 28249H104 1,148 20,000 SH   SOLE   20,000 0 0
Eli Lilly and Company Common 532457108 27,624 210,181 SH   SOLE   210,181 0 0
Endo International plc Shares G30401106 2,493 531,570 SH   SOLE   531,570 0 0
Epizyme, Inc. Common 29428V104 8,686 353,102 SH   SOLE   353,102 0 0
Esperion Therapeutics, Inc. Common 29664W105 12,735 213,562 SH   SOLE   213,562 0 0
Evolent Health, Inc. Common 30050B101 2,091 231,027 SH   SOLE   231,027 0 0
Exelixis, Inc. Common 30161Q104 9,077 515,125 SH   SOLE   515,125 0 0
Fate Therapeutics, Inc. Common 31189P102 3,242 165,672 SH   SOLE   165,672 0 0
FibroGen, Inc. Common 31572Q808 8,332 194,270 SH   SOLE   194,270 0 0
Foamix Pharmaceuticals Ltd Shares M46135105 1,002 300,781 SH   SOLE   300,781 0 0
Galapagos NV Sponsored ADR 36315X101 1,353 6,543 SH   SOLE   6,543 0 0
Galera Therapeutics, Inc. Common 36338D108 5,483 416,666 SH   SOLE   416,666 0 0
Genmab A/S Sponsored ADS 372303206 369 16,520 SH   SOLE   16,520 0 0
Gilead Sciences, Inc. Common 375558103 122,850 1,890,576 SH   SOLE   1,890,576 0 0
GlaxoSmithKline PLC Shares 37733W105 12,079 257,048 SH   SOLE   257,048 0 0
Global Blood Therapeutics, Inc. Common 37890U108 11,698 147,168 SH   SOLE   147,168 0 0
Global Medical REIT Inc. Common 37954A204 1,562 118,092 SH   SOLE   118,092 0 0
Guardant Health, Inc. Common 40131M109 339 4,333 SH   SOLE   4,333 0 0
GW Pharmaceuticals plc ADS 36197T103 5,239 50,101 SH   SOLE   50,101 0 0
HCA Healthcare, Inc. Common 40412C101 14,165 95,833 SH   SOLE   95,833 0 0
Health Care Select Sector SPDR Fund SBI Healthcare 81369Y209 5,477 53,773 SH   SOLE   53,773 0 0
Healthcare Realty Trust Incorporated Common 421946104 2,791 83,629 SH   SOLE   83,629 0 0
Healthcare Trust of America, Inc. Common 42225P501 1,393 46,000 SH   SOLE   46,000 0 0
HealthEquity, Inc. Common 42226A107 2,356 31,810 SH   SOLE   31,810 0 0
Healthpeak Properties, Inc. Common 42250P103 4,431 128,537 SH   SOLE   128,537 0 0
Heron Therapeutics, Inc. Common 427746102 1,406 59,842 SH   SOLE   59,842 0 0
Hologic, Inc. Common 436440101 2,229 42,701 SH   SOLE   42,701 0 0
Horizon Therapeutics Public Limited Company Shares G46188101 11,029 304,664 SH   SOLE   304,664 0 0
Humana Inc. Common 444859102 20,163 55,013 SH   SOLE   55,013 0 0
IDEXX Laboratories, Inc. Common 45168D104 11,389 43,614 SH   SOLE   43,614 0 0
Illumina, Inc. Common 452327109 90,433 272,601 SH   SOLE   272,601 0 0
ImmunoGen, Inc. Common 45253H101 859 168,190 SH   SOLE   168,190 0 0
Immunomedics, Inc. Common 452907108 10,307 487,103 SH   SOLE   487,103 0 0
Incyte Corporation Common 45337C102 33,464 383,230 SH   SOLE   383,230 0 0
Inogen, Inc. Common 45780L104 3,513 51,406 SH   SOLE   51,406 0 0
Insmed Incorporated Common 457669307 3,935 164,786 SH   SOLE   164,786 0 0
Intellia Therapeutics, Inc. Common 45826J105 808 55,050 SH   SOLE   55,050 0 0
Intercept Pharmaceuticals, Inc. Common 45845P108 4,265 34,414 SH   SOLE   34,414 0 0
Intra-Cellular Therapies, Inc. Common 46116X101 3,233 94,238 SH   SOLE   94,238 0 0
Intuitive Surgical, Inc. Common 46120E602 22,867 38,683 SH   SOLE   38,683 0 0
Ionis Pharmaceuticals, Inc. Common 462222100 12,682 209,924 SH   SOLE   209,924 0 0
Iovance Biotherapeutics, Inc. Common 462260100 6,740 243,483 SH   SOLE   243,483 0 0
IQVIA Holdings Inc. Common 46266C105 5,534 35,815 SH   SOLE   35,815 0 0
iShares Nasdaq Biotechnology ETF Nasdaq Biotech 464287556 4,680 38,834 SH   SOLE   38,834 0 0
Jazz Pharmaceuticals Public Limited Company Shares G50871105 12,789 85,673 SH   SOLE   85,673 0 0
Johnson & Johnson Common 478160104 133,738 916,827 SH   SOLE   916,827 0 0
Koninklijke Philips N.V. NY Reg Sh 500472303 2,084 42,700 SH   SOLE   42,700 0 0
Laboratory Corporation of America Holdings Sponsored ADR 50540R409 5,316 31,424 SH   SOLE   31,424 0 0
Ligand Pharmaceuticals Incorporated Common 53220K504 4,271 40,955 SH   SOLE   40,955 0 0
LTC Properties, Inc. Common 502175102 7,417 165,668 SH   SOLE   165,668 0 0
Madrigal Pharmaceuticals, Inc. Common 558868105 1,215 13,340 SH   SOLE   13,340 0 0
Magenta Therapeutics, Inc. Common 55910K108 254 16,757 SH   SOLE   16,757 0 0
Mallinckrodt public limited company Sponsored ADR G5785G107 115 32,980 SH   SOLE   32,980 0 0
Masimo Corporation Common 574795100 3,441 21,773 SH   SOLE   21,773 0 0
McKesson Corporation Common 58155Q103 9,312 67,325 SH   SOLE   67,325 0 0
Medical Properties Trust, Inc. Common 58463J304 7,901 374,289 SH   SOLE   374,289 0 0
The Medicines Company Common 584688105 10,250 120,670 SH   SOLE   120,670 0 0
Medpace Holdings, Inc. Common 58506Q109 1,586 18,871 SH   SOLE   18,871 0 0
Medtronic Public Limited Company Shares G5960L103 53,414 470,812 SH   SOLE   470,812 0 0
Merck & Co., Inc. Common 58933Y105 110,175 1,211,384 SH   SOLE   1,211,384 0 0
Merus N.V. Common N5749R100 299 21,215 SH   SOLE   21,215 0 0
Mettler-Toledo International Inc. Common 592688105 3,350 4,223 SH   SOLE   4,223 0 0
Milestone Pharmaceuticals Inc. Common 59935V107 11,954 746,653 SH   SOLE   746,653 0 0
Mirati Therapeutics, Inc. Common 60468T105 9,133 70,873 SH   SOLE   70,873 0 0
Molecular Templates, Inc. Common 608550109 592 42,313 SH   SOLE   42,313 0 0
MorphoSys AG Sponsored ADS 617760202 692 19,390 SH   SOLE   19,390 0 0
Mylan N.V. Shares N59465109 20,875 1,038,554 SH   SOLE   1,038,554 0 0
MyoKardia, Inc. Common 62857M105 1,407 19,300 SH   SOLE   19,300 0 0
Myriad Genetics, Inc. Common 62855J104 512 18,805 SH   SOLE   18,805 0 0
Nektar Therapeutics Common 640268108 6,123 283,679 SH   SOLE   283,679 0 0
Neurocrine Biosciences, Inc. Common 64125C109 20,750 193,042 SH   SOLE   193,042 0 0
New Senior Investment Group Inc. Common 648691103 1,209 158,047 SH   SOLE   158,047 0 0
Novartis AG Sponsored ADR 66987V109 19,984 211,047 SH   SOLE   211,047 0 0
Novavax, Inc. Common 670002401 114 28,550 SH   SOLE   28,550 0 0
Novo Nordisk A/S Sponsored ADR 670100205 12,813 221,364 SH   SOLE   221,364 0 0
NovoCure Limited Ordinary Shares G6674U108 9,054 107,438 SH   SOLE   107,438 0 0
Omega Healthcare Investors, Inc. Common 681936100 12,061 284,795 SH   SOLE   284,795 0 0
Ovid Therapeutics Inc. Sponsored ADR 690469101 1,547 372,733 SH   SOLE   372,733 0 0
Pacific Biosciences of California, Inc. Common 69404D108 2,547 495,495 SH   SOLE   495,495 0 0
PerkinElmer, Inc. Common 714046109 1,846 19,011 SH   SOLE   19,011 0 0
Perrigo Company Public Limited Company Shares G97822103 559 10,818 SH   SOLE   10,818 0 0
Pfizer Inc. Common 717081103 81,704 2,085,348 SH   SOLE   2,085,348 0 0
Physicians Realty Trust Common 71943U104 8,651 456,756 SH   SOLE   456,756 0 0
Pieris Pharmaceuticals, Inc. Common 720795103 5,246 1,449,269 SH   SOLE   1,449,269 0 0
Portola Pharmaceuticals, Inc. Sponsored ADR 737010108 3,866 161,899 SH   SOLE   161,899 0 0
PRA Health Sciences, Inc. Common 69354M108 17,006 153,003 SH   SOLE   153,003 0 0
PTC Therapeutics, Inc. Common 69366J200 4,771 99,327 SH   SOLE   99,327 0 0
Puma Biotechnology, Inc. Common 74587V107 624 71,340 SH   SOLE   71,340 0 0
Quest Diagnostics Incorporated Common 74834L100 2,245 21,025 SH   SOLE   21,025 0 0
Quorum Health Corporation Common 74909E106 23 23,725 SH   SOLE   23,725 0 0
Quotient Limited Common G73268107 2,473 260,030 SH   SOLE   260,030 0 0
Ra Pharmaceuticals, Inc. Common 74933V108 2,620 55,829 SH   SOLE   55,829 0 0
Reata Pharmaceuticals, Inc. Class A 75615P103 5,399 26,412 SH   SOLE   26,412 0 0
Regeneron Pharmaceuticals, Inc. Common 75886F107 75,575 201,277 SH   SOLE   201,277 0 0
REGENXBIO Inc. Common 75901B107 1,454 35,500 SH   SOLE   35,500 0 0
ResMed Inc. Common 761152107 4,304 27,775 SH   SOLE   27,775 0 0
Revance Therapeutics, Inc. Common 761330109 1,393 85,840 SH   SOLE   85,840 0 0
Rocket Pharmaceuticals, Inc. Common 77313F106 4,724 207,555 SH   SOLE   207,555 0 0
Rubius Therapeutics, Inc. Common 78116T103 650 68,373 SH   SOLE   68,373 0 0
Sabra Health Care REIT, Inc. Common 78573L106 9,950 466,247 SH   SOLE   466,247 0 0
Sage Therapeutics Inc Common 78667J108 6,945 96,211 SH   SOLE   96,211 0 0
Sangamo Therapeutics, Inc. Common 800677106 1,254 149,835 SH   SOLE   149,835 0 0
Sanofi Sponsored ADR 80105N105 9,369 186,640 SH   SOLE   186,640 0 0
Sarepta Therapeutics, Inc. Common 803607100 23,437 181,623 SH   SOLE   181,623 0 0
Seattle Genetics, Inc. Common 812578102 31,623 276,766 SH   SOLE   276,766 0 0
Smith & Nephew plc Shares 83175M205 4,786 99,560 SH   SOLE   99,560 0 0
SPDR S&P Biotech ETF S&P Biotech ETF 78464A870 6,471 68,037 SH   SOLE   68,037 0 0
Spectrum Pharmaceuticals, Inc. Common 84763A108 417 114,670 SH   SOLE   114,670 0 0
STERIS plc Shares G8473T100 2,254 14,790 SH   SOLE   14,790 0 0
Stryker Corporation Common 863667101 23,863 113,667 SH   SOLE   113,667 0 0
Sutro Biopharma, Inc. Common 869367102 7,054 641,268 SH   SOLE   641,268 0 0
Syneos Health, Inc. Class A 87166B102 6,890 115,842 SH   SOLE   115,842 0 0
Takeda Pharmaceutical Company Limited Sponsored ADS 874060205 4,146 210,146 SH   SOLE   210,146 0 0
Teleflex Incorporated Common 879369106 5,875 15,608 SH   SOLE   15,608 0 0
Tenet Healthcare Corporation Common 88033G407 4,314 113,436 SH   SOLE   113,436 0 0
Tetraphase Pharmaceuticals, Inc. Common 88165N204 121 42,965 SH   SOLE   42,965 0 0
Teva Pharmaceutical Industries Limited Sponsored ADR 881624209 7,701 785,851 SH   SOLE   785,851 0 0
Theravance Biopharma, Inc. Common G8807B106 3,048 117,725 SH   SOLE   117,725 0 0
Thermo Fisher Scientific Inc. Common 883556102 40,092 123,408 SH   SOLE   123,408 0 0
Trillium Therapeutics Inc. Common 89620X506 459 446,099 SH   SOLE   446,099 0 0
Turning Point Therapeutics, Inc. Common 90041T108 354 5,677 SH   SOLE   5,677 0 0
Ultragenyx Pharmaceutical Inc. Common 90400D108 4,163 97,480 SH   SOLE   97,480 0 0
uniQure N.V. Shares N90064101 5,102 71,191 SH   SOLE   71,191 0 0
United Therapeutics Corporation Class B 91307C102 4,765 54,094 SH   SOLE   54,094 0 0
Unitedhealth Group Incorporated Common 91324P102 73,151 248,829 SH   SOLE   248,829 0 0
Universal Health Realty Income Trust Shares 91359E105 674 5,742 SH   SOLE   5,742 0 0
Ventas, Inc. Common 92276F100 11,051 191,388 SH   SOLE   191,388 0 0
Verona Pharma plc Sponsored ADR 925050106 1,581 275,000 SH   SOLE   275,000 0 0
Vertex Pharmaceuticals Incorporated Common 92532F100 108,115 493,789 SH   SOLE   493,789 0 0
WaVe Life Sciences Ltd. Shares Y95308105 802 100,012 SH   SOLE   100,012 0 0
Welltower Inc. Common 95040Q104 15,673 191,646 SH   SOLE   191,646 0 0
Xencor, Inc. Common 98401F105 5,098 148,231 SH   SOLE   148,231 0 0
Xenon Pharmaceuticals Inc. Common 98420N105 1,271 96,961 SH   SOLE   96,961 0 0
Y-mAbs Therapeutics, Inc. Common 984241109 354 11,326 SH   SOLE   11,326 0 0
Zai Lab Limited ADR 98887Q104 1,561 37,523 SH   SOLE   37,523 0 0
Zimmer Biomet Holdings, Inc. Common 98956P102 9,530 63,671 SH   SOLE   63,671 0 0
Zoetis Inc. Class A 98978V103 25,197 190,384 SH   SOLE   190,384 0 0
Zogenix, Inc. Common 98978L204 5,615 107,703 SH   SOLE   107,703 0 0
Zymeworks Inc. Common 98985W102 691 15,192 SH   SOLE   15,192 0 0