The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10x Genomics Inc CL A COM 88025U109 11,848 190,109 SH   SOLE 1,2,3 190,109 0 0
Adverum Biotechnologies Inc COM 00773U108 64,791 6,631,627 SH   SOLE 1,2,3 6,631,627 0 0
Agenus Inc COM NEW 00847G705 32,087 13,096,625 SH   SOLE 1,2,3 13,096,625 0 0
Alnylam Pharmaceuticals Inc COM 02043Q107 183,047 1,681,645 SH   SOLE 1,2,3 1,681,645 0 0
Apyx Med Corp COM 03837C106 12,175 3,391,279 SH   SOLE 1,2,3 3,391,279 0 0
Arbutus Biopharma Corp COM 03879J100 6,938 6,869,281 SH   SOLE 1,2,3 6,869,281 0 0
argenx SE SPONSORED ADR 04016X101 4,183 31,752 SH   SOLE 1,2 31,752 0 0
Arvinas Inc COM 04335A105 13,901 344,937 SH   SOLE 1,2,3 344,937 0 0
Avadel Pharmaceuticals plc SPONSORED ADR 05337M104 36,253 4,616,570 SH   SOLE 1,2,3 4,616,570 0 0
Axonics Modulation Technolog COM 05465P101 43,426 1,709,000 SH   SOLE 1,2,3 1,709,000 0 0
Axsome Therapeutics Inc COM 05464T104 61,946 1,052,969 SH   SOLE 1,2,3 1,052,969 0 0
Bellus Health Inc New COM NEW 07987C204 54,732 5,490,992 SH   SOLE 1,2,3 5,490,992 0 0
BiomX Inc *W EXP 10/16/202 09090D111 360 600,000 SH   SOLE 1,2 600,000 0 0
Biomx Inc COM 09090D103 4,200 600,000 SH   SOLE 1,2 600,000 0 0
Brainsway Ltd SPONSORED ADS 10501L106 8,793 1,107,420 SH   SOLE 1,2,3 1,107,420 0 0
Bristol-Myers Squibb Co COM 110122108 93,974 1,685,934 SH   SOLE 1,2,3 1,685,934 0 0
Castle Biosciences Inc COM 14843C105 20,811 698,118 SH   SOLE 1,2,3 698,118 0 0
Clearside Biomedical Inc COM 185063104 6,602 3,883,490 SH   SOLE 1,2,3 3,883,490 0 0
Cytomx Therapeutics Inc COM 23284F105 8,182 1,066,791 SH   SOLE 1,2,3 1,066,791 0 0
DermTech Inc COM 24984K105 29,087 2,600,729 SH   SOLE 1,2,3 2,600,729 0 0
Dicerna Pharmaceuticals Inc COM 253031108 127,913 6,963,135 SH   SOLE 1,2,3 6,963,135 0 0
Establishment Labs Hldgs Inc COM G31249108 33,512 2,319,138 SH   SOLE 1,2,3 2,319,138 0 0
Exagen Inc COM 30068X103 20,015 1,255,640 SH   SOLE 1,2,3 1,255,640 0 0
Frequency Therapeutics Inc COM 35803L108 36,888 2,071,199 SH   SOLE 1,2,3 2,071,199 0 0
Fulgent Genetics Inc COM 359664109 807 75,000 SH   SOLE 1,2,3 75,000 0 0
Global Blood Therapeutics In COM 37890U108 36,759 719,489 SH   SOLE 1,2,3 719,489 0 0
Homology Medicines Inc COM 438083107 68,364 4,399,250 SH   SOLE 1,2,3 4,399,250 0 0
Immunovant Inc COM 45258J102 65,876 4,426,106 SH   SOLE 1,2,3 4,426,106 0 0
Inmode Ltd SHS M5425M103 5,375 250,000 SH   SOLE 1,2 250,000 0 0
Itamar Med Ltd SPONSORED ADS 465437101 5,386 457,218 SH   SOLE 1,2,3 457,218 0 0
Johnson & Johnson COM 478160104 15,324 116,858 SH   SOLE 1,2 116,858 0 0
La Jolla Pharmaceutical Co COM PAR $.0001 2 503459604 9,890 2,354,734 SH   SOLE 1,2,3 2,354,734 0 0
Lifesci Acquisition Corp UNIT 03/31/2025 53228P208 4,999 500,000 SH   SOLE 1,2,3 500,000 0 0
Masimo Corp COM 574795100 67,822 382,915 SH   SOLE 1,2,3 382,915 0 0
Milestone Pharmaceuticals In COM 59935V107 7,940 4,315,102 SH   SOLE 1,2,3 4,315,102 0 0
MiMedx Group Inc COM 602496101 9,424 2,700,320 SH   SOLE 1,2,3 2,700,320 0 0
Mirati Therapeutics Inc COM 60468T105 75,730 985,166 SH   SOLE 1,2,3 985,166 0 0
Motus Gi Hldgs Inc COM 62014P108 523 775,640 SH   SOLE 1,2 775,640 0 0
Myokardia Inc COM 62857M105 36,608 780,898 SH   SOLE 1,2,3 780,898 0 0
NanoString Technologies Inc COM 63009R109 25,484 1,059,621 SH   SOLE 1,2,3 1,059,621 0 0
Natera Inc COM 632307104 37,806 1,266,125 SH   SOLE 1,2,3 1,266,125 0 0
Odonate Therapeutics Inc COM 676079106 10,108 366,085 SH   SOLE 1,2,3 366,085 0 0
Oyster Pt Pharma Inc COM 69242L106 33,932 969,478 SH   SOLE 1,2,3 969,478 0 0
Personalis Inc COM 71535D106 2,058 255,000 SH   SOLE 1,2 255,000 0 0
Profound Med Corp COM NEW 74319B502 1,697 174,193 SH   SOLE 1,2,3 174,193 0 0
ProQR Thrapeutics N V SHS EURO N71542109 26,237 4,779,135 SH   SOLE 1,2,3 4,779,135 0 0
Protagonist Therapeutics Inc COM 74366E102 18,782 2,660,392 SH   SOLE 1,2,3 2,660,392 0 0
PTC Therapeutics Inc COM 69366J200 175,440 3,932,746 SH   SOLE 1,2,3 3,932,746 0 0
Regenxbio Inc COM 75901B107 10,155 313,606 SH   SOLE 1,2,3 313,606 0 0
Relmada Therapeutics Inc COM 75955J402 33,583 984,542 SH   SOLE 1,2,3 984,542 0 0
Rocket Pharmaceuticals Inc COM 77313F106 234,534 16,812,491 SH   SOLE 1,2,3,4 16,812,491 0 0
Sarepta Therapeutics Inc COM 803607100 51,772 529,261 SH   SOLE 1,2,3 529,261 0 0
STAAR Surgical Co COM PAR $0.01 852312305 21,796 675,650 SH   SOLE 1,2,3 675,650 0 0
Stoke Therapeutics Inc COM 86150R107 81,163 3,544,248 SH   SOLE 1,2,3 3,544,248 0 0
Tandem Diabetes Care Inc COM NEW 875372203 28,554 443,725 SH   SOLE 1,2,3 443,725 0 0
Tela Bio Inc COM 872381108 8,910 1,139,358 SH   SOLE 1,2,3 1,139,358 0 0
Translate Bio Inc COM 89374L104 36,813 3,692,424 SH   SOLE 1,2,3 3,692,424 0 0
Transmedics Group Inc COM 89377M109 6,079 503,266 SH   SOLE 1,2 503,266 0 0
Twist Bioscience Corp COM 90184D100 469 15,324 SH   SOLE 1,2,3 15,324 0 0
Uniqure NV SHS N90064101 7,406 156,076 SH   SOLE 1,2,3 156,076 0 0
Vericel Corp COM 92346J108 40,905 4,460,755 SH   SOLE 1,2,3 4,460,755 0 0
Viewray Inc COM 92672L107 375 150,000 SH   SOLE 1,2,3 150,000 0 0
Vivus Inc 4.5 05/01/2020 NOTE4.500% 5/0 928551AA8 2,973 4,000,000 SH   SOLE 1 4,000,000 0 0
WAVE Life Sciences Ltd SHS Y95308105 31,764 3,389,933 SH   SOLE 1,2,3 3,389,933 0 0
Zimmer Biomet Holdings Inc COM 98956P102 67,871 671,457 SH   SOLE 1,2,3 671,457 0 0