The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10x Genomics Inc CL A COM 88025U109 93,588 660,933 SH   SOLE 1,2,3 660,933 0 0
5 01 Acquisition Corp COM CL A 33836P105 3,987 392,000 SH   SOLE 1,2,3 392,000 0 0
908 Devices Inc COM 65443P102 2,278 40,000 SH   SOLE 1,2,3 40,000 0 0
Acutus Med Inc COM 005111109 13,017 451,834 SH   SOLE 1,2,3 451,834 0 0
Adverum Biotechnologies Inc COM 00773U108 78,345 7,227,364 SH   SOLE 1,2,3 7,227,364 0 0
Agenus Inc COM NEW 00847G705 40,910 12,864,677 SH   SOLE 1,2,3 12,864,677 0 0
Alnylam Pharmaceuticals Inc COM 02043Q107 218,563 1,681,645 SH   SOLE 1,2,3 1,681,645 0 0
Aptevo Therapeutics Inc COM NEW 03835L207 10,564 288,236 SH   SOLE 1,2,3 288,236 0 0
Apyx Medical Corporation COM 03837C106 24,417 3,391,279 SH   SOLE 1,2,3 3,391,279 0 0
Arbutus Biopharma Corp COM 03879J100 21,223 5,978,355 SH   SOLE 1,2,3 5,978,355 0 0
argenx SE SPONSORED ADR 04016X101 9,338 31,752 SH   SOLE 1,2 31,752 0 0
Arvinas Inc COM 04335A105 152,109 1,790,996 SH   SOLE 1,2,3 1,790,996 0 0
Arya Sciences Acquisition Co COM CL A G3166W106 5,425 500,000 SH   SOLE 1,2,3 500,000 0 0
Athira Pharma Inc COM 04746L104 88,899 2,685,779 SH   SOLE 1,2,3 2,685,779 0 0
Avadel Pharmaceuticals plc SPONSORED ADR 05337M104 35,989 5,387,513 SH   SOLE 1,2,3 5,387,513 0 0
Avidity Biosciences Inc COM 05370A108 101,952 3,995,000 SH   SOLE 1,2,3 3,995,000 0 0
Axonics Modulation Technolog COM 05465P101 94,042 1,883,864 SH   SOLE 1,2,3 1,883,864 0 0
Axsome Therapeutics Inc COM 05464T104 136,252 1,672,416 SH   SOLE 1,2,3 1,672,416 0 0
Aziyo Biologics Inc COM CL A 05479K106 1,704 125,000 SH   SOLE 1,2,3 125,000 0 0
Bcls Acquisition Corp COM CL A G0904B105 6,823 612,500 SH   SOLE 1,2,3 612,500 0 0
BCTG Acquisition Corp COM 05492W103 6,864 600,000 SH   SOLE 1,2,3 600,000 0 0
Bellus Health Inc New COM NEW 07987C204 15,778 5,189,862 SH   SOLE 1,2,3 5,189,862 0 0
Berkeley Lts Inc COM 084310101 29,034 324,734 SH   SOLE 1,2,3 324,734 0 0
Bioatla Inc COM 09077B104 340 10,000 SH   SOLE 1,2,3 10,000 0 0
Biodesix Inc COM 09075X108 2,520 125,000 SH   SOLE 1,2,3 125,000 0 0
BiomX Inc *W EXP 10/16/202 09090D111 480 600,000 SH   SOLE 1,2 600,000 0 0
Biomx Inc COM 09090D103 3,828 600,000 SH   SOLE 1,2 600,000 0 0
Brainsway Ltd SPONSORED ADS 10501L106 8,320 1,103,474 SH   SOLE 1,2,3 1,103,474 0 0
Burning Rock Biotech Ltd SPONSORED ADS 12233L107 693 30,000 SH   SOLE 1,2,3 30,000 0 0
C4 Therapeutics Inc COM STK 12529R107 68,679 2,149,228 SH   SOLE 1,2,3 2,149,228 0 0
Castle Biosciences Inc COM 14843C105 53,653 799,009 SH   SOLE 1,2,3 799,009 0 0
Celldex Therapeutics Inc New COM NEW 15117B202 59,968 3,422,855 SH   SOLE 1,2,3 3,422,855 0 0
Cerevel Therapeutics Hldng I COM 15678U128 8,290 500,000 SH   SOLE 1,2,3 500,000 0 0
Cerevel Therapeutics Hldng I *W EXP 06/09/202 15678U102 942 166,666 SH   SOLE 1,2,3 166,666 0 0
Cerner Corp COM 156782104 133,548 1,701,680 SH   SOLE 1,2,3 1,701,680 0 0
Chardan Healthcr Acqstn 2 Co UNIT 99/99/9999 15957T206 3,707 350,000 SH   SOLE 1,2,3 350,000 0 0
Clearside Biomedical Inc COM 185063104 10,845 3,958,130 SH   SOLE 1,2,3 3,958,130 0 0
Curis Inc COM NEW 231269200 30,527 3,727,360 SH   SOLE 1,2,3 3,727,360 0 0
Cytokinetics Inc COM NEW 23282W605 41,311 2,000,000 SH   SOLE 1,2,3 2,000,000 0 0
Cytomx Therapeutics Inc COM 23284F105 10,004 1,527,352 SH   SOLE 1,2,3 1,527,352 0 0
DermTech Inc COM 24984K105 93,661 2,887,215 SH   SOLE 1,2,3 2,887,215 0 0
Dicerna Pharmaceuticals Inc COM 253031108 159,802 7,253,857 SH   SOLE 1,2,3 7,253,857 0 0
Establishment Labs Hldgs Inc COM G31249108 87,292 2,319,138 SH   SOLE 1,2,3 2,319,138 0 0
Exagen Inc COM 30068X103 16,502 1,250,131 SH   SOLE 1,2,3 1,250,131 0 0
Five Prime Therapeutics Inc COM 33830X104 42,794 2,515,788 SH   SOLE 1,2,3 2,515,788 0 0
Frequency Therapeutics Inc COM 35803L108 86,792 2,461,486 SH   SOLE 1,2,3 2,461,486 0 0
Fulcrum Therapeutics Inc COM 359616109 24,256 2,071,409 SH   SOLE 1,2,3 2,071,409 0 0
GenMark Diagnostics Inc COM 372309104 11,140 762,994 SH   SOLE 1,2,3 762,994 0 0
Globus Med Inc CL A 379577208 107,017 1,640,859 SH   SOLE 1,2,3 1,640,859 0 0
Guardant Health Inc COM 40131M109 75,004 581,970 SH   SOLE 1,2,3 581,970 0 0
Helix Acquisition Corp COM CL A G4444C102 8,528 750,000 SH   SOLE 1,2,3 750,000 0 0
Ideaya Biosciences Inc COM 45166A102 25,856 1,846,843 SH   SOLE 1,2,3 1,846,843 0 0
Illumina Inc COM 452327109 133,858 361,778 SH   SOLE 1,2,3 361,778 0 0
Immatics N.V SHS N44445109 3,777 350,000 SH   SOLE 1,2,3 350,000 0 0
Immunic Inc COM 4525EP101 14,079 920,814 SH   SOLE 1,2,3 920,814 0 0
Immunovant Inc COM 45258J102 350,686 7,592,253 SH   SOLE 1,2,3 7,592,253 0 0
Inmode Ltd SHS M5425M103 5,935 124,999 SH   SOLE 1,2 124,999 0 0
Itamar Med Ltd SPONSORED ADS 465437101 4,540 228,609 SH   SOLE 1,2,3 228,609 0 0
Iteos Therapeutics Inc COM 46565G104 35,975 1,074,166 SH   SOLE 1,2,3 1,074,166 0 0
IVERIC bio Inc COM 46583P102 46,453 6,722,624 SH   SOLE 1,2,3 6,722,624 0 0
Johnson & Johnson COM 478160104 23,569 149,761 SH   SOLE 1,2,3 149,761 0 0
Kura Oncology Inc COM 50127T109 55,580 1,701,781 SH   SOLE 1,2,3 1,701,781 0 0
La Jolla Pharmaceutical Co COM PAR $.0001 2 503459604 9,302 2,397,378 SH   SOLE 1,2,3 2,397,378 0 0
Lifesci Acquisition Ii Corp COM 53229E103 6,936 650,000 SH   SOLE 1,2,3 650,000 0 0
MacroGenics Inc COM 556099109 28,722 1,256,409 SH   SOLE 1,2,3 1,256,409 0 0
Maravai Lifesciences Hldgs I COM CL A 56600D107 1,964 70,000 SH   SOLE 1,2,3 70,000 0 0
Masimo Corp COM 574795100 125,982 469,416 SH   SOLE 1,2,3 469,416 0 0
Milestone Pharmaceuticals In COM 59935V107 28,911 4,315,102 SH   SOLE 1,2,3 4,315,102 0 0
MiMedx Group Inc COM 602496101 24,519 2,700,320 SH   SOLE 1,2,3 2,700,320 0 0
Mirati Therapeutics Inc COM 60468T105 231,581 1,054,364 SH   SOLE 1,2,3 1,054,364 0 0
NanoString Technologies Inc COM 63009R109 53,773 804,029 SH   SOLE 1,2,3 804,029 0 0
Natera Inc COM 632307104 170,402 1,712,234 SH   SOLE 1,2,3 1,712,234 0 0
Odonate Therapeutics Inc COM 676079106 19,203 1,000,139 SH   SOLE 1,2,3 1,000,139 0 0
OraSure Technologies Inc COM 68554V108 1,948 184,000 SH   SOLE 1,2,3 184,000 0 0
Outset Med Inc COM 690145107 33,256 585,074 SH   SOLE 1,2,3 585,074 0 0
Oyster Pt Pharma Inc COM 69242L106 36,240 1,925,594 SH   SOLE 1,2,3 1,925,594 0 0
Panacea Acquisition Corp UNIT 99/99/9999 698102209 3,828 300,000 SH   SOLE 1,2,3 300,000 0 0
Penumbra Inc COM 70975L107 20,698 118,273 SH   SOLE 1,2,3 118,273 0 0
Personalis Inc COM 71535D106 4,668 127,501 SH   SOLE 1,2 127,501 0 0
Pmv Pharmaceuticals Inc COM 69353Y103 30,809 500,882 SH   SOLE 1,2,3 500,882 0 0
Profound Med Corp COM NEW 74319B502 2,510 122,098 SH   SOLE 1,2,3 122,098 0 0
Progenity Inc COM 74319F107 531 100,000 SH   SOLE 1,2,3 100,000 0 0
ProQR Thrapeutics N V SHS EURO N71542109 21,041 5,009,768 SH   SOLE 1,2,3 5,009,768 0 0
Protagonist Therapeutics Inc COM 74366E102 73,585 3,650,069 SH   SOLE 1,2,3 3,650,069 0 0
PTC Therapeutics Inc COM 69366J200 257,659 4,221,836 SH   SOLE 1,2,3 4,221,836 0 0
Pulmonx Corp COM 745848101 74,839 1,129,600 SH   SOLE 1,2,3 1,129,600 0 0
Regenxbio Inc COM 75901B107 12,803 282,260 SH   SOLE 1,2,3 282,260 0 0
Relmada Therapeutics Inc COM 75955J402 48,511 1,512,673 SH   SOLE 1,2,3 1,512,673 0 0
Rocket Pharmaceuticals Inc COM 77313F106 935,582 17,060,211 SH   SOLE 1,2,3,4 17,060,211 0 0
Scholar Rock Hldg Corp COM 80706P103 8,065 166,183 SH   SOLE 1,2,3 166,183 0 0
Seer Inc COM CL A 81578P106 225 4,000 SH   SOLE 1,2,3 4,000 0 0
Stoke Therapeutics Inc COM 86150R107 219,495 3,544,248 SH   SOLE 1,2,3 3,544,248 0 0
Tandem Diabetes Care Inc COM NEW 875372203 63,243 660,982 SH   SOLE 1,2,3 660,982 0 0
Tarsus Pharmaceuticals Inc. COM 87650L103 98,987 2,463,601 SH   SOLE 1,2,3 2,463,601 0 0
Tela Bio Inc COM 872381108 20,813 1,383,816 SH   SOLE 1,2,3 1,383,816 0 0
Therapeutics Acquisition Cor COM CL A 88339T103 6,821 490,000 SH   SOLE 1,2,3 490,000 0 0
Translate Bio Inc COM 89374L104 54,892 2,978,427 SH   SOLE 1,2,3 2,978,427 0 0
Trillium Therapeutics Inc COM NEW 89620X506 31,850 2,165,197 SH   SOLE 1,2,3 2,165,197 0 0
Twist Bioscience Corp COM 90184D100 2,610 18,473 SH   SOLE 1,2,3 18,473 0 0
Vericel Corp COM 92346J108 139,503 4,517,570 SH   SOLE 1,2,3 4,517,570 0 0
Vincera Pharma Inc *W EXP 12/24/202 92731L114 1,650 500,000 SH   SOLE 1,2,3 500,000 0 0
Vincera Pharma Inc COM 92731L106 10,455 500,000 SH   SOLE 1,2,3 500,000 0 0