The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
1LIFE HEALTHCARE INC COM 68269G107 27,829 637,553 SH   DFND 2 637,553 0 0
10X GENOMICS INC CL A COM 88025U109 23,381 165,123 SH   DFND 2 165,123 0 0
ABBOTT LABS COM 002824100 152,944 1,396,873 SH   DFND 2 1,396,873 0 0
ABBVIE INC COM 00287Y109 40,235 375,500 SH   DFND 2 375,500 0 0
ABIOMED INC COM 003654100 34,870 107,557 SH   DFND 2 107,557 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 2,400 44,900 SH   DFND 2 44,900 0 0
ACCOLADE INC COM 00437E102 16,761 385,308 SH   DFND 2 385,308 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 2,773 23,400 SH   DFND 2 23,400 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 1,824 42,100 SH   DFND 2 42,100 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 180,205 4,158,902 SH   DFND 1,2 4,158,902 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 15,405 98,600 SH   DFND 2 98,600 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 202,241 1,294,428 SH   DFND 1,2 1,294,428 0 0
ALIGN TECHNOLOGY INC COM 016255101 60,261 112,768 SH   DFND 2 112,768 0 0
ALLAKOS INC COM 01671P100 2,590 18,500 SH   DFND 2 18,500 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 8,188 63,000 SH   DFND 2 63,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 150,115 1,155,000 SH   DFND 1,2 1,155,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 50,103 385,500 SH   DFND 3 385,500 0 0
AMEDISYS INC COM 023436108 20,882 71,190 SH   DFND 2 71,190 0 0
AMERICAN EXPRESS CO COM 025816109 435 3,600 SH   DFND 2 3,600 0 0
AMERICAN WELL CORP CL A 03044L105 23,865 942,154 SH   DFND 2 942,154 0 0
AMGEN INC COM 031162100 11,232 48,850 SH   DFND 2 48,850 0 0
AMGEN INC COM 031162100 38,889 169,140 SH   DFND 3 169,140 0 0
ANALOG DEVICES INC COM 032654105 606 4,100 SH   DFND 2 4,100 0 0
ANSYS INC COM 03662Q105 451 1,240 SH   DFND 2 1,240 0 0
ANTHEM INC COM 036752103 45,716 142,378 SH   DFND 2 142,378 0 0
ANTHEM INC COM 036752103 62,104 193,415 SH   DFND 3 193,415 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 2,746 48,000 SH   DFND 2 48,000 0 0
ARCUS BIOSCIENCES INC COM 03969F109 1,324 51,000 SH   DFND 2 51,000 0 0
ARGENX SE SPONSORED ADR 04016X101 7,063 24,016 SH   DFND 2 24,016 0 0
ARGENX SE SPONSORED ADR 04016X101 270,955 921,332 SH   DFND 1,2 921,332 0 0
ARVINAS INC COM 04335A105 1,240 14,600 SH   DFND 2 14,600 0 0
ARVINAS INC COM 04335A105 184,884 2,176,903 SH   DFND 1,2 2,176,903 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 2,585 15,500 SH   DFND 2 15,500 0 0
ASPEN TECHNOLOGY INC COM 045327103 391 3,000 SH   DFND 2 3,000 0 0
ATRICURE INC COM 04963C209 30,973 556,374 SH   DFND 3 556,374 0 0
AUTOLIV INC COM 052800109 626 6,800 SH   DFND 2 6,800 0 0
AVANTOR INC COM 05352A100 14,419 512,216 SH   DFND 2 512,216 0 0
AVIENT CORPORATION COM 05368V106 548 13,600 SH   DFND 2 13,600 0 0
AXONICS MODULATION TECHNOLOG COM 05465P101 35,261 706,357 SH   DFND 2 706,357 0 0
AXONICS MODULATION TECHNOLOG COM 05465P101 23,094 462,621 SH   DFND 3 462,621 0 0
BAXTER INTL INC COM 071813109 38,084 474,623 SH   DFND 2 474,623 0 0
BEAM THERAPEUTICS INC COM 07373V105 32,396 396,821 SH   DFND 1,2 396,821 0 0
BECTON DICKINSON & CO COM 075887109 82,011 327,756 SH   DFND 2 327,756 0 0
BEIGENE LTD SPONSORED ADR 07725L102 27,674 107,100 SH   DFND 2 107,100 0 0
BERKELEY LTS INC COM 084310101 14,351 160,505 SH   DFND 2 160,505 0 0
BIOGEN INC COM 09062X103 6,611 27,000 SH   DFND 2 27,000 0 0
BIOGEN INC COM 09062X103 131,490 537,000 SH   DFND 1,2 537,000 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 1,071 12,500 SH   DFND 2 12,500 0 0
BIONTECH SE SPONSORED ADS 09075V102 1,467 18,000 SH   DFND 2 18,000 0 0
BIO RAD LABS INC CL A 090572207 37,544 64,405 SH   DFND 3 64,405 0 0
BLACKBAUD INC COM 09227Q100 236 4,107 SH   DFND 2 4,107 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 417 13,000 SH   DFND 2 13,000 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 44,550 1,390,000 SH   DFND 1,2 1,390,000 0 0
BOOKING HOLDINGS INC COM 09857L108 445 200 SH   DFND 2 200 0 0
BOSTON SCIENTIFIC CORP COM 101137107 79,444 2,209,859 SH   DFND 2 2,209,859 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 36,163 583,000 SH   DFND 2 583,000 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 75,768 1,221,472 SH   DFND 3 1,221,472 0 0
BRISTOL-MYERS SQUIBB CO RIGHT 99/99/9999 110122157 552 800,000 SH   DFND 1,2 800,000 0 0
BRISTOL-MYERS SQUIBB CO RIGHT 99/99/9999 110122157 1,944 2,817,446 SH   DFND 3 2,817,446 0 0
BROADRIDGE FINL SOLUTIONS IN COM 11133T103 521 3,400 SH   DFND 2 3,400 0 0
BROWN FORMAN CORP CL B 115637209 445 5,600 SH   DFND 2 5,600 0 0
BURNING ROCK BIOTECH LTD SPONSORED ADR 12233L107 4,280 185,286 SH   DFND 2 185,286 0 0
CAREDX INC COM 14167L103 24,922 343,983 SH   DFND 3 343,983 0 0
CATALENT INC COM 148806102 489 4,700 SH   DFND 2 4,700 0 0
CELLECTIS S A SPON ADS 15117K103 2,260 83,500 SH   DFND 2 83,500 0 0
CENTENE CORP DEL COM 15135B101 71,138 1,185,047 SH   DFND 2 1,185,047 0 0
CHANGE HEALTHCARE INC COM 15912K100 33,308 1,785,974 SH   DFND 2 1,785,974 0 0
CHARLES RIV LABS INTL INC COM 159864107 35,734 143,018 SH   DFND 3 143,018 0 0
CIDARA THERAPEUTICS INC COM 171757107 5,645 2,822,495 SH   DFND 1,2 2,822,495 0 0
CIGNA CORP NEW COM 125523100 86,022 413,208 SH   DFND 2 413,208 0 0
CLOROX CO DEL COM 189054109 404 2,000 SH   DFND 2 2,000 0 0
COHERUS BIOSCIENCES INC COM 19249H103 2,590 149,000 SH   DFND 2 149,000 0 0
CONSTELLATION BRANDS INC CL A 21036P108 451 2,059 SH   DFND 2 2,059 0 0
COOPER COS INC COM NEW 216648402 15,808 43,510 SH   DFND 2 43,510 0 0
COSTAR GROUP INC COM 22160N109 462 500 SH   DFND 2 500 0 0
COVETRUS INC COM 22304C100 44 1,520 SH   DFND 2 1,520 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 1,347 8,800 SH   DFND 2 8,800 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 137,934 900,884 SH   DFND 1,2 900,884 0 0
CUREVAC NV COM N2451R105 1,378 17,000 SH   DFND 2 17,000 0 0
CVS HEALTH CORP COM 126650100 8,237 120,595 SH   DFND 2 120,595 0 0
CYBERARK SOFTWARE LTD SHS M2682V108 695 4,300 SH   DFND 2 4,300 0 0
DANAHER CORPORATION COM 235851102 118,577 533,794 SH   DFND 2 533,794 0 0
DAVITA INC COM 23918K108 41,466 353,200 SH   DFND 2 353,200 0 0
DENTSPLY SIRONA INC COM 24906P109 8,332 159,129 SH   DFND 2 159,129 0 0
DEXCOM INC COM 252131107 78,864 213,307 SH   DFND 2 213,307 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 1,498 68,000 SH   DFND 2 68,000 0 0
DOMINOS PIZZA INC COM 25754A201 383 1,000 SH   DFND 2 1,000 0 0
DR REDDYS LABS LTD ADR 256135203 606 8,500 SH   DFND 2 8,500 0 0
EARGO INC COM 270087109 8,808 196,522 SH   DFND 2 196,522 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 75,440 826,918 SH   DFND 2 826,918 0 0
ELECTRONIC ARTS INC COM 285512109 470 3,270 SH   DFND 2 3,270 0 0
ENTEGRIS INC COM 29362U104 509 5,300 SH   DFND 2 5,300 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 1,071 41,200 SH   DFND 2 41,200 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 102,647 3,947,964 SH   DFND 1,2 3,947,964 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 29,881 1,149,287 SH   DFND 3 1,149,287 0 0
EVOLENT HEALTH INC CL A 30050B101 25,304 1,578,529 SH   DFND 2 1,578,529 0 0
EVOLENT HEALTH INC CL A 30050B101 25,176 1,570,582 SH   DFND 3 1,570,582 0 0
EXACT SCIENCES CORP COM 30063P105 25,836 195,000 SH   DFND 3 195,000 0 0
EXELIXIS INC COM 30161Q104 2,198 109,500 SH   DFND 2 109,500 0 0
EXELIXIS INC COM 30161Q104 56,898 2,835,000 SH   DFND 1,2 2,835,000 0 0
FACTSET RESH SYS INC COM 303075105 432 1,300 SH   DFND 2 1,300 0 0
FASTENAL CO COM 311900104 488 10,000 SH   DFND 2 10,000 0 0
FATE THERAPEUTICS INC COM 31189P102 7,047 77,500 SH   DFND 2 77,500 0 0
FATE THERAPEUTICS INC COM 31189P102 184,588 2,030,000 SH   DFND 1,2 2,030,000 0 0
FIBROGEN INC COM 31572Q808 1,966 53,000 SH   DFND 2 53,000 0 0
FORTINET INC COM 34959E109 431 2,900 SH   DFND 2 2,900 0 0
GALAPAGOS NV SPON ADR 36315X101 940 9,500 SH   DFND 2 9,500 0 0
GARTNER INC COM 366651107 545 3,400 SH   DFND 2 3,400 0 0
GENERATION BIO CO COM 37148K100 66,146 2,333,180 SH   DFND 1,2 2,333,180 0 0
GENETRON HLDGS LTD ADS 37186H100 2,448 174,849 SH   DFND 2 174,849 0 0
GENMARK DIAGNOSTICS INC COM 372309104 38,057 2,606,636 SH   DFND 3 2,606,636 0 0
GILEAD SCIENCES INC COM 375558103 4,929 84,600 SH   DFND 2 84,600 0 0
GLAUKOS CORP COM 377322102 33,817 449,332 SH   DFND 2 449,332 0 0
GLOBUS MED INC CL A 379577208 38,128 584,612 SH   DFND 2 584,612 0 0
GOHEALTH INC COM CL A 38046W105 4,609 337,423 SH   DFND 2 337,423 0 0
GRACO INC COM 384109104 478 6,600 SH   DFND 2 6,600 0 0
GUARDANT HEALTH INC COM 40131M109 23,101 179,241 SH   DFND 2 179,241 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 1,154 10,000 SH   DFND 2 10,000 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 53,364 462,389 SH   DFND 3 462,389 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 3,203 75,000 SH   DFND 2 75,000 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 169,559 3,970,000 SH   DFND 1,2 3,970,000 0 0
HCA HEALTHCARE INC COM 40412C101 60,364 367,044 SH   DFND 2 367,044 0 0
HEALTH CATALYST INC COM 42225T107 26,998 620,210 SH   DFND 2 620,210 0 0
HILL ROM HLDGS INC COM 431475102 63,928 652,525 SH   DFND 3 652,525 0 0
HOLOGIC INC COM 436440101 37,686 517,448 SH   DFND 2 517,448 0 0
HOLOGIC INC COM 436440101 28,487 391,140 SH   DFND 3 391,140 0 0
HOMOLOGY MEDICINES INC COM 438083107 19,612 1,737,122 SH   DFND 1,2 1,737,122 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 27,812 380,200 SH   DFND 2 380,200 0 0
HUMANA INC COM 444859102 54,131 131,941 SH   DFND 2 131,941 0 0
HUMANA INC COM 444859102 43,130 105,126 SH   DFND 3 105,126 0 0
HUTCHISON CHINA MEDITECH LTD SPONSORED ADR 44842L103 30,345 947,674 SH   DFND 3 947,674 0 0
IDEXX LABS INC COM 45168D104 39,032 78,085 SH   DFND 2 78,085 0 0
ILLUMINA INC COM 452327109 19,375 52,366 SH   DFND 2 52,366 0 0
I MAB SPONSORED ADS 44975P103 9,581 203,212 SH   DFND 2 203,212 0 0
INCYTE CORP COM 45337C102 9,455 108,700 SH   DFND 2 108,700 0 0
INCYTE CORP COM 45337C102 252,242 2,900,000 SH   DFND 1,2 2,900,000 0 0
INOGEN INC COM 45780L104 8,004 179,143 SH   DFND 2 179,143 0 0
INSMED INC COM PAR $.01 457669307 53,830 1,617,000 SH   DFND 3 1,617,000 0 0
INSPIRE MED SYS INC COM 457730109 56,280 299,217 SH   DFND 2 299,217 0 0
INSULET CORP COM 45784P101 86,267 337,468 SH   DFND 2 337,468 0 0
INTERACTIVE BROKERS GROUP IN COM CL A 45841N107 573 9,400 SH   DFND 2 9,400 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 198 8,000 SH   DFND 2 8,000 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 553 4,800 SH   DFND 2 4,800 0 0
INTERSECT ENT INC COM 46071F103 14,186 619,481 SH   DFND 2 619,481 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 3,864 121,500 SH   DFND 2 121,500 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 112,522 3,538,419 SH   DFND 1,2 3,538,419 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 160,364 196,020 SH   DFND 2 196,020 0 0
IONIS PHARMACEUTICALS INC COM 462222100 10,576 187,050 SH   DFND 2 187,050 0 0
IONIS PHARMACEUTICALS INC COM 462222100 464,759 8,220,000 SH   DFND 1,2 8,220,000 0 0
IONIS PHARMACEUTICALS INC COM 462222100 36,358 643,042 SH   DFND 3 643,042 0 0
IPG PHOTONICS CORP COM 44980X109 526 2,350 SH   DFND 2 2,350 0 0
IQVIA HLDGS INC COM 46266C105 520 2,900 SH   DFND 2 2,900 0 0
IRHYTHM TECHNOLOGIES INC COM 450056106 23,389 98,602 SH   DFND 2 98,602 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 6,569 39,800 SH   DFND 2 39,800 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 57,613 349,065 SH   DFND 3 349,065 0 0
JD.COM INC SPON ADR CL A 47215P106 466 5,300 SH   DFND 2 5,300 0 0
JOHNSON & JOHNSON COM 478160104 4,407 28,000 SH   DFND 2 28,000 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 23,663 4,533,148 SH   DFND 1,2 4,533,148 0 0
KOSMOS ENERGY LTD COM 500688106 999 425,000 SH   DFND 2 425,000 0 0
KURA ONCOLOGY INC COM 50127T109 1,894 58,000 SH   DFND 2 58,000 0 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409 3,874 19,033 SH   DFND 2 19,033 0 0
LAUDER ESTEE COS INC CL A 518439104 598 2,248 SH   DFND 2 2,248 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102 11,724 416,341 SH   DFND 2 416,341 0 0
LIVE NATION ENTERTAINMENT IN COM 538034109 456 6,200 SH   DFND 2 6,200 0 0
MACROGENICS INC COM 556099109 1,142 49,950 SH   DFND 2 49,950 0 0
MACROGENICS INC COM 556099109 110,084 4,815,564 SH   DFND 1,2 4,815,564 0 0
MACROGENICS INC COM 556099109 23,752 1,039,003 SH   DFND 3 1,039,003 0 0
MARKEL CORP COM 570535104 413 400 SH   DFND 2 400 0 0
MARKETAXESS HLDGS INC COM 57060D108 469 822 SH   DFND 2 822 0 0
MASIMO CORP COM 574795100 28,938 107,824 SH   DFND 2 107,824 0 0
MATCH GROUP INC NEW COM 57667L107 586 3,878 SH   DFND 2 3,878 0 0
MCCORMICK & CO INC COM NON VTG 579780206 421 4,400 SH   DFND 2 4,400 0 0
MCKESSON CORP COM 58155Q103 423 2,430 SH   DFND 2 2,430 0 0
MEDTRONIC PLC SHS G5960L103 54,032 461,258 SH   DFND 2 461,258 0 0
MERCADOLIBRE INC COM 58733R102 570 340 SH   DFND 2 340 0 0
MERSANA THERAPEUTICS INC COM 59045L106 1,091 41,010 SH   DFND 2 41,010 0 0
MERSANA THERAPEUTICS INC COM 59045L106 50,160 1,885,000 SH   DFND 1,2 1,885,000 0 0
METTLER TOLEDO INTERNATIONAL COM 592688105 479 420 SH   DFND 2 420 0 0
MIRATI THERAPEUTICS INC COM 60468T105 2,702 12,300 SH   DFND 2 12,300 0 0
MODERNA INC COM 60770K107 9,606 91,950 SH   DFND 2 91,950 0 0
MODERNA INC COM 60770K107 298,258 2,854,963 SH   DFND 1,2 2,854,963 0 0
MOLECULAR TEMPLATES INC COM 608550109 300 32,000 SH   DFND 2 32,000 0 0
MOLECULAR TEMPLATES INC COM 608550109 59,911 6,380,331 SH   DFND 1,2 6,380,331 0 0
MOLINA HEALTHCARE INC COM 60855R100 42,470 199,688 SH   DFND 2 199,688 0 0
MOODYS CORP COM 615369105 435 1,500 SH   DFND 2 1,500 0 0
MSCI INC COM 55354G100 530 1,186 SH   DFND 2 1,186 0 0
MYOVANT SCIENCES LTD COM G637AM102 1,298 47,000 SH   DFND 2 47,000 0 0
MYOVANT SCIENCES LTD COM G637AM102 131,389 4,757,039 SH   DFND 1,2 4,757,039 0 0
NEKTAR THERAPEUTICS COM 640268108 490 28,800 SH   DFND 2 28,800 0 0
NEKTAR THERAPEUTICS COM 640268108 44,551 2,620,676 SH   DFND 1,2 2,620,676 0 0
NEKTAR THERAPEUTICS COM 640268108 20,685 1,216,782 SH   DFND 3 1,216,782 0 0
NEOGENOMICS INC COM NEW 64049M209 29,528 548,446 SH   DFND 3 548,446 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 34,664 361,651 SH   DFND 2 361,651 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 290,905 3,035,000 SH   DFND 1,2 3,035,000 0 0
NEVRO CORP COM 64157F103 22,573 130,402 SH   DFND 2 130,402 0 0
OMNICELL INC COM 68213N109 35,562 296,303 SH   DFND 2 296,303 0 0
OPTHEA LTD SPONSORED ADS 68386J208 568 50,000 SH   DFND 2 50,000 0 0
OUTSET MED INC COM 690145107 10,783 189,711 SH   DFND 2 189,711 0 0
OXFORD IMMUNOTEC GLOBAL PLC ORD SHS G6855A103 13,975 800,157 SH   DFND 2 800,157 0 0
PACIFIC BIOSIENCES CALIF IN COM 69404D108 44,051 1,698,179 SH   DFND 2 1,698,179 0 0
PAYCHEX INC COM 704326107 503 5,400 SH   DFND 2 5,400 0 0
PENUMBRA INC COM 70975L107 25,812 147,495 SH   DFND 2 147,495 0 0
PERKINELMER INC COM 714046109 502 3,500 SH   DFND 2 3,500 0 0
PFIZER INC COM 717081103 2,720 73,900 SH   DFND 2 73,900 0 0
PHREESIA INC COM 71944F106 25,650 472,720 SH   DFND 2 472,720 0 0
POOL CORP COM 73278L105 447 1,200 SH   DFND 2 1,200 0 0
PULMONX CORP COM 745848101 12,183 176,510 SH   DFND 2 176,510 0 0
QUANTERIX CORP COM 74766Q101 33,154 712,999 SH   DFND 2 712,999 0 0
QUEST DIAGNOSTICS INC COM 74834L100 804 6,749 SH   DFND 2 6,749 0 0
QUOTIENT LTD SHS G73268107 3,425 657,354 SH   DFND 2 657,354 0 0
RADIUS HEALTH INC COM NEW 750469207 1,352 75,700 SH   DFND 2 75,700 0 0
RADIUS HEALTH INC COM NEW 750469207 133,159 7,455,714 SH   DFND 1,2 7,455,714 0 0
REGENERON PHARMACEUTICALS COM 75886F107 13,382 27,700 SH   DFND 2 27,700 0 0
RELAY THERAPEUTICS INC COM 75943R102 58,573 1,409,357 SH   DFND 1,2 1,409,357 0 0
RESMED INC COM 761152107 21,038 98,975 SH   DFND 2 98,975 0 0
REVOLUTION MEDICINES INC COM 76155X100 1,584 40,000 SH   DFND 2 40,000 0 0
S&P GLOBAL INC COM 78409V104 394 1,200 SH   DFND 2 1,200 0 0
SAGE THERAPEUTICS INC COM 78667J108 2,370 27,400 SH   DFND 2 27,400 0 0
SAGE THERAPEUTICS INC COM 78667J108 133,234 1,540,104 SH   DFND 1,2 1,540,104 0 0
SAREPTA THERAPEUTICS INC COM 803607100 3,461 20,300 SH   DFND 2 20,300 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 1,504 31,000 SH   DFND 2 31,000 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 109,467 2,255,651 SH   DFND 1,2 2,255,651 0 0
SEAGEN INC COM 81181C104 8,162 46,600 SH   DFND 2 46,600 0 0
SEER INC COM CL A 81578P106 4,229 75,336 SH   DFND 2 75,336 0 0
SENSATA TECHNOLOGIES HLDNG PL SHS G8060N102 522 9,900 SH   DFND 2 9,900 0 0
SERVICE CORP INTL COM 817565104 417 8,500 SH   DFND 2 8,500 0 0
SHOCKWAVE MED INC COM 82489T104 44,116 425,335 SH   DFND 2 425,335 0 0
SILK RD MED INC COM 82710M100 23,485 372,890 SH   DFND 2 372,890 0 0
SKYWORKS SOLUTIONS INC COM 83088M102 428 2,800 SH   DFND 2 2,800 0 0
SOCIEDAD QUIMICA Y MINERA DE SPON ADR SER B 833635105 893 18,200 SH   DFND 2 18,200 0 0
STARBUCKS CORP COM 855244109 464 4,334 SH   DFND 2 4,334 0 0
STONECO LTD COM CL A G85158106 629 7,500 SH   DFND 2 7,500 0 0
STRYKER CORPORATION COM 863667101 82,827 338,015 SH   DFND 2 338,015 0 0
TABULA RASA HEALTHCARE INC COM 873379101 9,338 217,975 SH   DFND 2 217,975 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 36,854 385,184 SH   DFND 2 385,184 0 0
TELADOC HEALTH INC COM 87918A105 42,062 210,352 SH   DFND 2 210,352 0 0
TELEFLEX INCORPORATED COM 879369106 48,474 117,778 SH   DFND 2 117,778 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 20,706 44,455 SH   DFND 2 44,455 0 0
TRADEWEB MKTS INC CL A 892672106 425 6,800 SH   DFND 2 6,800 0 0
TRANSMEDICS GROUP INC COM 89377M109 12,768 641,612 SH   DFND 2 641,612 0 0
TRANSUNION COM 89400J107 506 5,096 SH   DFND 2 5,096 0 0
TRIMBLE INC COM 896239100 554 8,300 SH   DFND 2 8,300 0 0
TRIP COM GROUP LTD ADS 89677Q107 442 13,100 SH   DFND 2 13,100 0 0
TYLER TECHNOLOGIES INC COM 902252105 480 1,100 SH   DFND 2 1,100 0 0
ULTA BEAUTY INC COM 90384S303 574 2,000 SH   DFND 2 2,000 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 5,676 41,000 SH   DFND 2 41,000 0 0
UNIQURE NV SHS N90064101 1,246 34,500 SH   DFND 2 34,500 0 0
UNITEDHEALTH GROUP INC COM 91324P102 75,122 214,218 SH   DFND 2 214,218 0 0
UNITEDHEALTH GROUP INC COM 91324P102 32,202 91,827 SH   DFND 3 91,827 0 0
VEEVA SYS INC CL A COM 922475108 30,476 111,941 SH   DFND 2 111,941 0 0
VERISIGN INC COM 92343E102 454 2,100 SH   DFND 2 2,100 0 0
VERISK ANALYTICS INC COM 92345Y106 517 2,489 SH   DFND 2 2,489 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 16,213 68,600 SH   DFND 2 68,600 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 63,903 270,385 SH   DFND 3 270,385 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 212,706 900,000 SH   DFND 1,2 900,000 0 0
VIATRIS INC COM 92556V106 172 9,169 SH   DFND 2 9,169 0 0
VOCERA COMMUNICATONS INC COM 92857F107 11,137 268,171 SH   DFND 2 268,171 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 227 31,800 SH   DFND 2 31,800 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 19,164 2,680,283 SH   DFND 1,2 2,680,283 0 0
WABTEC COM 929740108 468 6,400 SH   DFND 2 6,400 0 0
WATSCO INC COM 942622200 408 1,800 SH   DFND 2 1,800 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 20,484 2,602,858 SH   DFND 1,2 2,602,858 0 0
XENCOR INC COM 98401F105 1,531 35,100 SH   DFND 2 35,100 0 0
XILINX INC COM 983919101 595 4,200 SH   DFND 2 4,200 0 0
ZAI LAB LTD ADR 98887Q104 4,426 32,700 SH   DFND 2 32,700 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 37,715 244,761 SH   DFND 2 244,761 0 0