The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ACCELERON PHARMA INC | COM | 00434H108 | 47,445 | 421,619 | SH | DFND | 1 | 421,619 | 0 | 0 | |
| ACCOLADE INC | COM | 00437E102 | 24,255 | 624,001 | SH | DFND | 1 | 624,001 | 0 | 0 | |
| ACUTUS MEDICAL INC | COM | 005111109 | 129,386 | 4,341,799 | SH | DFND | 1 | 4,341,799 | 0 | 0 | |
| ADAPTHEALTH CORP | COM CL A | 00653Q102 | 37,310 | 1,710,674 | SH | DFND | 1 | 1,710,674 | 0 | 0 | |
| ADC THERAPEUTICS SA | SHS | H0036K147 | 9,897 | 300,000 | SH | DFND | 1 | 300,000 | 0 | 0 | |
| ADVERUM BIOTECHNOLOGIES INC | COM | 00773U108 | 24,766 | 2,404,439 | SH | DFND | 1 | 2,404,439 | 0 | 0 | |
| AERIE PHARMACEUTICALS INC | NOTE 1.500%10/0 | 00771VAB4 | 120,099 | 149,600,000 | PRN | DFND | 1 | 149,600,000 | 0 | 0 | |
| AERIE PHARMACEUTICALS INC | COM | 00771V108 | 5,817 | 494,216 | SH | DFND | 1 | 494,216 | 0 | 0 | |
| ALECTOR INC | COM | 014442107 | 15,402 | 1,461,978 | SH | DFND | 1 | 1,461,978 | 0 | 0 | |
| ALEXION PHARMACEUTICALS INC | COM | 015351109 | 66,283 | 579,248 | SH | DFND | 1 | 579,248 | 0 | 0 | |
| ALIMERA SCIENCES INC | COM NEW | 016259202 | 332 | 68,413 | SH | DFND | 1 | 68,413 | 0 | 0 | |
| AMERICAN WELL CORP | CL A | 03044L105 | 23,449 | 791,115 | SH | DFND | 1 | 791,115 | 0 | 0 | |
| ANNEXON INC | COM | 03589W102 | 48,907 | 1,617,826 | SH | DFND | 1 | 1,617,826 | 0 | 0 | |
| APELLIS PHARMACEUTICALS INC | NOTE 3.500% 9/1 | 03753UAB2 | 69,727 | 64,825,000 | PRN | DFND | 1 | 64,825,000 | 0 | 0 | |
| ARDELYX INC | COM | 039697107 | 13,448 | 2,561,554 | SH | DFND | 1 | 2,561,554 | 0 | 0 | |
| ARVINAS INC | COM | 04335A105 | 14,500 | 614,156 | SH | DFND | 1 | 614,156 | 0 | 0 | |
| ARYA SCIENCES ACQUISTION CO | UNIT 06/09/2027 | G31655114 | 5,500 | 500,000 | SH | DFND | 1 | 500,000 | 0 | 0 | |
| ATHENEX INC | COM | 04685N103 | 13,915 | 1,150,000 | SH | DFND | 1 | 1,150,000 | 0 | 0 | |
| ATHIRA PHARMA INC | COM | 04746L104 | 8,307 | 450,000 | SH | DFND | 1 | 450,000 | 0 | 0 | |
| AVIDITY BIOSCIENCES INC | COM | 05370A108 | 13,348 | 474,186 | SH | DFND | 1 | 474,186 | 0 | 0 | |
| AXONICS MODULATION TECHNOLOG | COM | 05465P101 | 39,607 | 776,000 | SH | DFND | 1 | 776,000 | 0 | 0 | |
| BIOCRYST PHARMACEUTICALS INC | COM | 09058V103 | 15,308 | 4,456,519 | SH | DFND | 1 | 4,456,519 | 0 | 0 | |
| BIODELIVERY SCIENCES INTL IN | COM | 09060J106 | 28,481 | 7,635,750 | SH | DFND | 1 | 7,635,750 | 0 | 0 | |
| BLACK DIAMOND THERAPEUTICS I | COM | 09203E105 | 24,260 | 802,511 | SH | DFND | 1 | 802,511 | 0 | 0 | |
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 37,579 | 405,386 | SH | DFND | 1 | 405,386 | 0 | 0 | |
| BROOKDALE SR LIVING INC | COM | 112463104 | 45,009 | 17,720,000 | SH | DFND | 1 | 17,720,000 | 0 | 0 | |
| CABALETTA BIO INC | COM | 12674W109 | 5,032 | 464,252 | SH | DFND | 1 | 464,252 | 0 | 0 | |
| CENTENE CORP DEL | COM | 15135B101 | 106,627 | 1,828,000 | SH | DFND | 1 | 1,828,000 | 0 | 0 | |
| CERUS CORP | COM | 157085101 | 533 | 85,143 | SH | DFND | 1 | 85,143 | 0 | 0 | |
| CLOVIS ONCOLOGY INC | NOTE 2.500% 9/1 | 189464AB6 | 44,114 | 49,064,000 | PRN | DFND | 1 | 49,064,000 | 0 | 0 | |
| CONSTELLATION PHARMCETICLS I | COM | 210373106 | 20,371 | 1,005,487 | SH | DFND | 1 | 1,005,487 | 0 | 0 | |
| DECIPHERA PHARMACEUTICALS IN | COM | 24344T101 | 27,116 | 528,585 | SH | DFND | 1 | 528,585 | 0 | 0 | |
| DEERFIELD HEALTHCARE TECHNOL | UNIT 07/16/2025 | 244413209 | 35,717 | 3,360,000 | SH | DFND | 1 | 3,360,000 | 0 | 0 | |
| DEXCOM INC | NOTE 0.750%12/0 | 252131AH0 | 85,863 | 34,000,000 | PRN | DFND | 1 | 34,000,000 | 0 | 0 | |
| DFP HEALTHCARE ACQUISITNS CO | UNIT 03/31/2025 | 23343Q209 | 114,328 | 10,460,000 | SH | DFND | 1 | 10,460,000 | 0 | 0 | |
| DYNE THERAPEUTICS INC | COM | 26818M108 | 8,303 | 411,267 | SH | DFND | 1 | 411,267 | 0 | 0 | |
| EDITAS MEDICINE INC | COM | 28106W103 | 27,747 | 988,841 | SH | DFND | 1 | 988,841 | 0 | 0 | |
| EHEALTH INC | COM | 28238P109 | 26,339 | 333,411 | SH | DFND | 1 | 333,411 | 0 | 0 | |
| FATE THERAPEUTICS INC | COM | 31189P102 | 26,703 | 668,067 | SH | DFND | 1 | 668,067 | 0 | 0 | |
| FUSION PHARMACEUTICALS INC | COM | 36118A100 | 11,684 | 972,046 | SH | DFND | 1 | 972,046 | 0 | 0 | |
| GENERATION BIO CO | COM | 37148K100 | 29,711 | 961,215 | SH | DFND | 1 | 961,215 | 0 | 0 | |
| GENMARK DIAGNOSTICS INC | COM | 372309104 | 2,496 | 175,806 | SH | DFND | 1 | 175,806 | 0 | 0 | |
| GLAUKOS CORP | COM | 377322102 | 34,442 | 695,523 | SH | DFND | 1 | 695,523 | 0 | 0 | |
| GOHEALTH INC | COM CL A | 38046W105 | 9,118 | 700,000 | SH | DFND | 1 | 700,000 | 0 | 0 | |
| GRAYBUG VISION INC | COM SHS | 38942Q103 | 67,131 | 5,281,713 | SH | DFND | 1 | 5,281,713 | 0 | 0 | |
| HIGHCAPE CAP ACQUISITION COR | UNIT 09/30/2027 | 42984L204 | 10,120 | 1,000,000 | SH | DFND | 1 | 1,000,000 | 0 | 0 | |
| HOLOGIC INC | COM | 436440101 | 25,790 | 388,000 | SH | DFND | 1 | 388,000 | 0 | 0 | |
| HORIZON THERAPEUTICS PUB L | SHS | G46188101 | 142,369 | 1,832,767 | SH | DFND | 1 | 1,832,767 | 0 | 0 | |
| IMARA INC | COM | 45249V107 | 10,529 | 517,653 | SH | DFND | 1 | 517,653 | 0 | 0 | |
| IMMUNOMEDICS INC | COM | 452907108 | 195,986 | 2,304,900 | SH | DFND | 1 | 2,304,900 | 0 | 0 | |
| INOZYME PHARMA INC | COM | 45790W108 | 30,241 | 1,150,299 | SH | DFND | 1 | 1,150,299 | 0 | 0 | |
| INSMED INC | NOTE 1.750% 1/1 | 457669AA7 | 65,987 | 61,000,000 | PRN | DFND | 1 | 61,000,000 | 0 | 0 | |
| INTERCEPT PHARMACEUTICALS IN | NOTE 3.250% 7/0 | 45845PAA6 | 46,521 | 57,791,000 | PRN | DFND | 1 | 57,791,000 | 0 | 0 | |
| INTERSECT ENT INC | COM | 46071F103 | 25,664 | 1,573,534 | SH | DFND | 1 | 1,573,534 | 0 | 0 | |
| ITAMAR MED LTD | SPONSORED ADS | 465437101 | 10,197 | 499,136 | SH | DFND | 1 | 499,136 | 0 | 0 | |
| IVERIC BIO INC | COM | 46583P102 | 32,528 | 5,767,409 | SH | DFND | 1 | 5,767,409 | 0 | 0 | |
| KODIAK SCIENCES INC | COM | 50015M109 | 29,427 | 497,000 | SH | DFND | 1 | 497,000 | 0 | 0 | |
| LARIMAR THERAPEUTICS INC | COM | 517125100 | 78,043 | 5,144,539 | SH | DFND | 1 | 5,144,539 | 0 | 0 | |
| LONGVIEW ACQUISITION CORP | UNIT 99/99/9999 | 543195200 | 22,330 | 2,200,000 | SH | DFND | 1 | 2,200,000 | 0 | 0 | |
| LUMOS PHARMA INC | COM | 55028X109 | 12,940 | 936,291 | SH | DFND | 1 | 936,291 | 0 | 0 | |
| MALLINCKRODT PUB LTD CO | SHS | G5785G107 | 1,918 | 1,970,687 | SH | DFND | 1 | 1,970,687 | 0 | 0 | |
| MERIDIAN BIOSCIENCE INC | COM | 589584101 | 25,613 | 1,508,398 | SH | DFND | 1 | 1,508,398 | 0 | 0 | |
| METACRINE INC | COM | 59101E103 | 9,469 | 927,469 | SH | DFND | 1 | 927,469 | 0 | 0 | |
| MIRUM PHARMACEUTICALS INC | COM | 604749101 | 66,461 | 3,448,912 | SH | DFND | 1 | 3,448,912 | 0 | 0 | |
| MOLINA HEALTHCARE INC | COM | 60855R100 | 28,005 | 153,000 | SH | DFND | 1 | 153,000 | 0 | 0 | |
| MYLAN NV | SHS EURO | N59465109 | 196,853 | 13,274,000 | SH | DFND | 1 | 13,274,000 | 0 | 0 | |
| MYOKARDIA INC | COM | 62857M105 | 95,976 | 704,000 | SH | DFND | 1 | 704,000 | 0 | 0 | |
| NANO X IMAGING LTD | ORD SHS | M70700105 | 17,922 | 762,000 | SH | DFND | 1 | 762,000 | 0 | 0 | |
| NATERA INC | COM | 632307104 | 15,050 | 208,333 | SH | DFND | 1 | 208,333 | 0 | 0 | |
| NEOS THERAPEUTICS INC | COM | 64052L106 | 170 | 320,993 | SH | DFND | 1 | 320,993 | 0 | 0 | |
| NEURONETICS INC | COM | 64131A105 | 7,655 | 1,575,000 | SH | DFND | 1 | 1,575,000 | 0 | 0 | |
| NEVRO CORP | NOTE 1.750% 6/0 | 64157FAA1 | 172,933 | 115,776,000 | PRN | DFND | 1 | 115,776,000 | 0 | 0 | |
| NEVRO CORP | NOTE 2.750% 4/0 | 64157FAC7 | 18,784 | 12,000,000 | PRN | DFND | 1 | 12,000,000 | 0 | 0 | |
| NKARTA INC | COM | 65487U108 | 72,708 | 2,418,772 | SH | DFND | 1 | 2,418,772 | 0 | 0 | |
| NUVASIVE INC | NOTE 2.250% 3/1 | 670704AG0 | 87,389 | 85,000,000 | PRN | DFND | 1 | 85,000,000 | 0 | 0 | |
| INVITAE CORP | NOTE 2.000% 9/0 | 46185LAB9 | 267,693 | 163,385,000 | PRN | DFND | 1 | 163,385,000 | 0 | 0 | |
| OAK STR HEALTH INC | COM | 67181A107 | 50,825 | 951,063 | SH | DFND | 1 | 951,063 | 0 | 0 | |
| ORASURE TECHNOLOGIES INC | COM | 68554V108 | 26,299 | 2,160,983 | SH | DFND | 1 | 2,160,983 | 0 | 0 | |
| ORCHARD THERAPEUTICS PLC | ADS | 68570P101 | 28,562 | 6,949,416 | SH | DFND | 1 | 6,949,416 | 0 | 0 | |
| OUTSET MED INC | COM | 690145107 | 6,250 | 125,000 | SH | DFND | 1 | 125,000 | 0 | 0 | |
| OWENS & MINOR INC NEW | COM | 690732102 | 37,087 | 1,477,000 | SH | DFND | 1 | 1,477,000 | 0 | 0 | |
| OXFORD IMMUNOTEC GLOBAL PLC | ORD SHS | G6855A103 | 7,349 | 628,139 | SH | DFND | 1 | 628,139 | 0 | 0 | |
| PACIRA BIOSCIENCES | COM | 695127100 | 72,013 | 1,197,825 | SH | DFND | 1 | 1,197,825 | 0 | 0 | |
| PACIRA BIOSCIENCES | NOTE 2.375% 4/0 | 695127AD2 | 22,835 | 20,000,000 | PRN | DFND | 1 | 20,000,000 | 0 | 0 | |
| PANACEA ACQUISITION CORP | UNIT 99/99/9999 | 698102209 | 6,000 | 500,000 | SH | DFND | 1 | 500,000 | 0 | 0 | |
| PMV PHARMACEUTICALS INC | COM | 69353Y103 | 1,775 | 50,000 | SH | DFND | 1 | 50,000 | 0 | 0 | |
| PROFOUND MED CORP | COM NEW | 74319B502 | 12,260 | 695,000 | SH | DFND | 1 | 695,000 | 0 | 0 | |
| PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 23,068 | 1,179,971 | SH | DFND | 1 | 1,179,971 | 0 | 0 | |
| PROTARA THERAPEUTICS INC | COM STK | 74365U107 | 13,172 | 782,670 | SH | DFND | 1 | 782,670 | 0 | 0 | |
| PTC THERAPEUTICS INC | NOTE 3.000% 8/1 | 69366JAB7 | 16,476 | 14,527,000 | PRN | DFND | 1 | 14,527,000 | 0 | 0 | |
| PUMA BIOTECHNOLOGY INC | COM | 74587V107 | 28,518 | 2,826,327 | SH | DFND | 1 | 2,826,327 | 0 | 0 | |
| QUIDEL CORP | COM | 74838J101 | 28,634 | 130,521 | SH | DFND | 1 | 130,521 | 0 | 0 | |
| REATA PHARMACEUTICALS INC | CL A | 75615P103 | 43,644 | 448,000 | SH | DFND | 1 | 448,000 | 0 | 0 | |
| REVOLUTION MEDICINES INC | COM | 76155X100 | 62,514 | 1,796,383 | SH | DFND | 1 | 1,796,383 | 0 | 0 | |
| RHYTHM PHARMACEUTICALS INC | COM | 76243J105 | 41,109 | 1,897,047 | SH | DFND | 1 | 1,897,047 | 0 | 0 | |
| SELECT MED HLDGS CORP | COM | 81619Q105 | 11,763 | 565,000 | SH | DFND | 1 | 565,000 | 0 | 0 | |
| SELECTQUOTE INC | COM | 816307300 | 15,188 | 750,000 | SH | DFND | 1 | 750,000 | 0 | 0 | |
| SIENTRA INC | COM | 82621J105 | 7,889 | 2,320,222 | SH | DFND | 1 | 2,320,222 | 0 | 0 | |
| SPRINGWORKS THERAPEUTICS INC | COM | 85205L107 | 58,837 | 1,234,262 | SH | DFND | 1 | 1,234,262 | 0 | 0 | |
| TAYSHA GENE THERAPIES INC | COM SHS | 877619106 | 5,600 | 250,000 | SH | DFND | 1 | 250,000 | 0 | 0 | |
| TCR2 THERAPEUTICS INC | COM | 87808K106 | 24,384 | 1,200,000 | SH | DFND | 1 | 1,200,000 | 0 | 0 | |
| VERICEL CORP | COM | 92346J108 | 27,612 | 1,490,118 | SH | DFND | 1 | 1,490,118 | 0 | 0 | |
| VIKING THERAPEUTICS INC | COM | 92686J106 | 2,028 | 348,441 | SH | DFND | 1 | 348,441 | 0 | 0 | |
| WINDTREE THERAPEUTICS INC | COM | 97382D303 | 111 | 20,148 | SH | DFND | 1 | 20,148 | 0 | 0 | |
| XERIS PHARMACEUTICALS INC | NOTE 5.000% 7/1 | 98422LAA5 | 36,116 | 18,000,000 | PRN | DFND | 1 | 18,000,000 | 0 | 0 | |