The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABIOMED INC COM 003654100 118,928 492,333 SH   SOLE 0 492,333 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 75,851 1,564,900 SH   SOLE 0 1,564,900 0 0
AIMMUNE THERAPEUTICS INC COM 00900T107 55,447 3,318,212 SH   SOLE 0 3,318,212 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 306 73,500 SH   SOLE 0 73,500 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 49,905 444,629 SH   SOLE 0 444,629 0 0
ALIGN TECHNOLOGY INC COM 016255101 18,526 67,505 SH   SOLE 0 67,505 0 0
ALIMERA SCIENCES INC COM 016259202 1,266 200,919 SH   SOLE 0 200,919 0 0
AMAG PHARMACEUTICALS INC COM 00163U106 22,641 2,959,587 SH   SOLE 0 2,959,587 0 0
AMICUS THERAPEUTICS INC COM 03152W109 110,607 7,334,714 SH   SOLE 0 7,334,714 0 0
APREA THERAPEUTICS INC COM 03836J102 1,832 47,234 SH   SOLE 0 47,234 0 0
ATHENEX INC COM 04685N103 2,548 185,200 SH   SOLE 0 185,200 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 173,410 1,405,950 SH   SOLE 0 1,405,950 0 0
CLOVIS ONCOLOGY INC COM 189464100 29,440 4,361,411 SH   SOLE 0 4,361,411 0 0
CYTOKINETICS INC COM 23282W605 2,915 123,686 SH   SOLE 0 123,686 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 8,428 331,813 SH   SOLE 0 331,813 0 0
EPIZYME INC COM 29428V104 88,550 5,513,676 SH   SOLE 0 5,513,676 0 0
GOSSAMER BIO INC COM 38341P102 2,655 204,214 SH   SOLE 0 204,214 0 0
IDERA PHARMACEUTICALS INC COM 45168K405 138 77,044 SH   SOLE 0 77,044 0 0
IMMUNOMEDICS INC COM 452907108 183,685 5,182,983 SH   SOLE 0 5,182,983 0 0
INSMED INC COM 457669307 165,303 6,002,289 SH   SOLE 0 6,002,289 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101 960 37,400 SH   SOLE 0 37,400 0 0
KALEIDO BIOSCIENCES INC COM 483347100 5,843 786,400 SH   SOLE 0 786,400 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 79,916 4,219,452 SH   SOLE 0 4,219,452 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 1,062 205,086 SH   SOLE 0 205,086 0 0
MAGENTA THERAPEUTICS INC COM 55910K108 1,461 194,600 SH   SOLE 0 194,600 0 0
MARINUS PHARMACEUTICALS INC COM 56854Q101 318 125,321 SH   SOLE 0 125,321 0 0
MINERVA NEUROSCIENCES INC COM 603380106 131 36,319 SH   SOLE 0 36,319 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 49,224 1,479,524 SH   SOLE 0 1,479,524 0 0
PROTHENA CORP PLC COM G72800108 8,065 771,065 SH   SOLE 0 771,065 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 14,017 1,343,897 SH   SOLE 0 1,343,897 0 0
RETROPHIN INC COM 761299106 959 47,000 SH   SOLE 0 47,000 0 0
REVANCE THERAPEUTICS INC COM 761330109 41,621 1,704,372 SH   SOLE 0 1,704,372 0 0
RIGEL PHARMACEUTICALS INC COM 766559603 6,483 3,542,551 SH   SOLE 0 3,542,551 0 0
SAGE THERAPEUTICS INC COM 78667J108 23,917 575,200 SH   SOLE 0 575,200 0 0
STAAR SURGICAL CO COM 852312305 173,614 2,821,154 SH   SOLE 0 2,821,154 0 0
SUNESIS PHARMACEUTICALS INC COM 867328700 306 1,162,473 SH   SOLE 0 1,162,473 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 1,893 127,700 SH   SOLE 0 127,700 0 0
UNITED THERAPEUTICS CORP COM 91307C102 92,735 766,406 SH   SOLE 0 766,406 0 0
UROGEN PHARMA LTD COM M96088105 640 24,500 SH   SOLE 0 24,500 0 0
VANDA PHARMACEUTICALS INC COM 921659108 47,093 4,116,548 SH   SOLE 0 4,116,548 0 0
ZOGENIX INC COM 98978L204 2,812 104,100 SH   SOLE 0 104,100 0 0