The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AbCellera Biologics Inc. COM 00288U106 420,515 10,450,180 SH   SOLE   10,450,180 0 0
ACADIA Pharmaceuticals Inc. COM 004225108 2,240,219 41,904,586 SH   SOLE   41,904,586 0 0
Acceleron Pharma Inc. COM 00434H108 2,870 22,430 SH   SOLE   22,430 0 0
Adamas Pharmaceuticals, Inc. COM 00548A106 641 147,996 SH   SOLE   147,996 0 0
Adaptive Biotechnologies Corporation COM 00650F109 22,451 379,682 SH   SOLE   379,682 0 0
Adaptimmune Therapeutics plc SPONSORED ADR 00653A107 52,988 9,830,877 SH   SOLE   9,830,877 0 0
ADC Therapeutics SA SHS H0036K147 45,394 1,418,107 SH   SOLE   1,418,107 0 0
Aeglea BioTherapeutics, Inc. COM 00773J103 26,838 3,410,106 SH   SOLE   3,410,106 0 0
Affimed N.V. COM N01045108 958 164,605 SH   SOLE   164,605 0 0
Akero Therapeutics, Inc. COM 00973Y108 3,054 118,378 SH   SOLE   118,378 0 0
Albireo Pharma, Inc. COM 01345P106 15,472 412,466 SH   SOLE   412,466 0 0
Alector, Inc. COM 014442107 3,620 239,228 SH   SOLE   239,228 0 0
Alexion Pharmaceuticals, Inc. COM 015351109 1,368,786 8,760,794 SH   SOLE   8,760,794 0 0
Aligos Therapeutics, Inc. COM 01626L105 44,517 1,610,000 SH   SOLE   1,610,000 0 0
Alkermes plc SHS G01767105 30,626 1,535,149 SH   SOLE   1,535,149 0 0
Allakos Inc. COM 01671P100 99,995 714,250 SH   SOLE   714,250 0 0
Altimmune, Inc. COM 02155H200 21,257 1,884,451 SH   SOLE   1,884,451 0 0
Amarin Corporation plc SPONSORED ADR 023111206 136,880 27,991,761 SH   SOLE   27,991,761 0 0
AnaptysBio, Inc. COM 032724106 9,184 427,179 SH   SOLE   427,179 0 0
Apellis Pharmaceuticals, Inc. COM 03753U106 51,283 896,551 SH   SOLE   896,551 0 0
Arcus Biosciences, Inc. COM 03969F109 1,888 72,709 SH   SOLE   72,709 0 0
argenx SE SPONSORED ADR 04016X101 299,842 1,019,557 SH   SOLE   1,019,557 0 0
Ascendis Pharma A/S SPONSORED ADR 04351P101 590,446 3,540,270 SH   SOLE   3,540,270 0 0
Assembly Biosciences, Inc. COM 045396108 9,326 1,541,418 SH   SOLE   1,541,418 0 0
Atreca, Inc. CL A COM 04965G109 57,054 3,532,760 SH   SOLE   3,532,760 0 0
Athira Pharma, Inc. COM 04746L104 27,618 806,367 SH   SOLE   806,367 0 0
Aurinia Pharmaceuticals Inc. COM 05156V102 19,501 1,410,064 SH   SOLE   1,410,064 0 0
Autolus Therapeutics plc SPONSORED ADS 05280R100 6,993 782,183 SH   SOLE   782,183 0 0
Axsome Therapeutics, Inc. COM 05464T104 63,452 778,834 SH   SOLE   778,834 0 0
BeiGene, Ltd. SPONSORED ADR 07725L102 3,015,126 11,668,897 SH   SOLE   11,668,897 0 0
Bellicum Pharmaceuticals, Inc. COM 079481404 879 249,123 SH   SOLE   249,123 0 0
BioAtla, Inc. COM 09077B104 28,058 825,000 SH   SOLE   825,000 0 0
BioCryst Pharmaceuticals, Inc. COM 09058V103 94,584 12,695,818 SH   SOLE   12,695,818 0 0
BioMarin Pharmaceutical Inc. COM 09061G101 665,505 7,589,294 SH   SOLE   7,589,294 0 0
bluebird bio, Inc. COM 09609G100 9,822 226,988 SH   SOLE   226,988 0 0
Burning Rock Biotech Limited SPONSORED ADS 12233L107 4,831 209,131 SH   SOLE   209,131 0 0
Cabaletta Bio, Inc. COM 12674W109 7,942 636,363 SH   SOLE   636,363 0 0
Cerus Corporation COM 157085101 94,895 13,713,195 SH   SOLE   13,713,195 0 0
ChemoCentryx, Inc. COM 16383L106 40,663 656,710 SH   SOLE   656,710 0 0
Chiasma, Inc. COM 16706W102 3,228 742,133 SH   SOLE   742,133 0 0
Chinook Therapeutics, Inc. COM 16961L106 11,874 748,693 SH   SOLE   748,693 0 0
Constellation Pharmaceuticals, Inc. COM 210373106 3,304 114,735 SH   SOLE   114,735 0 0
Crinetics Pharmaceuticals, Inc. COM 22663K107 8,699 616,520 SH   SOLE   616,520 0 0
Cymabay Therapeutics, Inc. COM 23257D103 16,607 2,893,276 SH   SOLE   2,893,276 0 0
DBV Technologies S.A. SPONSORED ADR 23306J101 38,289 14,614,264 SH   SOLE   14,614,264 0 0
Denali Therapeutics Inc. COM 24823R105 7,433 88,738 SH   SOLE   88,738 0 0
Dicerna Pharmaceuticals, Inc. COM 253031108 2,250 102,121 SH   SOLE   102,121 0 0
Evofem Biosciences, Inc. COM 30048L104 991 411,396 SH   SOLE   411,396 0 0
Five Prime Therapeutics, Inc. COM 33830X104 11,363 668,000 SH   SOLE   668,000 0 0
Frequency Therapeutics, Inc. COM 35803L108 30,200 856,507 SH   SOLE   856,507 0 0
Forma Therapeutics Holdings, Inc. SHS 34633R104 70,668 2,024,876 SH   SOLE   2,024,876 0 0
Fulgent Genetics, Inc. COM 359664109 25,819 495,573 SH   SOLE   495,573 0 0
Galapagos NV SPONSORED ADR 36315X101 1,107 11,180 SH   SOLE   11,180 0 0
Galmed Pharmaceuticals Ltd. SHS M47238106 575 184,927 SH   SOLE   184,927 0 0
Gamida Cell Ltd. SHS M47364100 12,990 1,548,314 SH   SOLE   1,548,314 0 0
Genetron Holdings Limited ADS 37186H100 6,374 455,306 SH   SOLE   455,306 0 0
Genfit SA ADS 372279109 71 14,720 SH   SOLE   14,720 0 0
Global Blood Therapeutics, Inc. COM 37890U108 39,861 920,375 SH   SOLE   920,375 0 0
Gossamer Bio, Inc. COM 38341P102 4,649 480,729 SH   SOLE   480,729 0 0
GW Pharmaceuticals plc ADS 36197T103 13,029 112,897 SH   SOLE   112,897 0 0
Harmony Biosciences Holdings, Inc. COM 413197104 6,507 180,000 SH   SOLE   180,000 0 0
Heron Therapeutics, Inc. COM 427746102 126,878 5,994,704 SH   SOLE   5,994,704 0 0
HOOKIPA Pharma Inc. COM 43906K100 7,768 700,481 SH   SOLE   700,481 0 0
Horizon Therapeutics Public Ltd Co SHS G46188101 43,825 599,110 SH   SOLE   599,110 0 0
Idera Pharmaceuticals, Inc. COM PAR 45168K405 16,914 4,608,786 SH   SOLE   4,608,786 0 0
IGM Biosciences, Inc. COM 449585108 277,663 3,144,892 SH   SOLE   3,144,892 0 0
Immatics N.V. SHS N44445109 19,476 1,805,025 SH   SOLE   1,805,025 0 0
Incyte Corporation COM 45337C102 2,783,337 31,999,741 SH   SOLE   31,999,741 0 0
Infinity Pharmaceuticals, Inc. COM 45665G303 1,107 522,360 SH   SOLE   522,360 0 0
Inflarx N.V. COM N44821101 4,307 856,228 SH   SOLE   856,228 0 0
Inozyme Pharma, Inc. COM 45790W108 2,208 106,999 SH   SOLE   106,999 0 0
Insmed Incorporated COM PAR $.01 457669307 71,773 2,156,001 SH   SOLE   2,156,001 0 0
Intellia Therapeutics, Inc. COM 45826J105 6,055 111,296 SH   SOLE   111,296 0 0
Invitae Corporation COM 46185L103 654,292 15,649,182 SH   SOLE   15,649,182 0 0
Iteos Therapeutics, Inc. COM 46565G104 5,085 150,346 SH   SOLE   150,346 0 0
IVERIC bio, Inc. COM 46583P102 9,716 1,406,037 SH   SOLE   1,406,037 0 0
Karuna Therapeutics, Inc. COM 48576A100 7,108 69,966 SH   SOLE   69,966 0 0
Kezar Life Sciences, Inc. COM 49372L100 729 139,676 SH   SOLE   139,676 0 0
Kiniksa Pharmaceuticals, Ltd. COM CL A G5269C101 49,469 2,799,577 SH   SOLE   2,799,577 0 0
Kymera Therapeutics, Inc. COM 501575104 121,471 1,959,211 SH   SOLE   1,959,211 0 0
Kodiak Sciences Inc. COM 50015M109 2,039,104 13,879,952 SH   SOLE   13,879,952 0 0
Krystal Biotech, Inc. COM 501147102 41,932 698,874 SH   SOLE   698,874 0 0
Leap Therapeutics, Inc. COM 52187K101 1,259 559,705 SH   SOLE   559,705 0 0
Legend Biotech Corporation SPONSORED ADS 52490G102 3,256 115,626 SH   SOLE   115,626 0 0
LogicBio Therapeutics, Inc. COM 54142F102 3,445 451,478 SH   SOLE   451,478 0 0
MacroGenics, Inc. COM 556099109 4,588 200,679 SH   SOLE   200,679 0 0
Madrigal Pharmaceuticals, Inc. COM 558868105 166,668 1,499,213 SH   SOLE   1,499,213 0 0
Mereo BioPharma Group plc ADS 589492107 21,588 6,030,293 SH   SOLE   6,030,293 0 0
Merus N.V. COM N5749R100 35,717 2,037,469 SH   SOLE   2,037,469 0 0
Mirati Therapeutics, Inc. COM 60468T105 309,645 1,409,784 SH   SOLE   1,409,784 0 0
Mirum Pharmaceuticals, Inc. COM 604749101 11,302 647,313 SH   SOLE   647,313 0 0
Molecular Templates, Inc. COM 608550109 1,257 133,833 SH   SOLE   133,833 0 0
Neoleukin Therapeutics, Inc. COM 64049K104 53,887 3,821,740 SH   SOLE   3,821,740 0 0
Neurocrine Biosciences, Inc. COM 64125C109 64,888 676,975 SH   SOLE   676,975 0 0
NGM Biopharmaceuticals, Inc. COM 62921N105 3,230 106,616 SH   SOLE   106,616 0 0
Novavax, Inc. COM 670002401 18,924 169,706 SH   SOLE   169,706 0 0
Nurix Therapeutics, Inc. COM 67080M103 58,820 1,788,921 SH   SOLE   1,788,921 0 0
Opthea Limited SPONSORED ADS 68386J208 37,107 3,308,705 SH   SOLE   3,308,705 0 0
Orchard Therapeutics plc ADS 68570P101 1,436 332,502 SH   SOLE   332,502 0 0
Ovid Therapeutics Inc. COM 690469101 2,208 955,690 SH   SOLE   955,690 0 0
Oyster Point Pharma, Inc. COM 69242L106 1,156 61,424 SH   SOLE   61,424 0 0
Pacific Biosciences of California, Inc. COM 69404D108 83,059 3,201,972 SH   SOLE   3,201,972 0 0
Passage Bio, Inc. COM 702712100 6,018 235,362 SH   SOLE   235,362 0 0
Prelude Therapeutics Incorporated COM 74065P101 723,988 10,118,636 SH   SOLE   10,118,636 0 0
Protagonist Therapeutics, Inc. COM 74366E102 28,954 1,436,192 SH   SOLE   1,436,192 0 0
Protara Therapeutics, Inc. COM STK 74365U107 4,834 199,671 SH   SOLE   199,671 0 0
Reata Pharmaceuticals, Inc. CL A 75615P103 27,688 223,976 SH   SOLE   223,976 0 0
Replimune Group, Inc. COM 76029N106 5,856 153,512 SH   SOLE   153,512 0 0
Rhythm Pharmaceuticals, Inc. COM 76243J105 68,821 2,314,873 SH   SOLE   2,314,873 0 0
Sangamo Therapeutics, Inc. COM 800677106 13,379 857,339 SH   SOLE   857,339 0 0
Seagen Inc. COM 81181C104 8,278,767 47,269,424 SH   SOLE   47,269,424 0 0
Silverback Therapeutics, Inc. COM 82835W108 11,033 238,095 SH   SOLE   238,095 0 0
Sunesis Pharmaceuticals, Inc. COM 867328874 106 53,066 SH   SOLE   53,066 0 0
Syros Pharmaceuticals, Inc. COM 87184Q107 7,488 690,167 SH   SOLE   690,167 0 0
TCR2 Therapeutics Inc. COM 87808K106 3,430 110,888 SH   SOLE   110,888 0 0
Tricida, Inc. COM 89610F101 4,437 629,300 SH   SOLE   629,300 0 0
Ultragenyx Pharmaceutical Inc. COM 90400D108 61,524 444,444 SH   SOLE   444,444 0 0
uniQure N.V. SHS N90064101 244 6,740 SH   SOLE   6,740 0 0
Vaxart, Inc. COM 92243A200 7,987 1,398,795 SH   SOLE   1,398,795 0 0
Verastem, Inc. COM 92337C104 21,607 10,144,039 SH   SOLE   10,144,039 0 0
Viking Therapeutics, Inc. COM 92686J106 2,049 363,980 SH   SOLE   363,980 0 0
Xencor, Inc. COM 98401F105 16,116 369,370 SH   SOLE   369,370 0 0
Xenon Pharmaceuticals Inc. COM 98420N105 10,572 687,386 SH   SOLE   687,386 0 0
Zymeworks Inc. COM 98985W102 80,742 1,708,472 SH   SOLE   1,708,472 0 0
BioMarin Pharmaceutical Inc. NOTE 0.599% 8/1/2024 09061GAH4 16,033 15,000,000 PRN   SOLE   15,000,000 0 0
Invitae Corporation NOTE 2.0% 9/1/2024 46185LAB9 16,446 10,300,000 PRN   SOLE   10,300,000 0 0