The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABEONA THERAPEUTICS INC COM 00289Y107 21,026 7,213,012 SH   DFND 1,2 7,213,012 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 87,488 1,804,993 SH   DFND 1,2 1,804,993 0 0
ACCELERON PHARMA INC COM 00434H108 5,531 58,056 SH   DFND 1,2 58,056 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 47,667 3,510,073 SH   DFND 1,2 3,510,073 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 81,986 1,302,399 SH   DFND 1,2 1,302,399 0 0
ARVINAS INC COM 04335A105 6,825 203,500 SH Call DFND 1,2 203,500 0 0
AXONICS MODULATION TECHNOLOG COM 05465P101 16,133 459,503 SH   DFND 1,2 459,503 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 61,478 840,900 SH   DFND 1,2 840,900 0 0
CALITHERA BIOSCIENCES INC COM 13089P101 11,942 2,261,700 SH   DFND 1,2 2,261,700 0 0
CONSTELLATION PHARMCETICLS I COM 210373106 104,574 3,480,000 SH   DFND 1,2 3,480,000 0 0
CYTOKINETICS INC COM NEW 23282W605 35,841 1,520,635 SH   DFND 1,2 1,520,635 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 12,067 1,448,604 SH   DFND 1,2 1,448,604 0 0
DENALI THERAPEUTICS INC COM 24823R105 6,770 280,000 SH   DFND 1,2 280,000 0 0
GERON CORP COM 374163103 33,568 15,398,079 SH   DFND 1,2 15,398,079 0 0
GLAUKOS CORP COM 377322102 19,210 500,000 SH   DFND 1,2 500,000 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 34,229 542,200 SH   DFND 1,2 542,200 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 55,224 450,000 SH   DFND 1,2 450,000 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 102,251 3,724,976 SH   DFND 1,2 3,724,976 0 0
KADMON HLDGS INC COM 48283N106 3,459 675,679 SH   DFND 1,2 675,679 0 0
LIQUIDIA TECHNOLOGIES INC COM 53635D202 10,760 1,277,955 SH   DFND 1,2 1,277,955 0 0
MACROGENICS INC COM 556099109 41,880 1,500,000 SH   DFND 1,2 1,500,000 0 0
MILLENDO THERAPEUTICS INC COM 60040X103 2,571 1,460,697 SH   DFND 1,2 1,460,697 0 0
MOLECULAR TEMPLATES INC COM 608550109 18,553 1,345,397 SH   DFND 1,2 1,345,397 0 0
NEOLEUKIN THERAPEUTICS INC COM 64049K104 233 14,065 SH   DFND 1,2 14,065 0 0
NEXTCURE INC COM 65343E108 21,433 999,666 SH   DFND 1,2 999,666 0 0
OYSTER PT PHARMA INC COM 69242L106 6,199 214,631 SH   DFND 1,2 214,631 0 0
PROTHENA CORP PLC SHS G72800108 21,787 2,082,841 SH   DFND 1,2 2,082,841 0 0
PTC THERAPEUTICS INC COM 69366J200 16,744 330,000 SH   DFND 1,2 330,000 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 965 92,502 SH   DFND 1,2 92,502 0 0
SAGE THERAPEUTICS INC COM 78667J108 87,416 2,102,368 SH   DFND 1,2 2,102,368 0 0
SANGAMO THERAPEUTICS INC COM 800677106 14,156 1,579,891 SH   DFND 1,2 1,579,891 0 0
TG THERAPEUTICS INC COM 88322Q108 64,689 3,320,808 SH   DFND 1,2 3,320,808 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 75,020 620,000 SH   DFND 1,2 620,000 0 0
VERICEL CORP COM 92346J108 22,252 1,610,154 SH   DFND 1,2 1,610,154 0 0
VIEWRAY INC COM 92672L107 6,213 2,773,811 SH   DFND 1,2 2,773,811 0 0
ZYMEWORKS INC COM 98985W102 92,869 2,574,688 SH   DFND 1,2 2,574,688 0 0