The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACLARIS THERAPEUTICS INC COM 00461U105 3,568 1,888,039 SH   DFND 1 1,888,039 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 8,987 83,100 SH   DFND 1 83,100 0 0
AMARIN CORP PLC SPONS ADR NEW 023111206 22,496 1,049,244 SH   DFND 1 1,049,244 0 0
ANAPTYSBIO INC COM 032724106 3,601 221,600 SH   DFND 1 221,600 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 8,104 400,000 SH   DFND 1 400,000 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 7,769 1,029,012 SH   DFND 1 1,029,012 0 0
BIODELIVERY SCIENCES INTL IN COM 09060J106 27,176 4,300,066 SH   DFND 1 4,300,066 0 0
DERMIRA INC COM 24983L104 13,588 896,334 SH   DFND 1 896,334 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 18,422 1,236,368 SH   DFND 1 1,236,368 0 0
EXICURE INC COM 30205M101 7,744 2,707,851 SH   DFND 1 2,707,851 0 0
HERON THERAPEUTICS INC COM 427746102 2,109 89,730 SH   DFND 1 89,730 0 0
ICU MED INC COM 44930G107 5,614 30,000 SH   DFND 1 30,000 0 0
INTERSECT ENT INC COM 46071F103 15,712 631,023 SH   DFND 1 631,023 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 14,762 533,301 SH   DFND 1 533,301 0 0
ISHARES TR RUSSELL 2000 ETF 464287655 132,536 800,000 SH Put DFND 1 800,000 0 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 10,564 2,688,068 SH   DFND 1 2,688,068 0 0
LANTHEUS HLDGS INC COM 516544103 12,674 617,953 SH   DFND 1 617,953 0 0
LUMINEX CORP DEL COM 55027E102 4,807 207,553 SH   DFND 1 207,553 0 0
NANOSTRING TECHNOLOGIES INC COM 63009R109 15,457 555,600 SH   DFND 1 555,600 0 0
PALATIN TECHNOLOGIES INC COM PAR $ .01 696077403 819 1,047,310 SH   DFND 1 1,047,310 0 0
PROGENICS PHARMACEUTICALS IN COM 743187106 15,580 3,060,923 SH   DFND 1 3,060,923 0 0
RECRO PHARMA INC COM 75629F109 13,217 721,073 SH   DFND 1 721,073 0 0
RELMADA THERAPEUTICS INC COM 75955J402 8,608 220,724 SH   DFND 1 220,724 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 141,618 440,000 SH Put DFND 1 440,000 0 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 33,289 350,000 SH Put DFND 1 350,000 0 0
SCYNEXIS INC COM 811292101 1,820 2,000,000 SH   DFND 1 2,000,000 0 0
SIENTRA INC COM 82621J105 11,506 1,286,987 SH   DFND 1 1,286,987 0 0
STAAR SURGICAL CO COM PAR $0.01 852312305 16,253 462,118 SH   DFND 1 462,118 0 0
STRATA SKIN SCIENCES INC COM NEW 86272A206 3,826 1,839,372 SH   DFND 1 1,839,372 0 0
VAPOTHERM INC COM 922107107 12,198 1,003,099 SH   DFND 1 1,003,099 0 0
VERICEL CORP COM 92346J108 10,791 620,199 SH   DFND 1 620,199 0 0
VIEWRAY INC COM 92672L107 23,524 5,574,366 SH   DFND 1 5,574,366 0 0
ZOGENIX INC COM NEW 98978L204 7,034 134,937 SH   DFND 1 134,937 0 0
ALKERMES PLC SHS G01767105 21,083 1,033,500 SH   DFND 1 1,033,500 0 0
ALKERMES PLC SHS G01767105 4,080 200,000 SH Call DFND 1 200,000 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 22,284 409,338 SH   DFND 1 409,338 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 32,664 600,000 SH Call DFND 1 600,000 0 0
QUOTIENT LTD SHS G73268107 18,965 1,994,183 SH   DFND 1 1,994,183 0 0
SOL GEL TECHNOLOGIES SHS M8694L103 8,949 521,819 SH   DFND 1 521,819 0 0
MYLAN N V SHS EURO N59465109 3,015 150,000 SH   DFND 1 150,000 0 0