The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ADAMAS PHARMACEUTICALS INC COM 00548A106 11,297 2,742,000 SH   DFND   2,742,000 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 57,215 500,000 SH   DFND   500,000 0 0
ALKERMES PLC SHS G01767105 35,195 2,124,000 SH   DFND   2,124,000 0 0
ALTIMMUNE INC COM NEW 02155H200 18,955 1,436,000 SH   DFND   1,436,000 0 0
AMAG PHARMACEUTICALS INC COM 00163U106 38,728 4,120,000 SH   DFND   4,120,000 0 0
AMAZON COM INC COM 023135106 31,245 9,923 SH   DFND   9,923 0 0
AMRYT PHARMA PLC SPONSORED ADS 03217L106 3,782 306,000 SH   DFND   306,000 0 0
ANAPLAN INC COM 03272L108 5,507 88,000 SH   DFND   88,000 0 0
ANTARES PHARMA INC COM 036642106 1,156 428,000 SH   DFND   428,000 0 0
ARGENX SE SPONSORED ADR 04016X101 22,314 85,000 SH   DFND   85,000 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 12,626 768,000 SH   DFND   768,000 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 7,365 500,000 SH   DFND   500,000 0 0
AUTOZONE INC COM 053332102 60,402 51,291 SH   DFND   51,291 0 0
AVANOS MED INC COM 05350V106 6,544 197,000 SH   DFND   197,000 0 0
AVANTOR INC COM 05352A100 13,764 612,000 SH   DFND   612,000 0 0
AVAYA HLDGS CORP COM 05351X101 11,187 736,000 SH   DFND   736,000 0 0
AXONICS MODULATION TECHNOLOG COM 05465P101 7,146 140,000 SH   DFND   140,000 0 0
BIO RAD LABS INC CL A 090572207 10,309 20,000 SH   DFND   20,000 0 0
BIOGEN INC COM 09062X103 28,368 100,000 SH   DFND   100,000 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 58,509 900,000 SH   DFND   900,000 0 0
BIONTECH SE SPONSORED ADS 09075V102 23,261 336,000 SH   DFND   336,000 0 0
BLUCORA INC COM 095229100 28,260 3,000,000 SH   DFND   3,000,000 0 0
BLUEBIRD BIO INC COM 09609G100 43,160 800,000 SH   DFND   800,000 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 60,290 1,000,000 SH   DFND   1,000,000 0 0
CAMPBELL SOUP CO COM 134429109 44,307 916,000 SH   DFND   916,000 0 0
CATALYST PHARMACEUTICALS INC COM 14888U101 29,700 10,000,000 SH   DFND   10,000,000 0 0
CENTRAL GARDEN & PET CO CL A NON-VTG 153527205 35,128 972,000 SH   DFND   972,000 0 0
CERECOR INC COM 15671L109 68,282 30,014,285 SH   DFND   30,014,285 0 0
CLEARONE INC COM 18506U104 802 350,000 SH   DFND   350,000 0 0
CLOVIS ONCOLOGY INC COM 189464100 10,774 1,848,000 SH   DFND   1,848,000 0 0
COCA COLA CO COM 191216100 31,992 648,000 SH   DFND   648,000 0 0
COLGATE PALMOLIVE CO COM 194162103 23,145 300,000 SH   DFND   300,000 0 0
CONFORMIS INC COM 20717E101 6,262 7,477,385 SH   DFND   7,477,385 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 17,063 204,000 SH   DFND   204,000 0 0
CVS HEALTH CORP COM 126650100 29,200 500,000 SH   DFND   500,000 0 0
DECKERS OUTDOOR CORP COM 243537107 17,547 79,755 SH   DFND   79,755 0 0
DICKS SPORTING GOODS INC COM 253393102 24,310 420,000 SH   DFND   420,000 0 0
DOLLAR TREE INC COM 256746108 20,163 220,747 SH   DFND   220,747 0 0
EAGLE PHARMACEUTICALS INC COM 269796108 28,547 672,000 SH   DFND   672,000 0 0
EDGEWELL PERS CARE CO COM 28035Q102 30,055 1,078,000 SH   DFND   1,078,000 0 0
ENANTA PHARMACEUTICALS INC COM 29251M106 23,989 524,000 SH   DFND   524,000 0 0
ENERGIZER HLDGS INC NEW COM 29272W109 65,677 1,678,000 SH   DFND   1,678,000 0 0
ENTASIS THERAPEUTICS HLDGS I COM 293614103 7,162 3,510,981 SH   DFND   3,510,981 0 0
EXACT SCIENCES CORP COM 30063P105 4,078 40,000 SH   DFND   40,000 0 0
EYEGATE PHARMACEUTICALS INC COM NEW 30233M503 7,117 1,815,500 SH   DFND   1,815,500 0 0
FIVE BELOW INC COM 33829M101 15,773 124,200 SH   DFND   124,200 0 0
FRONTDOOR INC COM 35905A109 33,930 872,000 SH   DFND   872,000 0 0
GAP INC COM 364760108 8,515 500,000 SH   DFND   500,000 0 0
GENMARK DIAGNOSTICS INC COM 372309104 11,246 792,000 SH   DFND   792,000 0 0
GEOVAX LABS INC *W EXP 09/29/202 373678119 845 391,700 SH   DFND   391,700 0 0
GEOVAX LABS INC COM 373678507 161 50,464 SH   DFND   50,464 0 0
HILL ROM HLDGS INC COM 431475102 13,696 164,000 SH   DFND   164,000 0 0
HOSTESS BRANDS INC CL A 44109J106 26,189 2,124,000 SH   DFND   2,124,000 0 0
INCYTE CORP COM 45337C102 57,075 636,000 SH   DFND   636,000 0 0
ISHARES TR RUSSELL 2000 ETF 464287655 239,664 16,000 SH Put DFND   16,000 0 0
JACK IN THE BOX INC COM 466367109 13,914 175,438 SH   DFND   175,438 0 0
KRAFT HEINZ CO COM 500754106 29,950 1,000,000 SH   DFND   1,000,000 0 0
KUBIENT INC *W EXP 07/09/202 50116V115 367 275,000 SH   DFND   275,000 0 0
LANTHEUS HLDGS INC COM 516544103 61,272 4,836,000 SH   DFND   4,836,000 0 0
LIVANOVA PLC SHS G5509L101 2,261 50,000 SH   DFND   50,000 0 0
LOWES COS INC COM 548661107 34,224 206,340 SH   DFND   206,340 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 33,007 278,000 SH   DFND   278,000 0 0
MALLINCKRODT PUB LTD CO SHS G5785G107 3,893 40,000 SH Call DFND   40,000 0 0
MEDIGUS LTD *W EXP 07/23/202 58471G128 634 1,285,715 SH   DFND   1,285,715 0 0
MEDTRONIC PLC SHS G5960L103 44,478 428,000 SH   DFND   428,000 0 0
MERCK & CO. INC COM 58933Y105 43,466 524,000 SH   DFND   524,000 0 0
MICROSOFT CORP COM 594918104 6,731 32,000 SH   DFND   32,000 0 0
MINERVA NEUROSCIENCES INC COM 603380106 1,590 500,000 SH   DFND   500,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 27,896 168,000 SH   DFND   168,000 0 0
MONDELEZ INTL INC CL A 609207105 22,750 396,000 SH   DFND   396,000 0 0
MOTUS GI HLDGS INC COM 62014P108 2,811 2,876,456 SH   DFND   2,876,456 0 0
MYLAN NV SHS EURO N59465109 16,728 1,128,000 SH   DFND   1,128,000 0 0
NEMAURA MED INC COM NEW 640442208 315 88,830 SH   DFND   88,830 0 0
NUVASIVE INC COM 670704105 21,857 450,000 SH   DFND   450,000 0 0
OBALON THERAPEUTICS INC COM NEW 67424L209 674 740,000 SH   DFND   740,000 0 0
OBSEVA SA COM H5861P103 10,761 4,338,927 SH   DFND   4,338,927 0 0
ONCTERNAL THERAPEUTICS INC COM 68236P107 2,237 1,316,163 SH   DFND   1,316,163 0 0
PAINREFORM LTD SHS M77798102 2,939 638,961 SH   DFND   638,961 0 0
PROGENITY INC COM 74319F107 3,608 400,000 SH   DFND   400,000 0 0
PTC THERAPEUTICS INC COM 69366J200 33,847 724,000 SH   DFND   724,000 0 0
REGENERON PHARMACEUTICALS COM 75886F107 47,022 84,000 SH   DFND   84,000 0 0
ROSS STORES INC COM 778296103 41,061 440,000 SH   DFND   440,000 0 0
SI BONE INC COM 825704109 6,072 256,000 SH   DFND   256,000 0 0
SIYATA MOBILE INC *W EXP 09/24/202 83013Q152 485 150,000 SH   DFND   150,000 0 0
SMARTSHEET INC COM CL A 83200N103 4,942 100,000 SH   DFND   100,000 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 368,379 11,000 SH Put DFND   11,000 0 0
SPECTRUM PHARMACEUTICALS INC COM 84763A108 30,894 7,572,000 SH   DFND   7,572,000 0 0
SUPERNUS PHARMACEUTICALS INC COM 868459108 66,688 3,200,000 SH   DFND   3,200,000 0 0
TELA BIO INC COM 872381108 2,646 160,000 SH   DFND   160,000 0 0
TENAX THERAPEUTICS INC COM NEW 88032L209 3,111 2,019,995 SH   DFND   2,019,995 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 7,064 16,000 SH   DFND   16,000 0 0
UBER TECHNOLOGIES INC COM 90353T100 5,472 150,000 SH   DFND   150,000 0 0
UNDER ARMOUR INC CL A 904311107 5,953 530,108 SH   DFND   530,108 0 0
UNITEDHEALTH GROUP INC COM 91324P102 46,766 150,000 SH   DFND   150,000 0 0
VANDA PHARMACEUTICALS INC COM 921659108 52,647 5,450,000 SH   DFND   5,450,000 0 0
VAXART INC COM NEW 92243A200 968 145,523 SH   DFND   145,523 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 28,809 2,700,000 SH   DFND   2,700,000 0 0
WHOLE EARTH BRANDS INC COM CL A 96684W100 6,872 824,000 SH   DFND   824,000 0 0
WILLIAMS SONOMA INC COM 969904101 40,246 445,000 SH   DFND   445,000 0 0
WYNN RESORTS LTD COM 983134107 6,032 84,000 SH   DFND   84,000 0 0
ZYMEWORKS INC COM 98985W102 33,351 716,000 SH   DFND   716,000 0 0