The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10x Genomics Inc CL A COM 88025U109 82,405 660,933 SH   SOLE 1,2,3 660,933 0 0
Acutus Medical Inc COM 005111109 13,465 451,834 SH   SOLE 1,2,3 451,834 0 0
Adaptimmune Therapeutics PLC SPONDS ADR 00653A107 20,889 2,617,626 SH   SOLE 1,2,3 2,617,626 0 0
Adverum Biotechnologies Inc COM 00773U108 74,518 7,234,764 SH   SOLE 1,2,3 7,234,764 0 0
Agenus Inc COM NEW 00847G705 51,459 12,864,677 SH   SOLE 1,2,3 12,864,677 0 0
Alnylam Pharmaceuticals Inc COM 02043Q107 244,848 1,681,645 SH   SOLE 1,2,3 1,681,645 0 0
Altimmune Inc COM NEW 02155H200 17,621 1,334,940 SH   SOLE 1,2,3 1,334,940 0 0
Amyris Inc COM NEW 03236M200 15,071 5,161,347 SH   SOLE 1,2,3 5,161,347 0 0
Apyx Medical Corp COM 03837C106 15,973 3,391,279 SH   SOLE 1,2,3 3,391,279 0 0
Arbutus Biopharma Corp COM 03879J100 18,712 5,978,355 SH   SOLE 1,2,3 5,978,355 0 0
Arcturus Therapeutics Ltd COM 03969T109 10,778 251,236 SH   SOLE 1,2,3 251,236 0 0
argenx SE SPONSORED ADR 04016X101 8,336 31,752 SH   SOLE 1,2 31,752 0 0
Arya Sciences Acquisition Corp COM CL A G3166W106 5,408 500,000 SH   SOLE 1,2,3 500,000 0 0
Arya Sciences Acquisition II Corp UNIT 06/09/2027 G31655114 5,500 500,000 SH   SOLE 1,2,3 500,000 0 0
Athira Pharma Inc COM 04746L104 45,372 2,668,913 SH   SOLE 1,2,3 2,668,913 0 0
Avadel Pharmaceuticals plc SPONSORED ADR 05337M104 27,048 5,366,705 SH   SOLE 1,2,3 5,366,705 0 0
Avidity Biosciences Inc COM 05370A108 109,888 3,995,000 SH   SOLE 1,2,3 3,995,000 0 0
Axonics Modulation Technologies Inc COM 05465P101 96,152 1,883,864 SH   SOLE 1,2,3 1,883,864 0 0
Axsome Therapeutics Inc COM 05464T104 119,054 1,670,938 SH   SOLE 1,2,3 1,670,938 0 0
Baxter International Inc COM 071813109 86,634 1,077,268 SH   SOLE 1,2,3 1,077,268 0 0
BCTG Acquisition Corp COM 05492W103 6,216 600,000 SH   SOLE 1,2,3 600,000 0 0
Bellus Health Inc COM NEW 07987C204 9,547 4,195,356 SH   SOLE 1,2,3 4,195,356 0 0
Berkeley Lights Inc COM 084310101 22,934 300,338 SH   SOLE 1,2,3 300,338 0 0
BiomX Equities Warrant Exp 13 Dec 2023 *W EXP 10/16/202 09090D111 426 600,000 SH   SOLE 1,2 600,000 0 0
Biomx Inc COM 09090D103 3,804 600,000 SH   SOLE 1,2 600,000 0 0
Brainsway Ltd SPONSORED ADS 10501L106 6,459 1,107,420 SH   SOLE 1,2,3 1,107,420 0 0
Burning Rock Biotech Ltd SPONSORED ADS 12233L107 752 30,000 SH   SOLE 1,2,3 30,000 0 0
Castle Biosciences Inc COM 14843C105 38,260 743,642 SH   SOLE 1,2,3 743,642 0 0
Celldex Therapeutics Inc COM NEW 15117B202 46,272 3,120,137 SH   SOLE 1,2,3 3,120,137 0 0
Cerner Corp COM 156782104 100,631 1,392,049 SH   SOLE 1,2,3 1,392,049 0 0
Chardan Healthcare Acquisition 2 Corp UNIT 99/99/9999 15957T206 3,588 350,000 SH   SOLE 1,2,3 350,000 0 0
Clearside Biomedical Inc COM 185063104 6,079 3,947,518 SH   SOLE 1,2,3 3,947,518 0 0
Cytokinetics Inc Private COM NEW 23282W605 40,702 2,000,000 SH   SOLE 1,2,3 2,000,000 0 0
Cytomx Therapeutics Inc COM 23284F105 10,148 1,526,003 SH   SOLE 1,2,3 1,526,003 0 0
DermTech Inc COM 24984K105 34,502 2,887,215 SH   SOLE 1,2,3 2,887,215 0 0
Dicerna Pharmaceuticals Inc COM 253031108 130,021 7,227,413 SH   SOLE 1,2,3 7,227,413 0 0
Equillium Inc COM 29446K106 5,798 1,004,784 SH   SOLE 1,2,3 1,004,784 0 0
Establishment Labs Holdings Inc COM G31249108 42,974 2,319,138 SH   SOLE 1,2,3 2,319,138 0 0
Exagen Inc COM 30068X103 13,551 1,250,131 SH   SOLE 1,2,3 1,250,131 0 0
Frequency Therapeutics Inc COM 35803L108 47,285 2,461,486 SH   SOLE 1,2,3 2,461,486 0 0
Fulcrum Therapeutics Inc COM 359616109 9,124 1,150,565 SH   SOLE 1,2,3 1,150,565 0 0
GenMark Diagnostics Inc COM 372309104 10,835 762,994 SH   SOLE 1,2,3 762,994 0 0
Guardant Health Inc COM 40131M109 52,480 469,498 SH   SOLE 1,2,3 469,498 0 0
Homology Medicines Inc COM 438083107 26,942 2,517,906 SH   SOLE 1,2,3 2,517,906 0 0
Illumina Inc COM 452327109 54,089 175,000 SH   SOLE 1,2,3 175,000 0 0
Immatics Nv SHS N44445109 3,714 350,000 SH   SOLE 1,2,3 350,000 0 0
Immunic Inc COM 4525EP101 16,945 912,496 SH   SOLE 1,2,3 912,496 0 0
Immunovant Inc COM 45258J102 264,291 7,510,412 SH   SOLE 1,2,3 7,510,412 0 0
Incyte Corp COM 45337C102 29,986 334,144 SH   SOLE 1,2,3 334,144 0 0
Inmode Ltd SHS M5425M103 9,045 250,000 SH   SOLE 1,2 250,000 0 0
Itamar Medical Ltd SPONSORED ADS 465437101 9,341 457,218 SH   SOLE 1,2,3 457,218 0 0
Iteos Therapeutics Inc COM 46565G104 20,904 902,855 SH   SOLE 1,2,3 902,855 0 0
IVERIC bio Inc COM 46583P102 37,582 6,663,439 SH   SOLE 1,2,3 6,663,439 0 0
Johnson & Johnson COM 478160104 22,296 149,761 SH   SOLE 1,2 149,761 0 0
La Jolla Pharmaceutical Co COM PAR $.0001 2 503459604 9,652 2,395,029 SH   SOLE 1,2,3 2,395,029 0 0
Lifesci Acquisition Corp UNIT 03/31/2025 53228P208 6,800 500,000 SH   SOLE 1,2,3 500,000 0 0
MacroGenics Inc COM 556099109 31,621 1,255,299 SH   SOLE 1,2,3 1,255,299 0 0
Masimo Corp COM 574795100 106,319 450,390 SH   SOLE 1,2,3 450,390 0 0
Milestone Pharmaceuticals Inc COM 59935V107 31,587 4,315,102 SH   SOLE 1,2,3 4,315,102 0 0
MiMedx Group Inc COM 602496101 17,161 2,700,320 SH   SOLE 1,2,3 2,700,320 0 0
Mirati Therapeutics Inc COM 60468T105 181,992 1,096,005 SH   SOLE 1,2,3 1,096,005 0 0
Myokardia Inc COM 62857M105 127,732 936,931 SH   SOLE 1,2,3 936,931 0 0
NanoString Technologies Inc COM 63009R109 42,337 947,134 SH   SOLE 1,2,3 947,134 0 0
Natera Inc COM 632307104 123,586 1,710,769 SH   SOLE 1,2,3 1,710,769 0 0
Odonate Therapeutics Inc COM 676079106 13,420 999,256 SH   SOLE 1,2,3 999,256 0 0
OraSure Technologies Inc COM 68554V108 25,254 2,075,082 SH   SOLE 1,2,3 2,075,082 0 0
Outset Medical Inc COM 690145107 20,250 405,000 SH   SOLE 1,2,3 405,000 0 0
Oyster Point Pharma Inc COM 69242L106 40,613 1,923,893 SH   SOLE 1,2,3 1,923,893 0 0
Panacea Acquisition Corp UNIT 99/99/9999 698102209 3,600 300,000 SH   SOLE 1,2,3 300,000 0 0
Personalis Inc COM 71535D106 5,526 255,000 SH   SOLE 1,2 255,000 0 0
Pmv Pharmaceuticals Inc COM 69353Y103 17,750 500,000 SH   SOLE 1,2,3 500,000 0 0
Profound Medical Corp COM NEW 74319B502 4,308 244,193 SH   SOLE 1,2,3 244,193 0 0
Progenity Inc COM 74319F107 2,481 275,000 SH   SOLE 1,2,3 275,000 0 0
ProQR Therapeutics NV SHS EURO N71542109 23,822 4,973,174 SH   SOLE 1,2,3 4,973,174 0 0
Protagonist Therapeutics Inc COM 74366E102 66,645 3,408,961 SH   SOLE 1,2,3 3,408,961 0 0
PTC Therapeutics Inc COM 69366J200 186,686 3,993,286 SH   SOLE 1,2,3 3,993,286 0 0
Regenxbio Inc COM 75901B107 8,763 318,434 SH   SOLE 1,2,3 318,434 0 0
Relmada Therapeutics Inc COM 75955J402 56,857 1,511,337 SH   SOLE 1,2,3 1,511,337 0 0
Rocket Pharmaceuticals Inc COM 77313F106 384,334 16,812,491 SH   SOLE 1,2,3,4 16,812,491 0 0
Stoke Therapeutics Inc COM 86150R107 118,697 3,544,248 SH   SOLE 1,2,3 3,544,248 0 0
Tandem Diabetes Care Inc COM NEW 875372203 68,495 603,481 SH   SOLE 1,2,3 603,481 0 0
Tela Bio Inc COM 872381108 22,805 1,378,776 SH   SOLE 1,2,3 1,378,776 0 0
Therapeutics Acquisition Corp COM CL A 88339T103 7,046 490,000 SH   SOLE 1,2,3 490,000 0 0
Translate Bio Inc COM 89374L104 50,973 3,745,286 SH   SOLE 1,2,3 3,745,286 0 0
Transmedics Group Inc COM 89377M109 6,935 503,266 SH   SOLE 1,2 503,266 0 0
Trillium Therapeutics Inc COM NEW 89620X506 30,705 2,160,800 SH   SOLE 1,2,3 2,160,800 0 0
Twist Bioscience Corp COM 90184D100 1,403 18,473 SH   SOLE 1,2,3 18,473 0 0
Uniqure NV SHS N90064101 5,837 158,479 SH   SOLE 1,2,3 158,479 0 0
Vaxart Inc COM NEW 92243A200 23,390 3,517,345 SH   SOLE 1,2,3 3,517,345 0 0
Vericel Corp COM 92346J108 71,356 3,850,851 SH   SOLE 1,2,3 3,850,851 0 0