The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ADAMAS PHARMACEUTICALS INC COM 00548A106 8,323 2,196,000 SH   DFND   2,196,000 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 7,354 68,000 SH   DFND   68,000 0 0
ALIMERA SCIENCES INC COM NEW 016259202 2,577 340,000 SH   DFND   340,000 0 0
AMAG PHARMACEUTICALS INC COM 00163U106 49,410 4,060,000 SH   DFND   4,060,000 0 0
AMAZON COM INC COM 023135106 7,391 4,000 SH   DFND   4,000 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 23,652 1,156,000 SH   DFND   1,156,000 0 0
AUTOZONE INC COM 053332102 29,367 24,651 SH   DFND   24,651 0 0
AVAYA HLDGS CORP COM 05351X101 22,842 1,692,000 SH   DFND   1,692,000 0 0
AYTU BIOSCIENCE INC COM PAR 054754700 7,731 7,950,000 SH   DFND   7,950,000 0 0
BIO RAD LABS INC CL A 090572207 7,401 20,000 SH   DFND   20,000 0 0
BIOGEN INC COM 09062X103 37,981 128,000 SH   DFND   128,000 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 33,317 612,000 SH   DFND   612,000 0 0
BJS WHSL CLUB HLDGS INC COM 05550J101 10,818 475,746 SH   DFND   475,746 0 0
BLUEBIRD BIO INC COM 09609G100 29,484 336,000 SH   DFND   336,000 0 0
BRISTOL MYERS SQUIBB CO COM 110122108 32,095 500,000 SH   DFND   500,000 0 0
CAPRI HOLDINGS LIMITED SHS G1890L107 12,460 326,611 SH   DFND   326,611 0 0
CARMAX INC COM 143130102 7,189 82,000 SH   DFND   82,000 0 0
CATALYST PHARMACEUTICALS INC COM 14888U101 19,125 5,100,000 SH   DFND   5,100,000 0 0
CENTRAL GARDEN & PET CO CL A NON-VTG 153527205 25,778 878,000 SH   DFND   878,000 0 0
CERECOR INC COM 15671L109 111,483 20,683,233 SH   DFND   20,683,233 0 0
CHIPOTLE MEXICAN GRILL INC COM 169656105 28,246 33,742 SH   DFND   33,742 0 0
CIGNA CORP NEW COM 125523100 7,566 37,000 SH   DFND   37,000 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 9,014 148,000 SH   DFND   148,000 0 0
DECKERS OUTDOOR CORP COM 243537107 31,087 184,100 SH   DFND   184,100 0 0
DROPBOX INC CL A 26210C104 26,113 1,458,000 SH   DFND   1,458,000 0 0
DUNKIN BRANDS GROUP INC COM 265504100 7,403 98,000 SH   DFND   98,000 0 0
EDGEWELL PERS CARE CO COM 28035Q102 46,440 15,000 SH Call DFND   15,000 0 0
EKSO BIONICS HLDGS INC COM NEW 282644202 1,218 3,114,399 SH   DFND   3,114,399 0 0
ENANTA PHARMACEUTICALS INC COM 29251M106 24,335 393,895 SH   DFND   393,895 0 0
ENVISTA HLDGS CORP COM 29415F104 25,135 848,000 SH   DFND   848,000 0 0
EYEGATE PHARMACEUTICALS INC COM NEW 30233M503 17,961 1,792,500 SH   DFND   1,792,500 0 0
FIVE BELOW INC COM 33829M101 11,566 90,457 SH   DFND   90,457 0 0
FRONTDOOR INC COM 35905A109 23,710 500,000 SH   DFND   500,000 0 0
HOSTESS BRANDS INC CL A 44109J106 14,947 1,028,000 SH   DFND   1,028,000 0 0
INCYTE CORP COM 45337C102 24,013 275,000 SH   DFND   275,000 0 0
ISHARES TR RUSSELL 2000 ETF 464287655 231,938 14,000 SH Put DFND   14,000 0 0
KOHLS CORP COM 500255104 12,738 250,000 SH   DFND   250,000 0 0
KRAFT HEINZ CO COM 500754106 22,170 690,000 SH   DFND   690,000 0 0
LAUDER ESTEE COS INC CL A 518439104 20,654 100,000 SH   DFND   100,000 0 0
LULULEMON ATHLETICA INC COM 550021109 19,391 83,700 SH   DFND   83,700 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 14,578 160,000 SH   DFND   160,000 0 0
MALLINCKRODT PUB LTD CO SHS G5785G107 13,960 40,000 SH Call DFND   40,000 0 0
MALLINCKRODT PUB LTD CO SHS G5785G107 9,346 2,678,000 SH   DFND   2,678,000 0 0
MEDIGUS LTD SPONSORED ADS 58471G300 742 1,285,715 SH   DFND   1,285,715 0 0
MERCK & CO INC COM 58933Y105 7,276 80,000 SH   DFND   80,000 0 0
MINERVA NEUROSCIENCES INC COM 603380106 3,982 560,000 SH   DFND   560,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 15,463 120,000 SH   DFND   120,000 0 0
NN INC COM 629337106 2,701 292,021 SH   DFND   292,021 0 0
O REILLY AUTOMOTIVE INC NEW COM 67103H107 14,463 33,000 SH   DFND   33,000 0 0
OLLIES BARGAIN OUTLT HLDGS I COM 681116109 7,010 107,339 SH   DFND   107,339 0 0
PARATEK PHARMACEUTICALS INC COM 699374302 9,140 2,268,000 SH   DFND   2,268,000 0 0
PTC THERAPEUTICS INC COM 69366J200 36,407 758,000 SH   DFND   758,000 0 0
QIAGEN NV SHS NEW N72482123 14,872 440,000 SH   DFND   440,000 0 0
RALPH LAUREN CORP CL A 751212101 17,837 152,168 SH   DFND   152,168 0 0
REGENERON PHARMACEUTICALS COM 75886F107 37,548 100,000 SH   DFND   100,000 0 0
RESTAURANT BRANDS INTL INC COM 76131D103 19,950 312,850 SH   DFND   312,850 0 0
RESTORBIO INC COM 76133L103 5,251 3,524,000 SH   DFND   3,524,000 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 193,116 6,000 SH Put DFND   6,000 0 0
SUPERNUS PHARMACEUTICALS INC COM 868459108 40,609 1,712,000 SH   DFND   1,712,000 0 0
TAPESTRY INC COM 876030107 7,876 292,046 SH   DFND   292,046 0 0
TETRAPHASE PHARMACEUTICALS I COM NEW 88165N204 420 149,507 SH   DFND   149,507 0 0
TG THERAPEUTICS INC COM 88322Q108 8,880 800,000 SH   DFND   800,000 0 0
TJX COS INC NEW COM 872540109 12,884 211,000 SH   DFND   211,000 0 0
TROVAGENE INC COM 897238606 103 82,928 SH   DFND   82,928 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 11,274 128,000 SH   DFND   128,000 0 0
VANDA PHARMACEUTICALS INC COM 921659108 46,407 2,828,000 SH   DFND   2,828,000 0 0
VAXART INC COM NEW 92243A200 8,833 25,200,000 SH   DFND   25,200,000 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 14,232 65,000 SH   DFND   65,000 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 22,655 1,624,000 SH   DFND   1,624,000 0 0
WELBILT INC COM 949090104 11,302 724,000 SH   DFND   724,000 0 0
WILLIAMS SONOMA INC COM 969904101 32,843 447,206 SH   DFND   447,206 0 0