The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
1LIFE HEALTHCARE INC COM 68269G107 13,288 468,564 SH   DFND 2 468,564 0 0
10X GENOMICS INC CL A COM 88025U109 19,199 153,989 SH   DFND 2 153,989 0 0
ABBOTT LABS COM 002824100 140,204 1,288,285 SH   DFND 2 1,288,285 0 0
ABBVIE INC COM 00287Y109 3,241 37,000 SH   DFND 2 37,000 0 0
ABIOMED INC COM 003654100 28,093 101,398 SH   DFND 2 101,398 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 1,852 44,900 SH   DFND 2 44,900 0 0
ACCOLADE INC COM 00437E102 8,137 209,327 SH   DFND 2 209,327 0 0
ADOBE SYSTEMS INCORPORATED COM 00724F101 539 1,100 SH   DFND 2 1,100 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 626 6,200 SH   DFND 2 6,200 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 1,474 42,100 SH   DFND 2 42,100 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 143,812 4,108,902 SH   DFND 1,2 4,108,902 0 0
AKCEA THERAPEUTICS INC COM 00972L107 6,172 340,264 SH   DFND 3 340,264 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 14,498 126,700 SH   DFND 2 126,700 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 148,121 1,294,428 SH   DFND 1,2 1,294,428 0 0
ALIGN TECHNOLOGY INC COM 016255101 27,706 84,635 SH   DFND 2 84,635 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 8,256 56,700 SH   DFND 2 56,700 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 174,720 1,200,000 SH   DFND 1,2 1,200,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 44,132 303,105 SH   DFND 3 303,105 0 0
AMEDISYS INC COM 023436108 14,623 61,851 SH   DFND 2 61,851 0 0
AMERICAN EXPRESS CO COM 025816109 361 3,600 SH   DFND 2 3,600 0 0
AMERICAN WELL CORP CL A 03044L105 11,259 379,854 SH   DFND 2 379,854 0 0
AMGEN INC COM 031162100 14,195 55,850 SH   DFND 2 55,850 0 0
AMGEN INC COM 031162100 31,456 123,763 SH   DFND 3 123,763 0 0
ANALOG DEVICES INC COM 032654105 479 4,100 SH   DFND 2 4,100 0 0
ANSYS INC COM 03662Q105 590 1,802 SH   DFND 2 1,802 0 0
ANTHEM INC COM 036752103 25,956 96,638 SH   DFND 2 96,638 0 0
ANTHEM INC COM 036752103 67,815 252,485 SH   DFND 3 252,485 0 0
ARGENX SE SPONSORED ADR 04016X101 6,305 24,016 SH   DFND 2 24,016 0 0
ARGENX SE SPONSORED ADR 04016X101 245,456 935,000 SH   DFND 1,2 935,000 0 0
ARVINAS INC COM 04335A105 345 14,600 SH   DFND 2 14,600 0 0
ARVINAS INC COM 04335A105 38,411 1,626,903 SH   DFND 1,2 1,626,903 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 2,392 15,500 SH   DFND 2 15,500 0 0
ASPEN TECHNOLOGY INC COM 045327103 380 3,000 SH   DFND 2 3,000 0 0
AUTOLIV INC COM 052800109 496 6,800 SH   DFND 2 6,800 0 0
AVANTOR INC COM 05352A100 6,906 307,089 SH   DFND 2 307,089 0 0
AVIENT CORPORATION COM 05368V106 360 13,600 SH   DFND 2 13,600 0 0
AXONICS MODULATION TECHNOLOG COM 05465P101 21,356 418,408 SH   DFND 2 418,408 0 0
AXONICS MODULATION TECHNOLOG COM 05465P101 11,562 226,536 SH   DFND 3 226,536 0 0
BAXTER INTL INC COM 071813109 38,169 474,623 SH   DFND 2 474,623 0 0
BECTON DICKINSON & CO COM 075887109 60,694 260,846 SH   DFND 2 260,846 0 0
BEIGENE LTD SPONSORED ADR 07725L102 11,286 39,400 SH   DFND 2 39,400 0 0
BERKELEY LTS INC COM 084310101 8,209 107,510 SH   DFND 2 107,510 0 0
BIOGEN INC COM 09062X103 2,440 8,600 SH   DFND 2 8,600 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 1,593 24,500 SH   DFND 2 24,500 0 0
BIONTECH SE SPONSORED ADS 09075V102 3,427 49,500 SH   DFND 2 49,500 0 0
BIO RAD LABS INC CL A 090572207 40,302 78,186 SH   DFND 3 78,186 0 0
BLACKBAUD INC COM 09227Q100 229 4,107 SH   DFND 2 4,107 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 393 13,000 SH   DFND 2 13,000 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 42,020 1,390,000 SH   DFND 1,2 1,390,000 0 0
BOOKING HOLDINGS INC COM 09857L108 342 200 SH   DFND 2 200 0 0
BOSTON SCIENTIFIC CORP COM 101137107 72,075 1,886,297 SH   DFND 2 1,886,297 0 0
BRISTOL MYERS SQUIBB CO COM 110122108 28,541 473,400 SH   DFND 2 473,400 0 0
BRISTOL MYERS SQUIBB CO COM 110122108 70,691 1,172,512 SH   DFND 3 1,172,512 0 0
BRISTOL MYERS SQUIBB CO RIGHT 99/99/9999 110122157 1,800 800,000 SH   DFND 1,2 800,000 0 0
BROADRIDGE FINL SOLUTIONS IN COM 11133T103 449 3,400 SH   DFND 2 3,400 0 0
BROWN FORMAN CORP CL B 115637209 572 7,600 SH   DFND 2 7,600 0 0
BURNING ROCK BIOTECH LTD SPONSORED ADR 12233L107 3,681 146,761 SH   DFND 2 146,761 0 0
CAREDX INC COM 14167L103 42,337 1,115,903 SH   DFND 3 1,115,903 0 0
CATALENT INC COM 148806102 488 5,700 SH   DFND 2 5,700 0 0
CELLECTIS S A SPON ADS 15117K103 1,545 83,500 SH   DFND 2 83,500 0 0
CENTENE CORP DEL COM 15135B101 60,293 1,033,647 SH   DFND 2 1,033,647 0 0
CHANGE HEALTHCARE INC COM 15912K100 24,637 1,697,939 SH   DFND 2 1,697,939 0 0
CHARLES RIV LABS INTL INC COM 159864107 32,133 141,900 SH   DFND 2 141,900 0 0
CHARLES RIV LABS INTL INC COM 159864107 47,369 209,183 SH   DFND 3 209,183 0 0
CIDARA THERAPEUTICS INC COM 171757107 8,044 2,822,495 SH   DFND 1,2 2,822,495 0 0
CIGNA CORP NEW COM 125523100 56,877 335,737 SH   DFND 2 335,737 0 0
CLOROX CO DEL COM 189054109 420 2,000 SH   DFND 2 2,000 0 0
COHERUS BIOSCIENCES INC COM 19249H103 25,738 1,403,400 SH   DFND 2 1,403,400 0 0
CONSTELLATION BRANDS INC CL A 21036P108 390 2,059 SH   DFND 2 2,059 0 0
COOPER COS INC COM NEW 216648402 8,544 25,345 SH   DFND 2 25,345 0 0
COSTAR GROUP INC COM 22160N109 594 700 SH   DFND 2 700 0 0
COVETRUS INC COM 22304C100 37 1,520 SH   DFND 2 1,520 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 736 8,800 SH   DFND 2 8,800 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 78,660 940,462 SH   DFND 1,2 940,462 0 0
CUREVAC NV COM N2451R105 2,351 50,500 SH   DFND 2 50,500 0 0
CVS HEALTH CORP COM 126650100 10,920 186,981 SH   DFND 2 186,981 0 0
CYBERARK SOFTWARE LTD SHS M2682V108 445 4,300 SH   DFND 2 4,300 0 0
DANAHER CORPORATION COM 235851102 97,627 453,384 SH   DFND 2 453,384 0 0
DAVITA INC COM 23918K108 27,956 326,400 SH   DFND 2 326,400 0 0
DENTSPLY SIRONA INC COM 24906P109 6,959 159,129 SH   DFND 2 159,129 0 0
DEXCOM INC COM 252131107 50,170 121,705 SH   DFND 2 121,705 0 0
DOMINOS PIZZA INC COM 25754A201 425 1,000 SH   DFND 2 1,000 0 0
DR REDDYS LABS LTD ADR 256135203 591 8,500 SH   DFND 2 8,500 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 66,076 827,818 SH   DFND 2 827,818 0 0
ELECTRONIC ARTS INC COM 285512109 609 4,670 SH   DFND 2 4,670 0 0
ENTEGRIS INC COM 29362U104 543 7,300 SH   DFND 2 7,300 0 0
ESPERION THERAPEUTICS INC NEW COM 29664W105 1,531 41,200 SH   DFND 2 41,200 0 0
ESPERION THERAPEUTICS INC NEW COM 29664W105 139,312 3,747,964 SH   DFND 1,2 3,747,964 0 0
ESPERION THERAPEUTICS INC NEW COM 29664W105 62,317 1,676,551 SH   DFND 3 1,676,551 0 0
EVOLENT HEALTH INC CL A 30050B101 14,629 1,178,839 SH   DFND 2 1,178,839 0 0
EVOLENT HEALTH INC CL A 30050B101 25,993 2,094,486 SH   DFND 3 2,094,486 0 0
EXACT SCIENCES CORP COM 30063P105 31,043 304,490 SH   DFND 3 304,490 0 0
EXELIXIS INC COM 30161Q104 5,831 238,500 SH   DFND 2 238,500 0 0
EXELIXIS INC COM 30161Q104 69,316 2,835,000 SH   DFND 1,2 2,835,000 0 0
FACTSET RESH SYS INC COM 303075105 569 1,700 SH   DFND 2 1,700 0 0
FASTENAL CO COM 311900104 451 10,000 SH   DFND 2 10,000 0 0
FATE THERAPEUTICS INC COM 31189P102 3,098 77,500 SH   DFND 2 77,500 0 0
FATE THERAPEUTICS INC COM 31189P102 85,536 2,140,000 SH   DFND 1,2 2,140,000 0 0
FIBROGEN INC COM 31572Q808 2,179 53,000 SH   DFND 2 53,000 0 0
FORTINET INC COM 34959E109 342 2,900 SH   DFND 2 2,900 0 0
G1 THERAPEUTICS INC COM 3621LQ109 8,338 721,925 SH   DFND 1,2 721,925 0 0
GARTNER INC COM 366651107 425 3,400 SH   DFND 2 3,400 0 0
GENERATION BIO CO COM 37148K100 58,111 1,880,000 SH   DFND 1,2 1,880,000 0 0
GENETRON HLDGS LTD ADS 37186H100 1,915 160,410 SH   DFND 2 160,410 0 0
GENMARK DIAGNOSTICS INC COM 372309104 17,946 1,263,811 SH   DFND 3 1,263,811 0 0
GILEAD SCIENCES INC COM 375558103 7,817 123,700 SH   DFND 2 123,700 0 0
GLAUKOS CORP COM 377322102 25,540 515,754 SH   DFND 2 515,754 0 0
GLOBUS MED INC CL A 379577208 20,290 409,735 SH   DFND 2 409,735 0 0
GOHEALTH INC COM CL A 38046W105 4,099 314,672 SH   DFND 2 314,672 0 0
GRACO INC COM 384109104 595 9,700 SH   DFND 2 9,700 0 0
GUARDANT HEALTH INC COM 40131M109 18,151 162,383 SH   DFND 2 162,383 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 1,947 20,000 SH   DFND 2 20,000 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 52,856 542,943 SH   DFND 3 542,943 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 1,971 75,000 SH   DFND 2 75,000 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 141,758 5,394,131 SH   DFND 1,2 5,394,131 0 0
HCA HEALTHCARE INC COM 40412C101 43,025 345,085 SH   DFND 2 345,085 0 0
HEALTH CATALYST INC COM 42225T107 19,101 521,896 SH   DFND 2 521,896 0 0
HILL ROM HLDGS INC COM 431475102 47,690 571,069 SH   DFND 3 571,069 0 0
HMS HLDGS CORP COM 40425J101 21,962 916,984 SH   DFND 2 916,984 0 0
HOLOGIC INC COM 436440101 21,689 326,305 SH   DFND 2 326,305 0 0
HOLOGIC INC COM 436440101 24,639 370,675 SH   DFND 3 370,675 0 0
HOMOLOGY MEDICINES INC COM 438083107 18,587 1,737,122 SH   DFND 1,2 1,737,122 0 0
HORIZON THERAPEUTICS PUB LTD SHS G46188101 6,012 77,400 SH   DFND 2 77,400 0 0
HUAZHU GROUP LTD SPONSORED ADS 44332N106 584 13,500 SH   DFND 2 13,500 0 0
HUMANA INC COM 444859102 54,609 131,941 SH   DFND 2 131,941 0 0
HUMANA INC COM 444859102 46,378 112,055 SH   DFND 3 112,055 0 0
HUTCHISON CHINA MEDITECH LTD SPONSORED ADR 44842L103 30,610 947,674 SH   DFND 3 947,674 0 0
IDEXX LABS INC COM 45168D104 30,819 78,398 SH   DFND 2 78,398 0 0
ILLUMINA INC COM 452327109 18,096 58,547 SH   DFND 2 58,547 0 0
I MAB SPONSORED ADS 44975P103 3,057 65,000 SH   DFND 2 65,000 0 0
INCYTE CORP COM 45337C102 34,052 379,450 SH   DFND 2 379,450 0 0
INCYTE CORP COM 45337C102 260,246 2,900,000 SH   DFND 1,2 2,900,000 0 0
INOGEN INC COM 45780L104 4,318 148,912 SH   DFND 2 148,912 0 0
INSMED INC COM PAR $.01 457669307 39,216 1,220,169 SH   DFND 3 1,220,169 0 0
INSPIRE MED SYS INC COM 457730109 35,228 272,983 SH   DFND 2 272,983 0 0
INSULET CORP COM 45784P101 63,850 269,875 SH   DFND 2 269,875 0 0
INTEGRA LIFESCIENCES HLDGS C COM NEW 457985208 5,781 122,426 SH   DFND 2 122,426 0 0
INTERACTIVE BROKERS GROUP IN COM CL A 45841N107 454 9,400 SH   DFND 2 9,400 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 332 8,000 SH   DFND 2 8,000 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 28,897 696,976 SH   DFND 1,2 696,976 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 480 4,800 SH   DFND 2 4,800 0 0
INTERSECT ENT INC COM 46071F103 7,721 473,382 SH   DFND 2 473,382 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 3,118 121,500 SH   DFND 2 121,500 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 88,743 3,458,419 SH   DFND 1,2 3,458,419 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 108,690 153,184 SH   DFND 2 153,184 0 0
IONIS PHARMACEUTICALS INC COM 462222100 8,876 187,050 SH   DFND 2 187,050 0 0
IONIS PHARMACEUTICALS INC COM 462222100 389,086 8,199,913 SH   DFND 1,2 8,199,913 0 0
IONIS PHARMACEUTICALS INC COM 462222100 15,626 329,307 SH   DFND 3 329,307 0 0
IPG PHOTONICS CORP COM 44980X109 459 2,700 SH   DFND 2 2,700 0 0
IQVIA HLDGS INC COM 46266C105 457 2,900 SH   DFND 2 2,900 0 0
IRHYTHM TECHNOLOGIES INC COM 450056106 21,553 90,518 SH   DFND 2 90,518 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 5,675 39,800 SH   DFND 2 39,800 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 45,137 316,550 SH   DFND 3 316,550 0 0
JD.COM INC SPON ADR CL A 47215P106 675 8,700 SH   DFND 2 8,700 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 21,940 4,533,148 SH   DFND 1,2 4,533,148 0 0
KOSMOS ENERGY LTD COM 500688106 417 425,000 SH   DFND 2 425,000 0 0
KURA ONCOLOGY INC COM 50127T109 1,471 48,000 SH   DFND 2 48,000 0 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409 10,211 54,234 SH   DFND 2 54,234 0 0
LAUDER ESTEE COS INC CL A 518439104 491 2,248 SH   DFND 2 2,248 0 0
LIVE NATION ENTERTAINMENT IN COM 538034109 334 6,200 SH   DFND 2 6,200 0 0
LIVONGO HEALTH INC COM 539183103 28,476 203,329 SH   DFND 2 203,329 0 0
MACROGENICS INC COM 556099109 2,757 109,450 SH   DFND 2 109,450 0 0
MACROGENICS INC COM 556099109 118,463 4,702,761 SH   DFND 1,2 4,702,761 0 0
MACROGENICS INC COM 556099109 11,839 469,977 SH   DFND 3 469,977 0 0
MARKEL CORP COM 570535104 389 400 SH   DFND 2 400 0 0
MARKETAXESS HLDGS INC COM 57060D108 396 822 SH   DFND 2 822 0 0
MASIMO CORP COM 574795100 24,114 102,153 SH   DFND 2 102,153 0 0
MATCH GROUP INC NEW COM 57667L107 606 5,478 SH   DFND 2 5,478 0 0
MCCORMICK & CO INC COM NON VTG 579780206 543 2,800 SH   DFND 2 2,800 0 0
MCKESSON CORP COM 58155Q103 580 3,892 SH   DFND 2 3,892 0 0
MEDTRONIC PLC SHS G5960L103 86,404 831,450 SH   DFND 2 831,450 0 0
MERCADOLIBRE INC COM 58733R102 541 500 SH   DFND 2 500 0 0
METTLER TOLEDO INTERNATIONAL COM 592688105 676 700 SH   DFND 2 700 0 0
MIRATI THERAPEUTICS INC COM 60468T105 2,956 17,800 SH   DFND 2 17,800 0 0
MODERNA INC COM 60770K107 6,505 91,950 SH   DFND 2 91,950 0 0
MODERNA INC COM 60770K107 229,938 3,250,000 SH   DFND 1,2 3,250,000 0 0
MOLECULAR TEMPLATES INC COM 608550109 349 32,000 SH   DFND 2 32,000 0 0
MOLECULAR TEMPLATES INC COM 608550109 54,491 4,989,996 SH   DFND 1,2 4,989,996 0 0
MOLINA HEALTHCARE INC COM 60855R100 30,123 164,572 SH   DFND 2 164,572 0 0
MOODYS CORP COM 615369105 580 2,000 SH   DFND 2 2,000 0 0
MSCI INC COM 55354G100 423 1,186 SH   DFND 2 1,186 0 0
MYOKARDIA INC COM 62857M105 3,872 28,400 SH   DFND 2 28,400 0 0
MYOKARDIA INC COM 62857M105 149,963 1,100,000 SH   DFND 1,2 1,100,000 0 0
MYOVANT SCIENCES LTD COM G637AM102 660 47,000 SH   DFND 2 47,000 0 0
MYOVANT SCIENCES LTD COM G637AM102 70,882 5,045,000 SH   DFND 1,2 5,045,000 0 0
NEKTAR THERAPEUTICS COM 640268108 478 28,800 SH   DFND 2 28,800 0 0
NEKTAR THERAPEUTICS COM 640268108 43,477 2,620,676 SH   DFND 1,2 2,620,676 0 0
NEKTAR THERAPEUTICS COM 640268108 16,306 982,882 SH   DFND 3 982,882 0 0
NEOGENOMICS INC COM NEW 64049M209 15,748 426,892 SH   DFND 3 426,892 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 29,084 302,451 SH   DFND 2 302,451 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 287,999 2,995,000 SH   DFND 1,2 2,995,000 0 0
NEVRO CORP COM 64157F103 16,795 120,569 SH   DFND 2 120,569 0 0
NUVASIVE INC COM 670704105 3,988 82,100 SH   DFND 2 82,100 0 0
OMNICELL INC COM 68213N109 20,787 278,421 SH   DFND 2 278,421 0 0
OUTSET MED INC COM 690145107 3,996 79,921 SH   DFND 2 79,921 0 0
OXFORD IMMUNOTEC GLOBAL PLC ORD SHS G6855A103 9,362 800,157 SH   DFND 2 800,157 0 0
PACIFIC BIOSIENCES CALIF IN COM 69404D108 21,004 2,128,100 SH   DFND 2 2,128,100 0 0
PACIFIC BIOSIENCES CALIF IN COM 69404D108 17,533 1,776,367 SH   DFND 3 1,776,367 0 0
PAYCHEX INC COM 704326107 431 5,400 SH   DFND 2 5,400 0 0
PENUMBRA INC COM 70975L107 23,558 121,194 SH   DFND 2 121,194 0 0
PERKINELMER INC COM 714046109 602 4,800 SH   DFND 2 4,800 0 0
PFIZER INC COM 717081103 2,712 73,900 SH   DFND 2 73,900 0 0
PHREESIA INC COM 71944F106 13,718 426,956 SH   DFND 2 426,956 0 0
POOL CORP COM 73278L105 736 2,200 SH   DFND 2 2,200 0 0
QUANTERIX CORP COM 74766Q101 24,417 723,674 SH   DFND 2 723,674 0 0
QUEST DIAGNOSTICS INC COM 74834L100 6,870 60,005 SH   DFND 2 60,005 0 0
QUOTIENT LTD SHS G73268107 4,714 917,074 SH   DFND 2 917,074 0 0
RADIUS HEALTH INC COM NEW 750469207 858 75,700 SH   DFND 2 75,700 0 0
RADIUS HEALTH INC COM NEW 750469207 83,414 7,355,714 SH   DFND 1,2 7,355,714 0 0
REGENERON PHARMACEUTICALS COM 75886F107 11,196 20,000 SH   DFND 2 20,000 0 0
RELAY THERAPEUTICS INC COM 75943R102 55,367 1,300,000 SH   DFND 1,2 1,300,000 0 0
RESMED INC COM 761152107 13,338 77,805 SH   DFND 2 77,805 0 0
S&P GLOBAL INC COM 78409V104 613 1,700 SH   DFND 2 1,700 0 0
SAGE THERAPEUTICS INC COM 78667J108 2,408 39,400 SH   DFND 2 39,400 0 0
SAGE THERAPEUTICS INC COM 78667J108 94,131 1,540,104 SH   DFND 1,2 1,540,104 0 0
SANGAMO THERAPEUTICS INC COM 800677106 36,383 3,850,000 SH   DFND 1,2 3,850,000 0 0
SANOFI SPONSORED ADR 80105N105 2,860 57,000 SH   DFND 2 57,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 2,851 20,300 SH   DFND 2 20,300 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 548 31,000 SH   DFND 2 31,000 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 49,736 2,811,515 SH   DFND 1,2 2,811,515 0 0
SEATTLE GENETICS INC COM 812578102 9,119 46,600 SH   DFND 2 46,600 0 0
SENSATA TECHNOLOGIES HLDNG P SHS G8060N102 427 9,900 SH   DFND 2 9,900 0 0
SERVICE CORP INTL COM 817565104 359 8,500 SH   DFND 2 8,500 0 0
SHOCKWAVE MED INC COM 82489T104 34,963 461,253 SH   DFND 2 461,253 0 0
SILK RD MED INC COM 82710M100 20,205 300,619 SH   DFND 2 300,619 0 0
SKYWORKS SOLUTIONS INC COM 83088M102 538 3,700 SH   DFND 2 3,700 0 0
SOCIEDAD QUIMICA Y MINERA DE SPON ADR SER B 833635105 590 18,200 SH   DFND 2 18,200 0 0
STARBUCKS CORP COM 855244109 372 4,334 SH   DFND 2 4,334 0 0
STONECO LTD COM CL A G85158106 566 10,700 SH   DFND 2 10,700 0 0
STRYKER CORPORATION COM 863667101 67,256 322,771 SH   DFND 2 322,771 0 0
TABULA RASA HEALTHCARE INC COM 873379101 9,967 244,469 SH   DFND 2 244,469 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 35,576 313,444 SH   DFND 2 313,444 0 0
TELADOC HEALTH INC COM 87918A105 26,606 121,354 SH   DFND 2 121,354 0 0
TELEFLEX INCORPORATED COM 879369106 26,772 78,644 SH   DFND 2 78,644 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 31,288 70,865 SH   DFND 2 70,865 0 0
TRADEWEB MKTS INC CL A 892672106 394 6,800 SH   DFND 2 6,800 0 0
TRANSMEDICS GROUP INC COM 89377M109 7,953 577,147 SH   DFND 2 577,147 0 0
TRANSUNION COM 89400J107 429 5,096 SH   DFND 2 5,096 0 0
TRIMBLE INC COM 896239100 570 11,700 SH   DFND 2 11,700 0 0
TRIP COM GROUP LTD ADS 89677Q107 408 13,100 SH   DFND 2 13,100 0 0
TYLER TECHNOLOGIES INC COM 902252105 532 1,525 SH   DFND 2 1,525 0 0
ULTA BEAUTY INC COM 90384S303 448 2,000 SH   DFND 2 2,000 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 3,370 41,000 SH   DFND 2 41,000 0 0
UNIQURE NV SHS N90064101 1,271 34,500 SH   DFND 2 34,500 0 0
UNITEDHEALTH GROUP INC COM 91324P102 66,787 214,218 SH   DFND 2 214,218 0 0
UNITEDHEALTH GROUP INC COM 91324P102 34,243 109,835 SH   DFND 3 109,835 0 0
VARIAN MED SYS INC COM 92220P105 705 4,100 SH   DFND 2 4,100 0 0
VEEVA SYS INC CL A COM 922475108 26,816 95,367 SH   DFND 2 95,367 0 0
VERISIGN INC COM 92343E102 430 2,100 SH   DFND 2 2,100 0 0
VERISK ANALYTICS INC COM 92345Y106 461 2,489 SH   DFND 2 2,489 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 16,490 60,600 SH   DFND 2 60,600 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 244,908 900,000 SH   DFND 1,2 900,000 0 0
VOCERA COMMUNICATONS INC COM 92857F107 5,856 201,390 SH   DFND 2 201,390 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 339 31,800 SH   DFND 2 31,800 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 28,599 2,680,283 SH   DFND 1,2 2,680,283 0 0
WABTEC COM 929740108 396 6,400 SH   DFND 2 6,400 0 0
WATSCO INC COM 942622200 652 2,800 SH   DFND 2 2,800 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 22,098 2,602,858 SH   DFND 1,2 2,602,858 0 0
XILINX INC COM 983919101 438 4,200 SH   DFND 2 4,200 0 0
ZAI LAB LTD ADR 98887Q104 13,407 161,200 SH   DFND 2 161,200 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 30,732 225,740 SH   DFND 2 225,740 0 0