The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CL A COM 88025U109 9,846 129,127 SH   DFND 2 129,127 0 0
ABBOTT LABS COM 002824100 115,126 1,325,420 SH   DFND 2 1,325,420 0 0
ABBVIE INC COM 00287Y109 3,763 42,500 SH   DFND 2 42,500 0 0
ABIOMED INC COM 003654100 14,984 87,839 SH   DFND 2 87,839 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 1,711 40,000 SH   DFND 2 40,000 0 0
ACCELERON PHARMA INC COM 00434H108 1,283 24,200 SH   DFND 2 24,200 0 0
ADOBE INC COM 00724F101 495 1,500 SH   DFND 2 1,500 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 1,536 18,000 SH   DFND 2 18,000 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 1,337 28,000 SH   DFND 2 28,000 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 186,080 3,896,954 SH   DFND 1,2 3,896,954 0 0
AKCEA THERAPEUTICS INC COM 00972L107 12,090 713,695 SH   DFND 2 713,695 0 0
AKCEA THERAPEUTICS INC COM 00972L107 41,485 2,448,948 SH   DFND 1,2 2,448,948 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 8,057 74,500 SH   DFND 2 74,500 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 142,155 1,314,428 SH   DFND 1,2 1,314,428 0 0
ALIGN TECHNOLOGY INC COM 016255101 77,769 278,703 SH   DFND 2 278,703 0 0
ALKERMES PLC SHS G01767105 3,435 168,400 SH   DFND 2 168,400 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 30,495 264,783 SH   DFND 2 264,783 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 184,272 1,600,000 SH   DFND 1,2 1,600,000 0 0
AMEDISYS INC COM 023436108 8,908 53,365 SH   DFND 2 53,365 0 0
AMERICAN EXPRESS CO COM 025816109 448 3,600 SH   DFND 2 3,600 0 0
AMGEN INC COM 031162100 9,727 40,350 SH   DFND 2 40,350 0 0
AMNEAL PHARMACEUTICALS INC COM STK CL A 03168L105 1,446 300,000 SH   DFND 2 300,000 0 0
ANALOG DEVICES INC COM 032654105 487 4,100 SH   DFND 2 4,100 0 0
ANSYS INC COM 03662Q105 464 1,802 SH   DFND 2 1,802 0 0
ANTHEM INC COM 036752103 98,212 325,174 SH   DFND 2 325,174 0 0
ARGENX SE SPONSORED ADR 04016X101 3,732 23,250 SH   DFND 2 23,250 0 0
ARGENX SE SPONSORED ADR 04016X101 152,338 944,739 SH   DFND 1,2 944,739 0 0
ARVINAS INC COM 04335A105 51,030 1,241,903 SH   DFND 1,2 1,241,903 0 0
ASPEN TECHNOLOGY INC COM 045327103 363 3,000 SH   DFND 2 3,000 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 736 12,300 SH   DFND 2 12,300 0 0
AUTOLIV INC COM 052800109 574 6,800 SH   DFND 2 6,800 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 821 62,200 SH   DFND 2 62,200 0 0
AVANTOR INC COM 05352A100 5,709 314,566 SH   DFND 2 314,566 0 0
BAXTER INTL INC COM 071813109 45,128 539,675 SH   DFND 2 539,675 0 0
BECTON DICKINSON & CO COM 075887109 68,540 252,012 SH   DFND 2 252,012 0 0
BEIGENE LTD SPONSORED ADR 07725L102 7,767 46,856 SH   DFND 2 46,856 0 0
BENEFITFOCUS INC COM 08180D106 1,985 90,463 SH   DFND 2 90,463 0 0
BIOGEN INC COM 09062X103 148 500 SH   DFND 2 500 0 0
BIOGEN INC COM 09062X103 8 160 SH Call DFND 2 160 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 1,236 22,700 SH   DFND 2 22,700 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 5,682 67,200 SH   DFND 2 67,200 0 0
BIO RAD LABS INC CL A 090572207 17,312 46,785 SH   DFND 2 46,785 0 0
BLACKBAUD INC COM 09227Q100 327 4,107 SH   DFND 2 4,107 0 0
BLUEBIRD BIO INC COM 09609G100 1,606 18,300 SH   DFND 2 18,300 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 1,618 20,200 SH   DFND 2 20,200 0 0
BOOKING HLDGS INC COM 09857L108 411 200 SH   DFND 2 200 0 0
BOSTON SCIENTIFIC CORP COM 101137107 71,385 1,578,621 SH   DFND 2 1,578,621 0 0
BRISTOL MYERS SQUIBB CO COM 110122108 82,756 1,289,242 SH   DFND 2 1,289,242 0 0
BRISTOL MYERS SQUIBB CO COM 110122108 51,352 800,000 SH   DFND 1,2 800,000 0 0
BRISTOL MYERS SQUIBB CO RIGHT 99/99/9999 110122157 50 16,600 SH   DFND 2 16,600 0 0
BRISTOL MYERS SQUIBB CO RIGHT 99/99/9999 110122157 2,408 800,000 SH   DFND 1,2 800,000 0 0
BROADRIDGE FINL SOLUTIONS IN COM 11133T103 420 3,400 SH   DFND 2 3,400 0 0
BROWN FORMAN CORP CL B 115637209 514 7,600 SH   DFND 2 7,600 0 0
CAREDX INC COM 14167L103 25,382 1,176,730 SH   DFND 2 1,176,730 0 0
CATALENT INC COM 148806102 1,931 34,300 SH   DFND 2 34,300 0 0
CENTENE CORP DEL COM 15135B101 46,562 740,611 SH   DFND 2 740,611 0 0
CERNER CORP COM 156782104 455 6,200 SH   DFND 2 6,200 0 0
CHANGE HEALTHCARE INC COM 15912K100 14,160 863,922 SH   DFND 2 863,922 0 0
CHARLES RIV LABS INTL INC COM 159864107 43,246 283,098 SH   DFND 2 283,098 0 0
CHINA BIOLOGIC PRODS HLDGS I COM G21515104 524 4,500 SH   DFND 2 4,500 0 0
CIDARA THERAPEUTICS INC COM 171757107 8,814 2,295,272 SH   DFND 1,2 2,295,272 0 0
CIGNA CORP NEW COM 125523100 65,262 319,146 SH   DFND 2 319,146 0 0
CLOROX CO DEL COM 189054109 430 2,800 SH   DFND 2 2,800 0 0
CLOVIS ONCOLOGY INC COM 189464100 760 72,900 SH   DFND 2 72,900 0 0
COHERUS BIOSCIENCES INC COM 19249H103 2,674 148,500 SH   DFND 2 148,500 0 0
COLGATE PALMOLIVE CO COM 194162103 420 6,100 SH   DFND 2 6,100 0 0
CONSTELLATION BRANDS INC CL A 21036P108 391 2,059 SH   DFND 2 2,059 0 0
COOPER COS INC COM NEW 216648402 13,345 41,535 SH   DFND 2 41,535 0 0
COVETRUS INC COM 22304C100 20 1,520 SH   DFND 2 1,520 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 44,489 730,462 SH   DFND 1,2 730,462 0 0
CVS HEALTH CORP COM 126650100 15,399 207,279 SH   DFND 2 207,279 0 0
DANAHER CORPORATION COM 235851102 56,265 366,593 SH   DFND 2 366,593 0 0
DENTSPLY SIRONA INC COM 24906P109 9,396 166,039 SH   DFND 2 166,039 0 0
DEXCOM INC COM 252131107 17,166 78,475 SH   DFND 2 78,475 0 0
DOMINOS PIZZA INC COM 25754A201 558 1,900 SH   DFND 2 1,900 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 47,298 202,743 SH   DFND 2 202,743 0 0
ELECTRONIC ARTS INC COM 285512109 516 4,800 SH   DFND 2 4,800 0 0
ENTEGRIS INC COM 29362U104 516 10,300 SH   DFND 2 10,300 0 0
ESPERION THERAPEUTICS INC NEW COM 29664W105 47,528 797,046 SH   DFND 2 797,046 0 0
ESPERION THERAPEUTICS INC NEW COM 29664W105 222,298 3,727,964 SH   DFND 1,2 3,727,964 0 0
EVOLENT HEALTH INC CL A 30050B101 32,115 3,548,613 SH   DFND 2 3,548,613 0 0
EXELIXIS INC COM 30161Q104 19,306 1,095,700 SH   DFND 2 1,095,700 0 0
EXELIXIS INC COM 30161Q104 49,953 2,835,000 SH   DFND 1,2 2,835,000 0 0
FACTSET RESH SYS INC COM 303075105 456 1,700 SH   DFND 2 1,700 0 0
FASTENAL CO COM 311900104 713 19,299 SH   DFND 2 19,299 0 0
FATE THERAPEUTICS INC COM 31189P102 1,620 82,800 SH   DFND 2 82,800 0 0
FIBROGEN INC COM 31572Q808 1,651 38,500 SH   DFND 2 38,500 0 0
FITBIT INC CL A 33812L102 3,751 570,959 SH   DFND 2 570,959 0 0
G1 THERAPEUTICS INC COM 3621LQ109 19,080 721,925 SH   DFND 1,2 721,925 0 0
GENMARK DIAGNOSTICS INC COM 372309104 11,742 2,441,241 SH   DFND 2 2,441,241 0 0
GILEAD SCIENCES INC COM 375558103 552 8,500 SH   DFND 2 8,500 0 0
GLAUKOS CORP COM 377322102 21,905 402,148 SH   DFND 2 402,148 0 0
GLOBUS MED INC CL A 379577208 19,892 337,837 SH   DFND 2 337,837 0 0
GRACO INC COM 384109104 504 9,700 SH   DFND 2 9,700 0 0
GUARDANT HEALTH INC COM 40131M109 8,606 110,136 SH   DFND 2 110,136 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 1,171 11,200 SH   DFND 2 11,200 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 1,308 73,800 SH   DFND 2 73,800 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 141,185 7,963,056 SH   DFND 1,2 7,963,056 0 0
HCA HEALTHCARE INC COM 40412C101 37,341 252,628 SH   DFND 2 252,628 0 0
HEALTH CATALYST INC COM 42225T107 7,790 224,508 SH   DFND 2 224,508 0 0
HENRY SCHEIN INC COM 806407102 397 5,948 SH   DFND 2 5,948 0 0
HILL ROM HLDGS INC COM 431475102 26,939 237,286 SH   DFND 2 237,286 0 0
HMS HLDGS CORP COM 40425J101 15,314 517,377 SH   DFND 2 517,377 0 0
HOLOGIC INC COM 436440101 13,667 261,779 SH   DFND 2 261,779 0 0
HOMOLOGY MEDICINES INC COM 438083107 33,371 1,612,122 SH   DFND 1,2 1,612,122 0 0
HORIZON THERAPEUTICS PUB LTD SHS G46188101 11,428 315,700 SH   DFND 2 315,700 0 0
HUAZHU GROUP LTD SPONSORED ADS 44332N106 541 13,500 SH   DFND 2 13,500 0 0
HUMANA INC COM 444859102 83,364 227,447 SH   DFND 2 227,447 0 0
HUTCHISON CHINA MEDITECH LTD SPONSORED ADR 44842L103 20,503 817,817 SH   DFND 2 817,817 0 0
IDEXX LABS INC COM 45168D104 12,393 47,461 SH   DFND 2 47,461 0 0
ILLUMINA INC COM 452327109 73,536 221,667 SH   DFND 2 221,667 0 0
INCYTE CORP COM 45337C102 10,216 117,000 SH   DFND 2 117,000 0 0
INCYTE CORP COM 45337C102 296,888 3,400,000 SH   DFND 1,2 3,400,000 0 0
INOGEN INC COM 45780L104 9,415 137,787 SH   DFND 2 137,787 0 0
INSMED INC COM PAR $.01 457669307 37,815 1,583,560 SH   DFND 2 1,583,560 0 0
INSPIRE MED SYS INC COM 457730109 19,533 263,217 SH   DFND 2 263,217 0 0
INSULET CORP COM 45784P101 17,365 101,430 SH   DFND 2 101,430 0 0
INTEGRA LIFESCIENCES HLDGS C COM NEW 457985208 15,023 257,772 SH   DFND 2 257,772 0 0
INTERACTIVE BROKERS GROUP IN COM CL A 45841N107 438 9,400 SH   DFND 2 9,400 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 2,255 18,200 SH   DFND 2 18,200 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 86,369 696,976 SH   DFND 1,2 696,976 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 444 4,800 SH   DFND 2 4,800 0 0
INTERSECT ENT INC COM 46071F103 14,215 570,902 SH   DFND 2 570,902 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 2,264 66,000 SH   DFND 2 66,000 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 78,913 2,300,000 SH   DFND 1,2 2,300,000 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 104,206 176,276 SH   DFND 2 176,276 0 0
IONIS PHARMACEUTICALS INC COM 462222100 26,391 436,865 SH   DFND 2 436,865 0 0
IONIS PHARMACEUTICALS INC COM 462222100 482,975 7,994,955 SH   DFND 1,2 7,994,955 0 0
IPG PHOTONICS CORP COM 44980X109 507 3,500 SH   DFND 2 3,500 0 0
IRHYTHM TECHNOLOGIES INC COM 450056106 9,299 136,563 SH   DFND 2 136,563 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 56,921 381,303 SH   DFND 2 381,303 0 0
JD COM INC SPON ADR CL A 47215P106 518 14,700 SH   DFND 2 14,700 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 6,218 1,550,669 SH   DFND 1,2 1,550,669 0 0
KOSMOS ENERGY LTD COM 500688106 342 60,000 SH   DFND 2 60,000 0 0
KURA ONCOLOGY INC COM 50127T109 2,170 157,800 SH   DFND 2 157,800 0 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409 935 5,526 SH   DFND 2 5,526 0 0
LAUDER ESTEE COS INC CL A 518439104 464 2,248 SH   DFND 2 2,248 0 0
LIGAND PHARMACEUTICALS INC COM NEW 53220K504 1,616 15,500 SH   DFND 2 15,500 0 0
LIVANOVA PLC SHS G5509L101 9,552 126,639 SH   DFND 2 126,639 0 0
LIVE NATION ENTERTAINMENT IN COM 538034109 443 6,200 SH   DFND 2 6,200 0 0
LIVONGO HEALTH INC COM 539183103 4,575 182,574 SH   DFND 2 182,574 0 0
M & T BK CORP COM 55261F104 509 3,000 SH   DFND 2 3,000 0 0
MACROGENICS INC COM 556099109 14,734 1,354,197 SH   DFND 2 1,354,197 0 0
MACROGENICS INC COM 556099109 49,168 4,519,159 SH   DFND 1,2 4,519,159 0 0
MARKEL CORP COM 570535104 457 400 SH   DFND 2 400 0 0
MARKETAXESS HLDGS INC COM 57060D108 501 1,322 SH   DFND 2 1,322 0 0
MASIMO CORP COM 574795100 12,494 79,049 SH   DFND 2 79,049 0 0
MCCORMICK & CO INC COM NON VTG 579780206 475 2,800 SH   DFND 2 2,800 0 0
MCKESSON CORP COM 58155Q103 812 5,874 SH   DFND 2 5,874 0 0
MEDTRONIC PLC SHS G5960L103 96,243 848,330 SH   DFND 2 848,330 0 0
MERCK & CO INC COM 58933Y105 2,729 30,000 SH   DFND 2 30,000 0 0
METTLER TOLEDO INTERNATIONAL COM 592688105 555 700 SH   DFND 2 700 0 0
MIRATI THERAPEUTICS INC COM 60468T105 2,100 16,300 SH   DFND 2 16,300 0 0
MODERNA INC COM 60770K107 2,294 117,300 SH   DFND 2 117,300 0 0
MODERNA INC COM 60770K107 94,236 4,817,781 SH   DFND 1,2 4,817,781 0 0
MOLECULAR TEMPLATES INC COM 608550109 18,120 1,295,687 SH   DFND 1,2 1,295,687 0 0
MOLINA HEALTHCARE INC COM 60855R100 17,724 130,619 SH   DFND 2 130,619 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 3,204 162,400 SH   DFND 2 162,400 0 0
MOODYS CORP COM 615369105 475 2,000 SH   DFND 2 2,000 0 0
MSCI INC COM 55354G100 461 1,786 SH   DFND 2 1,786 0 0
MYLAN N V SHS EURO N59465109 1,608 80,000 SH   DFND 2 80,000 0 0
MYOKARDIA INC COM 62857M105 3,017 41,400 SH   DFND 2 41,400 0 0
MYOKARDIA INC COM 62857M105 92,193 1,264,913 SH   DFND 1,2 1,264,913 0 0
MYOVANT SCIENCES LTD COM G637AM102 74,730 4,815,109 SH   DFND 1,2 4,815,109 0 0
NEKTAR THERAPEUTICS COM 640268108 17,189 796,322 SH   DFND 2 796,322 0 0
NEKTAR THERAPEUTICS COM 640268108 56,567 2,620,676 SH   DFND 1,2 2,620,676 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 9,706 90,300 SH   DFND 2 90,300 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 346,986 3,228,074 SH   DFND 1,2 3,228,074 0 0
NEURONETICS INC COM 64131A105 1,464 325,961 SH   DFND 2 325,961 0 0
NEVRO CORP COM 64157F103 12,895 109,705 SH   DFND 2 109,705 0 0
OMNICELL INC COM 68213N109 16,045 196,339 SH   DFND 2 196,339 0 0
OXFORD IMMUNOTEC GLOBAL PLC ORD SHS G6855A103 10,590 637,972 SH   DFND 2 637,972 0 0
PACIFIC BIOSIENCES CALIF IN COM 69404D108 29,474 5,734,309 SH   DFND 2 5,734,309 0 0
PAYCHEX INC COM 704326107 459 5,400 SH   DFND 2 5,400 0 0
PENUMBRA INC COM 70975L107 11,311 68,855 SH   DFND 2 68,855 0 0
PERKINELMER INC COM 714046109 466 4,800 SH   DFND 2 4,800 0 0
PFIZER INC COM 717081103 2,351 60,000 SH   DFND 2 60,000 0 0
PHREESIA INC COM 71944F106 7,221 271,045 SH   DFND 2 271,045 0 0
POLYONE CORP COM 73179P106 500 13,600 SH   DFND 2 13,600 0 0
POOL CORPORATION COM 73278L105 467 2,200 SH   DFND 2 2,200 0 0
PROSHARES TR PSHS ULT NASB 74347R214 1,544 25,000 SH   DFND 2 25,000 0 0
PTC THERAPEUTICS INC COM 69366J200 2,694 56,100 SH   DFND 2 56,100 0 0
QIAGEN NV SHS NEW N72482123 5,437 160,846 SH   DFND 2 160,846 0 0
QUANTERIX CORP COM 74766Q101 10,284 435,217 SH   DFND 2 435,217 0 0
QUIDEL CORP COM 74838J101 25,325 337,528 SH   DFND 2 337,528 0 0
QUOTIENT LTD SHS G73268107 3,385 355,899 SH   DFND 2 355,899 0 0
RADIUS HEALTH INC COM NEW 750469207 1,224 60,700 SH   DFND 2 60,700 0 0
RADIUS HEALTH INC COM NEW 750469207 138,735 6,881,685 SH   DFND 1,2 6,881,685 0 0
REGENERON PHARMACEUTICALS COM 75886F107 8,261 22,000 SH   DFND 2 22,000 0 0
REGENXBIO INC COM 75901B107 856 20,900 SH   DFND 2 20,900 0 0
REPLIGEN CORP COM 759916109 1,258 13,600 SH   DFND 2 13,600 0 0
RESMED INC COM 761152107 11,748 75,810 SH   DFND 2 75,810 0 0
S&P GLOBAL INC COM 78409V104 464 1,700 SH   DFND 2 1,700 0 0
SAGE THERAPEUTICS INC COM 78667J108 2,075 28,750 SH   DFND 2 28,750 0 0
SAGE THERAPEUTICS INC COM 78667J108 92,411 1,280,104 SH   DFND 1,2 1,280,104 0 0
SANGAMO THERAPEUTICS INC COM 800677106 32,225 3,850,000 SH   DFND 1,2 3,850,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 2,000 15,500 SH   DFND 2 15,500 0 0
SCHOLAR ROCK HOLDING CORP COM 80706P103 34,722 2,634,466 SH   DFND 1,2 2,634,466 0 0
SEATTLE GENETICS INC COM 812578102 4,273 37,400 SH   DFND 2 37,400 0 0
SENSATA TECHNOLOGIES HLDNG P SHS G8060N102 533 9,900 SH   DFND 2 9,900 0 0
SERVICE CORP INTL COM 817565104 391 8,500 SH   DFND 2 8,500 0 0
SHOCKWAVE MED INC COM 82489T104 9,256 210,758 SH   DFND 2 210,758 0 0
SILK RAOD MEDICAL INC COM 82710M100 7,426 183,896 SH   DFND 2 183,896 0 0
SKYWORKS SOLUTIONS INC COM 83088M102 689 5,700 SH   DFND 2 5,700 0 0
SMILEDIRECTCLUB INC CL A COM 83192H106 4,634 530,230 SH   DFND 2 530,230 0 0
SOCIEDAD QUIMICA MINERA DE C SPON ADR SER B 833635105 486 18,200 SH   DFND 2 18,200 0 0
STARBUCKS CORP COM 855244109 381 4,334 SH   DFND 2 4,334 0 0
STRYKER CORP COM 863667101 33,854 161,255 SH   DFND 2 161,255 0 0
SUPERNUS PHARMACEUTICALS INC COM 868459108 13,653 575,600 SH   DFND 2 575,600 0 0
SYNEOS HEALTH INC CL A 87166B102 2,712 45,600 SH   DFND 2 45,600 0 0
TABULA RASA HEALTHCARE INC COM 873379101 9,816 201,635 SH   DFND 2 201,635 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 11,931 200,147 SH   DFND 2 200,147 0 0
TELADOC HEALTH INC COM 87918A105 62,794 750,045 SH   DFND 2 750,045 0 0
TELEFLEX INC COM 879369106 28,127 74,719 SH   DFND 2 74,719 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 2,607 266,000 SH   DFND 2 266,000 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 21,051 64,797 SH   DFND 2 64,797 0 0
TRANSUNION COM 89400J107 436 5,096 SH   DFND 2 5,096 0 0
TRIMBLE INC COM 896239100 488 11,700 SH   DFND 2 11,700 0 0
TRIP COM GROUP LTD ADS 89677Q107 439 13,100 SH   DFND 2 13,100 0 0
TYLER TECHNOLOGIES INC COM 902252105 458 1,525 SH   DFND 2 1,525 0 0
UNIQURE NV SHS N90064101 2,071 28,900 SH   DFND 2 28,900 0 0
UNITEDHEALTH GROUP INC COM 91324P102 80,906 275,210 SH   DFND 2 275,210 0 0
VARIAN MED SYS INC COM 92220P105 582 4,100 SH   DFND 2 4,100 0 0
VEEVA SYS INC CL A COM 922475108 7,157 50,884 SH   DFND 2 50,884 0 0
VERISIGN INC COM 92343E102 405 2,100 SH   DFND 2 2,100 0 0
VERISK ANALYTICS INC COM 92345Y106 372 2,489 SH   DFND 2 2,489 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 32,687 149,289 SH   DFND 2 149,289 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 271,498 1,240,000 SH   DFND 1,2 1,240,000 0 0
VOCERA COMMUNICATONS INC COM 92857F107 6,314 304,143 SH   DFND 2 304,143 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 335 24,000 SH   DFND 2 24,000 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 37,390 2,680,283 SH   DFND 1,2 2,680,283 0 0
WABTEC CORP COM 929740108 498 6,400 SH   DFND 2 6,400 0 0
WATSCO INC COM 942622200 504 2,800 SH   DFND 2 2,800 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 19,259 2,402,858 SH   DFND 1,2 2,402,858 0 0
WRIGHT MED GROUP NV ORD SHS N96617118 17,078 560,311 SH   DFND 2 560,311 0 0
XILINX INC COM 983919101 411 4,200 SH   DFND 2 4,200 0 0
ZAI LAB LTD ADR 98887Q104 5,023 120,782 SH   DFND 2 120,782 0 0
ZIMMER BIOMET HLDGS INC COM 98956P102 32,186 215,032 SH   DFND 2 215,032 0 0
ZOGENIX INC COM NEW 98978L204 1,361 26,100 SH   DFND 2 26,100 0 0