The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
1LIFE HEALTHCARE INC COM 68269G107 4,538 250,000 SH   DFND 2 250,000 0 0
10X GENOMICS INC CL A COM 88025U109 5,849 93,847 SH   DFND 2 93,847 0 0
111 INC ADS 68247Q102 763 115,429 SH   DFND 2 115,429 0 0
ABBOTT LABS COM 002824100 101,342 1,284,272 SH   DFND 2 1,284,272 0 0
ABBVIE INC COM 00287Y109 1,935 25,400 SH   DFND 2 25,400 0 0
ABIOMED INC COM 003654100 15,688 108,072 SH   DFND 2 108,072 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 1,775 42,000 SH   DFND 2 42,000 0 0
ACCELERON PHARMA INC COM 00434H108 1,950 21,700 SH   DFND 2 21,700 0 0
ADOBE INC COM 00724F101 477 1,500 SH   DFND 2 1,500 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 444 6,200 SH   DFND 2 6,200 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 2,597 73,200 SH   DFND 2 73,200 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 135,968 3,832,244 SH   DFND 1,2 3,832,244 0 0
AKCEA THERAPEUTICS INC COM 00972L107 10,801 755,296 SH   DFND 2 755,296 0 0
AKCEA THERAPEUTICS INC COM 00972L107 35,020 2,448,948 SH   DFND 1,2 2,448,948 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 3,313 36,900 SH   DFND 2 36,900 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 116,227 1,294,428 SH   DFND 1,2 1,294,428 0 0
ALIGN TECHNOLOGY INC COM 016255101 35,325 203,076 SH   DFND 2 203,076 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 34,316 315,264 SH   DFND 2 315,264 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 158,921 1,460,000 SH   DFND 1,2 1,460,000 0 0
AMEDISYS INC COM 023436108 11,222 61,143 SH   DFND 2 61,143 0 0
AMERICAN EXPRESS CO COM 025816109 308 3,600 SH   DFND 2 3,600 0 0
AMGEN INC COM 031162100 26,674 131,573 SH   DFND 2 131,573 0 0
ANALOG DEVICES INC COM 032654105 368 4,100 SH   DFND 2 4,100 0 0
ANSYS INC COM 03662Q105 419 1,802 SH   DFND 2 1,802 0 0
ANTHEM INC COM 036752103 83,007 365,603 SH   DFND 2 365,603 0 0
APELLIS PHARMACUETICALS INC COM 03753U106 801 29,900 SH   DFND 2 29,900 0 0
ARGENX SE SPONSORED ADR 04016X101 3,921 29,765 SH   DFND 2 29,765 0 0
ARGENX SE SPONSORED ADR 04016X101 124,450 944,739 SH   DFND 1,2 944,739 0 0
ARVINAS INC COM 04335A105 1,104 27,400 SH   DFND 2 27,400 0 0
ARVINAS INC COM 04335A105 50,049 1,241,903 SH   DFND 1,2 1,241,903 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 1,340 11,900 SH   DFND 2 11,900 0 0
ASPEN TECHNOLOGY INC COM 045327103 285 3,000 SH   DFND 2 3,000 0 0
AUTOLIV INC COM 052800109 313 6,800 SH   DFND 2 6,800 0 0
AVANTOR INC COM 05352A100 3,929 314,566 SH   DFND 2 314,566 0 0
AXONICS MODULATION TECHNOLOG COM 05465P101 4,557 179,333 SH   DFND 2 179,333 0 0
BAXTER INTL INC COM 071813109 48,058 591,921 SH   DFND 2 591,921 0 0
BECTON DICKINSON & CO COM 075887109 56,768 247,064 SH   DFND 2 247,064 0 0
BEIGENE LTD SPONSORED ADR 07725L102 7,202 58,500 SH   DFND 2 58,500 0 0
BIOGEN INC COM 09062X103 2,689 8,500 SH   DFND 2 8,500 0 0
BIOGEN INC COM 09062X103 7 160 SH Call DFND 2 160 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 844 24,800 SH   DFND 2 24,800 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 6,092 72,100 SH   DFND 2 72,100 0 0
BIO RAD LABS INC CL A 090572207 21,865 62,373 SH   DFND 2 62,373 0 0
BLACKBAUD INC COM 09227Q100 228 4,107 SH   DFND 2 4,107 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 33,184 1,330,000 SH   DFND 1,2 1,330,000 0 0
BLUEBIRD BIO INC COM 09609G100 910 19,800 SH   DFND 2 19,800 0 0
BOOKING HLDGS INC COM 09857L108 269 200 SH   DFND 2 200 0 0
BOSTON SCIENTIFIC CORP COM 101137107 50,290 1,541,225 SH   DFND 2 1,541,225 0 0
BRISTOL MYERS SQUIBB CO COM 110122108 67,193 1,205,472 SH   DFND 2 1,205,472 0 0
BRISTOL MYERS SQUIBB CO RIGHT 99/99/9999 110122157 63 16,600 SH   DFND 2 16,600 0 0
BRISTOL MYERS SQUIBB CO RIGHT 99/99/9999 110122157 3,040 800,000 SH   DFND 1,2 800,000 0 0
BROADRIDGE FINL SOLUTIONS IN COM 11133T103 322 3,400 SH   DFND 2 3,400 0 0
BROWN FORMAN CORP CL B 115637209 422 7,600 SH   DFND 2 7,600 0 0
CAREDX INC COM 14167L103 27,878 1,277,051 SH   DFND 2 1,277,051 0 0
CATALENT INC COM 148806102 2,447 47,100 SH   DFND 2 47,100 0 0
CELLECTIS S A SPONSORED ADS 15117K103 693 75,300 SH   DFND 2 75,300 0 0
CENTENE CORP DEL COM 15135B101 48,138 810,270 SH   DFND 2 810,270 0 0
CHANGE HEALTHCARE INC COM 15912K100 10,765 1,077,575 SH   DFND 2 1,077,575 0 0
CHARLES RIV LABS INTL INC COM 159864107 41,854 331,623 SH   DFND 2 331,623 0 0
CHINA BIOLOGIC PRODS HLDGS I COM G21515104 486 4,500 SH   DFND 2 4,500 0 0
CIDARA THERAPEUTICS INC COM 171757107 7,000 2,822,495 SH   DFND 1,2 2,822,495 0 0
CIGNA CORP NEW COM 125523100 61,887 349,289 SH   DFND 2 349,289 0 0
CLOROX CO DEL COM 189054109 485 2,800 SH   DFND 2 2,800 0 0
CLOVIS ONCOLOGY INC COM 189464100 453 71,200 SH   DFND 2 71,200 0 0
COHERUS BIOSCIENCES INC COM 19249H103 787 48,500 SH   DFND 2 48,500 0 0
COLGATE PALMOLIVE CO COM 194162103 405 6,100 SH   DFND 2 6,100 0 0
CONSTELLATION BRANDS INC CL A 21036P108 295 2,059 SH   DFND 2 2,059 0 0
COOPER COS INC COM NEW 216648402 6,987 25,345 SH   DFND 2 25,345 0 0
COSTAR GROUP INC COM 22160N109 411 700 SH   DFND 2 700 0 0
COVETRUS INC COM 22304C100 12 1,520 SH   DFND 2 1,520 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 33,948 800,462 SH   DFND 1,2 800,462 0 0
CVS HEALTH CORP COM 126650100 12,636 212,981 SH   DFND 2 212,981 0 0
DANAHER CORPORATION COM 235851102 47,818 345,481 SH   DFND 2 345,481 0 0
DENTSPLY SIRONA INC COM 24906P109 4,972 128,038 SH   DFND 2 128,038 0 0
DEXCOM INC COM 252131107 27,285 101,328 SH   DFND 2 101,328 0 0
DIREXION SHS ETF TR SP BIOTECH BL NEW 25490K323 338 15,000 SH   DFND 2 15,000 0 0
DOMINOS PIZZA INC COM 25754A201 616 1,900 SH   DFND 2 1,900 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 44,130 233,965 SH   DFND 2 233,965 0 0
ELECTRONIC ARTS INC COM 285512109 481 4,800 SH   DFND 2 4,800 0 0
ENTEGRIS INC COM 29362U104 461 10,300 SH   DFND 2 10,300 0 0
ESPERION THERAPEUTICS INC NEW COM 29664W105 40,671 1,289,926 SH   DFND 2 1,289,926 0 0
ESPERION THERAPEUTICS INC NEW COM 29664W105 118,173 3,747,964 SH   DFND 1,2 3,747,964 0 0
EVOLENT HEALTH INC CL A 30050B101 24,872 4,580,458 SH   DFND 2 4,580,458 0 0
EXELIXIS INC COM 30161Q104 19,638 1,140,400 SH   DFND 2 1,140,400 0 0
EXELIXIS INC COM 30161Q104 48,819 2,835,000 SH   DFND 1,2 2,835,000 0 0
FACTSET RESH SYS INC COM 303075105 443 1,700 SH   DFND 2 1,700 0 0
FASTENAL CO COM 311900104 603 19,299 SH   DFND 2 19,299 0 0
FATE THERAPEUTICS INC COM 31189P102 1,950 87,800 SH   DFND 2 87,800 0 0
FATE THERAPEUTICS INC COM 31189P102 32,769 1,475,400 SH   DFND 1,2 1,475,400 0 0
FIBROGEN INC COM 31572Q808 1,307 37,600 SH   DFND 2 37,600 0 0
G1 THERAPEUTICS INC COM 3621LQ109 7,956 721,925 SH   DFND 1,2 721,925 0 0
GENMARK DIAGNOSTICS INC COM 372309104 9,937 2,411,926 SH   DFND 2 2,411,926 0 0
GILEAD SCIENCES INC COM 375558103 10,803 144,500 SH   DFND 2 144,500 0 0
GLAUKOS CORP COM 377322102 12,734 412,623 SH   DFND 2 412,623 0 0
GLOBUS MED INC CL A 379577208 14,378 338,067 SH   DFND 2 338,067 0 0
GRACO INC COM 384109104 473 9,700 SH   DFND 2 9,700 0 0
GUARDANT HEALTH INC COM 40131M109 7,328 105,294 SH   DFND 2 105,294 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 21,977 250,966 SH   DFND 2 250,966 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 1,725 95,900 SH   DFND 2 95,900 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 136,149 7,568,056 SH   DFND 1,2 7,568,056 0 0
HCA HEALTHCARE INC COM 40412C101 24,526 272,966 SH   DFND 2 272,966 0 0
HEALTH CATALYST INC COM 42225T107 6,616 253,000 SH   DFND 2 253,000 0 0
HILL ROM HLDGS INC COM 431475102 29,725 295,479 SH   DFND 2 295,479 0 0
HMS HLDGS CORP COM 40425J101 14,535 575,177 SH   DFND 2 575,177 0 0
HOLOGIC INC COM 436440101 19,929 567,779 SH   DFND 2 567,779 0 0
HOMOLOGY MEDICINES INC COM 438083107 25,052 1,612,122 SH   DFND 1,2 1,612,122 0 0
HORIZON THERAPEUTICS PUB LTD SHS G46188101 4,917 166,000 SH   DFND 2 166,000 0 0
HUAZHU GROUP LTD SPONSORED ADS 44332N106 388 13,500 SH   DFND 2 13,500 0 0
HUMANA INC COM 444859102 62,213 198,118 SH   DFND 2 198,118 0 0
HUTCHISON CHINA MEDITECH LTD SPONSORED ADR 44842L103 15,208 851,994 SH   DFND 2 851,994 0 0
IDEXX LABS INC COM 45168D104 10,153 41,911 SH   DFND 2 41,911 0 0
ILLUMINA INC COM 452327109 54,348 198,988 SH   DFND 2 198,988 0 0
INCYTE CORP COM 45337C102 11,277 154,000 SH   DFND 2 154,000 0 0
INCYTE CORP COM 45337C102 232,139 3,170,000 SH   DFND 1,2 3,170,000 0 0
INOGEN INC COM 45780L104 6,375 123,395 SH   DFND 2 123,395 0 0
INSMED INC COM PAR $.01 457669307 25,864 1,613,470 SH   DFND 2 1,613,470 0 0
INSPIRE MED SYS INC COM 457730109 8,272 137,225 SH   DFND 2 137,225 0 0
INSULET CORP COM 45784P101 16,957 102,350 SH   DFND 2 102,350 0 0
INTEGRA LIFESCIENCES HLDGS C COM NEW 457985208 8,819 197,420 SH   DFND 2 197,420 0 0
INTERACTIVE BROKERS GROUP IN COM CL A 45841N107 406 9,400 SH   DFND 2 9,400 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 756 12,000 SH   DFND 2 12,000 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 43,882 696,976 SH   DFND 1,2 696,976 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 388 4,800 SH   DFND 2 4,800 0 0
INTERSECT ENT INC COM 46071F103 6,459 545,022 SH   DFND 2 545,022 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 1,128 73,400 SH   DFND 2 73,400 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 56,230 3,658,419 SH   DFND 1,2 3,658,419 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 109,130 220,371 SH   DFND 2 220,371 0 0
IONIS PHARMACEUTICALS INC COM 462222100 22,334 472,387 SH   DFND 2 472,387 0 0
IONIS PHARMACEUTICALS INC COM 462222100 373,855 7,907,255 SH   DFND 1,2 7,907,255 0 0
IPG PHOTONICS CORP COM 44980X109 386 3,500 SH   DFND 2 3,500 0 0
IQVIA HLDGS INC COM 46266C105 205 1,900 SH   DFND 2 1,900 0 0
IRHYTHM TECHNOLOGIES INC COM 450056106 10,841 133,259 SH   DFND 2 133,259 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 37,037 371,337 SH   DFND 2 371,337 0 0
JD COM INC SPON ADR CL A 47215P106 595 14,700 SH   DFND 2 14,700 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 15,342 3,518,889 SH   DFND 1,2 3,518,889 0 0
KOSMOS ENERGY LTD COM 500688106 54 60,000 SH   DFND 2 60,000 0 0
KURA ONCOLOGY INC COM 50127T109 568 57,100 SH   DFND 2 57,100 0 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409 2,257 17,861 SH   DFND 2 17,861 0 0
LAUDER ESTEE COS INC CL A 518439104 358 2,248 SH   DFND 2 2,248 0 0
LIVE NATION ENTERTAINMENT IN COM 538034109 282 6,200 SH   DFND 2 6,200 0 0
LIVONGO HEALTH INC COM 539183103 7,738 271,232 SH   DFND 2 271,232 0 0
M & T BK CORP COM 55261F104 310 3,000 SH   DFND 2 3,000 0 0
MACROGENICS INC COM 556099109 8,090 1,389,991 SH   DFND 2 1,389,991 0 0
MACROGENICS INC COM 556099109 27,524 4,729,159 SH   DFND 1,2 4,729,159 0 0
MARKEL CORP COM 570535104 371 400 SH   DFND 2 400 0 0
MARKETAXESS HLDGS INC COM 57060D108 440 1,322 SH   DFND 2 1,322 0 0
MASIMO CORP COM 574795100 16,338 92,245 SH   DFND 2 92,245 0 0
MATCH GROUP INC COM 57665R106 350 5,300 SH   DFND 2 5,300 0 0
MCCORMICK & CO INC COM NON VTG 579780206 395 2,800 SH   DFND 2 2,800 0 0
MCKESSON CORP COM 58155Q103 526 3,892 SH   DFND 2 3,892 0 0
MEDTRONIC PLC SHS G5960L103 85,249 945,316 SH   DFND 2 945,316 0 0
METTLER TOLEDO INTERNATIONAL COM 592688105 483 700 SH   DFND 2 700 0 0
MIRATI THERAPEUTICS INC COM 60468T105 1,222 15,900 SH   DFND 2 15,900 0 0
MODERNA INC COM 60770K107 3,965 132,400 SH   DFND 2 132,400 0 0
MODERNA INC COM 60770K107 114,343 3,817,781 SH   DFND 1,2 3,817,781 0 0
MOLECULAR TEMPLATES INC COM 608550109 38,682 2,910,640 SH   DFND 1,2 2,910,640 0 0
MOLINA HEALTHCARE INC COM 60855R100 17,912 128,206 SH   DFND 2 128,206 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 1,833 67,400 SH   DFND 2 67,400 0 0
MOODYS CORP COM 615369105 423 2,000 SH   DFND 2 2,000 0 0
MSCI INC COM 55354G100 516 1,786 SH   DFND 2 1,786 0 0
MYOKARDIA INC COM 62857M105 2,194 46,800 SH   DFND 2 46,800 0 0
MYOKARDIA INC COM 62857M105 59,299 1,264,913 SH   DFND 1,2 1,264,913 0 0
MYOVANT SCIENCES LTD COM G637AM102 36,354 4,815,109 SH   DFND 1,2 4,815,109 0 0
NEKTAR THERAPEUTICS COM 640268108 15,423 864,037 SH   DFND 2 864,037 0 0
NEKTAR THERAPEUTICS COM 640268108 46,779 2,620,676 SH   DFND 1,2 2,620,676 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 7,045 81,400 SH   DFND 2 81,400 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 275,062 3,178,074 SH   DFND 1,2 3,178,074 0 0
NEURONETICS INC COM 64131A105 616 325,961 SH   DFND 2 325,961 0 0
NEVRO CORP COM 64157F103 7,989 79,906 SH   DFND 2 79,906 0 0
OMNICELL INC COM 68213N109 12,863 196,136 SH   DFND 2 196,136 0 0
OXFORD IMMUNOTEC GLOBAL PLC ORD SHS G6855A103 6,133 662,315 SH   DFND 2 662,315 0 0
PACIFIC BIOSIENCES CALIF IN COM 69404D108 22,579 7,378,791 SH   DFND 2 7,378,791 0 0
PALO ALTO NETWORKS INC COM 697435105 2,787 17,000 SH   DFND 2 17,000 0 0
PAYCHEX INC COM 704326107 340 5,400 SH   DFND 2 5,400 0 0
PENUMBRA INC COM 70975L107 13,251 82,139 SH   DFND 2 82,139 0 0
PERKINELMER INC COM 714046109 361 4,800 SH   DFND 2 4,800 0 0
PERRIGO CO PLC SHS G97822103 981 20,400 SH   DFND 2 20,400 0 0
PFIZER INC COM 717081103 2,938 90,000 SH   DFND 2 90,000 0 0
PHREESIA INC COM 71944F106 7,592 360,998 SH   DFND 2 360,998 0 0
POLYONE CORP COM 73179P106 258 13,600 SH   DFND 2 13,600 0 0
POOL CORPORATION COM 73278L105 433 2,200 SH   DFND 2 2,200 0 0
PTC THERAPEUTICS INC COM 69366J200 2,909 65,200 SH   DFND 2 65,200 0 0
QIAGEN NV SHS NEW N72482123 3,852 92,600 SH   DFND 2 92,600 0 0
QUANTERIX CORP COM 74766Q101 8,187 445,673 SH   DFND 2 445,673 0 0
QUIDEL CORP COM 74838J101 11,146 113,955 SH   DFND 2 113,955 0 0
QUOTIENT LTD SHS G73268107 1,406 355,899 SH   DFND 2 355,899 0 0
RADIUS HEALTH INC COM NEW 750469207 1,322 101,700 SH   DFND 2 101,700 0 0
RADIUS HEALTH INC COM NEW 750469207 89,462 6,881,685 SH   DFND 1,2 6,881,685 0 0
REGENERON PHARMACEUTICALS COM 75886F107 9,326 19,100 SH   DFND 2 19,100 0 0
REGENXBIO INC COM 75901B107 1,195 36,900 SH   DFND 2 36,900 0 0
REPLIGEN CORP COM 759916109 1,313 13,600 SH   DFND 2 13,600 0 0
RESMED INC COM 761152107 11,563 78,505 SH   DFND 2 78,505 0 0
S&P GLOBAL INC COM 78409V104 417 1,700 SH   DFND 2 1,700 0 0
SAGE THERAPEUTICS INC COM 78667J108 517 18,000 SH   DFND 2 18,000 0 0
SAGE THERAPEUTICS INC COM 78667J108 40,211 1,400,104 SH   DFND 1,2 1,400,104 0 0
SANGAMO THERAPEUTICS INC COM 800677106 24,525 3,850,000 SH   DFND 1,2 3,850,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 1,956 20,000 SH   DFND 2 20,000 0 0
SCHOLAR ROCK HOLDING CORP COM 80706P103 32,880 2,715,106 SH   DFND 1,2 2,715,106 0 0
SEATTLE GENETICS INC COM 812578102 4,777 41,400 SH   DFND 2 41,400 0 0
SENSATA TECHNOLOGIES HLDNG P SHS G8060N102 286 9,900 SH   DFND 2 9,900 0 0
SERVICE CORP INTL COM 817565104 332 8,500 SH   DFND 2 8,500 0 0
SHOCKWAVE MED INC COM 82489T104 10,772 324,661 SH   DFND 2 324,661 0 0
SILK RD MED INC COM 82710M100 6,125 194,583 SH   DFND 2 194,583 0 0
SKYWORKS SOLUTIONS INC COM 83088M102 509 5,700 SH   DFND 2 5,700 0 0
SOCIEDAD QUIMICA MINERA DE C SPON ADR SER B 833635105 410 18,200 SH   DFND 2 18,200 0 0
STARBUCKS CORP COM 855244109 285 4,334 SH   DFND 2 4,334 0 0
STRYKER CORP COM 863667101 28,755 172,713 SH   DFND 2 172,713 0 0
SUPERNUS PHARMACEUTICALS INC COM 868459108 9,945 552,800 SH   DFND 2 552,800 0 0
SYNEOS HEALTH INC CL A 87166B102 2,440 61,900 SH   DFND 2 61,900 0 0
TABULA RASA HEALTHCARE INC COM 873379101 10,919 208,809 SH   DFND 2 208,809 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 12,551 195,038 SH   DFND 2 195,038 0 0
TELADOC HEALTH INC COM 87918A105 31,193 201,235 SH   DFND 2 201,235 0 0
TELEFLEX INCORPORATED COM 879369106 22,941 78,333 SH   DFND 2 78,333 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 2,721 303,000 SH   DFND 2 303,000 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 11,217 39,552 SH   DFND 2 39,552 0 0
TRANSUNION COM 89400J107 337 5,096 SH   DFND 2 5,096 0 0
TRIMBLE INC COM 896239100 372 11,700 SH   DFND 2 11,700 0 0
TRIP COM GROUP LTD ADS 89677Q107 307 13,100 SH   DFND 2 13,100 0 0
TYLER TECHNOLOGIES INC COM 902252105 452 1,525 SH   DFND 2 1,525 0 0
UBER TECHNOLOGIES INC COM 90353T100 2,792 100,000 SH   DFND 2 100,000 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 955 21,500 SH   DFND 2 21,500 0 0
UNIQURE NV SHS N90064101 1,495 31,500 SH   DFND 2 31,500 0 0
UNITEDHEALTH GROUP INC COM 91324P102 78,856 316,208 SH   DFND 2 316,208 0 0
VARIAN MED SYS INC COM 92220P105 421 4,100 SH   DFND 2 4,100 0 0
VEEVA SYS INC CL A COM 922475108 7,957 50,884 SH   DFND 2 50,884 0 0
VERISIGN INC COM 92343E102 378 2,100 SH   DFND 2 2,100 0 0
VERISK ANALYTICS INC COM 92345Y106 347 2,489 SH   DFND 2 2,489 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 38,807 163,089 SH   DFND 2 163,089 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 264,125 1,110,000 SH   DFND 1,2 1,110,000 0 0
VOCERA COMMUNICATONS INC COM 92857F107 7,449 350,724 SH   DFND 2 350,724 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 401 43,800 SH   DFND 2 43,800 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 24,525 2,680,283 SH   DFND 1,2 2,680,283 0 0
WABTEC CORP COM 929740108 308 6,400 SH   DFND 2 6,400 0 0
WATSCO INC COM 942622200 442 2,800 SH   DFND 2 2,800 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 24,389 2,602,858 SH   DFND 1,2 2,602,858 0 0
XILINX INC COM 983919101 327 4,200 SH   DFND 2 4,200 0 0
ZAI LAB LTD ADR 98887Q104 7,928 154,000 SH   DFND 2 154,000 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 10,596 104,832 SH   DFND 2 104,832 0 0
ZYMEWORKS INC COM 98985W102 653 18,400 SH   DFND 2 18,400 0 0