The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACADIA PHARMACEUTICALS INC COM 004225108 63 1,500 SH   SOLE   1,500 0 0
AMARIN CORP PLC SPONSORED ADR 023111206 1,820 455,000 SH   SOLE   455,000 0 0
APTOSE BIOSCIENCES INC COM NEW 03835T200 23,891 4,022,000 SH   SOLE   4,022,000 0 0
ARTARA THERAPEUTICS INC COM 04300J107 52,142 2,208,472 SH   SOLE   2,208,472 0 0
AVENUE THERAPEUTICS INC COM NEW 05360L205 9,253 1,035,000 SH   SOLE   1,035,000 0 0
BIOLINERX LTD SPONSORED ADR 09071M106 22 16,667 SH   SOLE   16,667 0 0
CATALYST PHARMACEUTICALS INC COM 14888U101 4,043 1,050,000 SH   SOLE   1,050,000 0 0
CERECOR INC COM 15671L109 5,464 2,203,100 SH   SOLE   2,203,100 0 0
CHEMOCENTRYX INC COM 16383L106 14,529 361,600 SH   SOLE   361,600 0 0
CIDARA THERAPEUTICS INC COM 171757107 2,247 906,056 SH   SOLE   906,056 0 0
CODEXIS INC COM 192005106 15,624 1,400,000 SH   SOLE   1,400,000 0 0
CRINETICS PHARMACEUTICALS INC COM 22663K107 5,421 368,750 SH   SOLE   368,750 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 9,140 222,000 SH   SOLE   222,000 0 0
EDAP TMS SA SPONSORED ADR 268311107 4,979 2,193,500 SH   SOLE   2,193,500 0 0
EIDOS THERAPEUTICS INC COM 28249H104 15,459 315,550 SH   SOLE   315,550 0 0
ETON PHARMACEUTICALS INC COM 29772L108 14,924 3,640,000 SH   SOLE   3,640,000 0 0
FIBROGEN INC COM 31572Q808 5,074 146,000 SH   SOLE   146,000 0 0
FLEXION THERAPEUTICS INC COM 33938J106 2,216 281,600 SH   SOLE   281,600 0 0
FORTRESS BIOTECH INC COM 034960Q19 7,239 3,830,000 SH   SOLE   3,830,000 0 0
FORTY SEVEN INC COM 34983P104 36,784 385,500 SH   SOLE   385,500 0 0
HARROW HEALTH COM 45323A201 9,550 2,500,000 SH   SOLE   2,500,000 0 0
KADMON HOLDINGS INC COM 48283N106 4,828 1,152,250 SH   SOLE   1,152,250 0 0
KALA PHARMACEUTICALS INC COM 483119103 7,234 782,000 SH   SOLE   782,000 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 1,721 225,000 SH   SOLE   225,000 0 0
MACROGENICS INC COM 556099109 2,458 422,300 SH   SOLE   422,300 0 0
MAGENTA THERAPEUTICS INC COM 55910K108 2,730 434,712 SH   SOLE   434,712 0 0
MINERVA NEUROSCIENCES INC COM 603380106 2,710 450,100 SH   SOLE   450,100 0 0
MOLECULAR TEMPLATES INC COM 608550109 7,089 533,400 SH   SOLE   533,400 0 0
MYOVANT SCIENCES LTD COM G637AM102 4,953 656,000 SH   SOLE   656,000 0 0
NEOLEUKIN THERAPEUTICS INC COM 64049K104 15,932 1,400,000 SH   SOLE   1,400,000 0 0
OCULAR THERAPEUTIX INC COM 67576A100 25,356 5,122,500 SH   SOLE   5,122,500 0 0
OCULAR THERAPEUTIX INC CALL 67576A900 53 1,000 SH Call SOLE   0 0 0
ODONATE THERAPEUTICS INC COM 676079106 9,940 360,000 SH   SOLE   360,000 0 0
PROVENTION BIO INC COM 74374N102 1,527 166,000 SH   SOLE   166,000 0 0
RADIUS HEALTH INC COM NEW 750469207 2,171 167,000 SH   SOLE   167,000 0 0
SELECTA BIOSCIENCES INC COM 816212104 940 390,000 SH   SOLE   390,000 0 0
STEREOTAXIS INC COM NEW 85916J409 11,662 3,861,500 SH   SOLE   3,861,500 0 0
TELA BIO INC COM 872381108 633 81,000 SH   SOLE   81,000 0 0
TG THERAPEUTICS INC COM 88322Q108 4,851 493,000 SH   SOLE   493,000 0 0
TRICIDA INC COM 89610F101 4,268 194,000 SH   SOLE   194,000 0 0
UNIQURE NV SHS N90064101 9,965 210,000 SH   SOLE   210,000 0 0
VERASTEM INC COM 92337C104 3,865 1,463,900 SH   SOLE   1,463,900 0 0
XOMA CORP DEL COM NEW 98419J206 7,875 387,000 SH   SOLE   387,000 0 0
ZYMEWORKS INC COM 98985W102 4,718 133,000 SH   SOLE   133,000 0 0