The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2U INC COM 90214J101 803 33,488 SH   DFND   0 0 33,488
ABIOMED INC COM 003654100 25,448 149,174 SH   DFND   0 0 149,174
ACACIA COMMUNICATIONS INC COM 00401C108 1,066 15,723 SH   DFND   0 0 15,723
ACCEL ENTMT INC COM CL A1 00436Q106 30 2,400 SH   DFND   0 0 2,400
ACTIVISION BLIZZARD INC COM 00507V109 1,276 21,468 SH   DFND   0 0 21,468
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 23,493 785,198 SH   DFND   0 0 785,198
ADESTO TECHNOLOGIES CORP COM 00687D101 12,889 1,516,387 SH   DFND   0 0 1,516,387
ADOBE INC COM 00724F101 53,726 162,901 SH   DFND   0 0 162,901
ADYEN NV 144A COM N3501V104 82,859 100,980 SH   DFND   0 0 100,980
AEROJET ROCKETDYNE HLDGS INC COM 007800105 44,108 966,002 SH   DFND   0 0 966,002
AFTERPAY TOUCH GROUP LTD ISIN AU000000APT1 SEDOL BF5L8B9 COM Q3583G105 1,044 50,706 SH   DFND   0 0 50,706
AFYA LTD CL A COM G01125106 9,245 340,909 SH   DFND   0 0 340,909
ALASKA COMMUNICATIONS SYS GR COM 01167P101 2,133 1,204,843 SH   DFND   0 0 1,204,843
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 77,808 366,847 SH   DFND   0 0 366,847
ALLAKOS INC COM 01671P100 33,733 353,743 SH   DFND   0 0 353,743
ALLEGIANT TRAVEL CO COM 01748X102 15,700 90,211 SH   DFND   0 0 90,211
ALLOGENE THERAPEUTICS INC COM 019770106 57 2,182 SH   DFND   0 0 2,182
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 107,854 936,479 SH   DFND   0 0 936,479
ALPHABET INC CAP STK CL A 02079K305 59,110 44,132 SH   DFND   0 0 44,132
ALPHABET INC CAP STK CL C 02079K107 66,430 49,685 SH   DFND   0 0 49,685
ALTERYX INC COM CL A 02156B103 959 9,586 SH   DFND   0 0 9,586
ALTIUS MINERALS CORP COM ISIN CA0209361009 SEDOL 2122355 COM 020936100 6,506 705,369 SH   DFND   0 0 705,369
ALTUS MIDSTREAM CO CL A 02215L100 6,084 2,127,206 SH   DFND   0 0 2,127,206
AMAZON COM INC COM 023135106 366,716 198,457 SH   DFND   0 0 198,457
AMERICAN TOWER CORP NEW COM 03027X100 18,688 81,315 SH   DFND   0 0 81,315
AMERICOLD RLTY TR COM 03064D108 2,353 67,104 SH   DFND   0 0 67,104
AMYRIS INC COM NEW 03236M200 157 50,942 SH   DFND   0 0 50,942
ANAPLAN INC COM 03272L108 14,576 278,174 SH   DFND   0 0 278,174
ANTERIX INC COM 03676C100 260 6,013 SH   DFND   0 0 6,013
APACHE CORP COM 037411105 7,514 293,619 SH   DFND   0 0 293,619
APPFOLIO INC COM CL A 03783C100 53,136 483,271 SH   DFND   0 0 483,271
APPIAN CORP CL A 03782L101 1,688 44,178 SH   DFND   0 0 44,178
APPLE INC COM 037833100 8,152 27,759 SH   DFND   0 0 27,759
APPLIED OPTOELECTRONICS INC COM 03823U102 85 7,115 SH   DFND   0 0 7,115
APTOSE BIOSCIENCES INC COM NEW 03835T200 1 125 SH   DFND   0 0 125
ARCO PLATFORM LTD COM CL A G04553106 17,700 400,463 SH   DFND   0 0 400,463
ARCUS BIOSCIENCES INC COM 03969F109 216 21,356 SH   DFND   0 0 21,356
ARGENX SE SPONSORED ADR 04016X101 995 6,198 SH   DFND   0 0 6,198
ARISTA NETWORKS INC COM 040413106 83,576 410,895 SH   DFND   0 0 410,895
ARITZIA INC SUB VTG SHS ISIN CA04045U1021 SEDOL BDCG2C2 COM 04045U102 11,864 807,610 SH   DFND   0 0 807,610
ATLASSIAN CORP PLC CL A G06242104 22,450 186,553 SH   DFND   0 0 186,553
AUDENTES THERAPEUTICS INC COM 05070R104 11,805 197,272 SH   DFND   0 0 197,272
AUDENTES THERAPEUTICS INC COM TENDER FROM CUSIP 05070R104 COM 050991405 37,303 623,376 SH   DFND   0 0 623,376
AUTO TRADER GROUP PLC ORD GBP001 ISIN GB00BVYVFW23 SEDOL BVYV COM G06708104 5,286 671,071 SH   DFND   0 0 671,071
AUTODESK INC COM 052769106 115,398 629,009 SH   DFND   0 0 629,009
AXIS BANK GDR EACH REPR 1 INR10 REG S ISIN US05462W1099 SEDOL COM 05462W109 801 15,085 SH   DFND   0 0 15,085
AXOGEN INC COM 05463X106 21,275 1,189,193 SH   DFND   0 0 1,189,193
AZUL S A SPONSR ADR PFD 05501U106 146,696 3,427,488 SH   DFND   0 0 3,427,488
BANK AMER CORP COM 060505104 2 50 SH   DFND   0 0 50
BARCLAYS BK PLC IPATH B SHRT TRM 06746P621 170 11,241 SH   DFND   0 0 11,241
BERKLEY W R CORP COM 084423102 6,124 88,627 SH   DFND   0 0 88,627
BERKSHIRE HATHAWAY INC DEL CL B NEW 084670702 724 3,198 SH   DFND   0 0 3,198
BEYOND MEAT INC COM 08862E109 15,304 202,440 SH   DFND   0 0 202,440
BLUEBIRD BIO INC COM 09609G100 44,762 510,113 SH   DFND   0 0 510,113
BLUEPRINT MEDICINES CORP COM 09627Y109 0 4 SH   DFND   0 0 4
BOOT BARN HLDGS INC COM 099406100 1,775 39,870 SH   DFND   0 0 39,870
BOSTON SCIENTIFIC CORP COM 101137107 1,882 41,618 SH   DFND   0 0 41,618
BRIGHTCOVE INC COM 10921T101 213 24,533 SH   DFND   0 0 24,533
CALIX INC COM 13100M509 1,038 129,728 SH   DFND   0 0 129,728
CARGOJET INC COMMON AND VARIABLE VOTING SHARES ISIN CA14179V503 COM 14179V503 12,431 156,004 SH   DFND   0 0 156,004
CARL ZEISS MEDITEC AG NPV ISIN DE0005313704 SEDOL 5922961 COM D14895102 2,217 17,374 SH   DFND   0 0 17,374
CARROLS RESTAURANT GROUP INC COM 14574X104 3,220 456,749 SH   DFND   0 0 456,749
CARVANA CO CL A 146869102 92,244 1,002,108 SH   DFND   0 0 1,002,108
CATAPULT GROUP INTERNATIONAL ISIN AU000000CAT9 SEDOL BTL0Y76 COM Q2159P101 209 188,098 SH   DFND   0 0 188,098
CELLNEX TELECOM SAU EUR025 144A REG S ISIN ES0105066007 SEDOL COM E2R41M104 2,948 68,442 SH   DFND   0 0 68,442
CHART INDS INC COM PAR $0.01 16115Q308 5,377 79,676 SH   DFND   0 0 79,676
CHEGG INC COM 163092109 158,922 4,192,099 SH   DFND   0 0 4,192,099
CHEWY INC CL A 16679L109 1 20 SH   DFND   0 0 20
CHIPOTLE MEXICAN GRILL INC COM 169656105 1 1 SH   DFND   0 0 1
CITIGROUP INC COM NEW 172967424 3 35 SH   DFND   0 0 35
CLOUDFLARE INC CL A COM 18915M107 48,501 2,842,938 SH   DFND   0 0 2,842,938
CODEXIS INC COM 192005106 44,598 2,789,143 SH   DFND   0 0 2,789,143
COLLATERAL DELV TO BANK OF AMERICA NA SECURITIES ON LOAN NOT COV COM L0C990089 0 1,265,601 SH   DFND   0 0 1,265,601
CONTROLADORA VUELA CIA DE AV SPON ADR RP 10 21240E105 13,510 1,296,543 SH   DFND   0 0 1,296,543
CORECIVIC INC COM 21871N101 140 8,079 SH   DFND   0 0 8,079
COUPA SOFTWARE INC COM 22266L106 24,992 170,888 SH   DFND   0 0 170,888
COVANTA HLDG CORP COM 22282E102 11,041 744,007 SH   DFND   0 0 744,007
COVETRUS INC COM 22304C100 0 8 SH   DFND   0 0 8
CRIMSON WINE GROUP COM USD001 COM 22662X100 661 89,338 SH   DFND   0 0 89,338
CROWDSTRIKE HLDGS INC CL A 22788C105 5,215 104,574 SH   DFND   0 0 104,574
DATADOG INC CL A COM 23804L103 3,717 98,389 SH   DFND   0 0 98,389
DEERE & CO COM 244199105 17 100 SH   DFND   0 0 100
DEXCOM INC COM 252131107 141,320 646,063 SH   DFND   0 0 646,063
DIAMONDBACK ENERGY INC COM 25278X109 2,556 27,526 SH   DFND   0 0 27,526
DIGI INTL INC COM 253798102 1,155 65,162 SH   DFND   0 0 65,162
DISNEY WALT CO COM DISNEY 254687106 15,184 104,982 SH   DFND   0 0 104,982
DOCUSIGN INC COM 256163106 2,709 36,554 SH   DFND   0 0 36,554
DOWNEY FINL CORP COM 261018105 0 200 SH   DFND   0 0 200
EHEALTH INC COM 28238P109 20,376 212,071 SH   DFND   0 0 212,071
EIDOS THERAPEUTICS INC COM 28249H104 21,158 368,664 SH   DFND   0 0 368,664
ELASTIC N V ORD SHS N14506104 7,355 114,383 SH   DFND   0 0 114,383
ELECTRONIC ARTS INC COM 285512109 220 2,049 SH   DFND   0 0 2,049
ENPHASE ENERGY INC COM 29355A107 97,129 3,717,133 SH   DFND   0 0 3,717,133
ENTERCOM COMMUNICATIONS CORP CL A 293639100 2,548 549,231 SH   DFND   0 0 549,231
EPAM SYS INC COM 29414B104 108,661 512,165 SH   DFND   0 0 512,165
EQUATOR EXPLORATION COM STK NPV COM G3084F128 0 215,000 SH   DFND   0 0 215,000
EROS INTL PLC SHS NEW G3788M114 371 109,294 SH   DFND   0 0 109,294
ESPERION THERAPEUTICS INC NE COM 29664W105 68 1,132 SH   DFND   0 0 1,132
ETSY INC COM 29786A106 69,097 1,559,756 SH   DFND   0 0 1,559,756
EXACT SCIENCES CORP COM 30063P105 161,859 1,750,209 SH   DFND   0 0 1,750,209
FACEBOOK INC CL A 30303M102 76,975 375,030 SH   DFND   0 0 375,030
FASTLY INC CL A 31188V100 11,261 561,104 SH   DFND   0 0 561,104
FERGUSON PLC ORD GBP010 ISIN JE00BJVNSS43 SEDOL BJVNSS4 COM G3421J106 12,033 132,601 SH   DFND   0 0 132,601
FIVE BELOW INC COM 33829M101 85,920 671,982 SH   DFND   0 0 671,982
FLEX LNG LTD BM USD010 ISIN BMG359472021 SEDOL BJJMGB2 COM ZZCKKNHC2 2,686 259,415 SH   DFND   0 0 259,415
FLEXION THERAPEUTICS INC COM 33938J106 8,882 429,101 SH   DFND   0 0 429,101
FLOOR & DECOR HLDGS INC CL A 339750101 5,422 106,715 SH   DFND   0 0 106,715
FORESCOUT TECHNOLOGIES INC COM 34553D101 10,694 326,031 SH   DFND   0 0 326,031
FORTESCUE METALS GROUP LTD NPV ISIN AU000000FMG4 SEDOL 6086253 COM Q39360104 13,346 1,776,078 SH   DFND   0 0 1,776,078
FOUR SEAS MERCANTILE HLDGS HKD010 ISIN KYG365451049 SEDOL 634 COM G36545104 101 270,000 SH   DFND   0 0 270,000
FRANCO NEVADA CORP COM 351858105 7,901 76,486 SH   DFND   0 0 76,486
FRESHPET INC COM 358039105 142,609 2,413,426 SH   DFND   0 0 2,413,426
FRIENDLY ENERGY EXPLORATION COM NPV COM 35846A200 0 690 SH   DFND   0 0 690
GALAPAGOS NV NPV ISIN BE0003818359 SEDOL B07Q2V5 COM B44170106 140,996 673,508 SH   DFND   0 0 673,508
GASLOG LTD SHS G37585109 398 40,625 SH   DFND   0 0 40,625
GEOPARK LTD USD SHS G38327105 9,348 422,984 SH   DFND   0 0 422,984
GLAUKOS CORP COM 377322102 77,363 1,420,280 SH   DFND   0 0 1,420,280
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 4,114 51,755 SH   DFND   0 0 51,755
GLOBANT S A COM L44385109 78,461 739,846 SH   DFND   0 0 739,846
GOL LINHAS AEREAS INTLG S A SPON ADR PFD NEW 38045R206 6,946 384,374 SH   DFND   0 0 384,374
GOLAR LNG LTD BERMUDA SHS G9456A100 365 25,662 SH   DFND   0 0 25,662
GOLDEN MINERALS CO COM 381119106 15 47,167 SH   DFND   0 0 47,167
GOLDMAN SACHS GROUP INC COM 38141G104 86,802 377,517 SH   DFND   0 0 377,517
GOOSEHEAD INS INC COM CL A 38267D109 712 16,792 SH   DFND   0 0 16,792
GRACE W R & CO DEL NEW COM 38388F108 2,114 30,267 SH   DFND   0 0 30,267
GTT COMMUNICATIONS INC COM 362393100 14,794 1,303,414 SH   DFND   0 0 1,303,414
GUARDANT HEALTH INC COM 40131M109 53 676 SH   DFND   0 0 676
HDFC BANK LTD SPONSORED ADS 40415F101 52,409 827,029 SH   DFND   0 0 827,029
HEALTH INS INNOVATIONS INC COM CL A 42225K106 250 12,971 SH   DFND   0 0 12,971
HEALTHEQUITY INC COM 42226A107 4,956 66,908 SH   DFND   0 0 66,908
HEARUSA INC NEW COM 422360305 0 375 SH   DFND   0 0 375
HEICO CORP NEW CL A 422806208 5,748 64,199 SH   DFND   0 0 64,199
HEICO CORP NEW COM 422806109 149 1,309 SH   DFND   0 0 1,309
HOWARD HUGHES CORP COM 44267D107 465 3,669 SH   DFND   0 0 3,669
HUBSPOT INC COM 443573100 113,091 713,507 SH   DFND   0 0 713,507
ICICI BK LTD ADR 45104G104 6,231 412,898 SH   DFND   0 0 412,898
ILLUMINA INC COM 452327109 37,677 113,575 SH   DFND   0 0 113,575
IMPINJ INC COM 453204109 1,176 45,467 SH   DFND   0 0 45,467
INPHI CORP COM 45772F107 659 8,909 SH   DFND   0 0 8,909
INSPIRE MED SYS INC COM 457730109 37,787 509,184 SH   DFND   0 0 509,184
INSULET CORP COM 45784P101 3,306 19,311 SH   DFND   0 0 19,311
INTERBREW PLC GDREACH REPR 1 A SH REG S USD ISIN US86677C302 COM 86677C302 0 200 SH   DFND   0 0 200
INTUITIVE SURGICAL INC COM NEW 46120E602 114,316 193,379 SH   DFND   0 0 193,379
INVITAE CORP COM 46185L103 77,778 4,821,977 SH   DFND   0 0 4,821,977
IRHYTHM TECHNOLOGIES INC COM 450056106 24,704 362,818 SH   DFND   0 0 362,818
JPMORGAN CHASE & CO COM 46625H100 2,377 17,053 SH   DFND   0 0 17,053
KARUNA THERAPEUTICS INC COM 48576A100 678 9,002 SH   DFND   0 0 9,002
KB HOME COM 48666K109 287 8,376 SH   DFND   0 0 8,376
KIRKLAND LAKE GOLD LTD COM 49741E100 17,588 399,092 SH   DFND   0 0 399,092
KORNIT DIGITAL LTD SHS M6372Q113 35,307 1,031,464 SH   DFND   0 0 1,031,464
KRATOS DEFENSE & SEC SOLUTIO COM NEW 50077B207 2,979 165,411 SH   DFND   0 0 165,411
KRYSTAL BIOTECH INC COM 501147102 1 22 SH   DFND   0 0 22
KURA SUSHI USA INC CL A COM 501270102 6,707 263,530 SH   DFND   0 0 263,530
LGI HOMES INC COM 50187T106 94,994 1,344,571 SH   DFND   0 0 1,344,571
LHC GROUP INC COM 50187A107 2,342 17,004 SH   DFND   0 0 17,004
LIBERTY MEDIA CORP DELAWARE COM A BRAVES GRP 531229706 4,495 151,605 SH   DFND   0 0 151,605
LIBERTY MEDIA CORP DELAWARE COM C BRAVES GRP 531229888 17,514 592,876 SH   DFND   0 0 592,876
LIBERTY MEDIA CORP DELAWARE COM SER C FRMLA 531229854 4,316 93,899 SH   DFND   0 0 93,899
LIVEPERSON INC COM 538146101 97,370 2,631,610 SH   DFND   0 0 2,631,610
LIVONGO HEALTH INC COM 539183103 841 33,550 SH   DFND   0 0 33,550
LONZA GROUP AGREG ISIN CH0013841017 SEDOL 7333378 COM H50524133 39,311 106,777 SH   DFND   0 0 106,777
LOVESAC COMPANY COM 54738L109 460 28,630 SH   DFND   0 0 28,630
LUCKIN COFFEE INC SPONSORED ADS 54951L109 1,217 30,932 SH   DFND   0 0 30,932
LULULEMON ATHLETICA INC COM 550021109 12,594 54,363 SH   DFND   0 0 54,363
LUMENTUM HLDGS INC COM 55024U109 768 9,680 SH   DFND   0 0 9,680
LYFT INC CL A COM 55087P104 51,547 1,198,205 SH   DFND   0 0 1,198,205
MADISON SQUARE GARDEN CO NEW CL A 55825T103 3,768 12,809 SH   DFND   0 0 12,809
MAG SILVER CORP COM 55903Q104 17,085 1,442,963 SH   DFND   0 0 1,442,963
MAGENTA THERAPEUTICS INC COM 55910K108 62,208 4,103,425 SH   DFND   0 0 4,103,425
MAGNOLIA OIL & GAS CORP CL A 559663109 8,868 704,963 SH   DFND   0 0 704,963
MARTIN MARIETTA MATLS INC COM 573284106 127,950 457,552 SH   DFND   0 0 457,552
MASTEC INC COM 576323109 5,864 91,391 SH   DFND   0 0 91,391
MASTERCARD INC CL A 57636Q104 27,443 91,908 SH   DFND   0 0 91,908
MATCH GROUP INC COM 57665R106 84,963 1,034,752 SH   DFND   0 0 1,034,752
MAYVILLE ENGINEERING CO INC COM 578605107 1,201 127,993 SH   DFND   0 0 127,993
MERCADOLIBRE INC COM 58733R102 90,092 157,520 SH   DFND   0 0 157,520
MICROSOFT CORP COM 594918104 94,986 602,322 SH   DFND   0 0 602,322
MISONIX INC COM 604871103 3,459 185,883 SH   DFND   0 0 185,883
MOLECULAR TEMPLATES INC COM 608550109 13,376 956,422 SH   DFND   0 0 956,422
MONGODB INC CL A 60937P106 138,986 1,056,045 SH   DFND   0 0 1,056,045
MONOLITHIC PWR SYS INC COM 609839105 17,271 97,019 SH   DFND   0 0 97,019
NATERA INC COM 632307104 38,954 1,156,246 SH   DFND   0 0 1,156,246
NEOPHOTONICS CORP COM 64051T100 1,129 128,051 SH   DFND   0 0 128,051
NETFLIX INC COM 64110L106 421,286 1,301,994 SH   DFND   0 0 1,301,994
NEW PACIFIC METALS CORP COM NPV ISIN CA6478241012 SEDOL BF4CP8 COM 647824101 8,099 1,777,004 SH   DFND   0 0 1,777,004
NEW YORK TIMES CO CL A 650111107 100,767 3,132,317 SH   DFND   0 0 3,132,317
NIKE INC CL B 654106103 9,409 92,873 SH   DFND   0 0 92,873
NINTENDO CO LTD ADR8 CNV INTO 1 ORDNPV COM 654445303 2,094 41,394 SH   DFND   0 0 41,394
NOBLE MIDSTREAM PARTNERS LP COM UNIT REPST 65506L105 27 1,001 SH   DFND   0 0 1,001
NV5 GLOBAL INC COM 62945V109 197 3,899 SH   DFND   0 0 3,899
NVIDIA CORP COM 67066G104 42,528 180,739 SH   DFND   0 0 180,739
OCADO GROUP PLC ORD GBP002 ISIN GB00B3MBS747 SEDOL B3MBS74 COM G6718L106 203,028 11,982,585 SH   DFND   0 0 11,982,585
OKTA INC CL A 679295105 212,036 1,837,876 SH   DFND   0 0 1,837,876
OPTION CARE HEALTH INC COM 68404L102 57,864 15,513,046 SH   DFND   0 0 15,513,046
PAGERDUTY INC COM 69553P100 1,164 49,763 SH   DFND   0 0 49,763
PALO ALTO NETWORKS INC COM 697435105 4,483 19,387 SH   DFND   0 0 19,387
PALOMAR HLDGS INC COM 69753M105 4,944 97,927 SH   DFND   0 0 97,927
PARAMOUNT RESOURCES LIMITED COM NPV CLASS A ISIN CA6993202069 S COM 699320206 900 154,860 SH   DFND   0 0 154,860
PAYPAL HLDGS INC COM 70450Y103 23,273 215,153 SH   DFND   0 0 215,153
PDF SOLUTIONS INC COM 693282105 927 54,897 SH   DFND   0 0 54,897
PELOTON INTERACTIVE INC CL A COM 70614W100 90,665 3,192,417 SH   DFND   0 0 3,192,417
PENN TREATY AMERN CORP COM NEW COM 707874400 0 125 SH   DFND   0 0 125
PENSKE AUTOMOTIVE GRP INC COM 70959W103 3,442 68,547 SH   DFND   0 0 68,547
PENUMBRA INC COM 70975L107 2,145 13,056 SH   DFND   0 0 13,056
PIERIS PHARMACEUTICALS INC COM 720795103 269 74,376 SH   DFND   0 0 74,376
PINDUODUO INC SPONSORED ADS 722304102 601 15,903 SH   DFND   0 0 15,903
PINTEREST INC CL A 72352L106 1,608 86,286 SH   DFND   0 0 86,286
POOL CORPORATION COM 73278L105 78,981 371,885 SH   DFND   0 0 371,885
PREVAIL THERAPEUTICS INC COM 74140Y101 0 5 SH   DFND   0 0 5
PROLOGIS INC COM 74340W103 2,161 24,242 SH   DFND   0 0 24,242
PROOFPOINT INC COM 743424103 5,573 48,556 SH   DFND   0 0 48,556
Q2 HLDGS INC COM 74736L109 97,660 1,204,495 SH   DFND   0 0 1,204,495
QUANTERIX CORP COM 74766Q101 78,994 3,342,955 SH   DFND   0 0 3,342,955
QUOTIENT LTD SHS G73268107 5,315 558,851 SH   DFND   0 0 558,851
R1 RCM INC COM 749397105 4,684 360,901 SH   DFND   0 0 360,901
REDFIN CORP COM 75737F108 1,531 72,433 SH   DFND   0 0 72,433
REECE LIMITED NPV ISIN AU000000REH4 SEDOL 6728801 COM Q80528138 7,685 953,972 SH   DFND   0 0 953,972
RENALYTIX AI PLC ORD GBP00025 REG S REG S ISIN GB00BYWL4Y04 COM G7489R108 577 119,637 SH   DFND   0 0 119,637
REPLIGEN CORP COM 759916109 49,296 532,930 SH   DFND   0 0 532,930
RH COM 74967X103 651 3,047 SH   DFND   0 0 3,047
RIGHTMOVE ORD GBP0001 ISIN GB00BGDT3G23 SEDOL BGDT3G2 COM G7565D106 18,530 2,207,677 SH   DFND   0 0 2,207,677
RINGCENTRAL INC CL A 76680R206 193,871 1,149,408 SH   DFND   0 0 1,149,408
ROKU INC COM CL A 77543R102 410,166 3,063,225 SH   DFND   0 0 3,063,225
ROYAL GOLD INC COM 780287108 24 198 SH   DFND   0 0 198
SAFARICOM PLC KES005 ISIN KE1000001402 SEDOL B2QN3J6 COM V74587102 39,338 126,568,849 SH   DFND   0 0 126,568,849
SAFETY INS GROUP INC COM 78648T100 437 4,720 SH   DFND   0 0 4,720
SALESFORCE COM INC COM 79466L302 88,347 543,206 SH   DFND   0 0 543,206
SAREPTA THERAPEUTICS INC COM 803607100 121,789 943,811 SH   DFND   0 0 943,811
SCORPIO BULKERS INC COM Y7546A122 341 53,529 SH   DFND   0 0 53,529
SCORPIO TANKERS INC SHS Y7542C130 524 13,317 SH   DFND   0 0 13,317
SEMLER SCIENTIFIC INC COM USD0001 COM 81684M104 4,519 94,145 SH   DFND   0 0 94,145
SENESTECH INC COM 81720R109 625 1,136,787 SH   DFND   0 0 1,136,787
SENSEONICS HLDGS INC COM 81727U105 14,455 15,780,806 SH   DFND   0 0 15,780,806
SERVICENOW INC COM 81762P102 28,401 100,600 SH   DFND   0 0 100,600
SHAKE SHACK INC CL A 819047101 134,379 2,255,820 SH   DFND   0 0 2,255,820
SHERWIN WILLIAMS CO COM 824348106 1,158 1,984 SH   DFND   0 0 1,984
SHOCKWAVE MED INC COM 82489T104 89,799 2,044,597 SH   DFND   0 0 2,044,597
SHOPIFY INC CL A 82509L107 189,497 476,627 SH   DFND   0 0 476,627
SHOTSPOTTER INC COM 82536T107 54,129 2,122,718 SH   DFND   0 0 2,122,718
SI BONE INC COM 825704109 23,422 1,089,382 SH   DFND   0 0 1,089,382
SILK ROAD MEDICAL INC COM 82710M100 5,358 132,680 SH   DFND   0 0 132,680
SILVERCREST METALS INC COM 828363101 67,651 10,037,285 SH   DFND   0 0 10,037,285
SINTX TECHNOLOGIES INC COM NEW 829392307 0 72 SH   DFND   0 0 72
SITEONE LANDSCAPE SUPPLY INC COM 82982L103 26,899 296,739 SH   DFND   0 0 296,739
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SIX FLAGS ENTMT CORP NEW COM 83001A102 3,442 76,310 SH   DFND   0 0 76,310
SLACK TECHNOLOGIES INC COM CL A 83088V102 43,411 1,931,097 SH   DFND   0 0 1,931,097
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SNAP INC CL A 83304A106 14,733 902,229 SH   DFND   0 0 902,229
SOLARIS OILFIELD INFRSTR INC COM CL A 83418M103 6,682 477,278 SH   DFND   0 0 477,278
SONOS INC COM 83570H108 9,667 618,868 SH   DFND   0 0 618,868
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STAR BULK CARRIERS CORP SHS PAR Y8162K204 286 24,226 SH   DFND   0 0 24,226
STITCH FIX INC COM CL A 860897107 17,645 687,628 SH   DFND   0 0 687,628
STOKE THERAPEUTICS INC COM 86150R107 51,738 1,826,890 SH   DFND   0 0 1,826,890
STONECO LTD COM CL A G85158106 50,477 1,265,407 SH   DFND   0 0 1,265,407
SUNRUN INC COM 86771W105 259 18,731 SH   DFND   0 0 18,731
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SVB FINL GROUP COM 78486Q101 10,803 43,032 SH   DFND   0 0 43,032
T MOBILE US INC COM 872590104 98,510 1,256,187 SH   DFND   0 0 1,256,187
TACTILE SYS TECHNOLOGY INC COM 87357P100 5,309 78,641 SH   DFND   0 0 78,641
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 145 2,501 SH   DFND   0 0 2,501
TAL EDUCATION GROUP SPONSORED ADS 874080104 58,834 1,220,617 SH   DFND   0 0 1,220,617
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TANDEM DIABETES CARE INC COM NEW 875372203 73,414 1,231,566 SH   DFND   0 0 1,231,566
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TENCENT HOLDINGS LIMITED HKD000002 ISIN KYG875721634 SEDOL BM COM G87572163 66,159 1,372,454 SH   DFND   0 0 1,372,454
TESLA INC COM 88160R101 232,639 556,114 SH   DFND   0 0 556,114
THE A2 MILK COMPANY LTD NPV ISIN NZATME0002S8 SEDOL BWSRTS7 COM ZZCXTSUT2 2,017 200,665 SH   DFND   0 0 200,665
THOR INDS INC COM 885160101 9,293 125,097 SH   DFND   0 0 125,097
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TRANSDIGM GROUP INC COM 893641100 8,727 15,584 SH   DFND   0 0 15,584
TRUPANION INC COM 898202106 17,260 460,762 SH   DFND   0 0 460,762
TWILIO INC CL A 90138F102 7,984 81,233 SH   DFND   0 0 81,233
TWIST BIOSCIENCE CORP COM 90184D100 4,697 223,676 SH   DFND   0 0 223,676
TWITTER INC COM 90184L102 2,568 80,139 SH   DFND   0 0 80,139
UBER TECHNOLOGIES INC COM 90353T100 1,279 42,994 SH   DFND   0 0 42,994
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VANECK VECTORS ETF TRUST GOLD MINERS ETF 92189F106 12,160 415,285 SH   DFND   0 0 415,285
VEEVA SYS INC CL A COM 922475108 13,448 95,604 SH   DFND   0 0 95,604
VERACYTE INC COM 92337F107 105,313 3,771,959 SH   DFND   0 0 3,771,959
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VIRGIN GALACTIC HOLDINGS INC UNIT 99/99/9999 92766K205 2,137 168,292 SH   DFND   0 0 168,292
VULCAN MATLS CO COM 929160109 5,214 36,208 SH   DFND   0 0 36,208
WAYFAIR INC CL A 94419L101 1,025 11,345 SH   DFND   0 0 11,345
WHEATON PRECIOUS METALS CORP COM 962879102 2,369 79,639 SH   DFND   0 0 79,639
WILLSCOT CORP COM 971375126 378 20,420 SH   DFND   0 0 20,420
WORKDAY INC CL A 98138H101 29,075 176,799 SH   DFND   0 0 176,799
WORLD WRESTLING ENTMT INC CL A 98156Q108 60,729 936,166 SH   DFND   0 0 936,166
WUXI BIOLOGICS CAYMAN INC USD0000025 144A REG S ISIN KYG9700 COM G97008109 18,350 1,449,371 SH   DFND   0 0 1,449,371
XP INC CL A G98239109 23,109 599,931 SH   DFND   0 0 599,931
YETI HLDGS INC COM 98585X104 2,453 70,529 SH   DFND   0 0 70,529
ZAI LAB LTD ADR 98887Q104 49,126 1,181,186 SH   DFND   0 0 1,181,186
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