The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 4,329 550,000 SH   OTR   550,000 0 0
AKERO THERAPEUTICS INC COM 00973Y108 21,453 831,495 SH   OTR   831,495 0 0
AGENUS INC COM NEW 00847G705 12,720 4,000,000 SH   OTR   4,000,000 0 0
ALIGOS THERAPEUTICS INC COM 01626L105 42,195 1,526,048 SH   OTR   1,526,048 0 0
AMARIN CORP PLC SPONS ADR NEW 023111206 29,340 6,000,000 SH   OTR   6,000,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 53,684 2,325,000 SH   OTR   2,325,000 0 0
ANAPTYSBIO INC COM 032724106 27,950 1,300,000 SH   OTR   1,300,000 0 0
ARCUS BIOSCIENCES INC COM 03969F109 54,124 2,084,883 SH   OTR   2,084,883 0 0
ARGENX SE SPONSORED ADR 04016X101 50,268 170,926 SH   OTR   170,926 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 9,075 1,500,000 SH   OTR   1,500,000 0 0
ARYA SCIENCES ACQUISTION CO COM CL A G31655122 6,510 600,000 SH   OTR   600,000 0 0
ATRECA INC CL A COM 04965G109 35,568 2,202,333 SH   OTR   2,202,333 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 28,616 1,121,327 SH   OTR   1,121,327 0 0
BCLS ACQUISITION CORP COM CL A G0904B105 6,005 500,000 SH   OTR   500,000 0 0
BEIGENE LTD SPONSORED ADR 07725L102 287,895 1,114,188 SH   OTR   1,114,188 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 9,104 2,975,000 SH   OTR   2,975,000 0 0
BIOATLA INC COM 09077B104 23,343 686,347 SH   OTR   686,347 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 21,923 250,000 SH   OTR   250,000 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 64,576 2,014,858 SH   OTR   2,014,858 0 0
CABALETTA BIO INC COM 12674W109 20,010 1,603,361 SH   OTR   1,603,361 0 0
CELLECTAR BIOSCIENCES INC COM PAR 15117F500 1,914 920,000 SH   OTR   920,000 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 17,520 1,000,000 SH   OTR   1,000,000 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128 11,846 714,500 SH   OTR   714,500 0 0
CODIAK BIOSCIENCES INC COM 192010106 19,466 602,650 SH   OTR   602,650 0 0
CONSONANCE HFW ACQUISITION C UNIT 99/99/9999 G2445M129 2,094 200,000 SH   OTR   200,000 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 22,960 4,000,000 SH   OTR   4,000,000 0 0
CYTOKINETICS INC COM NEW 23282W605 43,638 2,100,000 SH   OTR   2,100,000 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 13,035 7,534,598 SH   OTR   7,534,598 0 0
DIREXION SHS ETF TR DAILY S&P BIOTEC 25460G716 56,858 2,250,000 SH   OTR   2,250,000 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 13,000 500,000 SH   OTR   500,000 0 0
FS DEV CORP COM CL A 303020101 7,700 700,000 SH   OTR   700,000 0 0
GENOCEA BIOSCIENCES INC COM NEW 372427401 2,745 1,134,453 SH   OTR   1,134,453 0 0
GOSSAMER BIO INC COM 38341P102 24,778 2,562,358 SH   OTR   2,562,358 0 0
HEALTH SCIENCES ACQ CORP 2 ORD SHS G4411D109 5,124 400,000 SH   OTR   400,000 0 0
HELIX ACQUISITION CORP COM CL A G4444C102 4,548 400,000 SH   OTR   400,000 0 0
IDEAYA BIOSCIENCES INC COM 45166A102 30,839 2,202,812 SH   OTR   2,202,812 0 0
ITEOS THERAPEUTICS INC COM 46565G104 146,948 4,345,016 SH   OTR   4,345,016 0 0
JIYA ACQUISITION CORP COM CL A 47760M102 5,150 500,000 SH   OTR   500,000 0 0
KADMON HLDGS INC COM 48283N106 25,754 6,205,882 SH   OTR   6,205,882 0 0
KINIKSA PHARMACEUTICALS LTD COM CL A G5269C101 5,134 290,577 SH   OTR   290,577 0 0
KINNATE BIOPHARMA INC COM 49705R105 42,352 1,064,665 SH   OTR   1,064,665 0 0
KURA ONCOLOGY INC COM 50127T109 34,302 1,050,289 SH   OTR   1,050,289 0 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 3,456 890,700 SH   OTR   890,700 0 0
LIFESCI ACQUISITION II CORP COM 53229E103 2,134 200,000 SH   OTR   200,000 0 0
MARINUS PHARMACEUTICALS INC COM NEW 56854Q200 29,280 2,400,000 SH   OTR   2,400,000 0 0
MATINAS BIOPHARMA HLDGS INC COM 576810105 15,611 11,478,634 SH   OTR   11,478,634 0 0
MEI PHARMA INC COM NEW 55279B202 7,691 2,913,091 SH   OTR   2,913,091 0 0
MEREO BIOPHARMA GROUP PLC ADS 589492107 22,291 6,226,673 SH   OTR   6,226,673 0 0
MERUS N V COM N5749R100 25,030 1,427,849 SH   OTR   1,427,849 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 16,597 2,477,194 SH   OTR   2,477,194 0 0
MIRATI THERAPEUTICS INC COM 60468T105 387,788 1,765,560 SH   OTR   1,765,560 0 0
MIRUM PHARMACEUTICALS INC COM 604749101 5,535 317,000 SH   OTR   317,000 0 0
NEOLEUKIN THERAPEUTICS INC COM 64049K104 21,165 1,501,058 SH   OTR   1,501,058 0 0
NURIX THERAPEUTICS INC COM 67080M103 40,274 1,224,892 SH   OTR   1,224,892 0 0
ODONATE THERAPEUTICS INC COM 676079106 107,656 5,607,086 SH   OTR   5,607,086 0 0
ORIC PHARMACEUTICALS INC COM 68622P109 6,770 200,000 SH   OTR   200,000 0 0
PANACEA ACQUISITION CORP CL A 698102100 9,360 800,000 SH   OTR   800,000 0 0
PANDION THERAPEUTICS INC COM 698340106 31,297 2,107,513 SH   OTR   2,107,513 0 0
PASSAGE BIO INC COM 702712100 49,307 1,928,315 SH   OTR   1,928,315 0 0
PMV PHARMACEUTICALS INC COM 69353Y103 139,519 2,268,236 SH   OTR   2,268,236 0 0
POSEIDA THERAPEUTICS INC COM 73730P108 13,724 1,251,055 SH   OTR   1,251,055 0 0
PREVAIL THERAPEUTICS INC COM 74140Y101 25,910 1,123,105 SH   OTR   1,123,105 0 0
PROTARA THERAPEUTICS INC COM STK 74365U107 5,065 209,227 SH   OTR   209,227 0 0
RELAY THERAPEUTICS INC COM 75943R102 53,784 1,294,132 SH   OTR   1,294,132 0 0
REVOLUTION MEDICINES INC COM 76155X100 131,014 3,309,264 SH   OTR   3,309,264 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 80,398 1,466,051 SH   OTR   1,466,051 0 0
SAGE THERAPEUTICS INC COM 78667J108 94,642 1,094,000 SH   OTR   1,094,000 0 0
SEATTLE GENETICS INC COM 812578102 70,056 400,000 SH   OTR   400,000 0 0
SELECTA BIOSCIENCES INC COM 816212104 9,951 3,284,072 SH   OTR   3,284,072 0 0
SILVERBACK THERAPEUTICS INC COM 82835W108 77,637 1,675,377 SH   OTR   1,675,377 0 0
SOLID BIOSCIENCES INC COM 83422E105 32,098 4,234,574 SH   OTR   4,234,574 0 0
SPECTRUM PHARMACEUTICALS INC COM 84763A108 11,367 3,333,333 SH   OTR   3,333,333 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 150,545 2,075,905 SH   OTR   2,075,905 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 50,880 2,287,782 SH   OTR   2,287,782 0 0
THERAPEUTICS ACQUISITION COR COM CL A 88339T103 20,880 1,500,000 SH   OTR   1,500,000 0 0
UNIQURE NV SHS N90064101 9,033 250,000 SH   OTR   250,000 0 0
VINCERA PHARMA INC COM 92731L106 6,273 300,000 SH   OTR   300,000 0 0
ZOGENIX INC COM NEW 98978L204 546 27,300 SH   OTR   27,300 0 0