The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
1LIFE HEALTHCARE INC COM 68269G107 16,228 446,807 SH   DFND 2 446,807 0 0
10X GENOMICS INC CL A COM 88025U109 10,992 123,077 SH   DFND 2 123,077 0 0
111 INC ADS 68247Q102 1,083 170,525 SH   DFND 2 170,525 0 0
ABBOTT LABS COM 002824100 117,421 1,284,272 SH   DFND 2 1,284,272 0 0
ABBVIE INC COM 00287Y109 3,633 37,000 SH   DFND 2 37,000 0 0
ABIOMED INC COM 003654100 23,359 96,699 SH   DFND 2 96,699 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 2,176 44,900 SH   DFND 2 44,900 0 0
ADOBE INC COM 00724F101 479 1,100 SH   DFND 2 1,100 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 548 6,200 SH   DFND 2 6,200 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 2,252 42,100 SH   DFND 2 42,100 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 212,929 3,981,473 SH   DFND 1,2 3,981,473 0 0
AKCEA THERAPEUTICS INC COM 00972L107 11,813 862,296 SH   DFND 2 862,296 0 0
AKCEA THERAPEUTICS INC COM 00972L107 8,220 600,000 SH   DFND 1,2 600,000 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 13,289 118,400 SH   DFND 2 118,400 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 145,287 1,294,428 SH   DFND 1,2 1,294,428 0 0
ALIGN TECHNOLOGY INC COM 016255101 27,134 98,869 SH   DFND 2 98,869 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 50,367 340,065 SH   DFND 2 340,065 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 188,100 1,270,000 SH   DFND 1,2 1,270,000 0 0
AMEDISYS INC COM 023436108 12,139 61,143 SH   DFND 2 61,143 0 0
AMERICAN EXPRESS CO COM 025816109 343 3,600 SH   DFND 2 3,600 0 0
AMGEN INC COM 031162100 39,616 167,963 SH   DFND 2 167,963 0 0
ANALOG DEVICES INC COM 032654105 503 4,100 SH   DFND 2 4,100 0 0
ANSYS INC COM 03662Q105 526 1,802 SH   DFND 2 1,802 0 0
ANTHEM INC COM 036752103 81,530 310,025 SH   DFND 2 310,025 0 0
ARGENX SE SPONSORED ADR 04016X101 5,409 24,016 SH   DFND 2 24,016 0 0
ARGENX SE SPONSORED ADR 04016X101 209,464 930,000 SH   DFND 1,2 930,000 0 0
ARVINAS INC COM 04335A105 1,503 44,800 SH   DFND 2 44,800 0 0
ARVINAS INC COM 04335A105 51,548 1,536,903 SH   DFND 1,2 1,536,903 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 1,967 13,300 SH   DFND 2 13,300 0 0
ASPEN TECHNOLOGY INC COM 045327103 311 3,000 SH   DFND 2 3,000 0 0
AUTOLIV INC COM 052800109 439 6,800 SH   DFND 2 6,800 0 0
AVANTOR INC COM 05352A100 6,203 364,877 SH   DFND 2 364,877 0 0
AXONICS MODULATION TECHNOLOG COM 05465P101 18,132 516,428 SH   DFND 2 516,428 0 0
BAXTER INTL INC COM 071813109 53,855 625,495 SH   DFND 2 625,495 0 0
BECTON DICKINSON & CO COM 075887109 58,846 245,940 SH   DFND 2 245,940 0 0
BEIGENE LTD SPONSORED ADR 07725L102 10,927 58,000 SH   DFND 2 58,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 9,485 76,900 SH   DFND 2 76,900 0 0
BIONTECH SE SPONSORED ADS 09075V102 3,337 50,000 SH   DFND 2 50,000 0 0
BIO RAD LABS INC CL A 090572207 36,061 79,871 SH   DFND 2 79,871 0 0
BLACKBAUD INC COM 09227Q100 234 4,107 SH   DFND 2 4,107 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 548 13,000 SH   DFND 2 13,000 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 58,602 1,390,000 SH   DFND 1,2 1,390,000 0 0
BOOKING HLDGS INC COM 09857L108 318 200 SH   DFND 2 200 0 0
BOSTON SCIENTIFIC CORP COM 101137107 60,762 1,730,620 SH   DFND 2 1,730,620 0 0
BRISTOL MYERS SQUIBB CO COM 110122108 94,792 1,612,112 SH   DFND 2 1,612,112 0 0
BRISTOL MYERS SQUIBB CO RIGHT 99/99/9999 110122157 2,864 800,000 SH   DFND 1,2 800,000 0 0
BROADRIDGE FINL SOLUTIONS IN COM 11133T103 429 3,400 SH   DFND 2 3,400 0 0
BROWN FORMAN CORP CL B 115637209 484 7,600 SH   DFND 2 7,600 0 0
BURNING ROCK BIOTECH LTD SPONSORED ADR 12233L107 1,215 45,000 SH   DFND 2 45,000 0 0
CAREDX INC COM 14167L103 41,341 1,166,839 SH   DFND 2 1,166,839 0 0
CATALENT INC COM 148806102 418 5,700 SH   DFND 2 5,700 0 0
CELLECTIS S A SPON ADS 15117K103 1,486 83,500 SH   DFND 2 83,500 0 0
CENTENE CORP DEL COM 15135B101 66,267 1,042,747 SH   DFND 2 1,042,747 0 0
CHANGE HEALTHCARE INC COM 15912K100 16,299 1,455,240 SH   DFND 2 1,455,240 0 0
CHARLES RIV LABS INTL INC COM 159864107 63,783 365,833 SH   DFND 2 365,833 0 0
CIDARA THERAPEUTICS INC COM 171757107 10,415 2,822,495 SH   DFND 1,2 2,822,495 0 0
CIGNA CORP NEW COM 125523100 63,187 336,726 SH   DFND 2 336,726 0 0
CLOROX CO DEL COM 189054109 439 2,000 SH   DFND 2 2,000 0 0
COHERUS BIOSCIENCES INC COM 19249H103 20,671 1,157,400 SH   DFND 2 1,157,400 0 0
CONSTELLATION BRANDS INC CL A 21036P108 360 2,059 SH   DFND 2 2,059 0 0
COOPER COS INC COM NEW 216648402 7,189 25,345 SH   DFND 2 25,345 0 0
COSTAR GROUP INC COM 22160N109 497 700 SH   DFND 2 700 0 0
COVETRUS INC COM 22304C100 27 1,520 SH   DFND 2 1,520 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 58,826 800,462 SH   DFND 1,2 800,462 0 0
CVS HEALTH CORP COM 126650100 15,052 231,681 SH   DFND 2 231,681 0 0
DANAHER CORPORATION COM 235851102 79,862 451,633 SH   DFND 2 451,633 0 0
DAVITA INC COM 23918K108 23,758 300,200 SH   DFND 2 300,200 0 0
DENTSPLY SIRONA INC COM 24906P109 7,011 159,129 SH   DFND 2 159,129 0 0
DEXCOM INC COM 252131107 41,637 102,705 SH   DFND 2 102,705 0 0
DOMINOS PIZZA INC COM 25754A201 369 1,000 SH   DFND 2 1,000 0 0
DR REDDYS LABS LTD ADR 256135203 1,961 37,000 SH   DFND 2 37,000 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 54,713 791,682 SH   DFND 2 791,682 0 0
ELECTRONIC ARTS INC COM 285512109 617 4,670 SH   DFND 2 4,670 0 0
ENTEGRIS INC COM 29362U104 431 7,300 SH   DFND 2 7,300 0 0
ESPERION THERAPEUTICS INC NEW COM 29664W105 79,796 1,555,171 SH   DFND 2 1,555,171 0 0
ESPERION THERAPEUTICS INC NEW COM 29664W105 192,308 3,747,964 SH   DFND 1,2 3,747,964 0 0
EVOLENT HEALTH INC CL A 30050B101 35,802 5,028,363 SH   DFND 2 5,028,363 0 0
EXELIXIS INC COM 30161Q104 5,045 212,500 SH   DFND 2 212,500 0 0
EXELIXIS INC COM 30161Q104 67,303 2,835,000 SH   DFND 1,2 2,835,000 0 0
FACTSET RESH SYS INC COM 303075105 558 1,700 SH   DFND 2 1,700 0 0
FASTENAL CO COM 311900104 428 10,000 SH   DFND 2 10,000 0 0
FATE THERAPEUTICS INC COM 31189P102 3,122 91,000 SH   DFND 2 91,000 0 0
FATE THERAPEUTICS INC COM 31189P102 64,173 1,870,400 SH   DFND 1,2 1,870,400 0 0
FORTINET INC COM 34959E109 398 2,900 SH   DFND 2 2,900 0 0
G1 THERAPEUTICS INC COM 3621LQ109 17,514 721,925 SH   DFND 1,2 721,925 0 0
GENERATION BIO CO COM 37148K100 30,240 1,440,000 SH   DFND 1,2 1,440,000 0 0
GENETRON HLDGS LTD ADS 37186H100 1,207 100,000 SH   DFND 2 100,000 0 0
GENMARK DIAGNOSTICS INC COM 372309104 21,907 1,489,284 SH   DFND 2 1,489,284 0 0
GILEAD SCIENCES INC COM 375558103 10,348 134,500 SH   DFND 2 134,500 0 0
GLAUKOS CORP COM 377322102 18,972 493,811 SH   DFND 2 493,811 0 0
GLOBUS MED INC CL A 379577208 16,590 347,729 SH   DFND 2 347,729 0 0
GRACO INC COM 384109104 466 9,700 SH   DFND 2 9,700 0 0
GUARDANT HEALTH INC COM 40131M109 10,268 126,561 SH   DFND 2 126,561 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 42,899 349,566 SH   DFND 2 349,566 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 2,279 85,000 SH   DFND 2 85,000 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 178,167 6,645,552 SH   DFND 1,2 6,645,552 0 0
HCA HEALTHCARE INC COM 40412C101 33,308 343,166 SH   DFND 2 343,166 0 0
HEALTH CATALYST INC COM 42225T107 10,185 349,169 SH   DFND 2 349,169 0 0
HILL ROM HLDGS INC COM 431475102 46,250 421,294 SH   DFND 2 421,294 0 0
HMS HLDGS CORP COM 40425J101 26,374 814,264 SH   DFND 2 814,264 0 0
HOLOGIC INC COM 436440101 30,272 531,089 SH   DFND 2 531,089 0 0
HOMOLOGY MEDICINES INC COM 438083107 26,387 1,737,122 SH   DFND 1,2 1,737,122 0 0
HORIZON THERAPEUTICS PUB LTD SHS G46188101 8,793 158,200 SH   DFND 2 158,200 0 0
HUAZHU GROUP LTD SPONSORED ADS 44332N106 473 13,500 SH   DFND 2 13,500 0 0
HUMANA INC COM 444859102 91,369 235,640 SH   DFND 2 235,640 0 0
HUTCHISON CHINA MEDITECH LTD SPONSORED ADR 44842L103 26,137 947,674 SH   DFND 2 947,674 0 0
IDEXX LABS INC COM 45168D104 24,302 73,607 SH   DFND 2 73,607 0 0
ILLUMINA INC COM 452327109 35,571 96,047 SH   DFND 2 96,047 0 0
INARI MED INC COM 45332Y109 727 15,000 SH   DFND 2 15,000 0 0
INCYTE CORP COM 45337C102 38,739 372,600 SH   DFND 2 372,600 0 0
INCYTE CORP COM 45337C102 303,592 2,920,000 SH   DFND 1,2 2,920,000 0 0
INOGEN INC COM 45780L104 5,289 148,912 SH   DFND 2 148,912 0 0
INSMED INC COM PAR $.01 457669307 40,103 1,456,174 SH   DFND 2 1,456,174 0 0
INSPIRE MED SYS INC COM 457730109 21,255 244,250 SH   DFND 2 244,250 0 0
INSULET CORP COM 45784P101 45,020 231,749 SH   DFND 2 231,749 0 0
INTEGRA LIFESCIENCES HLDGS C COM NEW 457985208 9,440 200,897 SH   DFND 2 200,897 0 0
INTERACTIVE BROKERS GROUP IN COM CL A 45841N107 393 9,400 SH   DFND 2 9,400 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 383 8,000 SH   DFND 2 8,000 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 33,392 696,976 SH   DFND 1,2 696,976 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 440 4,800 SH   DFND 2 4,800 0 0
INTERSECT ENT INC COM 46071F103 7,624 563,090 SH   DFND 2 563,090 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 3,119 121,500 SH   DFND 2 121,500 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 93,912 3,658,419 SH   DFND 1,2 3,658,419 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 89,026 156,233 SH   DFND 2 156,233 0 0
IONIS PHARMACEUTICALS INC COM 462222100 26,832 455,087 SH   DFND 2 455,087 0 0
IONIS PHARMACEUTICALS INC COM 462222100 459,581 7,794,786 SH   DFND 1,2 7,794,786 0 0
IPG PHOTONICS CORP COM 44980X109 433 2,700 SH   DFND 2 2,700 0 0
IQVIA HLDGS INC COM 46266C105 411 2,900 SH   DFND 2 2,900 0 0
IRHYTHM TECHNOLOGIES INC COM 450056106 10,794 93,140 SH   DFND 2 93,140 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 32,124 291,136 SH   DFND 2 291,136 0 0
JD.COM INC SPON ADR CL A 47215P106 524 8,700 SH   DFND 2 8,700 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 21,973 4,241,940 SH   DFND 1,2 4,241,940 0 0
KOSMOS ENERGY LTD COM 500688106 100 60,000 SH   DFND 2 60,000 0 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409 9,009 54,234 SH   DFND 2 54,234 0 0
LAUDER ESTEE COS INC CL A 518439104 424 2,248 SH   DFND 2 2,248 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102 5,714 134,261 SH   DFND 2 134,261 0 0
LIVE NATION ENTERTAINMENT IN COM 538034109 275 6,200 SH   DFND 2 6,200 0 0
LIVONGO HEALTH INC COM 539183103 19,343 257,258 SH   DFND 2 257,258 0 0
MACROGENICS INC COM 556099109 16,253 582,116 SH   DFND 2 582,116 0 0
MACROGENICS INC COM 556099109 123,406 4,420,000 SH   DFND 1,2 4,420,000 0 0
MARKEL CORP COM 570535104 369 400 SH   DFND 2 400 0 0
MARKETAXESS HLDGS INC COM 57060D108 412 822 SH   DFND 2 822 0 0
MASIMO CORP COM 574795100 22,238 97,541 SH   DFND 2 97,541 0 0
MATCH GROUP INC COM 57665R106 567 5,300 SH   DFND 2 5,300 0 0
MCCORMICK & CO INC COM NON VTG 579780206 502 2,800 SH   DFND 2 2,800 0 0
MCKESSON CORP COM 58155Q103 597 3,892 SH   DFND 2 3,892 0 0
MEDTRONIC PLC SHS G5960L103 89,639 977,523 SH   DFND 2 977,523 0 0
MERCADOLIBRE INC COM 58733R102 493 500 SH   DFND 2 500 0 0
METTLER TOLEDO INTERNATIONAL COM 592688105 564 700 SH   DFND 2 700 0 0
MIRATI THERAPEUTICS INC COM 60468T105 2,032 17,800 SH   DFND 2 17,800 0 0
MODERNA INC COM 60770K107 7,702 119,950 SH   DFND 2 119,950 0 0
MODERNA INC COM 60770K107 207,077 3,225,000 SH   DFND 1,2 3,225,000 0 0
MOLECULAR TEMPLATES INC COM 608550109 441 32,000 SH   DFND 2 32,000 0 0
MOLECULAR TEMPLATES INC COM 608550109 47,510 3,445,240 SH   DFND 1,2 3,445,240 0 0
MOLINA HEALTHCARE INC COM 60855R100 29,291 164,572 SH   DFND 2 164,572 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 2,475 74,400 SH   DFND 2 74,400 0 0
MOODYS CORP COM 615369105 549 2,000 SH   DFND 2 2,000 0 0
MSCI INC COM 55354G100 396 1,186 SH   DFND 2 1,186 0 0
MYOKARDIA INC COM 62857M105 2,744 28,400 SH   DFND 2 28,400 0 0
MYOKARDIA INC COM 62857M105 114,003 1,179,913 SH   DFND 1,2 1,179,913 0 0
MYOVANT SCIENCES LTD COM G637AM102 969 47,000 SH   DFND 2 47,000 0 0
MYOVANT SCIENCES LTD COM G637AM102 94,852 4,600,000 SH   DFND 1,2 4,600,000 0 0
NEKTAR THERAPEUTICS COM 640268108 21,176 914,337 SH   DFND 2 914,337 0 0
NEKTAR THERAPEUTICS COM 640268108 60,695 2,620,676 SH   DFND 1,2 2,620,676 0 0
NEOGENOMICS INC COM NEW 64049M209 15,040 485,470 SH   DFND 2 485,470 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 35,490 290,900 SH   DFND 2 290,900 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 356,240 2,920,000 SH   DFND 1,2 2,920,000 0 0
NEURONETICS INC COM 64131A105 483 250,000 SH   DFND 2 250,000 0 0
NEVRO CORP COM 64157F103 13,352 111,762 SH   DFND 2 111,762 0 0
NUVASIVE INC COM 670704105 3,701 66,500 SH   DFND 2 66,500 0 0
OMNICELL INC COM 68213N109 14,274 202,131 SH   DFND 2 202,131 0 0
OXFORD IMMUNOTEC GLOBAL PLC ORD SHS G6855A103 8,889 683,795 SH   DFND 2 683,795 0 0
PACIFIC BIOSIENCES CALIF IN COM 69404D108 28,855 8,363,741 SH   DFND 2 8,363,741 0 0
PAYCHEX INC COM 704326107 409 5,400 SH   DFND 2 5,400 0 0
PENUMBRA INC COM 70975L107 17,552 98,152 SH   DFND 2 98,152 0 0
PERKINELMER INC COM 714046109 471 4,800 SH   DFND 2 4,800 0 0
PHREESIA INC COM 71944F106 10,666 377,169 SH   DFND 2 377,169 0 0
POLYONE CORP COM 73179P106 357 13,600 SH   DFND 2 13,600 0 0
POOL CORPORATION COM 73278L105 598 2,200 SH   DFND 2 2,200 0 0
PTC THERAPEUTICS INC COM 69366J200 2,882 56,800 SH   DFND 2 56,800 0 0
QUANTERIX CORP COM 74766Q101 13,079 477,515 SH   DFND 2 477,515 0 0
QUEST DIAGNOSTICS INC COM 74834L100 6,838 60,005 SH   DFND 2 60,005 0 0
QUOTIENT LTD SHS G73268107 4,434 599,154 SH   DFND 2 599,154 0 0
RADIUS HEALTH INC COM NEW 750469207 1,032 75,700 SH   DFND 2 75,700 0 0
RADIUS HEALTH INC COM NEW 750469207 94,479 6,931,685 SH   DFND 1,2 6,931,685 0 0
REGENERON PHARMACEUTICALS COM 75886F107 14,406 23,100 SH   DFND 2 23,100 0 0
REGENXBIO INC COM 75901B107 1,510 41,000 SH   DFND 2 41,000 0 0
RESMED INC COM 761152107 14,939 77,805 SH   DFND 2 77,805 0 0
S&P GLOBAL INC COM 78409V104 560 1,700 SH   DFND 2 1,700 0 0
SAGE THERAPEUTICS INC COM 78667J108 640 15,400 SH   DFND 2 15,400 0 0
SAGE THERAPEUTICS INC COM 78667J108 58,216 1,400,104 SH   DFND 1,2 1,400,104 0 0
SANGAMO THERAPEUTICS INC COM 800677106 34,496 3,850,000 SH   DFND 1,2 3,850,000 0 0
SANOFI SPONSORED ADR 80105N105 2,910 57,000 SH   DFND 2 57,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 3,255 20,300 SH   DFND 2 20,300 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 565 31,000 SH   DFND 2 31,000 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 49,442 2,715,106 SH   DFND 1,2 2,715,106 0 0
SEATTLE GENETICS INC COM 812578102 9,329 54,900 SH   DFND 2 54,900 0 0
SENSATA TECHNOLOGIES HLDNG P SHS G8060N102 369 9,900 SH   DFND 2 9,900 0 0
SERVICE CORP INTL COM 817565104 331 8,500 SH   DFND 2 8,500 0 0
SHOCKWAVE MED INC COM 82489T104 19,805 418,089 SH   DFND 2 418,089 0 0
SILK RD MED INC COM 82710M100 10,277 245,338 SH   DFND 2 245,338 0 0
SKYWORKS SOLUTIONS INC COM 83088M102 473 3,700 SH   DFND 2 3,700 0 0
SOCIEDAD QUIMICA MINERA DE C SPON ADR SER B 833635105 474 18,200 SH   DFND 2 18,200 0 0
STARBUCKS CORP COM 855244109 319 4,334 SH   DFND 2 4,334 0 0
STRYKER CORP COM 863667101 58,371 323,942 SH   DFND 2 323,942 0 0
TABULA RASA HEALTHCARE INC COM 873379101 11,853 216,581 SH   DFND 2 216,581 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 22,934 231,839 SH   DFND 2 231,839 0 0
TELADOC HEALTH INC COM 87918A105 28,874 151,299 SH   DFND 2 151,299 0 0
TELEFLEX INCORPORATED COM 879369106 28,512 78,333 SH   DFND 2 78,333 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 25,179 69,491 SH   DFND 2 69,491 0 0
TRADEWEB MKTS INC CL A 892672106 395 6,800 SH   DFND 2 6,800 0 0
TRANSMEDICS GROUP INC COM 89377M109 7,616 425,000 SH   DFND 2 425,000 0 0
TRANSUNION COM 89400J107 444 5,096 SH   DFND 2 5,096 0 0
TRIMBLE INC COM 896239100 505 11,700 SH   DFND 2 11,700 0 0
TRIP COM GROUP LTD ADS 89677Q107 340 13,100 SH   DFND 2 13,100 0 0
TYLER TECHNOLOGIES INC COM 902252105 529 1,525 SH   DFND 2 1,525 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 1,877 24,000 SH   DFND 2 24,000 0 0
UNIQURE NV SHS N90064101 1,555 34,500 SH   DFND 2 34,500 0 0
UNITEDHEALTH GROUP INC COM 91324P102 90,442 306,636 SH   DFND 2 306,636 0 0
VARIAN MED SYS INC COM 92220P105 502 4,100 SH   DFND 2 4,100 0 0
VEEVA SYS INC CL A COM 922475108 14,782 63,056 SH   DFND 2 63,056 0 0
VERISIGN INC COM 92343E102 434 2,100 SH   DFND 2 2,100 0 0
VERISK ANALYTICS INC COM 92345Y106 424 2,489 SH   DFND 2 2,489 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 18,173 62,600 SH   DFND 2 62,600 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 267,085 920,000 SH   DFND 1,2 920,000 0 0
VIR BIOTECHNOLOGY INC COM 92764N102 1,741 42,500 SH   DFND 2 42,500 0 0
VOCERA COMMUNICATONS INC COM 92857F107 7,295 344,081 SH   DFND 2 344,081 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 401 31,800 SH   DFND 2 31,800 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 33,825 2,680,283 SH   DFND 1,2 2,680,283 0 0
WABTEC COM 929740108 368 6,400 SH   DFND 2 6,400 0 0
WATSCO INC COM 942622200 498 2,800 SH   DFND 2 2,800 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 27,096 2,602,858 SH   DFND 1,2 2,602,858 0 0
XILINX INC COM 983919101 413 4,200 SH   DFND 2 4,200 0 0
ZAI LAB LTD ADR 98887Q104 14,381 175,100 SH   DFND 2 175,100 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 27,155 227,508 SH   DFND 2 227,508 0 0