The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ADAMAS PHARMACEUTICALS INC COM 00548A106 7,924 2,742,000 SH   DFND   2,742,000 0 0
ADDUS HOMECARE CORP COM 006739106 3,515 52,000 SH   DFND   52,000 0 0
AIMMUNE THERAPEUTICS INC COM 00900T107 8,652 600,000 SH   DFND   600,000 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 38,430 428,000 SH   DFND   428,000 0 0
AMAG PHARMACEUTICALS INC COM 00163U106 25,462 4,120,000 SH   DFND   4,120,000 0 0
AMAZON COM INC COM 023135106 44,844 23,000 SH   DFND   23,000 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 10,737 724,000 SH   DFND   724,000 0 0
APTARGROUP INC COM 038336103 14,931 150,000 SH   DFND   150,000 0 0
ACTIVISION BLIZZARD INC COM 00507V109 8,089 136,000 SH   DFND   136,000 0 0
AVAYA HLDGS CORP COM 05351X101 12,879 1,592,000 SH   DFND   1,592,000 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 35,936 1,056,000 SH   DFND   1,056,000 0 0
BIOGEN INC COM 09062X103 18,350 58,000 SH   DFND   58,000 0 0
BLUEBIRD BIO INC COM 09609G100 29,782 648,000 SH   DFND   648,000 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 36,120 648,000 SH   DFND   648,000 0 0
BURLINGTON STORES INC COM 122017106 40,883 258,004 SH   DFND   258,004 0 0
BWX TECHNOLOGIES INC COM 05605H100 4,871 100,000 SH   DFND   100,000 0 0
CAPRICOR THERAPEUTICS INC COM NEW 14070B309 322 268,630 SH   DFND   268,630 0 0
CENTRAL GARDEN & PET CO CL A NON-VTG 153527205 38,355 1,500,000 SH   DFND   1,500,000 0 0
CERECOR INC COM 15671L109 69,838 28,160,605 SH   DFND   28,160,605 0 0
COLGATE PALMOLIVE CO COM 194162103 11,945 180,000 SH   DFND   180,000 0 0
CHIPOTLE MEXICAN GRILL INC COM 169656105 10,993 16,799 SH   DFND   16,799 0 0
CAMPBELL SOUP CO COM 134429109 22,064 478,000 SH   DFND   478,000 0 0
CATALYST PHARMACEUTICALS INC COM 14888U101 20,790 5,400,000 SH   DFND   5,400,000 0 0
CARTERS INC COM 146229109 14,132 215,000 SH   DFND   215,000 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 10,009 236,000 SH   DFND   236,000 0 0
CVS HEALTH CORP COM 126650100 22,427 378,000 SH   DFND   378,000 0 0
DROPBOX INC CL A 26210C104 30,625 1,692,000 SH   DFND   1,692,000 0 0
DECKERS OUTDOOR CORP COM 243537107 30,487 227,518 SH   DFND   227,518 0 0
DOLLAR GEN CORP NEW COM 256677105 25,012 165,633 SH   DFND   165,633 0 0
DOLLAR TREE INC COM 256746108 22,422 305,183 SH   DFND   305,183 0 0
DOMINOS PIZZA INC COM 25754A201 7,889 24,342 SH   DFND   24,342 0 0
ENERGIZER HLDGS INC NEW COM 29272W109 26,378 872,000 SH   DFND   872,000 0 0
ENANTA PHARMACEUTICALS INC COM 29251M106 29,212 568,000 SH   DFND   568,000 0 0
EDGEWELL PERS CARE CO COM 28035Q102 19,264 800,000 SH   DFND   800,000 0 0
EDGEWELL PERS CARE CO COM 28035Q102 12,040 5,000 SH Call DFND   5,000 0 0
EYEGATE PHARMACEUTICALS INC COM NEW 30233M503 9,441 1,815,500 SH   DFND   1,815,500 0 0
FIVE BELOW INC COM 33829M101 23,549 334,594 SH   DFND   334,594 0 0
FRONTDOOR INC COM 35905A109 22,259 640,000 SH   DFND   640,000 0 0
HELIUS MED TECHNOLOGIES INC COM CL A 42328V504 607 1,840,567 SH   DFND   1,840,567 0 0
INCYTE CORP COM 45337C102 38,665 528,000 SH   DFND   528,000 0 0
ISHARES TR RUSSELL 2000 ETF 464287655 80,122 7,000 SH Put DFND   7,000 0 0
KORN FERRY COM NEW 500643200 3,648 150,000 SH   DFND   150,000 0 0
KRAFT HEINZ CO COM 500754106 29,688 1,200,000 SH   DFND   1,200,000 0 0
KIMBERLY CLARK CORP COM 494368103 11,253 88,000 SH   DFND   88,000 0 0
L BRANDS INC COM 501797104 3,030 262,114 SH   DFND   262,114 0 0
LANTHEUS HLDGS INC COM 516544103 16,894 1,324,000 SH   DFND   1,324,000 0 0
LOWES COS INC COM 548661107 9,400 109,239 SH   DFND   109,239 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 14,420 216,000 SH   DFND   216,000 0 0
MONDELEZ INTL INC CL A 609207105 15,024 300,000 SH   DFND   300,000 0 0
MALLINCKRODT PUB LTD CO SHS G5785G107 10,296 52,000 SH Call DFND   52,000 0 0
MERCK & CO. INC COM 58933Y105 23,082 300,000 SH   DFND   300,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 23,983 312,000 SH   DFND   312,000 0 0
MINERVA NEUROSCIENCES INC COM 603380106 1,806 300,000 SH   DFND   300,000 0 0
NN INC COM 629337106 865 500,000 SH   DFND   500,000 0 0
NEON THERAPEUTICS INC COM 64050Y100 2,772 1,050,000 SH   DFND   1,050,000 0 0
OUTLOOK THERAPEUTICS INC COM NEW 69012T206 849 1,412,382 SH   DFND   1,412,382 0 0
PFIZER INC COM 717081103 22,130 678,000 SH   DFND   678,000 0 0
PROGENICS PHARMACEUTICALS IN COM 743187106 1,330 350,000 SH   DFND   350,000 0 0
PREDICTIVE ONCOLOGY INC COM NEW 74039M200 410 260,000 SH   DFND   260,000 0 0
PTC THERAPEUTICS INC COM 69366J200 26,766 600,000 SH   DFND   600,000 0 0
REGENERON PHARMACEUTICALS COM 75886F107 31,251 64,000 SH   DFND   64,000 0 0
ROSS STORES INC COM 778296103 10,238 117,714 SH   DFND   117,714 0 0
SMARTSHEET INC COM CL A 83200N103 4,483 108,000 SH   DFND   108,000 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 154,650 6,000 SH Put DFND   6,000 0 0
SUPERNUS PHARMACEUTICALS INC COM 868459108 53,970 3,000,000 SH   DFND   3,000,000 0 0
TENAX THERAPEUTICS INC COM NEW 88032L209 104 181,153 SH   DFND   181,153 0 0
TARGET CORP COM 87612E106 16,735 180,000 SH   DFND   180,000 0 0
TG THERAPEUTICS INC COM 88322Q108 7,557 768,000 SH   DFND   768,000 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 7,941 28,000 SH   DFND   28,000 0 0
TETRAPHASE PHARMACEUTICALS I COM NEW 88165N204 1,817 1,419,507 SH   DFND   1,419,507 0 0
HOSTESS BRANDS INC CL A 44109J106 10,660 1,000,000 SH   DFND   1,000,000 0 0
UBER TECHNOLOGIES INC COM 90353T100 7,594 272,000 SH   DFND   272,000 0 0
UNITEDHEALTH GROUP INC COM 91324P102 21,945 88,000 SH   DFND   88,000 0 0
VISA INC COM CL A 92826C839 14,017 87,000 SH   DFND   87,000 0 0
VANDA PHARMACEUTICALS INC COM 921659108 47,324 4,568,000 SH   DFND   4,568,000 0 0
VAXART INC COM NEW 92243A200 44,604 25,200,000 SH   DFND   25,200,000 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 20,459 2,236,000 SH   DFND   2,236,000 0 0
MEDIGUS LTD SPONSORED ADS 58471G300 217 1,285,715 SH   DFND   1,285,715 0 0
ZENDESK INC COM 98936J101 3,713 58,000 SH   DFND   58,000 0 0