The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABEONA THERAPEUTICS INC COM 00289Y107 23,587 7,213,012 SH   DFND 1,2 7,213,012 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 53,475 1,250,000 SH   DFND 1,2 1,250,000 0 0
ACCELERON PHARMA INC COM 00434H108 53,020 1,000,000 SH   DFND 1,2 1,000,000 0 0
ARVINAS INC COM 04335A105 22,600 550,000 SH   DFND 1,2 550,000 0 0
ATARA BIOTHERAPEUTICS INC COM 046513107 1,153 70,000 SH   DFND 1,2 70,000 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 20,260 1,000,000 SH Call DFND 1,2 1,000,000 0 0
AXONICS MODULATION TECH INC COM 05465P101 12,927 466,507 SH   DFND 1,2 466,507 0 0
AXSOME THERAPEUTICS INC COM 05464T104 75,163 727,200 SH Call DFND 1,2 727,200 0 0
AXSOME THERAPEUTICS INC COM 05464T104 26 254 SH   DFND 1,2 254 0 0
BRIDGEBIO PHARMA INC COM 10806X102 2,748 78,400 SH   DFND 1,2 78,400 0 0
CONSTELLATION PHARMCETICLS I COM 210373106 53,476 1,135,122 SH   DFND 1,2 1,135,122 0 0
CYTOKINETICS INC COM NEW 23282W605 1,698 160,073 SH   DFND 1,2 160,073 0 0
DERMIRA INC COM 24983L104 39,739 2,621,333 SH   DFND 1,2 2,621,333 0 0
DEXCOM INC COM 252131107 5,709 26,100 SH   DFND 1,2 26,100 0 0
GENFIT S A ADS 372279109 4,135 207,766 SH   DFND 1,2 207,766 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 14,814 141,683 SH   DFND 1,2 141,683 0 0
INSMED INC COM PAR $.01 457669307 2,325 97,359 SH   DFND 1,2 97,359 0 0
IONIS PHARMACEUTICALS INC COM 462222100 3,927 65,000 SH   DFND 1,2 65,000 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 138,820 5,015,175 SH   DFND 1,2 5,015,175 0 0
KURA ONCOLOGY INC COM 50127T109 11,739 853,777 SH   DFND 1,2 853,777 0 0
LIQUIDIA TECHNOLOGIES INC COM 53635D202 5,463 1,277,955 SH   DFND 1,2 1,277,955 0 0
MENLO THERAPEUTICS INC COM 586858102 7,665 1,652,013 SH   DFND 1,2 1,652,013 0 0
MILLENDO THERAPEUTICS INC COM 60040X103 11,659 1,729,759 SH   DFND 1,2 1,729,759 0 0
MOLECULAR TEMPLATES INC COM 608550109 11,538 825,000 SH   DFND 1,2 825,000 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 55,055 2,790,400 SH   DFND 1,2 2,790,400 0 0
NEXTCURE INC COM 65343E108 63,911 1,134,584 SH   DFND 1,2 1,134,584 0 0
OPTINOSE INC COM 68404V100 10,897 1,181,834 SH   DFND 1,2 1,181,834 0 0
PROTHENA CORP PLC SHS G72800108 33,258 2,100,941 SH   DFND 1,2 2,100,941 0 0
PTC THERAPEUTICS INC COM 69366J200 84,053 1,750,000 SH   DFND 1,2 1,750,000 0 0
SAGE THERAPEUTICS INC COM 78667J108 57,467 796,057 SH   DFND 1,2 796,057 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 14,903 250,000 SH   DFND 1,2 250,000 0 0
TG THERAPEUTICS INC COM 88322Q108 60,326 5,434,783 SH   DFND 1,2 5,434,783 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 47,667 541,179 SH   DFND 1,2 541,179 0 0
VIEWRAY INC COM 92672L107 7,238 1,715,153 SH   DFND 1,2 1,715,153 0 0
ZOGENIX INC COM NEW 98978L204 21,895 420,000 SH   DFND 1,2 420,000 0 0
ZOGENIX INC COM NEW 98978L204 13,033 250,000 SH Call DFND 1,2 250,000 0 0
ZYMEWORKS INC COM 98985W102 101,093 2,223,789 SH   DFND 1,2 2,223,789 0 0