The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABIOMED INC COM 003654100 180,460 556,633 SH   SOLE 0 556,633 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 123,037 2,301,477 SH   SOLE 0 2,301,477 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 1,103 160,800 SH   SOLE 0 160,800 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 78,656 503,429 SH   SOLE 0 503,429 0 0
ALIGN TECHNOLOGY INC COM 016255101 36,073 67,505 SH   SOLE 0 67,505 0 0
ALIMERA SCIENCES INC COM NEW 016259202 848 200,919 SH   SOLE 0 200,919 0 0
ALKERMES PLC SHS G01767105 3,004 150,598 SH   SOLE 0 150,598 0 0
AMICUS THERAPEUTICS INC COM 03152W109 181,652 7,867,114 SH   SOLE 0 7,867,114 0 0
ANAPTYSBIO INC COM 032724106 8,950 416,292 SH   SOLE 0 416,292 0 0
APREA THERAPEUTICS INC COM 03836J102 634 128,770 SH   SOLE 0 128,770 0 0
ATHENEX INC COM 04685N103 3,519 318,200 SH   SOLE 0 318,200 0 0
BIOGEN INC COM 09062X103 57,371 234,300 SH   SOLE 0 234,300 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 188,976 2,155,050 SH   SOLE 0 2,155,050 0 0
CLOVIS ONCOLOGY INC COM 189464100 21,453 4,469,411 SH   SOLE 0 4,469,411 0 0
CYTOKINETICS INC COM NEW 23282W605 2,570 123,686 SH   SOLE 0 123,686 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 7,310 331,813 SH   SOLE 0 331,813 0 0
EHEALTH INC COM 28238P109 41,448 586,999 SH   SOLE 0 586,999 0 0
EPIZYME INC COM 29428V104 73,185 6,738,913 SH   SOLE 0 6,738,913 0 0
GOSSAMER BIO INC COM 38341P102 16,817 1,739,050 SH   SOLE 0 1,739,050 0 0
IDERA PHARMACEUTICALS INC COM PAR 45168K405 283 77,044 SH   SOLE 0 77,044 0 0
INSMED INC COM PAR $.01 457669307 203,268 6,105,980 SH   SOLE 0 6,105,980 0 0
KALEIDO BIOSCIENCES INC COM 483347100 7,156 786,400 SH   SOLE 0 786,400 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 81,543 5,267,652 SH   SOLE 0 5,267,652 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 2,862 548,206 SH   SOLE 0 548,206 0 0
MAGENTA THERAPEUTICS INC COM 55910K108 3,349 427,108 SH   SOLE 0 427,108 0 0
MARINUS PHARMACEUTICALS INC COM 56854Q101 382 31,330 SH   SOLE 0 31,330 0 0
MINERVA NEUROSCIENCES INC COM 603380106 85 36,319 SH   SOLE 0 36,319 0 0
PROTHENA CORP PLC SHS G72800108 20,319 1,691,805 SH   SOLE 0 1,691,805 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 14,096 1,373,897 SH   SOLE 0 1,373,897 0 0
REVANCE THERAPEUTICS INC COM 761330109 75,762 2,673,313 SH   SOLE 0 2,673,313 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 3,494 998,156 SH   SOLE 0 998,156 0 0
SAGE THERAPEUTICS INC COM 78667J108 51,058 590,200 SH   SOLE 0 590,200 0 0
STAAR SURGICAL CO COM PAR $0.01 852312305 225,725 2,849,348 SH   SOLE 0 2,849,348 0 0
SUNESIS PHARMACEUTICALS INC COM 867328700 231 116,246 SH   SOLE 0 116,246 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 5,876 264,200 SH   SOLE 0 264,200 0 0
TACTILE SYSTEMS TECHNOLOGY I COM 87357P100 1,218 27,100 SH   SOLE 0 27,100 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 4,304 157,900 SH   SOLE 0 157,900 0 0
UNITED THERAPEUTICS CORP COM 91307C102 119,217 785,406 SH   SOLE 0 785,406 0 0
UROGEN PHARMA LTD COM M96088105 441 24,500 SH   SOLE 0 24,500 0 0
VANDA PHARMACEUTICALS INC COM 921659108 55,589 4,230,548 SH   SOLE 0 4,230,548 0 0
ZOGENIX INC COM NEW 98978L204 4,292 214,700 SH   SOLE 0 214,700 0 0