The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM 88579Y101 19,029 108,866 SH   SOLE   108,866 0 0
ABBOTT LABS COM 002824100 2 15 SH   OTR 1 0 0 15
ABBOTT LABS COM 002824100 51,230 467,902 SH   SOLE   467,902 0 0
ABBVIE INC COM 00287Y109 56,798 530,067 SH   SOLE   530,067 0 0
ABIOMED INC COM 003654100 1,049 3,234 SH   SOLE   3,234 0 0
ACACIA COMMUNICATIONS INC COM 00401C108 13,144 180,151 SH   SOLE   180,151 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 15,979 298,888 SH   SOLE   298,888 0 0
ACCELERON PHARMA INC COM 00434H108 3 21 SH   OTR 1 0 0 21
ACCELERON PHARMA INC COM 00434H108 71,254 556,914 SH   SOLE   556,914 0 0
ACCURAY INC COM 004397105 300 71,884 SH   SOLE   71,884 0 0
ACTIVISION BLIZZARD INC COM 00507V109 33,741 364,536 SH   SOLE   364,536 0 0
ADC THERAPEUTICS SA SHS H0036K147 0 9 SH   OTR 1 0 0 9
ADOBE SYSTEMS INCORPORATED COM 00724F101 2 4 SH   OTR 1 0 0 4
ADOBE SYSTEMS INCORPORATED COM 00724F101 76,584 153,161 SH   SOLE   153,161 0 0
ADVANCE AUTO PARTS INC COM 00751Y106 489 3,105 SH   SOLE   3,105 0 0
ADVANCED DRAIN SYS INC DEL COM 00790R104 4 45 SH   OTR 1 0 0 45
ADVANCED DRAIN SYS INC DEL COM 00790R104 27,863 333,350 SH   SOLE   333,350 0 0
ADVANCED MICRO DEVICES INC COM 007903107 32,614 355,612 SH   SOLE   355,612 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 3,236 298,492 SH   SOLE   298,492 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 7,789 576,495 SH   SOLE   576,495 0 0
AFLAC INC COM 001055102 3,433 77,194 SH   SOLE   77,194 0 0
AFLAC INC COM 001055102 2 39 SH   OTR 1 0 0 39
AFYA LTD CL A COM G01125106 1,518 60,000 SH   SOLE   60,000 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 10,035 84,689 SH   SOLE   84,689 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 4 30 SH   OTR 1 0 0 30
AGIOS PHARMACEUTICALS INC COM 00847X104 10,486 241,987 SH   SOLE   241,987 0 0
AGNICO EAGLE MINES LTD COM 008474108 498 7,087 SH   SOLE   7,087 0 0
AIR PRODS & CHEMS INC COM 009158106 51,055 186,857 SH   SOLE   186,857 0 0
AIR PRODS & CHEMS INC COM 009158106 5 18 SH   OTR 1 0 0 18
AKAMAI TECHNOLOGIES INC COM 00971T101 5,444 51,853 SH   SOLE   51,853 0 0
AKAMAI TECHNOLOGIES INC NOTE 0.125% 5/0 00971TAJ0 3,717 3,000 PRN   SOLE   3,000 0 0
AKERO THERAPEUTICS INC COM 00973Y108 2,487 96,398 SH   SOLE   96,398 0 0
AKERS BIOSCIENCES INC COM 00973E409 72 36,146 SH   SOLE   36,146 0 0
ALBEMARLE CORP COM 012653101 1,078 7,307 SH   SOLE   7,307 0 0
ALECTOR INC COM 014442107 2,342 154,783 SH   SOLE   154,783 0 0
ALEXANDRIA REAL ESTATE EQ IN COM 015271109 3,023 2,625 PRN   SOLE   2,625 0 0
ALEXANDRIA REAL ESTATE EQ IN COM 015271109 1,606 9,013 SH   SOLE   9,013 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 95,354 610,282 SH   SOLE   610,282 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 99,960 429,659 SH   SOLE   429,659 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 2 7 SH   OTR 1 0 0 7
ALIGN TECHNOLOGY INC COM 016255101 2,386 4,464 SH   SOLE   4,464 0 0
ALLAKOS INC COM 01671P100 9,654 68,951 SH   SOLE   68,951 0 0
ALLSTATE CORP COM 020002101 2 15 SH   OTR 1 0 0 15
ALLSTATE CORP COM 020002101 48,135 437,848 SH   SOLE   437,848 0 0
ALLY FINL INC COM 02005N100 6,933 194,447 SH   SOLE   194,447 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 21,129 162,558 SH   SOLE   162,558 0 0
ALPHABET INC CAP STK CL A 02079K305 11 6 SH   OTR 1 0 0 6
ALPHABET INC CAP STK CL A 02079K305 306,694 175,012 SH   SOLE   175,012 0 0
ALPHABET INC CAP STK CL C 02079K107 64,241 36,686 SH   SOLE   36,686 0 0
ALTERYX INC COM CL A 02156B103 975 8,045 SH   SOLE   8,045 0 0
AMAZON COM INC COM 023135106 174,433 53,576 SH   SOLE   53,576 0 0
AMAZON COM INC COM 023135106 3 1 SH   OTR 1 0 0 1
AMBARELLA INC SHS G037AX101 23,164 252,262 SH   SOLE   252,262 0 0
AMERESCO INC CL A 02361E108 2 40 SH   OTR 1 0 0 40
AMERESCO INC CL A 02361E108 13,006 248,965 SH   SOLE   248,965 0 0
AMERICAN AIRLS GROUP INC COM 02376R102 3,061 194,139 SH   SOLE   194,139 0 0
AMERICAN EXPRESS CO COM 025816109 2 15 SH   OTR 1 0 0 15
AMERICAN EXPRESS CO COM 025816109 10,900 90,145 SH   SOLE   90,145 0 0
AMERICAN INTL GROUP INC COM NEW 026874784 5,606 148,094 SH   SOLE   148,094 0 0
AMERICAN TOWER CORP NEW COM 03027X100 16,807 74,876 SH   SOLE   74,876 0 0
AMERICAN WTR WKS CO INC NEW COM 030420103 48,870 318,423 SH   SOLE   318,423 0 0
AMERICAN WTR WKS CO INC NEW COM 030420103 4 23 SH   OTR 1 0 0 23
AMERIPRISE FINL INC COM 03076C106 11,946 61,468 SH   SOLE   61,468 0 0
AMERIPRISE FINL INC COM 03076C106 2 9 SH   OTR 1 0 0 9
AMERISOURCEBERGEN CORP COM 03073E105 1,360 13,910 SH   SOLE   13,910 0 0
AMETEK INC COM 031100100 2,763 22,843 SH   SOLE   22,843 0 0
AMGEN INC COM 031162100 9 40 SH   OTR 1 0 0 40
AMGEN INC COM 031162100 304,461 1,324,150 SH   SOLE   1,324,150 0 0
AMICUS THERAPEUTICS INC COM 03152W109 14,204 615,124 SH   SOLE   615,124 0 0
AMPHENOL CORP NEW CL A 032095101 2,835 21,679 SH   SOLE   21,679 0 0
ANALOG DEVICES INC COM 032654105 64,627 437,454 SH   SOLE   437,454 0 0
ANALOG DEVICES INC COM 032654105 2 13 SH   OTR 1 0 0 13
ANGIODYNAMICS INC COM 03475V101 1,574 102,687 SH   SOLE   102,687 0 0
ANNALY CAPITAL MANAGEMENT IN COM 035710409 946 111,974 SH   SOLE   111,974 0 0
ANSYS INC COM 03662Q105 3 8 SH   OTR 1 0 0 8
ANSYS INC COM 03662Q105 37,712 103,658 SH   SOLE   103,658 0 0
ANTHEM INC COM 036752103 21,730 67,672 SH   SOLE   67,672 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 31,769 555,374 SH   SOLE   555,374 0 0
APOLLO GLOBAL MGMT INC COM CL A 03768E105 856 17,570 SH   SOLE   17,570 0 0
APPLE INC COM 037833100 23 170 SH   OTR 1 0 0 170
APPLE INC COM 037833100 426,359 3,213,246 SH   SOLE   3,213,246 0 0
APPLIED MATLS INC COM 038222105 1 16 SH   OTR 1 0 0 16
APPLIED MATLS INC COM 038222105 49,589 574,864 SH   SOLE   574,864 0 0
APREA THERAPEUTICS INC COM 03836J102 0 27 SH   OTR 1 0 0 27
APREA THERAPEUTICS INC COM 03836J102 1,783 362,319 SH   SOLE   362,319 0 0
APTIV PLC SHS G6095L109 6 43 SH   OTR 1 0 0 43
ARCH CAP GROUP LTD ORD G0450A105 924 25,616 SH   SOLE   25,616 0 0
ARCHER DANIELS MIDLAND CO COM 039483102 2,068 41,024 SH   SOLE   41,024 0 0
ARCTURUS THERAPEUTICS HLDGS COM 03969T109 2,327 53,633 SH   SOLE   53,633 0 0
ARCUS BIOSCIENCES INC COM 03969F109 1 29 SH   OTR 1 0 0 29
ARCUS BIOSCIENCES INC COM 03969F109 10,617 408,977 SH   SOLE   408,977 0 0
ARDELYX INC COM 039697107 8,879 1,372,217 SH   SOLE   1,372,217 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 33,196 432,049 SH   SOLE   432,049 0 0
ARGENX SE SPONSORED ADR 04016X101 1 4 SH   OTR 1 0 0 4
ARGENX SE SPONSORED ADR 04016X101 11,403 38,773 SH   SOLE   38,773 0 0
ARISTA NETWORKS INC COM 040413106 2,481 8,538 SH   SOLE   8,538 0 0
ARK ETF TR GENOMIC REV ETF 00214Q302 696 7,500 SH   SOLE   7,500 0 0
ARK ETF TR INNOVATION ETF 00214Q104 786 6,350 SH   SOLE   6,350 0 0
ARRAY TECHNOLOGIES INC COM SHS 04271T100 13,826 320,484 SH   SOLE   320,484 0 0
ARRAY TECHNOLOGIES INC COM SHS 04271T100 1 29 SH   OTR 1 0 0 29
ARROWHEAD PHARMACEUTICALS IN COM 04280A100 12,581 163,958 SH   SOLE   163,958 0 0
ARVINAS INC COM 04335A105 24,580 289,401 SH   SOLE   289,401 0 0
ARVINAS INC COM 04335A105 1 13 SH   OTR 1 0 0 13
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 40,141 240,671 SH   SOLE   240,671 0 0
ASE TECHNOLOGY HLDG CO LTD SPONSORED ADS 00215W100 194 33,156 SH   SOLE   33,156 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 6,876 1,136,545 SH   SOLE   1,136,545 0 0
ASSURANT INC COM 04621X108 6,839 50,200 SH   SOLE   50,200 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 8,164 163,312 SH   SOLE   163,312 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 8 156 SH   OTR 1 0 0 156
ASURE SOFTWARE INC COM 04649U102 184 26,000 SH   SOLE   26,000 0 0
AT&T INC COM 00206R102 6 202 SH   OTR 1 0 0 202
AT&T INC COM 00206R102 32,195 1,119,463 SH   SOLE   1,119,463 0 0
ATMOS ENERGY CORP COM 049560105 9,736 102,017 SH   SOLE   102,017 0 0
ATMOS ENERGY CORP COM 049560105 2 20 SH   OTR 1 0 0 20
AUTODESK INC COM 052769106 3 10 SH   OTR 1 0 0 10
AUTODESK INC COM 052769106 79,111 259,083 SH   SOLE   259,083 0 0
AUTOLIV INC COM 052800109 4,188 45,469 SH   SOLE   45,469 0 0
AUTOMATIC DATA PROCESSING IN COM 053015103 14,392 81,676 SH   SOLE   81,676 0 0
AUTOZONE INC COM 053332102 6,173 5,207 SH   SOLE   5,207 0 0
AVALARA INC COM 05338G106 740 4,510 SH   SOLE   4,510 0 0
AVALONBAY CMNTYS INC COM 053484101 2,165 13,494 SH   SOLE   13,494 0 0
AVANTOR INC COM 05352A100 6,218 220,878 SH   SOLE   220,878 0 0
AVERY DENNISON CORP COM 053611109 3,846 24,797 SH   SOLE   24,797 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 498 19,497 SH   SOLE   19,497 0 0
AXALTA COATING SYS LTD COM G0750C108 1,608 56,334 SH   SOLE   56,334 0 0
AXSOME THERAPEUTICS INC COM 05464T104 9,435 115,802 SH   SOLE   115,802 0 0
B2GOLD CORP COM 11777Q209 147 26,281 SH   SOLE   26,281 0 0
BAIDU INC SPON ADR REP A 056752108 32,313 149,472 SH   SOLE   149,472 0 0
BAKER HUGHES COMPANY CL A 05722G100 8,788 421,457 SH   SOLE   421,457 0 0
BALL CORP COM 058498106 4 39 SH   OTR 1 0 0 39
BALL CORP COM 058498106 47,902 514,064 SH   SOLE   514,064 0 0
BALLARD PWR SYS INC NEW COM 058586108 4,253 181,941 SH   SOLE   181,941 0 0
BANCO BILBAO VIZCAYA ARGENTA SPONSORED ADR 05946K101 1 115 SH   OTR 1 0 0 115
BANCO BRADESCO S A SP ADR PFD NEW 059460303 1,338 254,295 SH   SOLE   254,295 0 0
BANCOLOMBIA S A SPON ADR PREF 05968L102 367 9,130 SH   SOLE   9,130 0 0
BANK MONTREAL QUE COM 063671101 1,737 22,862 SH   SOLE   22,862 0 0
BANK NEW YORK MELLON CORP COM 064058100 9,856 232,215 SH   SOLE   232,215 0 0
BANK NEW YORK MELLON CORP COM 064058100 1 31 SH   OTR 1 0 0 31
BANK NOVA SCOTIA B C COM 064149107 2,667 49,389 SH   SOLE   49,389 0 0
BAOZUN INC SPONSORED ADR 06684L103 344 10,000 SH   SOLE   10,000 0 0
BARRICK GOLD CORP COM 067901108 2,158 94,838 SH   SOLE   94,838 0 0
BAXTER INTL INC COM 071813109 9,737 121,346 SH   SOLE   121,346 0 0
BCE INC COM NEW 05534B760 3,533 82,694 SH   SOLE   82,694 0 0
BECTON DICKINSON & CO COM 075887109 10,771 43,045 SH   SOLE   43,045 0 0
BEIGENE LTD SPONSORED ADR 07725L102 2 9 SH   OTR 1 0 0 9
BEIGENE LTD SPONSORED ADR 07725L102 49,442 191,340 SH   SOLE   191,340 0 0
BERKSHIRE HATHAWAY INC DEL CL B NEW 084670702 9,199 39,765 SH   SOLE   39,765 0 0
BEST BUY INC COM 086516101 22,842 228,894 SH   SOLE   228,894 0 0
BEYOND MEAT INC COM 08862E109 1,526 12,209 SH   SOLE   12,209 0 0
BHP GROUP LTD SPONSORED ADS 088606108 5 73 SH   OTR 1 0 0 73
BHP GROUP PLC SPONSORED ADR 05545E209 1 23 SH   OTR 1 0 0 23
BILIBILI INC SPONS ADS REP Z 090040106 29,316 341,998 SH   SOLE   341,998 0 0
BIO RAD LABS INC CL A 090572207 3 6 SH   OTR 1 0 0 6
BIO RAD LABS INC CL A 090572207 76,233 130,769 SH   SOLE   130,769 0 0
BIOGEN INC COM 09062X103 95,711 390,870 SH   SOLE   390,870 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 4,206 49,067 SH   SOLE   49,067 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 31,397 358,030 SH   SOLE   358,030 0 0
BIOMARIN PHARMACEUTICAL INC NOTE 0.599% 8/0 09061GAH4 864 800 PRN   SOLE   800 0 0
BIONTECH SE SPONSORED ADS 09075V102 7,153 87,761 SH   SOLE   87,761 0 0
BIO-TECHNE CORP COM 09073M104 3 8 SH   OTR 1 0 0 8
BIO-TECHNE CORP COM 09073M104 34,385 108,279 SH   SOLE   108,279 0 0
BK OF AMERICA CORP COM 060505104 5 150 SH   OTR 1 0 0 150
BK OF AMERICA CORP COM 060505104 28,801 950,186 SH   SOLE   950,186 0 0
BLACKBERRY LTD COM 09228F103 147 22,191 SH   SOLE   22,191 0 0
BLACKROCK INC COM 09247X101 13,572 18,810 SH   SOLE   18,810 0 0
BLACKSTONE GROUP INC COM CL A 09260D107 2,206 34,031 SH   SOLE   34,031 0 0
BLOOM ENERGY CORP COM CL A 093712107 2 68 SH   OTR 1 0 0 68
BLOOM ENERGY CORP COM CL A 093712107 12,410 432,994 SH   SOLE   432,994 0 0
BLUEBIRD BIO INC COM 09609G100 1 16 SH   OTR 1 0 0 16
BLUEBIRD BIO INC COM 09609G100 18,308 423,098 SH   SOLE   423,098 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 39,463 351,867 SH   SOLE   351,867 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 2 15 SH   OTR 1 0 0 15
BOEING CO COM 097023105 1,108 5,179 SH   SOLE   5,179 0 0
BOOKING HOLDINGS INC COM 09857L108 13,065 5,866 SH   SOLE   5,866 0 0
BOOKING HOLDINGS INC COM 09857L108 1,015 1,000 PRN   SOLE   1,000 0 0
BOSTON PROPERTIES INC COM 101121101 1,464 15,490 SH   SOLE   15,490 0 0
BOSTON SCIENTIFIC CORP COM 101137107 3,103 86,333 SH   SOLE   86,333 0 0
BP PLC SPONSORED ADR 055622104 1 47 SH   OTR 1 0 0 47
BRISTOL-MYERS SQUIBB CO COM 110122108 6 94 SH   OTR 1 0 0 94
BRISTOL-MYERS SQUIBB CO COM 110122108 110,713 1,784,782 SH   SOLE   1,784,782 0 0
BRISTOL-MYERS SQUIBB CO RIGHT 99/99/9999 110122157 134 194,693 SH   SOLE   194,693 0 0
BROADCOM INC COM 11135F101 49,705 113,531 SH   SOLE   113,531 0 0
BROADRIDGE FINL SOLUTIONS IN COM 11133T103 2,630 17,169 SH   SOLE   17,169 0 0
BROOKFIELD ASSET MGMT INC CL A LTD VT SH 112585104 1,687 40,851 SH   SOLE   40,851 0 0
BROOKFIELD RENEWABLE PARTNER PARTNERSHIP UNIT G16258108 1,865 43,227 SH   SOLE   43,227 0 0
BROWN FORMAN CORP CL B 115637209 1,771 22,301 SH   SOLE   22,301 0 0
BRUKER CORP COM 116794108 3,421 63,199 SH   SOLE   63,199 0 0
BUNGE LIMITED COM G16962105 1,182 18,022 SH   SOLE   18,022 0 0
BURLINGTON STORES INC COM 122017106 935 3,574 SH   SOLE   3,574 0 0
CABOT OIL & GAS CORP COM 127097103 2,435 149,580 SH   SOLE   149,580 0 0
CADENCE DESIGN SYSTEM INC COM 127387108 6 45 SH   OTR 1 0 0 45
CADENCE DESIGN SYSTEM INC COM 127387108 25,980 190,425 SH   SOLE   190,425 0 0
CAMECO CORP COM 13321L108 245 18,346 SH   SOLE   18,346 0 0
CAMPBELL SOUP CO COM 134429109 7,094 146,723 SH   SOLE   146,723 0 0
CANADIAN IMP BK COMM COM 136069101 967 11,334 SH   SOLE   11,334 0 0
CANADIAN NAT RES LTD COM 136385101 640 26,649 SH   SOLE   26,649 0 0
CANADIAN NATL RY CO COM 136375102 8,343 75,955 SH   SOLE   75,955 0 0
CANADIAN PAC RY LTD COM 13645T100 4,764 13,747 SH   SOLE   13,747 0 0
CAPITAL ONE FINL CORP COM 14040H105 2,659 26,894 SH   SOLE   26,894 0 0
CARDINAL HEALTH INC COM 14149Y108 1 25 SH   OTR 1 0 0 25
CARDINAL HEALTH INC COM 14149Y108 2,558 47,753 SH   SOLE   47,753 0 0
CARMAX INC COM 143130102 833 8,815 SH   SOLE   8,815 0 0
CARNIVAL CORP UNIT 99/99/9999 143658300 865 39,928 SH   SOLE   39,928 0 0
CARRIER GLOBAL CORPORATION COM 14448C104 2,052 54,405 SH   SOLE   54,405 0 0
CATALENT INC COM 148806102 1,100 10,570 SH   SOLE   10,570 0 0
CATERPILLAR INC COM 149123101 10,825 59,469 SH   SOLE   59,469 0 0
CBOE GLOBAL MKTS INC COM 12503M108 741 7,962 SH   SOLE   7,962 0 0
CBRE GROUP INC CL A 12504L109 25,416 405,219 SH   SOLE   405,219 0 0
CDW CORP COM 12514G108 4,738 35,946 SH   SOLE   35,946 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 6,030 344,139 SH   SOLE   344,139 0 0
CELLULAR BIOMEDICINE GROUP I COM NEW 15117P102 4,325 235,317 SH   SOLE   235,317 0 0
CEMEX SAB DE CV SPON ADR NEW 151290889 393 76,375 SH   SOLE   76,375 0 0
CENOVUS ENERGY INC COM 15135U109 78 12,886 SH   SOLE   12,886 0 0
CENTENE CORP DEL COM 15135B101 2,106 35,073 SH   SOLE   35,073 0 0
CENTERPOINT ENERGY INC COM 15189T107 1,306 60,348 SH   SOLE   60,348 0 0
CERIDIAN HCM HLDG INC COM 15677J108 753 7,068 SH   SOLE   7,068 0 0
CERNER CORP COM 156782104 18,534 236,156 SH   SOLE   236,156 0 0
CERNER CORP COM 156782104 449 400 PRN   SOLE   400 0 0
CEVA INC COM 157210105 13,636 299,691 SH   SOLE   299,691 0 0
CF INDS HLDGS INC COM 125269100 2,434 62,869 SH   SOLE   62,869 0 0
CGI INC CL A SUB VTG 12532H104 476 6,007 SH   SOLE   6,007 0 0
CHARLES RIV LABS INTL INC COM 159864107 17,533 70,169 SH   SOLE   70,169 0 0
CHARTER COMMUNICATIONS INC N CL A 16119P108 14,595 22,061 SH   SOLE   22,061 0 0
CHENIERE ENERGY INC COM NEW 16411R208 7,525 125,347 SH   SOLE   125,347 0 0
CHEVRON CORP NEW COM 166764100 2,740 32,453 SH   SOLE   32,453 0 0
CHIASMA INC COM 16706W102 102 23,500 SH   SOLE   23,500 0 0
CHIPOTLE MEXICAN GRILL INC COM 169656105 7,556 5,449 SH   SOLE   5,449 0 0
CHUNGHWA TELECOM CO LTD SPON ADR NEW11 17133Q502 467 12,093 SH   SOLE   12,093 0 0
CHURCH & DWIGHT INC COM 171340102 14,845 170,172 SH   SOLE   170,172 0 0
CHURCH & DWIGHT INC COM 171340102 1 16 SH   OTR 1 0 0 16
CI FINL CORP COM 125491100 8,877 716,686 SH   SOLE   716,686 0 0
CIA ENERGETICA DE MINAS GERA SP ADR N-V PFD 204409601 299 103,718 SH   SOLE   103,718 0 0
CIGNA CORP NEW COM 125523100 19,791 95,065 SH   SOLE   95,065 0 0
CIGNA CORP NEW COM 125523100 2 8 SH   OTR 1 0 0 8
CINCINNATI BELL INC NEW COM NEW 171871502 1,850 121,050 SH   SOLE   121,050 0 0
CINCINNATI FINL CORP COM 172062101 721 8,251 SH   SOLE   8,251 0 0
CINTAS CORP COM 172908105 2,433 6,882 SH   SOLE   6,882 0 0
CISCO SYS INC COM 17275R102 3 61 SH   OTR 1 0 0 61
CISCO SYS INC COM 17275R102 58,459 1,306,471 SH   SOLE   1,306,471 0 0
CITIGROUP INC COM NEW 172967424 89,161 1,445,998 SH   SOLE   1,445,998 0 0
CITIGROUP INC COM NEW 172967424 7 113 SH   OTR 1 0 0 113
CITIZENS FINL GROUP INC COM 174610105 4,460 124,718 SH   SOLE   124,718 0 0
CITRIX SYS INC COM 177376100 1 7 SH   OTR 1 0 0 7
CITRIX SYS INC COM 177376100 17,142 131,758 SH   SOLE   131,758 0 0
CLOROX CO DEL COM 189054109 2 8 SH   OTR 1 0 0 8
CLOROX CO DEL COM 189054109 25,276 125,173 SH   SOLE   125,173 0 0
CLOVIS ONCOLOGY INC COM 189464100 2,562 533,832 SH   SOLE   533,832 0 0
CME GROUP INC COM 12572Q105 4,446 24,422 SH   SOLE   24,422 0 0
COCA COLA CO COM 191216100 37,358 681,232 SH   SOLE   681,232 0 0
COGENT BIOSCIENCES INC COM 19240Q201 0 29 SH   OTR 1 0 0 29
COGENT BIOSCIENCES INC COM 19240Q201 5,331 474,701 SH   SOLE   474,701 0 0
COGNEX CORP COM 192422103 651 8,108 SH   SOLE   8,108 0 0
COGNIZANT TECHNOLOGY SOLUTIO CL A 192446102 4,548 55,508 SH   SOLE   55,508 0 0
COHERUS BIOSCIENCES INC COM 19249H103 1 45 SH   OTR 1 0 0 45
COHERUS BIOSCIENCES INC COM 19249H103 11,833 680,812 SH   SOLE   680,812 0 0
COLGATE PALMOLIVE CO COM 194162103 11,354 132,781 SH   SOLE   132,781 0 0
COLGATE PALMOLIVE CO COM 194162103 1 16 SH   OTR 1 0 0 16
COMCAST CORP NEW CL A 20030N101 5 97 SH   OTR 1 0 0 97
COMCAST CORP NEW CL A 20030N101 16,574 316,323 SH   SOLE   316,323 0 0
COMERICA INC COM 200340107 694 12,416 SH   SOLE   12,416 0 0
CONAGRA BRANDS INC COM 205887102 1,263 34,843 SH   SOLE   34,843 0 0
CONCHO RES INC COM 20605P101 6,756 115,782 SH   SOLE   115,782 0 0
CONOCOPHILLIPS COM 20825C104 3,393 84,854 SH   SOLE   84,854 0 0
CONSOLIDATED EDISON INC COM 209115104 3,925 54,308 SH   SOLE   54,308 0 0
CONSTELLATION BRANDS INC CL A 21036P108 6,859 31,309 SH   SOLE   31,309 0 0
CONSTELLATION PHARMCETICLS I COM 210373106 1 18 SH   OTR 1 0 0 18
CONSTELLATION PHARMCETICLS I COM 210373106 11,852 411,494 SH   SOLE   411,494 0 0
COPART INC COM 217204106 4,217 33,158 SH   SOLE   33,158 0 0
CORNING INC COM 219350105 1,638 45,486 SH   SOLE   45,486 0 0
CORTEVA INC COM 22052L104 1,565 40,407 SH   SOLE   40,407 0 0
COSTAR GROUP INC COM 22160N109 1,774 1,919 SH   SOLE   1,919 0 0
COSTCO WHSL CORP NEW COM 22160K105 13,193 35,014 SH   SOLE   35,014 0 0
COUPA SOFTWARE INC COM 22266L106 1,544 4,560 SH   SOLE   4,560 0 0
CRH PLC ADR 12626K203 1,471 34,547 SH   SOLE   34,547 0 0
CRH PLC ADR 12626K203 1 33 SH   OTR 1 0 0 33
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 0 3 SH   OTR 1 0 0 3
CROWN CASTLE INTL CORP NEW COM 22822V101 11,777 73,976 SH   SOLE   73,976 0 0
CROWN HLDGS INC COM 228368106 2 18 SH   OTR 1 0 0 18
CRYOLIFE INC COM 228903100 689 29,166 SH   SOLE   29,166 0 0
CSX CORP COM 126408103 5,263 57,992 SH   SOLE   57,992 0 0
CSX CORP COM 126408103 2 19 SH   OTR 1 0 0 19
CUMMINS INC COM 231021106 3,796 16,713 SH   SOLE   16,713 0 0
CVS HEALTH CORP COM 126650100 3 49 SH   OTR 1 0 0 49
CVS HEALTH CORP COM 126650100 17,017 249,171 SH   SOLE   249,171 0 0
CYTOKINETICS INC COM NEW 23282W605 7,811 375,853 SH   SOLE   375,853 0 0
D R HORTON INC COM 23331A109 6,543 94,901 SH   SOLE   94,901 0 0
DANAHER CORPORATION COM 235851102 15 67 SH   OTR 1 0 0 67
DANAHER CORPORATION COM 235851102 176,489 794,463 SH   SOLE   794,463 0 0
DARDEN RESTAURANTS INC COM 237194105 848 7,115 SH   SOLE   7,115 0 0
DATADOG INC CL A COM 23804L103 974 9,899 SH   SOLE   9,899 0 0
DAVITA INC COM 23918K108 4,769 40,617 SH   SOLE   40,617 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 0 8 SH   OTR 1 0 0 8
DECIPHERA PHARMACEUTICALS IN COM 24344T101 10,081 176,628 SH   SOLE   176,628 0 0
DEERE & CO COM 244199105 14,180 52,700 SH   SOLE   52,700 0 0
DELL TECHNOLOGIES INC CL C 24703L202 8,700 118,717 SH   SOLE   118,717 0 0
DENTSPLY SIRONA INC COM 24906P109 1,056 20,193 SH   SOLE   20,193 0 0
DEVON ENERGY CORP NEW COM 25179M103 340 21,498 SH   SOLE   21,498 0 0
DEXCOM INC COM 252131107 5,444 14,725 SH   SOLE   14,725 0 0
DIAMONDBACK ENERGY INC COM 25278X109 326 6,752 SH   SOLE   6,752 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 31,041 1,408,993 SH   SOLE   1,408,993 0 0
DIGITAL RLTY TR INC COM 253868103 2,179 15,627 SH   SOLE   15,627 0 0
DIGITAL TURBINE INC COM NEW 25400W102 1,536 27,300 SH   SOLE   27,300 0 0
DISCOVER FINL SVCS COM 254709108 2,433 26,873 SH   SOLE   26,873 0 0
DISCOVERY INC COM SER C 25470F302 1,164 44,460 SH   SOLE   44,460 0 0
DISNEY WALT CO COM 254687106 7 39 SH   OTR 1 0 0 39
DISNEY WALT CO COM 254687106 99,892 551,460 SH   SOLE   551,460 0 0
DOCUSIGN INC COM 256163106 2,978 13,408 SH   SOLE   13,408 0 0
DOLLAR GEN CORP NEW COM 256677105 13,704 65,162 SH   SOLE   65,162 0 0
DOLLAR TREE INC COM 256746108 1,359 12,578 SH   SOLE   12,578 0 0
DOMINION ENERGY INC COM 25746U109 4,654 61,891 SH   SOLE   61,891 0 0
DOMINOS PIZZA INC COM 25754A201 4,617 12,039 SH   SOLE   12,039 0 0
DOVER CORP COM 260003108 2,350 18,615 SH   SOLE   18,615 0 0
DOW INC COM 260557103 3,956 71,280 SH   SOLE   71,280 0 0
DUKE REALTY CORP COM NEW 264411505 267 6,676 SH   SOLE   6,676 0 0
DUPONT DE NEMOURS INC COM 26614N102 4,950 69,604 SH   SOLE   69,604 0 0
EARGO INC COM 270087109 1,381 30,806 SH   SOLE   30,806 0 0
EATON CORP PLC SHS G29183103 3 22 SH   OTR 1 0 0 22
EATON VANCE CORP COM NON VTG 278265103 10,192 150,037 SH   SOLE   150,037 0 0
EBAY INC. COM 278642103 28,294 563,059 SH   SOLE   563,059 0 0
ECOLAB INC COM 278865100 2 10 SH   OTR 1 0 0 10
ECOLAB INC COM 278865100 31,127 143,860 SH   SOLE   143,860 0 0
EDISON INTL COM 281020107 2,448 38,968 SH   SOLE   38,968 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 8,776 96,190 SH   SOLE   96,190 0 0
EIDOS THERAPEUTICS INC COM 28249H104 8,889 67,551 SH   SOLE   67,551 0 0
ELANCO ANIMAL HEALTH INC COM 28414H103 670 21,840 SH   SOLE   21,840 0 0
ELECTRONIC ARTS INC COM 285512109 34,940 243,318 SH   SOLE   243,318 0 0
EMERSON ELEC CO COM 291011104 54,021 672,176 SH   SOLE   672,176 0 0
ENANTA PHARMACEUTICALS INC COM 29251M106 7,534 178,941 SH   SOLE   178,941 0 0
ENBRIDGE INC COM 29250N105 1,198 37,494 SH   SOLE   37,494 0 0
ENDURANCE INTL GROUP HLDGS I COM 29272B105 9,333 987,610 SH   SOLE   987,610 0 0
ENPHASE ENERGY INC COM 29355A107 4 21 SH   OTR 1 0 0 21
ENPHASE ENERGY INC COM 29355A107 28,474 162,265 SH   SOLE   162,265 0 0
ENTERGY CORP NEW COM 29364G103 3,577 35,829 SH   SOLE   35,829 0 0
ENVIVA PARTNERS LP COM UNIT 29414J107 1,259 27,711 SH   SOLE   27,711 0 0
EOG RES INC COM 26875P101 1,348 1,000 PRN   SOLE   1,000 0 0
EOG RES INC COM 26875P101 1,584 31,772 SH   SOLE   31,772 0 0
EPAM SYS INC COM 29414B104 9,067 25,300 SH   SOLE   25,300 0 0
EPIZYME INC COM 29428V104 1,150 105,890 SH   SOLE   105,890 0 0
EQUIFAX INC COM 294429105 1,452 7,527 SH   SOLE   7,527 0 0
EQUINIX INC COM 29444U700 4 5 SH   OTR 1 0 0 5
EQUINIX INC COM 29444U700 61,665 86,559 SH   SOLE   86,559 0 0
EQUINOR ASA SPONSORED ADR 29446M102 1 89 SH   OTR 1 0 0 89
EQUITABLE HLDGS INC COM 29452E101 315 12,310 SH   SOLE   12,310 0 0
EQUITY LIFESTYLE PPTYS INC COM 29472R108 776 12,246 SH   SOLE   12,246 0 0
EQUITY RESIDENTIAL SH BEN INT 29476L107 2,207 37,221 SH   SOLE   37,221 0 0
ERICSSON ADR B SEK 10 294821608 2 153 SH   OTR 1 0 0 153
ERICSSON ADR B SEK 10 294821608 2,156 180,451 SH   SOLE   180,451 0 0
ESSENTIAL UTILS INC COM 29670G102 1,689 35,712 SH   SOLE   35,712 0 0
ESSEX PPTY TR INC COM 297178105 1,454 6,122 SH   SOLE   6,122 0 0
ETF MANAGERS TR PRIME CYBR SCRTY 26924G201 1,716 29,965 SH   SOLE   29,965 0 0
ETF MANAGERS TR WEDBUSH VID GAME 26924G706 287 3,655 SH   SOLE   3,655 0 0
ETSY INC COM 29786A106 8,745 49,152 SH   SOLE   49,152 0 0
EVERSOURCE ENERGY COM 30040W108 5,480 63,339 SH   SOLE   63,339 0 0
EXACT SCIENCES CORP COM 30063P105 1 11 SH   OTR 1 0 0 11
EXACT SCIENCES CORP COM 30063P105 23,301 175,865 SH   SOLE   175,865 0 0
EXACT SCIENCES CORP NOTE 0.375% 3/0 30063PAC9 1,441 1,100 PRN   SOLE   1,100 0 0
EXACT SCIENCES CORP NOTE 0.375% 3/1 30063PAB1 278 200 PRN   SOLE   200 0 0
EXCHANGE TRADED CONCEPTS TR EMQQ EM INTERN 301505889 1,648 26,060 SH   SOLE   26,060 0 0
EXELIXIS INC COM 30161Q104 46,348 2,309,242 SH   SOLE   2,309,242 0 0
EXELIXIS INC COM 30161Q104 2 104 SH   OTR 1 0 0 104
EXELON CORP COM 30161N101 5,175 122,565 SH   SOLE   122,565 0 0
EXPEDIA GROUP INC COM NEW 30212P303 970 7,328 SH   SOLE   7,328 0 0
EXPEDITORS INTL WASH INC COM 302130109 5,782 60,793 SH   SOLE   60,793 0 0
EXTRA SPACE STORAGE INC COM 30225T102 782 6,753 SH   SOLE   6,753 0 0
EXXON MOBIL CORP COM 30231G102 13,789 334,520 SH   SOLE   334,520 0 0
F5 NETWORKS INC COM 315616102 14,821 84,236 SH   SOLE   84,236 0 0
FACEBOOK INC CL A 30303M102 2 7 SH   OTR 1 0 0 7
FACEBOOK INC CL A 30303M102 124,292 455,011 SH   SOLE   455,011 0 0
FAIR ISAAC CORP COM 303250104 8,376 16,389 SH   SOLE   16,389 0 0
FASTENAL CO COM 311900104 8,767 179,535 SH   SOLE   179,535 0 0
FATE THERAPEUTICS INC COM 31189P102 1 10 SH   OTR 1 0 0 10
FATE THERAPEUTICS INC COM 31189P102 24,561 270,101 SH   SOLE   270,101 0 0
FEDEX CORP COM 31428X106 4,711 18,146 SH   SOLE   18,146 0 0
FIBROGEN INC COM 31572Q808 6,848 184,625 SH   SOLE   184,625 0 0
FIDELITY NATIONAL FINANCIAL FNF GROUP COM 31620R303 588 15,041 SH   SOLE   15,041 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 7,875 55,670 SH   SOLE   55,670 0 0
FIFTH THIRD BANCORP COM 316773100 5,247 190,296 SH   SOLE   190,296 0 0
FIRST REP BK SAN FRANCISCO C COM 33616C100 6,966 47,407 SH   SOLE   47,407 0 0
FIRST SOLAR INC COM 336433107 3,008 30,405 SH   SOLE   30,405 0 0
FISERV INC COM 337738108 3,835 33,677 SH   SOLE   33,677 0 0
FLEETCOR TECHNOLOGIES INC COM 339041105 1,257 4,606 SH   SOLE   4,606 0 0
FLUIDIGM CORP DEL COM 34385P108 1,910 318,331 SH   SOLE   318,331 0 0
FMC CORP COM NEW 302491303 1,178 10,251 SH   SOLE   10,251 0 0
FOMENTO ECONOMICO MEXICANO S SPON ADR UNITS 344419106 264 3,484 SH   SOLE   3,484 0 0
FORD MTR CO DEL COM 345370860 6,837 777,815 SH   SOLE   777,815 0 0
FORMA THERAPEUTICS HLDGS INC SHS 34633R104 4,293 123,004 SH   SOLE   123,004 0 0
FORTINET INC COM 34959E109 17,558 118,207 SH   SOLE   118,207 0 0
FORTIVE CORP COM 34959J108 2,668 37,673 SH   SOLE   37,673 0 0
FORTIVE CORP NOTE 0.875% 2/1 34959JAK4 11,866 11,500 PRN   SOLE   11,500 0 0
FORTRESS BIOTECH INC COM 34960Q109 71 22,500 SH   SOLE   22,500 0 0
FORTUNE BRANDS HOME & SEC IN COM 34964C106 318 3,707 SH   SOLE   3,707 0 0
FOUNDATION BLDG MATLS INC COM 350392106 4,467 232,523 SH   SOLE   232,523 0 0
FOX CORP CL A COM 35137L105 302 10,379 SH   SOLE   10,379 0 0
FOX CORP CL B COM 35137L204 1,018 35,256 SH   SOLE   35,256 0 0
FRANCO NEV CORP COM 351858105 774 6,186 SH   SOLE   6,186 0 0
FRANKLIN RESOURCES INC COM 354613101 1,091 43,666 SH   SOLE   43,666 0 0
FREEPORT-MCMORAN INC CL B 35671D857 4,284 164,660 SH   SOLE   164,660 0 0
FRESHPET INC COM 358039105 1,782 12,548 SH   SOLE   12,548 0 0
FRONT YD RESIDENTIAL CORP COM 35904G107 10,074 621,829 SH   SOLE   621,829 0 0
GALLAGHER ARTHUR J & CO COM 363576109 1,105 8,931 SH   SOLE   8,931 0 0
GAP INC COM 364760108 334 16,601 SH   SOLE   16,601 0 0
GENERAC HLDGS INC COM 368736104 24,908 109,525 SH   SOLE   109,525 0 0
GENERAC HLDGS INC COM 368736104 2 9 SH   OTR 1 0 0 9
GENERAL ELECTRIC CO COM 369604103 8,070 747,223 SH   SOLE   747,223 0 0
GENERAL ELECTRIC CO COM 369604103 1 86 SH   OTR 1 0 0 86
GENERAL MLS INC COM 370334104 16,725 284,433 SH   SOLE   284,433 0 0
GENERAL MTRS CO COM 37045V100 4,636 111,325 SH   SOLE   111,325 0 0
GENMAB A/S SPONSORED ADS 372303206 3,103 76,307 SH   SOLE   76,307 0 0
GENMAB A/S SPONSORED ADS 372303206 3 75 SH   OTR 1 0 0 75
GENUINE PARTS CO COM 372460105 1,086 10,818 SH   SOLE   10,818 0 0
GILDAN ACTIVEWEAR INC COM 375916103 1,697 60,748 SH   SOLE   60,748 0 0
GILEAD SCIENCES INC COM 375558103 3 51 SH   OTR 1 0 0 51
GILEAD SCIENCES INC COM 375558103 128,461 2,204,889 SH   SOLE   2,204,889 0 0
GLADSTONE COMMERCIAL CORP COM 376536108 180 10,000 SH   SOLE   10,000 0 0
GLAXOSMITHKLINE PLC SPONSORED ADR 37733W105 1 40 SH   OTR 1 0 0 40
GLOBAL PMTS INC COM 37940X102 3,440 15,979 SH   SOLE   15,979 0 0
GODADDY INC CL A 380237107 721 8,690 SH   SOLE   8,690 0 0
GOLD FIELDS LTD SPONSORED ADR 38059T106 304 32,809 SH   SOLE   32,809 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 13,024 49,386 SH   SOLE   49,386 0 0
GOODYEAR TIRE & RUBR CO COM 382550101 141 13,031 SH   SOLE   13,031 0 0
GRACE W R & CO DEL NEW COM 38388F108 2,203 40,189 SH   SOLE   40,189 0 0
GRAINGER W W INC COM 384802104 4,002 9,801 SH   SOLE   9,801 0 0
GRUBHUB INC COM 400110102 18,043 242,931 SH   SOLE   242,931 0 0
GUARDANT HEALTH INC COM 40131M109 1 5 SH   OTR 1 0 0 5
GUARDANT HEALTH INC COM 40131M109 11,382 88,347 SH   SOLE   88,347 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 15,067 130,547 SH   SOLE   130,547 0 0
HALLIBURTON CO COM 406216101 2,171 115,125 SH   SOLE   115,125 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 31,338 733,720 SH   SOLE   733,720 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 1 34 SH   OTR 1 0 0 34
HANNON ARMSTRONG SUST INFR C COM 41068X100 15,640 246,562 SH   SOLE   246,562 0 0
HANNON ARMSTRONG SUST INFR C COM 41068X100 3 41 SH   OTR 1 0 0 41
HARTFORD FINL SVCS GROUP INC COM 416515104 9,780 199,656 SH   SOLE   199,656 0 0
HASBRO INC COM 418056107 9,048 96,727 SH   SOLE   96,727 0 0
HCA HEALTHCARE INC COM 40412C101 10,650 64,755 SH   SOLE   64,755 0 0
HDFC BANK LTD SPONSORED ADS 40415F101 2 22 SH   OTR 1 0 0 22
HDFC BANK LTD SPONSORED ADS 40415F101 18,392 254,515 SH   SOLE   254,515 0 0
HEALTHPEAK PROPERTIES INC COM 42250P103 1,341 44,360 SH   SOLE   44,360 0 0
HEICO CORP NEW CL A 422806208 887 7,577 SH   SOLE   7,577 0 0
HENRY JACK & ASSOC INC COM 426281101 706 4,357 SH   SOLE   4,357 0 0
HENRY SCHEIN INC COM 806407102 804 12,022 SH   SOLE   12,022 0 0
HERON THERAPEUTICS INC COM 427746102 27,299 1,289,773 SH   SOLE   1,289,773 0 0
HERSHEY CO COM 427866108 4 23 SH   OTR 1 0 0 23
HERSHEY CO COM 427866108 2,647 17,377 SH   SOLE   17,377 0 0
HESS CORP COM 42809H107 1,304 24,709 SH   SOLE   24,709 0 0
HEWLETT PACKARD ENTERPRISE C COM 42824C109 1,862 157,107 SH   SOLE   157,107 0 0
HILL ROM HLDGS INC COM 431475102 1 14 SH   OTR 1 0 0 14
HILL ROM HLDGS INC COM 431475102 17,260 176,171 SH   SOLE   176,171 0 0
HILTON WORLDWIDE HLDGS INC COM 43300A203 2,899 26,056 SH   SOLE   26,056 0 0
HMS HLDGS CORP COM 40425J101 9,039 245,943 SH   SOLE   245,943 0 0
HOLLYSYS AUTOMATION TCHNGY L SHS G45667105 12,402 844,237 SH   SOLE   844,237 0 0
HOLOGIC INC COM 436440101 69,606 955,700 SH   SOLE   955,700 0 0
HOLOGIC INC COM 436440101 4 58 SH   OTR 1 0 0 58
HOME DEPOT INC COM 437076102 59,243 223,027 SH   SOLE   223,027 0 0
HOME DEPOT INC COM 437076102 5 17 SH   OTR 1 0 0 17
HONEYWELL INTL INC COM 438516106 3,919 18,427 SH   SOLE   18,427 0 0
HORMEL FOODS CORP COM 440452100 1,249 26,788 SH   SOLE   26,788 0 0
HOST HOTELS & RESORTS INC COM 44107P104 2,098 143,432 SH   SOLE   143,432 0 0
HOWMET AEROSPACE INC COM 443201108 941 32,967 SH   SOLE   32,967 0 0
HP INC COM 40434L105 1 59 SH   OTR 1 0 0 59
HP INC COM 40434L105 8,051 327,409 SH   SOLE   327,409 0 0
HUAZHU GROUP LTD NOTE 0.375%11/0 16949NAC3 926 800 PRN   SOLE   800 0 0
HUBSPOT INC COM 443573100 2,218 5,613 SH   SOLE   5,613 0 0
HUMANA INC COM 444859102 13,876 33,821 SH   SOLE   33,821 0 0
HUNTINGTON BANCSHARES INC COM 446150104 3,370 266,831 SH   SOLE   266,831 0 0
HUNTINGTON INGALLS INDS INC COM 446413106 5,386 31,589 SH   SOLE   31,589 0 0
ICICI BANK LIMITED ADR 45104G104 14,555 979,441 SH   SOLE   979,441 0 0
IDEX CORP COM 45167R104 1,740 8,737 SH   SOLE   8,737 0 0
IDEXX LABS INC COM 45168D104 3,166 6,334 SH   SOLE   6,334 0 0
IGM BIOSCIENCES INC COM 449585108 9,614 108,887 SH   SOLE   108,887 0 0
IGM BIOSCIENCES INC COM 449585108 0 5 SH   OTR 1 0 0 5
IHS MARKIT LTD SHS G47567105 15,551 173,107 SH   SOLE   173,107 0 0
ILLINOIS TOOL WKS INC COM 452308109 5,665 27,785 SH   SOLE   27,785 0 0
ILLUMINA INC COM 452327109 87,631 236,832 SH   SOLE   236,832 0 0
ILLUMINA INC COM 452327109 1 4 SH   OTR 1 0 0 4
ILLUMINA INC NOTE 8/1 452327AK5 14,623 13,000 PRN   SOLE   13,000 0 0
IMMUNOVANT INC COM 45258J102 8,395 181,749 SH   SOLE   181,749 0 0
INCYTE CORP COM 45337C102 49,866 573,283 SH   SOLE   573,283 0 0
INCYTE CORP COM 45337C102 1 17 SH   OTR 1 0 0 17
INFOSYS LTD SPONSORED ADR 456788108 5,445 321,238 SH   SOLE   321,238 0 0
INGERSOLL RAND INC COM 45687V106 1,185 26,019 SH   SOLE   26,019 0 0
INGREDION INC COM 457187102 237 3,011 SH   SOLE   3,011 0 0
INPHI CORP COM 45772F107 10,150 63,252 SH   SOLE   63,252 0 0
INSMED INC COM PAR $.01 457669307 9,418 282,901 SH   SOLE   282,901 0 0
INSULET CORP COM 45784P101 894 3,498 SH   SOLE   3,498 0 0
INTEL CORP COM 458140100 33,743 677,335 SH   SOLE   677,335 0 0
INTEL CORP COM 458140100 3 58 SH   OTR 1 0 0 58
INTELLIA THERAPEUTICS INC COM 45826J105 9,951 182,917 SH   SOLE   182,917 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 4,300 37,299 SH   SOLE   37,299 0 0
INTERNATIONAL BUSINESS MACHS COM 459200101 3 20 SH   OTR 1 0 0 20
INTERNATIONAL BUSINESS MACHS COM 459200101 15,198 120,771 SH   SOLE   120,771 0 0
INTERNATIONAL FLAVORS&FRAGRA COM 459506101 1,260 11,581 SH   SOLE   11,581 0 0
INTERNATIONAL PAPER CO COM 460146103 2 33 SH   OTR 1 0 0 33
INTERNATIONAL PAPER CO COM 460146103 1,716 34,521 SH   SOLE   34,521 0 0
INTERPUBLIC GROUP COS INC COM 460690100 2 76 SH   OTR 1 0 0 76
INTERPUBLIC GROUP COS INC COM 460690100 5,587 237,553 SH   SOLE   237,553 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 14,502 456,022 SH   SOLE   456,022 0 0
INTUIT COM 461202103 29,811 78,478 SH   SOLE   78,478 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 34,683 42,394 SH   SOLE   42,394 0 0
INVESCO EXCHANGE TRADED FD T WILDERHIL CLAN 46137V134 525 5,100 SH   SOLE   5,100 0 0
INVITATION HOMES INC COM 46187W107 766 25,784 SH   SOLE   25,784 0 0
IONIS PHARMACEUTICALS INC COM 462222100 13,963 246,954 SH   SOLE   246,954 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 1 25 SH   OTR 1 0 0 25
IOVANCE BIOTHERAPEUTICS INC COM 462260100 27,472 592,037 SH   SOLE   592,037 0 0
IQVIA HLDGS INC COM 46266C105 2,507 13,993 SH   SOLE   13,993 0 0
IRON MTN INC NEW COM 46284V101 968 32,821 SH   SOLE   32,821 0 0
ISHARES INC MSCI CDA ETF 464286509 3,565 115,591 SH   SOLE   115,591 0 0
ISHARES TR GL CLEAN ENE ETF 464288224 208 7,400 SH   SOLE   7,400 0 0
ISHARES TR MSCI CHINA ETF 46429B671 1,208 15,000 SH   SOLE   15,000 0 0
ISHARES TR U.S. MED DVC ETF 464288810 225 690 SH   SOLE   690 0 0
ISIS PHARMACEUTICALS INC DEL NOTE 1.000%11/1 464337AJ3 2,074 1,900 PRN   SOLE   1,900 0 0
ITAU UNIBANCO HLDG S A SPON ADR REP PFD 465562106 1,329 218,200 SH   SOLE   218,200 0 0
JD.COM INC SPON ADR CL A 47215P106 55,411 630,404 SH   SOLE   630,404 0 0
JOHNSON & JOHNSON COM 478160104 7 45 SH   OTR 1 0 0 45
JOHNSON & JOHNSON COM 478160104 95,038 603,907 SH   SOLE   603,907 0 0
JPMORGAN CHASE & CO COM 46625H100 50,043 393,893 SH   SOLE   393,893 0 0
KANSAS CITY SOUTHERN COM NEW 485170302 9,074 44,450 SH   SOLE   44,450 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 1 48 SH   OTR 1 0 0 48
KARYOPHARM THERAPEUTICS INC COM 48576U106 14,730 951,530 SH   SOLE   951,530 0 0
KB FINL GROUP INC SPONSORED ADR 48241A105 268 6,776 SH   SOLE   6,776 0 0
KELLOGG CO COM 487836108 3,648 58,624 SH   SOLE   58,624 0 0
KEURIG DR PEPPER INC COM 49271V100 1,108 34,619 SH   SOLE   34,619 0 0
KEURIG DR PEPPER INC COM 49271V100 1 32 SH   OTR 1 0 0 32
KEYCORP COM 493267108 7,127 434,278 SH   SOLE   434,278 0 0
KEYSIGHT TECHNOLOGIES INC COM 49338L103 41,369 313,332 SH   SOLE   313,332 0 0
KEYSIGHT TECHNOLOGIES INC COM 49338L103 1 11 SH   OTR 1 0 0 11
KEZAR LIFE SCIENCES INC COM 49372L100 3,054 584,956 SH   SOLE   584,956 0 0
KIMBERLY-CLARK CORP COM 494368103 8,514 63,142 SH   SOLE   63,142 0 0
KIMCO RLTY CORP COM 49446R109 201 13,400 SH   SOLE   13,400 0 0
KINDER MORGAN INC DEL COM 49456B101 9,647 705,671 SH   SOLE   705,671 0 0
KINROSS GOLD CORP COM 496902404 333 45,375 SH   SOLE   45,375 0 0
KLA CORP COM NEW 482480100 11,951 46,169 SH   SOLE   46,169 0 0
KODIAK SCIENCES INC COM 50015M109 21,401 145,669 SH   SOLE   145,669 0 0
KRAFT HEINZ CO COM 500754106 1,839 53,104 SH   SOLE   53,104 0 0
KROGER CO COM 501044101 3 80 SH   OTR 1 0 0 80
KROGER CO COM 501044101 6,209 195,485 SH   SOLE   195,485 0 0
KURA ONCOLOGY INC COM 50127T109 1 41 SH   OTR 1 0 0 41
KURA ONCOLOGY INC COM 50127T109 30,350 929,241 SH   SOLE   929,241 0 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409 2 12 SH   OTR 1 0 0 12
LABORATORY CORP AMER HLDGS COM NEW 50540R409 42,796 210,239 SH   SOLE   210,239 0 0
LAM RESEARCH CORP COM 512807108 6,547 13,874 SH   SOLE   13,874 0 0
LAMB WESTON HLDGS INC COM 513272104 784 9,954 SH   SOLE   9,954 0 0
LAS VEGAS SANDS CORP COM 517834107 1,226 20,578 SH   SOLE   20,578 0 0
LAUDER ESTEE COS INC CL A 518439104 24,429 91,770 SH   SOLE   91,770 0 0
LEMONADE INC COM 52567D107 670 5,500 SH   SOLE   5,500 0 0
LENNAR CORP CL A 526057104 1,054 13,832 SH   SOLE   13,832 0 0
LIBERTY BROADBAND CORP COM SER C 530307305 26,535 167,543 SH   SOLE   167,543 0 0
LIBERTY MEDIA CORP DEL COM C SIRIUSXM 531229607 707 16,259 SH   SOLE   16,259 0 0
LILLY ELI & CO COM 532457108 33,893 200,735 SH   SOLE   200,735 0 0
LINCOLN NATL CORP IND COM 534187109 1,090 21,668 SH   SOLE   21,668 0 0
LITHIUM AMERS CORP NEW COM NEW 53680Q207 262 21,000 SH   SOLE   21,000 0 0
LIVE NATION ENTERTAINMENT IN COM 538034109 5,317 72,353 SH   SOLE   72,353 0 0
LOEWS CORP COM 540424108 979 21,743 SH   SOLE   21,743 0 0
LOOP INDS INC COM 543518104 862 103,898 SH   SOLE   103,898 0 0
LOWES COS INC COM 548661107 39,336 245,059 SH   SOLE   245,059 0 0
LULULEMON ATHLETICA INC COM 550021109 14,195 40,784 SH   SOLE   40,784 0 0
LUMEN TECHNOLOGIES INC COM 156700106 634 64,974 SH   SOLE   64,974 0 0
LUMENTUM HLDGS INC NOTE 0.500%12/1 55024UAD1 2,078 1,700 PRN   SOLE   1,700 0 0
LYFT INC CL A COM 55087P104 407 8,293 SH   SOLE   8,293 0 0
M & T BK CORP COM 55261F104 1,674 13,146 SH   SOLE   13,146 0 0
MACROGENICS INC COM 556099109 1 30 SH   OTR 1 0 0 30
MACROGENICS INC COM 556099109 15,456 676,095 SH   SOLE   676,095 0 0
MACYS INC COM 55616P104 280 25,000 SH   SOLE   25,000 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 3,527 31,722 SH   SOLE   31,722 0 0
MAGNA INTL INC COM 559222401 3,867 54,674 SH   SOLE   54,674 0 0
MANULIFE FINL CORP COM 56501R106 8,650 486,491 SH   SOLE   486,491 0 0
MARATHON OIL CORP COM 565849106 2,726 408,640 SH   SOLE   408,640 0 0
MARATHON PETE CORP COM 56585A102 1,709 41,307 SH   SOLE   41,307 0 0
MARKEL CORP COM 570535104 838 811 SH   SOLE   811 0 0
MARRIOTT INTL INC NEW CL A 571903202 2,748 20,829 SH   SOLE   20,829 0 0
MARSH & MCLENNAN COS INC COM 571748102 6,681 57,104 SH   SOLE   57,104 0 0
MARTIN MARIETTA MATLS INC COM 573284106 3,388 11,931 SH   SOLE   11,931 0 0
MARVELL TECHNOLOGY GROUP LTD ORD G5876H105 3,149 66,262 SH   SOLE   66,262 0 0
MASCO CORP COM 574599106 2 36 SH   OTR 1 0 0 36
MASCO CORP COM 574599106 35,255 641,793 SH   SOLE   641,793 0 0
MASIMO CORP COM 574795100 4,879 18,179 SH   SOLE   18,179 0 0
MASTERCARD INCORPORATED CL A 57636Q104 47,647 133,504 SH   SOLE   133,504 0 0
MATCH GROUP INC NEW COM 57667L107 1,913 12,654 SH   SOLE   12,654 0 0
MAXIM INTEGRATED PRODS INC COM 57772K101 17,524 197,664 SH   SOLE   197,664 0 0
MCCORMICK & CO INC COM NON VTG 579780206 5,749 60,136 SH   SOLE   60,136 0 0
MCDONALDS CORP COM 580135101 10,822 50,434 SH   SOLE   50,434 0 0
MCDONALDS CORP COM 580135101 2 8 SH   OTR 1 0 0 8
MCKESSON CORP COM 58155Q103 6,135 35,275 SH   SOLE   35,275 0 0
MEDTRONIC PLC SHS G5960L103 4 37 SH   OTR 1 0 0 37
MERCADOLIBRE INC COM 58733R102 40,533 24,196 SH   SOLE   24,196 0 0
MERCK & CO. INC COM 58933Y105 18 220 SH   OTR 1 0 0 220
MERCK & CO. INC COM 58933Y105 299,097 3,656,397 SH   SOLE   3,656,397 0 0
MERSANA THERAPEUTICS INC COM 59045L106 29,860 1,122,094 SH   SOLE   1,122,094 0 0
MERSANA THERAPEUTICS INC COM 59045L106 1 51 SH   OTR 1 0 0 51
MESA LABS INC COM 59064R109 1,884 6,571 SH   SOLE   6,571 0 0
METLIFE INC COM 59156R108 2 46 SH   OTR 1 0 0 46
METLIFE INC COM 59156R108 14,606 311,082 SH   SOLE   311,082 0 0
METTLER TOLEDO INTERNATIONAL COM 592688105 2,420 2,123 SH   SOLE   2,123 0 0
MGM RESORTS INTERNATIONAL COM 552953101 1,399 44,429 SH   SOLE   44,429 0 0
MICROCHIP TECHNOLOGY INC. COM 595017104 11,651 84,358 SH   SOLE   84,358 0 0
MICRON TECHNOLOGY INC COM 595112103 743 500 PRN   SOLE   500 0 0
MICRON TECHNOLOGY INC COM 595112103 2 24 SH   OTR 1 0 0 24
MICRON TECHNOLOGY INC COM 595112103 7,905 105,155 SH   SOLE   105,155 0 0
MICROSOFT CORP COM 594918104 20 92 SH   OTR 1 0 0 92
MICROSOFT CORP COM 594918104 434,399 1,953,491 SH   SOLE   1,953,491 0 0
MID-AMER APT CMNTYS INC COM 59522J103 883 6,967 SH   SOLE   6,967 0 0
MIRATI THERAPEUTICS INC COM 60468T105 41,534 189,091 SH   SOLE   189,091 0 0
MIRATI THERAPEUTICS INC COM 60468T105 2 7 SH   OTR 1 0 0 7
MODERNA INC COM 60770K107 41,387 396,167 SH   SOLE   396,167 0 0
MOHAWK INDS INC COM 608190104 296 2,112 SH   SOLE   2,112 0 0
MOLINA HEALTHCARE INC COM 60855R100 561 2,636 SH   SOLE   2,636 0 0
MOLSON COORS BEVERAGE CO CL B 60871R209 762 16,858 SH   SOLE   16,858 0 0
MONDELEZ INTL INC CL A 609207105 8,723 149,200 SH   SOLE   149,200 0 0
MONGODB INC CL A 60937P106 1,106 3,086 SH   SOLE   3,086 0 0
MONSTER BEVERAGE CORP NEW COM 61174X109 8,783 94,968 SH   SOLE   94,968 0 0
MOODYS CORP COM 615369105 8,377 28,861 SH   SOLE   28,861 0 0
MORGAN STANLEY COM NEW 617446448 30,504 445,107 SH   SOLE   445,107 0 0
MORGAN STANLEY COM NEW 617446448 5 71 SH   OTR 1 0 0 71
MORGAN STANLEY COM NEW 617446448 2,581 2,050 PRN   SOLE   2,050 0 0
MORPHOSYS AG SPONSORED ADS 617760202 2 62 SH   OTR 1 0 0 62
MORPHOSYS AG SPONSORED ADS 617760202 7,976 281,424 SH   SOLE   281,424 0 0
MOSAIC CO NEW COM 61945C103 340 14,784 SH   SOLE   14,784 0 0
MOTOROLA SOLUTIONS INC COM NEW 620076307 5,894 34,658 SH   SOLE   34,658 0 0
MSCI INC COM 55354G100 2,255 5,050 SH   SOLE   5,050 0 0
NATIONAL FUEL GAS CO N J COM 636180101 451 10,958 SH   SOLE   10,958 0 0
NAVISTAR INTL CORP NEW COM 63934E108 13,416 305,169 SH   SOLE   305,169 0 0
NEKTAR THERAPEUTICS COM 640268108 5,204 306,085 SH   SOLE   306,085 0 0
NEOGENOMICS INC COM NEW 64049M209 15,965 296,506 SH   SOLE   296,506 0 0
NEOGENOMICS INC COM NEW 64049M209 1 22 SH   OTR 1 0 0 22
NETAPP INC COM 64110D104 5,227 78,918 SH   SOLE   78,918 0 0
NETEASE INC SPONSORED ADS 64110W102 4,228 44,150 SH   SOLE   44,150 0 0
NETFLIX INC COM 64110L106 24,105 44,577 SH   SOLE   44,577 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 15,516 161,869 SH   SOLE   161,869 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 1,085 600 PRN   SOLE   600 0 0
NEW ORIENTAL ED & TECHNOLOGY SPON ADR 647581107 41,776 224,830 SH   SOLE   224,830 0 0
NEWMONT CORP COM 651639106 1 16 SH   OTR 1 0 0 16
NEWMONT CORP COM 651639106 12,407 207,176 SH   SOLE   207,176 0 0
NEXTERA ENERGY INC COM 65339F101 1 18 SH   OTR 1 0 0 18
NEXTERA ENERGY INC COM 65339F101 21,356 276,806 SH   SOLE   276,806 0 0
NEXTERA ENERGY PARTNERS LP COM UNIT PART IN 65341B106 16,754 249,866 SH   SOLE   249,866 0 0
NEXTERA ENERGY PARTNERS LP COM UNIT PART IN 65341B106 2 29 SH   OTR 1 0 0 29
NGM BIOPHARMACEUTICALS INC COM 62921N105 6,715 221,634 SH   SOLE   221,634 0 0
NIKE INC CL B 654106103 74,937 529,697 SH   SOLE   529,697 0 0
NIKE INC CL B 654106103 3 19 SH   OTR 1 0 0 19
NIO INC SPON ADS 62914V106 17,615 361,449 SH   SOLE   361,449 0 0
NKARTA INC COM 65487U108 4,127 67,142 SH   SOLE   67,142 0 0
NKARTA INC COM 65487U108 0 4 SH   OTR 1 0 0 4
NOMAD FOODS LTD USD ORD SHS G6564A105 2,183 85,859 SH   SOLE   85,859 0 0
NORBORD INC COM NEW 65548P403 16,653 386,005 SH   SOLE   386,005 0 0
NORFOLK SOUTHN CORP COM 655844108 8,571 36,069 SH   SOLE   36,069 0 0
NORTHERN TR CORP COM 665859104 15,152 162,673 SH   SOLE   162,673 0 0
NORTHERN TR CORP COM 665859104 1 14 SH   OTR 1 0 0 14
NORTONLIFELOCK INC COM 668771108 7,868 378,597 SH   SOLE   378,597 0 0
NOVAVAX INC COM NEW 670002401 8,090 72,549 SH   SOLE   72,549 0 0
NOVOCURE LTD ORD SHS G6674U108 1 4 SH   OTR 1 0 0 4
NOVO-NORDISK A S ADR 670100205 2 28 SH   OTR 1 0 0 28
NU SKIN ENTERPRISES INC CL A 67018T105 1,834 33,575 SH   SOLE   33,575 0 0
NUANCE COMMUNICATIONS INC COM 67020Y100 3,622 82,150 SH   SOLE   82,150 0 0
NUCOR CORP COM 670346105 2,742 51,554 SH   SOLE   51,554 0 0
NUCOR CORP COM 670346105 1 19 SH   OTR 1 0 0 19
NUTRIEN LTD COM 67077M108 691 14,370 SH   SOLE   14,370 0 0
NVIDIA CORPORATION COM 67066G104 79,530 152,300 SH   SOLE   152,300 0 0
NVR INC COM 62944T105 1,072 263 SH   SOLE   263 0 0
OCCIDENTAL PETE CORP COM 674599105 3,204 185,084 SH   SOLE   185,084 0 0
OKTA INC CL A 679295105 5,586 21,976 SH   SOLE   21,976 0 0
OKTA INC NOTE 0.125% 9/0 679295AD7 899 600 PRN   SOLE   600 0 0
OLD DOMINION FREIGHT LINE IN COM 679580100 6,675 34,199 SH   SOLE   34,199 0 0
OMNICOM GROUP INC COM 681919106 1 23 SH   OTR 1 0 0 23
OMNICOM GROUP INC COM 681919106 2,999 48,083 SH   SOLE   48,083 0 0
ON SEMICONDUCTOR CORP COM 682189105 42,152 1,287,831 SH   SOLE   1,287,831 0 0
ON SEMICONDUCTOR CORP COM 682189105 3 79 SH   OTR 1 0 0 79
ON SEMICONDUCTOR CORP NOTE 1.625%10/1 682189AP0 848 500 PRN   SOLE   500 0 0
ONEOK INC NEW COM 682680103 1,028 800 PRN   SOLE   800 0 0
ONEOK INC NEW COM 682680103 8,719 227,174 SH   SOLE   227,174 0 0
ORACLE CORP COM 68389X105 18,642 288,177 SH   SOLE   288,177 0 0
OREILLY AUTOMOTIVE INC COM 67103H107 1,825 4,032 SH   SOLE   4,032 0 0
ORMAT TECHNOLOGIES INC COM 686688102 1 12 SH   OTR 1 0 0 12
ORMAT TECHNOLOGIES INC COM 686688102 7,935 87,885 SH   SOLE   87,885 0 0
OTIS WORLDWIDE CORP COM 68902V107 5,315 78,675 SH   SOLE   78,675 0 0
OUTSET MED INC COM 690145107 2,918 51,343 SH   SOLE   51,343 0 0
OWENS CORNING NEW COM 690742101 5,664 74,764 SH   SOLE   74,764 0 0
PACCAR INC COM 693718108 3,615 41,896 SH   SOLE   41,896 0 0
PACKAGING CORP AMER COM 695156109 13,577 98,444 SH   SOLE   98,444 0 0
PAGSEGURO DIGITAL LTD COM CL A G68707101 13,361 234,950 SH   SOLE   234,950 0 0
PALO ALTO NETWORKS INC COM 697435105 2 7 SH   OTR 1 0 0 7
PALO ALTO NETWORKS INC COM 697435105 76,219 214,599 SH   SOLE   214,599 0 0
PALO ALTO NETWORKS INC NOTE 0.750% 7/0 697435AD7 4,731 3,500 PRN   SOLE   3,500 0 0
PARKER-HANNIFIN CORP COM 701094104 14,813 54,404 SH   SOLE   54,404 0 0
PAYCHEX INC COM 704326107 2,024 21,716 SH   SOLE   21,716 0 0
PAYCOM SOFTWARE INC COM 70432V102 1,312 2,901 SH   SOLE   2,901 0 0
PAYPAL HLDGS INC COM 70450Y103 126,036 538,730 SH   SOLE   538,730 0 0
PAYPAL HLDGS INC COM 70450Y103 1 6 SH   OTR 1 0 0 6
PELOTON INTERACTIVE INC CL A COM 70614W100 3,770 24,847 SH   SOLE   24,847 0 0
PEMBINA PIPELINE CORP COM 706327103 6,662 281,978 SH   SOLE   281,978 0 0
PEOPLES UNITED FINANCIAL INC COM 712704105 157 12,163 SH   SOLE   12,163 0 0
PEPSICO INC COM 713448108 6 40 SH   OTR 1 0 0 40
PEPSICO INC COM 713448108 66,908 451,154 SH   SOLE   451,154 0 0
PERSONALIS INC COM 71535D106 1 15 SH   OTR 1 0 0 15
PERSONALIS INC COM 71535D106 7,737 211,316 SH   SOLE   211,316 0 0
PETROLEO BRASILEIRO SA PETRO SPONSORED ADR 71654V408 281 25,150 SH   SOLE   25,150 0 0
PFIZER INC COM 717081103 5,503 149,694 SH   SOLE   149,694 0 0
PHILLIPS 66 COM 718546104 2 24 SH   OTR 1 0 0 24
PHILLIPS 66 COM 718546104 2,799 40,021 SH   SOLE   40,021 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 0 89 SH   OTR 1 0 0 89
PIERIS PHARMACEUTICALS INC COM 720795103 5,682 2,272,642 SH   SOLE   2,272,642 0 0
PINDUODUO INC NOTE 12/0 722304AC6 1,732 1,400 PRN   SOLE   1,400 0 0
PINDUODUO INC SPONSORED ADS 722304102 58,491 329,200 SH   SOLE   329,200 0 0
PINTEREST INC CL A 72352L106 1,436 21,794 SH   SOLE   21,794 0 0
PIONEER NAT RES CO COM 723787107 1,080 9,486 SH   SOLE   9,486 0 0
PLANET FITNESS INC CL A 72703H101 6,501 83,743 SH   SOLE   83,743 0 0
PLURALSIGHT INC COM CL A 72941B106 4,592 219,098 SH   SOLE   219,098 0 0
PNC FINL SVCS GROUP INC COM 693475105 15,416 103,458 SH   SOLE   103,458 0 0
POSCO SPONSORED ADR 693483109 232 3,720 SH   SOLE   3,720 0 0
POWER INTEGRATIONS INC COM 739276103 16,692 203,902 SH   SOLE   203,902 0 0
POWER INTEGRATIONS INC COM 739276103 3 33 SH   OTR 1 0 0 33
PPG INDS INC COM 693506107 3 19 SH   OTR 1 0 0 19
PPG INDS INC COM 693506107 4,814 33,377 SH   SOLE   33,377 0 0
PRICE T ROWE GROUP INC COM 74144T108 10,530 69,553 SH   SOLE   69,553 0 0
PRICELINE GRP INC NOTE 0.900% 9/1 741503AX4 20,543 17,522 PRN   SOLE   17,522 0 0
PRINCIPAL FINANCIAL GROUP IN COM 74251V102 1,306 26,320 SH   SOLE   26,320 0 0
PROCTER AND GAMBLE CO COM 742718109 7 53 SH   OTR 1 0 0 53
PROCTER AND GAMBLE CO COM 742718109 157,001 1,128,327 SH   SOLE   1,128,327 0 0
PROGRESSIVE CORP COM 743315103 9,395 7,100 PRN   SOLE   7,100 0 0
PROGRESSIVE CORP COM 743315103 9,221 93,246 SH   SOLE   93,246 0 0
PROLOGIS INC. COM 74340W103 20,218 202,866 SH   SOLE   202,866 0 0
PROOFPOINT INC NOTE 0.250% 8/1 743424AF0 2,911 2,600 PRN   SOLE   2,600 0 0
PRUDENTIAL FINL INC COM 744320102 17,356 222,308 SH   SOLE   222,308 0 0
PRUDENTIAL FINL INC COM 744320102 3 36 SH   OTR 1 0 0 36
PTC INC COM 69370C100 36,607 306,039 SH   SOLE   306,039 0 0
PTC THERAPEUTICS INC COM 69366J200 36,583 599,397 SH   SOLE   599,397 0 0
PUBLIC STORAGE COM 74460D109 2,251 9,749 SH   SOLE   9,749 0 0
PUBLIC SVC ENTERPRISE GRP IN COM 744573106 2,624 45,000 SH   SOLE   45,000 0 0
PULTE GROUP INC COM 745867101 3,316 76,899 SH   SOLE   76,899 0 0
QEP RESOURCES INC COM 74733V100 13,738 5,747,744 SH   SOLE   5,747,744 0 0
QIWI PLC SPON ADR REP B 74735M108 618 60,000 SH   SOLE   60,000 0 0
QORVO INC COM 74736K101 27,120 163,099 SH   SOLE   163,099 0 0
QUALCOMM INC COM 747525103 2 13 SH   OTR 1 0 0 13
QUALCOMM INC COM 747525103 110,380 724,565 SH   SOLE   724,565 0 0
QUEST DIAGNOSTICS INC COM 74834L100 6,668 56,010 SH   SOLE   56,010 0 0
RADIUS HEALTH INC COM NEW 750469207 6,296 352,567 SH   SOLE   352,567 0 0
RAYMOND JAMES FINL INC COM 754730109 255 2,666 SH   SOLE   2,666 0 0
RAYTHEON TECHNOLOGIES CORP COM 75513E101 231 3,250 SH   SOLE   3,250 0 0
REALPAGE INC COM 75606N109 17,973 206,012 SH   SOLE   206,012 0 0
REALTY INCOME CORP COM 756109104 1,242 19,976 SH   SOLE   19,976 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 18,755 151,707 SH   SOLE   151,707 0 0
REDHILL BIOPHARMA LTD SPONSORED ADS 757468103 663 82,523 SH   SOLE   82,523 0 0
REGENERON PHARMACEUTICALS COM 75886F107 6 13 SH   OTR 1 0 0 13
REGENERON PHARMACEUTICALS COM 75886F107 195,003 403,624 SH   SOLE   403,624 0 0
REGIONS FINANCIAL CORP NEW COM 7591EP100 11,822 733,357 SH   SOLE   733,357 0 0
REINSURANCE GRP OF AMERICA I COM NEW 759351604 771 6,648 SH   SOLE   6,648 0 0
RENEWABLE ENERGY GROUP INC COM NEW 75972A301 2,997 42,316 SH   SOLE   42,316 0 0
REPLIMUNE GROUP INC COM 76029N106 6,186 162,142 SH   SOLE   162,142 0 0
REPLIMUNE GROUP INC COM 76029N106 0 12 SH   OTR 1 0 0 12
REPUBLIC SVCS INC COM 760759100 4 43 SH   OTR 1 0 0 43
REPUBLIC SVCS INC COM 760759100 1,701 17,662 SH   SOLE   17,662 0 0
RESMED INC COM 761152107 3,778 17,775 SH   SOLE   17,775 0 0
RESTAURANT BRANDS INTL INC COM 76131D103 9,894 161,949 SH   SOLE   161,949 0 0
RINGCENTRAL INC CL A 76680R206 1,723 4,546 SH   SOLE   4,546 0 0
RIO TINTO PLC SPONSORED ADR 767204100 1 10 SH   OTR 1 0 0 10
RIO TINTO PLC SPONSORED ADR 767204100 802 10,665 SH   SOLE   10,665 0 0
ROBERT HALF INTL INC COM 770323103 294 4,702 SH   SOLE   4,702 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 7,061 128,749 SH   SOLE   128,749 0 0
ROCKWELL AUTOMATION INC COM 773903109 46,434 185,130 SH   SOLE   185,130 0 0
ROCKWELL AUTOMATION INC COM 773903109 3 11 SH   OTR 1 0 0 11
ROGERS COMMUNICATIONS INC CL B 775109200 616 13,245 SH   SOLE   13,245 0 0
ROGERS CORP COM 775133101 218 1,406 SH   SOLE   1,406 0 0
ROGERS CORP COM 775133101 1,268 1,000 PRN   SOLE   1,000 0 0
ROKU INC COM CL A 77543R102 1,812 5,458 SH   SOLE   5,458 0 0
ROPER TECHNOLOGIES INC COM 776696106 7,354 17,058 SH   SOLE   17,058 0 0
ROSS STORES INC COM 778296103 2,587 21,065 SH   SOLE   21,065 0 0
ROYAL BK CDA COM 780087102 7,237 88,150 SH   SOLE   88,150 0 0
ROYAL DUTCH SHELL PLC SPON ADR B 780259107 267 8,000 SH   SOLE   8,000 0 0
S&P GLOBAL INC COM 78409V104 2 7 SH   OTR 1 0 0 7
S&P GLOBAL INC COM 78409V104 42,952 130,659 SH   SOLE   130,659 0 0
SAGE THERAPEUTICS INC COM 78667J108 12,514 144,647 SH   SOLE   144,647 0 0
SALESFORCE COM INC COM 79466L302 59,870 269,070 SH   SOLE   269,070 0 0
SANOFI SPONSORED ADR 80105N105 3 66 SH   OTR 1 0 0 66
SANOFI SPONSORED ADR 80105N105 3,404 70,048 SH   SOLE   70,048 0 0
SAREPTA THERAPEUTICS INC COM 803607100 27,963 164,008 SH   SOLE   164,008 0 0
SBA COMMUNICATIONS CORP NEW CL A 78410G104 7,172 25,421 SH   SOLE   25,421 0 0
SCHLUMBERGER LTD COM 806857108 11,631 532,942 SH   SOLE   532,942 0 0
SCHWAB CHARLES CORP COM 808513105 5,123 96,577 SH   SOLE   96,577 0 0
SEA LTD SPONSORD ADS 81141R100 248 1,250 SH   SOLE   1,250 0 0
SEAGEN INC COM 81181C104 89,785 512,627 SH   SOLE   512,627 0 0
SEAGEN INC COM 81181C104 3 16 SH   OTR 1 0 0 16
SEMPRA ENERGY COM 816851109 4,759 37,347 SH   SOLE   37,347 0 0
SERVICENOW INC COM 81762P102 17,732 32,219 SH   SOLE   32,219 0 0
SHERWIN WILLIAMS CO COM 824348106 13,219 17,987 SH   SOLE   17,987 0 0
SHINHAN FINANCIAL GROUP CO L SPN ADR RESTRD 824596100 541 18,184 SH   SOLE   18,184 0 0
SHOPIFY INC CL A 82509L107 1,581 1,402 SH   SOLE   1,402 0 0
SHOPIFY INC NOTE 0.125%11/0 82509LAA5 3,005 2,450 PRN   SOLE   2,450 0 0
SILICON LABORATORIES INC COM 826919102 28,357 222,686 SH   SOLE   222,686 0 0
SIMON PPTY GROUP INC NEW COM 828806109 1,813 21,263 SH   SOLE   21,263 0 0
SIRIUS XM HOLDINGS INC COM 82968B103 65 10,254 SH   SOLE   10,254 0 0
SKYWORKS SOLUTIONS INC COM 83088M102 1,709 11,180 SH   SOLE   11,180 0 0
SLACK TECHNOLOGIES INC COM CL A 83088V102 22,661 536,463 SH   SOLE   536,463 0 0
SLEEP NUMBER CORP COM 83125X103 1,269 15,507 SH   SOLE   15,507 0 0
SLEEP NUMBER CORP COM 83125X103 838 750 PRN   SOLE   750 0 0
SMITH A O CORP COM 831865209 402 7,334 SH   SOLE   7,334 0 0
SMUCKER J M CO COM NEW 832696405 1,254 10,845 SH   SOLE   10,845 0 0
SNAP INC CL A 83304A106 2,421 48,350 SH   SOLE   48,350 0 0
SNAP INC NOTE 0.750% 8/0 83304AAB2 3,669 2,600 PRN   SOLE   2,600 0 0
SNAP ON INC COM 833034101 1,219 7,123 SH   SOLE   7,123 0 0
SOCIEDAD QUIMICA Y MINERA DE SPON ADR SER B 833635105 34,698 706,800 SH   SOLE   706,800 0 0
SOLAREDGE TECHNOLOGIES INC COM 83417M104 28,142 88,184 SH   SOLE   88,184 0 0
SOLAREDGE TECHNOLOGIES INC COM 83417M104 4 11 SH   OTR 1 0 0 11
SONY CORP SPONSORED ADR 835699307 2,507 24,820 SH   SOLE   24,820 0 0
SONY CORP SPONSORED ADR 835699307 4 37 SH   OTR 1 0 0 37
SOUTHERN COPPER CORP COM 84265V105 5,731 88,000 SH   SOLE   88,000 0 0
SOUTHWEST AIRLS CO NOTE 1.250% 5/0 844741BG2 4,677 3,200 PRN   SOLE   3,200 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 2,533 590,800 SH Put SOLE   590,800 0 0
SPLUNK INC COM 848637104 40,457 238,200 SH   SOLE   238,200 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 9,854 135,870 SH   SOLE   135,870 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 1 10 SH   OTR 1 0 0 10
SQUARE INC CL A 852234103 5,086 23,368 SH   SOLE   23,368 0 0
STANLEY BLACK & DECKER INC COM 854502101 3,233 18,109 SH   SOLE   18,109 0 0
STARBUCKS CORP COM 855244109 1 14 SH   OTR 1 0 0 14
STARBUCKS CORP COM 855244109 67,744 633,214 SH   SOLE   633,214 0 0
STATE STR CORP COM 857477103 9,450 129,832 SH   SOLE   129,832 0 0
STEEL DYNAMICS INC COM 858119100 2 60 SH   OTR 1 0 0 60
STEEL DYNAMICS INC COM 858119100 1,018 27,611 SH   SOLE   27,611 0 0
STRYKER CORPORATION COM 863667101 7,947 32,432 SH   SOLE   32,432 0 0
SUN CMNTYS INC COM 866674104 883 5,808 SH   SOLE   5,808 0 0
SUN LIFE FINANCIAL INC. COM 866796105 10,850 244,201 SH   SOLE   244,201 0 0
SUNCOR ENERGY INC NEW COM 867224107 852 50,853 SH   SOLE   50,853 0 0
SUTRO BIOPHARMA INC COM 869367102 7,991 368,086 SH   SOLE   368,086 0 0
SUTRO BIOPHARMA INC COM 869367102 1 28 SH   OTR 1 0 0 28
SVB FINANCIAL GROUP COM 78486Q101 6,292 16,224 SH   SOLE   16,224 0 0
SYNCHRONY FINANCIAL COM 87165B103 3,931 113,238 SH   SOLE   113,238 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 571 25,671 SH   SOLE   25,671 0 0
SYNOPSYS INC COM 871607107 24,638 95,035 SH   SOLE   95,035 0 0
SYNOPSYS INC COM 871607107 4 14 SH   OTR 1 0 0 14
SYSCO CORP COM 871829107 2,717 36,583 SH   SOLE   36,583 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 3 27 SH   OTR 1 0 0 27
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 113,149 1,037,755 SH   SOLE   1,037,755 0 0
TAKE-TWO INTERACTIVE SOFTWAR COM 874054109 6,927 33,341 SH   SOLE   33,341 0 0
TAL EDUCATION GROUP SPONSORED ADS 874080104 14,354 200,812 SH   SOLE   200,812 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 5,011 52,370 SH   SOLE   52,370 0 0
TANGER FACTORY OUTLET CTRS I COM 875465106 139 14,000 SH   SOLE   14,000 0 0
TARGET CORP COM 87612E106 5,608 31,765 SH   SOLE   31,765 0 0
TARGET CORP COM 87612E106 2 9 SH   OTR 1 0 0 9
TC ENERGY CORP COM 87807B107 959 23,613 SH   SOLE   23,613 0 0
TCR2 THERAPEUTICS INC COM 87808K106 1 20 SH   OTR 1 0 0 20
TCR2 THERAPEUTICS INC COM 87808K106 12,195 394,262 SH   SOLE   394,262 0 0
TE CONNECTIVITY LTD REG SHS H84989104 3 28 SH   OTR 1 0 0 28
TEAM INC NOTE 5.000% 8/0 878155AE0 186 200,000 PRN   SOLE   200,000 0 0
TECK RESOURCES LTD CL B 878742204 546 30,135 SH   SOLE   30,135 0 0
TELADOC HEALTH INC COM 87918A105 5,406 27,034 SH   SOLE   27,034 0 0
TELEDYNE TECHNOLOGIES INC COM 879360105 1,111 2,834 SH   SOLE   2,834 0 0
TELEFLEX INCORPORATED COM 879369106 943 2,292 SH   SOLE   2,292 0 0
TELEFONICA S A SPONSORED ADR 879382208 2 553 SH   OTR 1 0 0 553
TELUS CORPORATION COM 87971M103 7,319 369,843 SH   SOLE   369,843 0 0
TENABLE HLDGS INC COM 88025T102 32,846 628,489 SH   SOLE   628,489 0 0
TERNIUM SA SPONSORED ADS 880890108 23,213 798,200 SH   SOLE   798,200 0 0
TESLA INC COM 88160R101 2 3 SH   OTR 1 0 0 3
TESLA INC COM 88160R101 1,060 889 PRN   SOLE   889 0 0
TESLA INC COM 88160R101 109,523 154,968 SH   SOLE   154,968 0 0
TETRA TECH INC NEW COM 88162G103 15,901 137,334 SH   SOLE   137,334 0 0
TETRA TECH INC NEW COM 88162G103 2 21 SH   OTR 1 0 0 21
TEXAS INSTRS INC COM 882508104 28,557 174,003 SH   SOLE   174,003 0 0
TEXAS INSTRS INC COM 882508104 2 10 SH   OTR 1 0 0 10
TG THERAPEUTICS INC COM 88322Q108 52,552 1,010,190 SH   SOLE   1,010,190 0 0
TG THERAPEUTICS INC COM 88322Q108 2 37 SH   OTR 1 0 0 37
THERMO FISHER SCIENTIFIC INC COM 883556102 12 25 SH   OTR 1 0 0 25
THERMO FISHER SCIENTIFIC INC COM 883556102 170,373 365,807 SH   SOLE   365,807 0 0
THOMSON REUTERS CORP. COM NEW 884903709 7,725 94,467 SH   SOLE   94,467 0 0
TIFFANY & CO NEW COM 886547108 27,746 211,070 SH   SOLE   211,070 0 0
TILLYS INC CL A 886885102 974 120,000 SH   SOLE   120,000 0 0
TJX COS INC NEW COM 872540109 14,503 212,372 SH   SOLE   212,372 0 0
T-MOBILE US INC COM 872590104 3,732 27,679 SH   SOLE   27,679 0 0
TOPBUILD CORP COM 89055F103 33,743 183,296 SH   SOLE   183,296 0 0
TOPBUILD CORP COM 89055F103 4 24 SH   OTR 1 0 0 24
TORONTO DOMINION BK ONT COM NEW 891160509 8,068 142,913 SH   SOLE   142,913 0 0
TOYOTA MOTOR CORP SP ADR REP2COM 892331307 6 38 SH   OTR 1 0 0 38
TPI COMPOSITES INC COM 87266J104 2,135 40,443 SH   SOLE   40,443 0 0
TRACTOR SUPPLY CO COM 892356106 1 10 SH   OTR 1 0 0 10
TRACTOR SUPPLY CO COM 892356106 5,868 41,742 SH   SOLE   41,742 0 0
TRANE TECHNOLOGIES PLC SHS G8994E103 4 25 SH   OTR 1 0 0 25
TRANSUNION COM 89400J107 1,200 12,089 SH   SOLE   12,089 0 0
TRAVELERS COMPANIES INC COM 89417E109 1 8 SH   OTR 1 0 0 8
TRAVELERS COMPANIES INC COM 89417E109 17,145 122,137 SH   SOLE   122,137 0 0
TREX CO INC COM 89531P105 12,445 148,650 SH   SOLE   148,650 0 0
TREX CO INC COM 89531P105 2 20 SH   OTR 1 0 0 20
TRIMBLE INC COM 896239100 4 57 SH   OTR 1 0 0 57
TRIMBLE INC COM 896239100 57,358 859,007 SH   SOLE   859,007 0 0
TRUIST FINL CORP COM 89832Q109 4,103 85,593 SH   SOLE   85,593 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 2 18 SH   OTR 1 0 0 18
TURNING POINT THERAPEUTICS I COM 90041T108 55,679 456,928 SH   SOLE   456,928 0 0
TWILIO INC CL A 90138F102 3,899 11,538 SH   SOLE   11,538 0 0
TWITTER INC COM 90184L102 11,076 204,005 SH   SOLE   204,005 0 0
TWITTER INC NOTE 0.250% 6/1 90184LAF9 7,769 6,400 PRN   SOLE   6,400 0 0
TWITTER INC NOTE 1.000% 9/1 90184LAD4 8,410 208,000 PRN   SOLE   208,000 0 0
TYLER TECHNOLOGIES INC COM 902252105 1,036 2,374 SH   SOLE   2,374 0 0
UBER TECHNOLOGIES INC COM 90353T100 1,313 25,875 SH   SOLE   25,875 0 0
UDR INC COM 902653104 250 6,499 SH   SOLE   6,499 0 0
UGI CORP NEW COM 902681105 1,538 43,985 SH   SOLE   43,985 0 0
ULTA BEAUTY INC COM 90384S303 4,627 16,114 SH   SOLE   16,114 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 13,626 98,429 SH   SOLE   98,429 0 0
UNILEVER PLC SPON ADR NEW 904767704 2,774 45,955 SH   SOLE   45,955 0 0
UNILEVER PLC SPON ADR NEW 904767704 3 44 SH   OTR 1 0 0 44
UNION PAC CORP COM 907818108 58,327 280,111 SH   SOLE   280,111 0 0
UNION PAC CORP COM 907818108 2 10 SH   OTR 1 0 0 10
UNITED MICROELECTRONICS CORP SPON ADR NEW 910873405 547 64,827 SH   SOLE   64,827 0 0
UNITED PARCEL SERVICE INC CL B 911312106 24,745 146,937 SH   SOLE   146,937 0 0
UNITED RENTALS INC COM 911363109 11,144 48,052 SH   SOLE   48,052 0 0
UNITEDHEALTH GROUP INC COM 91324P102 57,475 163,891 SH   SOLE   163,891 0 0
UNITEDHEALTH GROUP INC COM 91324P102 1,034 1,000 PRN   SOLE   1,000 0 0
UNITEDHEALTH GROUP INC COM 91324P102 3 8 SH   OTR 1 0 0 8
UNIVERSAL DISPLAY CORP COM 91347P105 34,007 147,978 SH   SOLE   147,978 0 0
UNIVERSAL DISPLAY CORP COM 91347P105 2 8 SH   OTR 1 0 0 8
UROVANT SCIENCES LTD SHS G9381B108 2,707 167,787 SH   SOLE   167,787 0 0
US BANCORP DEL COM NEW 902973304 4,465 95,840 SH   SOLE   95,840 0 0
V F CORP COM 918204108 16,832 197,069 SH   SOLE   197,069 0 0
VAIL RESORTS INC COM 91879Q109 208 746 SH   SOLE   746 0 0
VALE S A SPONSORED ADS 91912E105 229 13,710 SH   SOLE   13,710 0 0
VALERO ENERGY CORP COM 91913Y100 1,673 29,573 SH   SOLE   29,573 0 0
VANGUARD INDEX FDS LARGE CAP ETF 922908637 206 1,180 SH   SOLE   1,180 0 0
VARIAN MED SYS INC COM 92220P105 32,662 186,621 SH   SOLE   186,621 0 0
VARONIS SYS INC COM 922280102 24,235 148,122 SH   SOLE   148,122 0 0
VEEVA SYS INC CL A COM 922475108 4,254 15,626 SH   SOLE   15,626 0 0
VENTAS INC COM 92276F100 1,762 35,930 SH   SOLE   35,930 0 0
VEREIT INC COM 92339V308 619 16,378 SH   SOLE   16,378 0 0
VERICEL CORP COM 92346J108 1,110 35,941 SH   SOLE   35,941 0 0
VERISIGN INC COM 92343E102 1,522 7,035 SH   SOLE   7,035 0 0
VERISIGN INC COM 92343E102 2 9 SH   OTR 1 0 0 9
VERISK ANALYTICS INC COM 92345Y106 16,511 79,533 SH   SOLE   79,533 0 0
VERISK ANALYTICS INC COM 92345Y106 2 11 SH   OTR 1 0 0 11
VERIZON COMMUNICATIONS INC COM 92343V104 39,065 664,918 SH   SOLE   664,918 0 0
VERIZON COMMUNICATIONS INC COM 92343V104 5 85 SH   OTR 1 0 0 85
VERTEX PHARMACEUTICALS INC COM 92532F100 184,242 779,532 SH   SOLE   779,532 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 2 7 SH   OTR 1 0 0 7
VIACOMCBS INC CL B 92556H206 1,226 32,908 SH   SOLE   32,908 0 0
VIATRIS INC COM 92556V106 4,807 256,550 SH   SOLE   256,550 0 0
VIEWRAY INC COM 92672L107 0 66 SH   OTR 1 0 0 66
VIEWRAY INC COM 92672L107 3,289 860,887 SH   SOLE   860,887 0 0
VIPSHOP HOLDINGS LIMITED SPONSORED ADS A 92763W103 44,980 1,600,094 SH   SOLE   1,600,094 0 0
VIR BIOTECHNOLOGY INC COM 92764N102 6,059 226,238 SH   SOLE   226,238 0 0
VISA INC COM CL A 92826C839 86,258 394,422 SH   SOLE   394,422 0 0
VISA INC COM CL A 92826C839 5 24 SH   OTR 1 0 0 24
VMWARE INC CL A COM 928563402 2 12 SH   OTR 1 0 0 12
VMWARE INC CL A COM 928563402 30,220 215,449 SH   SOLE   215,449 0 0
VODAFONE GROUP PLC NEW SPONSORED ADR 92857W308 1 49 SH   OTR 1 0 0 49
VONAGE HLDGS CORP COM 92886T201 1,384 79,500 SH   SOLE   79,500 0 0
VORNADO RLTY TR SH BEN INT 929042109 1,249 33,459 SH   SOLE   33,459 0 0
VORNADO RLTY TR SH BEN INT 929042109 1 33 SH   OTR 1 0 0 33
VOYA FINANCIAL INC COM 929089100 486 8,265 SH   SOLE   8,265 0 0
VULCAN MATLS CO COM 929160109 1,305 8,804 SH   SOLE   8,804 0 0
WABTEC COM 929740108 4,519 61,732 SH   SOLE   61,732 0 0
WALGREENS BOOTS ALLIANCE INC COM 931427108 2,920 73,216 SH   SOLE   73,216 0 0
WALGREENS BOOTS ALLIANCE INC COM 931427108 1 26 SH   OTR 1 0 0 26
WALMART INC COM 931142103 2,678 18,579 SH   SOLE   18,579 0 0
WASTE CONNECTIONS INC COM 94106B101 17,294 168,598 SH   SOLE   168,598 0 0
WASTE CONNECTIONS INC COM 94106B101 2 20 SH   OTR 1 0 0 20
WASTE MGMT INC DEL COM 94106L109 81,641 692,452 SH   SOLE   692,452 0 0
WASTE MGMT INC DEL COM 94106L109 10 89 SH   OTR 1 0 0 89
WATERS CORP COM 941848103 1,515 6,124 SH   SOLE   6,124 0 0
WAYFAIR INC CL A 94419L101 790 3,500 SH   SOLE   3,500 0 0
WEIBO CORP NOTE 1.250%11/1 948596AC5 3,902 4,000 PRN   SOLE   4,000 0 0
WELLS FARGO CO NEW COM 949746101 6,868 227,589 SH   SOLE   227,589 0 0
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WEST PHARMACEUTICAL SVSC INC COM 955306105 6,975 24,620 SH   SOLE   24,620 0 0
WESTERN DIGITAL CORP. COM 958102105 1,171 21,134 SH   SOLE   21,134 0 0
WESTERN DIGITAL CORP. NOTE 1.500% 2/0 958102AP0 7,220 7,000 PRN   SOLE   7,000 0 0
WESTERN UN CO COM 959802109 664 30,285 SH   SOLE   30,285 0 0
WESTERN UN CO COM 959802109 950 1,000 PRN   SOLE   1,000 0 0
WESTPAC BANKING CORP SPONSORED ADR 961214301 1 95 SH   OTR 1 0 0 95
WESTROCK CO COM 96145D105 2,403 55,192 SH   SOLE   55,192 0 0
WEYERHAEUSER CO MTN BE COM NEW 962166104 4,047 120,700 SH   SOLE   120,700 0 0
WHEATON PRECIOUS METALS CORP COM 962879102 467 11,191 SH   SOLE   11,191 0 0
WHIRLPOOL CORP COM 963320106 640 3,543 SH   SOLE   3,543 0 0
WILLIAMS COS INC COM 969457100 1,470 1,000 PRN   SOLE   1,000 0 0
WILLIAMS COS INC COM 969457100 8,497 423,768 SH   SOLE   423,768 0 0
WIPRO LTD SPON ADR 1 SH 97651M109 113 19,929 SH   SOLE   19,929 0 0
WORKDAY INC CL A 98138H101 9,458 39,472 SH   SOLE   39,472 0 0
WORKDAY INC NOTE 0.250%10/0 98138HAF8 3,407 2,130 PRN   SOLE   2,130 0 0
WORKIVA INC COM CL A 98139A105 818 8,970 SH   SOLE   8,970 0 0
WP CAREY INC COM 92936U109 904 12,809 SH   SOLE   12,809 0 0
WYNN RESORTS LTD COM 983134107 1,039 9,215 SH   SOLE   9,215 0 0
XENCOR INC COM 98401F105 22,487 515,390 SH   SOLE   515,390 0 0
XENCOR INC COM 98401F105 1 24 SH   OTR 1 0 0 24
XILINX INC COM 983919101 12,816 90,396 SH   SOLE   90,396 0 0
XP INC CL A G98239109 1,984 50,000 SH   SOLE   50,000 0 0
XPO LOGISTICS INC COM 983793100 604 5,068 SH   SOLE   5,068 0 0
XYLEM INC COM 98419M100 35,532 349,081 SH   SOLE   349,081 0 0
XYLEM INC COM 98419M100 3 34 SH   OTR 1 0 0 34
YAMANA GOLD INC COM 98462Y100 104 18,273 SH   SOLE   18,273 0 0
YETI HLDGS INC COM 98585X104 2,091 30,544 SH   SOLE   30,544 0 0
Y-MABS THERAPEUTICS INC COM 984241109 1 13 SH   OTR 1 0 0 13
Y-MABS THERAPEUTICS INC COM 984241109 8,909 179,933 SH   SOLE   179,933 0 0
YUM BRANDS INC COM 988498101 3,492 32,166 SH   SOLE   32,166 0 0
YUM CHINA HLDGS INC COM 98850P109 3,447 60,382 SH   SOLE   60,382 0 0
ZEBRA TECHNOLOGIES CORPORATI CL A 989207105 4,606 11,983 SH   SOLE   11,983 0 0
ZENDESK INC COM 98936J101 466 3,270 SH   SOLE   3,270 0 0
ZILLOW GROUP INC CL C CAP STK 98954M200 1,292 9,957 SH   SOLE   9,957 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 1,823 11,833 SH   SOLE   11,833 0 0
ZIONS BANCORPORATION N A COM 989701107 653 15,042 SH   SOLE   15,042 0 0
ZOETIS INC CL A 98978V103 5,855 35,379 SH   SOLE   35,379 0 0
ZOGENIX INC COM NEW 98978L204 17,283 864,526 SH   SOLE   864,526 0 0
ZOOM VIDEO COMMUNICATIONS IN CL A 98980L101 3,146 9,328 SH   SOLE   9,328 0 0
ZSCALER INC COM 98980G102 1,289 6,469 SH   SOLE   6,469 0 0
ZTO EXPRESS CAYMAN INC SPONSORED ADS A 98980A105 1,960 67,199 SH   SOLE   67,199 0 0
ZYMEWORKS INC COM 98985W102 17,086 361,522 SH   SOLE   361,522 0 0
ZYMEWORKS INC COM 98985W102 1 17 SH   OTR 1 0 0 17
ZYNGA INC NOTE 0.250% 6/0 98986TAB4 2,645 2,300 PRN   SOLE   2,300 0 0