The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10x Genomics Inc CL A COM 88025U109 56,809 636,092 SH   SOLE 1,2,3 636,092 0 0
Adaptimmune Therapeutics PLC SPONDS ADR 00653A107 26,026 2,600,000 SH   SOLE 1,2,3 2,600,000 0 0
Adverum Biotechnologies Inc COM 00773U108 141,776 6,790,027 SH   SOLE 1,2,3 6,790,027 0 0
Agenus Inc COM NEW 00847G705 50,558 12,864,677 SH   SOLE 1,2,3 12,864,677 0 0
Alnylam Pharmaceuticals Inc COM 02043Q107 249,068 1,681,645 SH   SOLE 1,2,3 1,681,645 0 0
Amyris Inc COM NEW 03236M200 12,401 3,103,535 SH   SOLE 1,2,3 3,103,535 0 0
Apyx Med Corp COM 03837C106 18,822 3,391,279 SH   SOLE 1,2,3 3,391,279 0 0
Arbutus Biopharma Corp COM 03879J100 12,502 6,869,281 SH   SOLE 1,2,3 6,869,281 0 0
argenx SE SPONSORED ADR 04016X101 7,152 31,752 SH   SOLE 1,2 31,752 0 0
Arvinas Inc COM 04335A105 5,840 174,118 SH   SOLE 1,2,3 174,118 0 0
ARYA Sciences Acquistion Co UNIT 06/09/2027 G31655114 5,798 500,000 SH   SOLE 1,2,3 500,000 0 0
Avadel Pharmaceuticals plc SPONSORED ADR 05337M104 42,877 5,306,570 SH   SOLE 1,2,3 5,306,570 0 0
Avidity Biosciences Inc COM 05370A108 103,863 3,995,000 SH   SOLE 1,2,3 3,995,000 0 0
Axonics Modulation Technolog COM 05465P101 66,121 1,883,257 SH   SOLE 1,2,3 1,883,257 0 0
Axsome Therapeutics Inc COM 05464T104 136,446 1,658,316 SH   SOLE 1,2,3 1,658,316 0 0
Baxter Intl Inc COM 071813109 83,463 969,370 SH   SOLE 1,2,3 969,370 0 0
Bellus Health Inc New COM NEW 07987C204 61,550 5,970,230 SH   SOLE 1,2,3 5,970,230 0 0
BiomX Inc *W EXP 10/16/202 09090D111 287 600,000 SH   SOLE 1,2 600,000 0 0
Biomx Inc COM 09090D103 3,312 600,000 SH   SOLE 1,2 600,000 0 0
Brainsway Ltd SPONSORED ADS 10501L106 6,556 1,107,420 SH   SOLE 1,2,3 1,107,420 0 0
Burning Rock Biotech Ltd SPONSORED ADS 12233L107 810 30,000 SH   SOLE 1,2,3 30,000 0 0
Castle Biosciences Inc COM 14843C105 30,284 803,510 SH   SOLE 1,2,3 803,510 0 0
Celldex Therapeutics Inc New COM NEW 15117B202 33,930 2,610,000 SH   SOLE 1,2,3 2,610,000 0 0
Cerner Corp COM 156782104 81,054 1,182,409 SH   SOLE 1,2,3 1,182,409 0 0
Chardan Healthcr Acqstn 2 Co UNIT 99/99/9999 15957T206 3,675 350,000 SH   SOLE 1,2,3 350,000 0 0
Clearside Biomedical Inc COM 185063104 7,365 3,917,622 SH   SOLE 1,2,3 3,917,622 0 0
Cytomx Therapeutics Inc COM 23284F105 12,616 1,514,476 SH   SOLE 1,2,3 1,514,476 0 0
DermTech Inc COM 24984K105 37,782 2,855,765 SH   SOLE 1,2,3 2,855,765 0 0
Dicerna Pharmaceuticals Inc COM 253031108 181,684 7,152,918 SH   SOLE 1,2,3 7,152,918 0 0
Establishment Labs Hldgs Inc COM G31249108 43,322 2,319,138 SH   SOLE 1,2,3 2,319,138 0 0
Exagen Inc COM 30068X103 15,576 1,255,131 SH   SOLE 1,2,3 1,255,131 0 0
Frequency Therapeutics Inc COM 35803L108 50,255 2,161,486 SH   SOLE 1,2,3 2,161,486 0 0
Fulgent Genetics Inc COM 359664109 1,200 75,000 SH   SOLE 1,2,3 75,000 0 0
GenMark Diagnostics Inc COM 372309104 13,757 935,206 SH   SOLE 1,2,3 935,206 0 0
Homology Medicines Inc COM 438083107 66,110 4,352,190 SH   SOLE 1,2,3 4,352,190 0 0
Immunovant Inc COM 45258J102 139,213 5,717,182 SH   SOLE 1,2,3 5,717,182 0 0
Inari Med Inc COM 45332Y109 2,173 44,860 SH   SOLE 1,2,3 44,860 0 0
Inmode Ltd SHS M5425M103 7,080 250,000 SH   SOLE 1,2 250,000 0 0
Itamar Med Ltd SPONSORED ADS 465437101 8,504 457,218 SH   SOLE 1,2,3 457,218 0 0
IVERIC bio Inc COM 46583P102 33,642 6,596,536 SH   SOLE 1,2,3 6,596,536 0 0
Johnson & Johnson COM 478160104 17,840 126,858 SH   SOLE 1,2 126,858 0 0
La Jolla Pharmaceutical Co COM PAR $.0001 2 503459604 10,117 2,374,952 SH   SOLE 1,2,3 2,374,952 0 0
Lifesci Acquisition Corp UNIT 03/31/2025 53228P208 5,500 500,000 SH   SOLE 1,2,3 500,000 0 0
MacroGenics Inc COM 556099109 34,783 1,245,816 SH   SOLE 1,2,3 1,245,816 0 0
Masimo Corp COM 574795100 88,637 388,776 SH   SOLE 1,2,3 388,776 0 0
Milestone Pharmaceuticals In COM 59935V107 16,311 4,315,102 SH   SOLE 1,2,3 4,315,102 0 0
MiMedx Group Inc COM 602496101 14,582 2,700,320 SH   SOLE 1,2,3 2,700,320 0 0
Mirati Therapeutics Inc COM 60468T105 124,186 1,087,726 SH   SOLE 1,2,3 1,087,726 0 0
Motus Gi Hldgs Inc COM 62014P108 1,024 775,640 SH   SOLE 1,2 775,640 0 0
Myokardia Inc COM 62857M105 90,526 936,931 SH   SOLE 1,2,3 936,931 0 0
NanoString Technologies Inc COM 63009R109 27,798 947,134 SH   SOLE 1,2,3 947,134 0 0
Natera Inc COM 632307104 76,242 1,529,128 SH   SOLE 1,2,3 1,529,128 0 0
Neogenomics Inc COM NEW 64049M209 13,786 445,000 SH   SOLE 1,2,3 445,000 0 0
Odonate Therapeutics Inc COM 676079106 20,367 481,027 SH   SOLE 1,2,3 481,027 0 0
OraSure Technologies Inc COM 68554V108 17,922 1,540,972 SH   SOLE 1,2,3 1,540,972 0 0
Oyster Pt Pharma Inc COM 69242L106 55,142 1,909,360 SH   SOLE 1,2,3 1,909,360 0 0
Personalis Inc COM 71535D106 3,307 255,000 SH   SOLE 1,2 255,000 0 0
Profound Med Corp COM NEW 74319B502 2,951 174,193 SH   SOLE 1,2,3 174,193 0 0
Progenity Inc COM 74319F107 2,475 275,000 SH   SOLE 1,2,3 275,000 0 0
ProQR Thrapeutics N V SHS EURO N71542109 29,809 4,902,785 SH   SOLE 1,2,3 4,902,785 0 0
Protagonist Therapeutics Inc COM 74366E102 59,747 3,383,208 SH   SOLE 1,2,3 3,383,208 0 0
PTC Therapeutics Inc COM 69366J200 201,089 3,963,120 SH   SOLE 1,2,3 3,963,120 0 0
Regenxbio Inc COM 75901B107 11,639 316,028 SH   SOLE 1,2,3 316,028 0 0
Relmada Therapeutics Inc COM 75955J402 66,268 1,480,852 SH   SOLE 1,2,3 1,480,852 0 0
Repare Therapeutics Inc COM 760273102 6,980 225,000 SH   SOLE 1,2,3 225,000 0 0
Rocket Pharmaceuticals Inc COM 77313F106 351,885 16,812,491 SH   SOLE 1,2,3,4 16,812,491 0 0
STAAR Surgical Co COM PAR $0.01 852312305 19,010 308,904 SH   SOLE 1,2,3 308,904 0 0
Stoke Therapeutics Inc COM 86150R107 84,459 3,544,248 SH   SOLE 1,2,3 3,544,248 0 0
Tandem Diabetes Care Inc COM NEW 875372203 59,245 598,923 SH   SOLE 1,2,3 598,923 0 0
Tela Bio Inc COM 872381108 17,682 1,364,358 SH   SOLE 1,2,3 1,364,358 0 0
Translate Bio Inc COM 89374L104 66,609 3,716,994 SH   SOLE 1,2,3 3,716,994 0 0
Transmedics Group Inc COM 89377M109 9,019 503,266 SH   SOLE 1,2 503,266 0 0
Twist Bioscience Corp COM 90184D100 837 18,473 SH   SOLE 1,2,3 18,473 0 0
Uniqure NV SHS N90064101 7,087 157,282 SH   SOLE 1,2,3 157,282 0 0
Vericel Corp COM 92346J108 53,212 3,850,347 SH   SOLE 1,2,3 3,850,347 0 0
Viewray Inc COM 92672L107 336 150,000 SH   SOLE 1,2,3 150,000 0 0
WAVE Life Sciences Ltd SHS Y95308105 24,885 2,390,496 SH   SOLE 1,2,3 2,390,496 0 0