The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10x Genomics Inc CL A COM 88025U109 128,784 711,515 SH   SOLE 1,2,3 711,515 0 0
5 01 Acquisition Corp COM CL A 33836P105 3,900 392,000 SH   SOLE 1,2,3 392,000 0 0
908 Devices Inc COM 65443P102 1,940 40,000 SH   SOLE 1,2,3 40,000 0 0
Acutus Med Inc COM 005111109 6,041 451,834 SH   SOLE 1,2,3 451,834 0 0
Adverum Biotechnologies Inc COM 00773U108 72,461 7,348,976 SH   SOLE 1,2,3 7,348,976 0 0
Agenus Inc COM NEW 00847G705 37,474 13,777,244 SH   SOLE 1,2,3 13,777,244 0 0
Alnylam Pharmaceuticals Inc COM 02043Q107 237,674 1,683,362 SH   SOLE 1,2,3 1,683,362 0 0
Aptevo Therapeutics Inc COM NEW 03835L207 8,588 281,402 SH   SOLE 1,2,3 281,402 0 0
Apyx Medical Corporation COM 03837C106 32,760 3,391,279 SH   SOLE 1,2,3 3,391,279 0 0
Arbutus Biopharma Corp COM 03879J100 19,908 5,978,355 SH   SOLE 1,2,3 5,978,355 0 0
argenx SE SPONSORED ADR 04016X101 8,744 31,752 SH   SOLE 1,2 31,752 0 0
Arvinas Inc COM 04335A105 107,267 1,622,799 SH   SOLE 1,2,3 1,622,799 0 0
Arya Sciences Acquisition Co COM CL A G3166W106 6,890 500,000 SH   SOLE 1,2,3 500,000 0 0
Arya Sciences Acqu Corp IV CL A G31659108 5,236 500,000 SH   SOLE 1,2,3 500,000 0 0
Aslan Pharmaceuticals Ltd ADS 04522R101 10,888 3,250,000 SH   SOLE 1,2,3 3,250,000 0 0
Athira Pharma Inc COM 04746L104 48,807 2,652,553 SH   SOLE 1,2,3 2,652,553 0 0
Avadel Pharmaceuticals plc SPONSORED ADR 05337M104 51,907 5,741,939 SH   SOLE 1,2,3 5,741,939 0 0
Avidity Biosciences Inc COM 05370A108 87,131 3,995,000 SH   SOLE 1,2,3 3,995,000 0 0
Avita Medical Inc COM 05380C102 5,550 280,000 SH   SOLE 1,2,3 280,000 0 0
Axonics Modulation Technolog COM 05465P101 112,825 1,883,864 SH   SOLE 1,2,3 1,883,864 0 0
Axsome Therapeutics Inc COM 05464T104 91,526 1,616,497 SH   SOLE 1,2,3 1,616,497 0 0
Aziyo Biologics Inc COM CL A 05479K106 1,728 125,000 SH   SOLE 1,2,3 125,000 0 0
Bcls Acquisition Corp COM CL A G0904B105 6,474 612,500 SH   SOLE 1,2,3 612,500 0 0
BCTG Acquisition Corp COM 05492W103 6,672 600,000 SH   SOLE 1,2,3 600,000 0 0
Bellus Health Inc New COM NEW 07987C204 19,040 4,968,017 SH   SOLE 1,2,3 4,968,017 0 0
Berkeley Lts Inc COM 084310101 12,937 257,546 SH   SOLE 1,2,3 257,546 0 0
Bioatla Inc COM 09077B104 508 10,000 SH   SOLE 1,2,3 10,000 0 0
Biodesix Inc COM 09075X108 2,539 125,000 SH   SOLE 1,2,3 125,000 0 0
Bolt Biotherapeutics Inc COM 097702104 4,937 150,000 SH   SOLE 1,2,3 150,000 0 0
Brainsway Ltd SPONSORED ADS 10501L106 14,468 1,602,181 SH   SOLE 1,2,3 1,602,181 0 0
Burning Rock Biotech Ltd SPONSORED ADS 12233L107 808 30,000 SH   SOLE 1,2,3 30,000 0 0
C4 Therapeutics Inc COM STK 12529R107 79,437 2,149,228 SH   SOLE 1,2,3 2,149,228 0 0
Castle Biosciences Inc COM 14843C105 54,700 799,009 SH   SOLE 1,2,3 799,009 0 0
Celldex Therapeutics Inc New COM NEW 15117B202 80,524 3,908,947 SH   SOLE 1,2,3 3,908,947 0 0
Cerevel Therapeutics Hldng I COM 15678U128 6,865 500,000 SH   SOLE 1,2,3 500,000 0 0
Cerevel Therapeutics Hldng I *W EXP 06/09/202 15678U102 718 166,666 SH   SOLE 1,2,3 166,666 0 0
Cerner Corp COM 156782104 127,550 1,774,485 SH   SOLE 1,2,3 1,774,485 0 0
Chardan Healthcr Acqstn 2 Co UNIT 99/99/9999 15957T206 3,682 350,000 SH   SOLE 1,2,3 350,000 0 0
Chardan Healthcr Acqstn 2 Co COM 15957T107 8,417 837,540 SH   SOLE 1,2,3 837,540 0 0
Clearside Biomedical Inc COM 185063104 10,391 4,206,765 SH   SOLE 1,2,3 4,206,765 0 0
Connect Biopharma Holdings Ltd ADS 207523101 8,325 450,000 SH   SOLE 1,2,3 450,000 0 0
Curis Inc COM NEW 231269200 40,973 3,619,544 SH   SOLE 1,2,3 3,619,544 0 0
Cytokinetics Inc COM NEW 23282W605 46,520 2,000,000 SH   SOLE 1,2,3 2,000,000 0 0
Cytomx Therapeutics Inc COM 23284F105 11,856 1,533,758 SH   SOLE 1,2,3 1,533,758 0 0
DermTech Inc COM 24984K105 158,397 3,118,665 SH   SOLE 1,2,3 3,118,665 0 0
Dicerna Pharmaceuticals Inc COM 253031108 190,836 7,463,291 SH   SOLE 1,2,3 7,463,291 0 0
Essa Pharma Inc COM NEW 29668H708 8,241 283,692 SH   SOLE 1,2,3 283,692 0 0
Establishment Labs Hldgs Inc COM G31249108 145,016 2,319,138 SH   SOLE 1,2,3 2,319,138 0 0
Exagen Inc COM 30068X103 28,461 1,626,365 SH   SOLE 1,2,3 1,626,365 0 0
Fulcrum Therapeutics Inc COM 359616109 37,758 3,205,291 SH   SOLE 1,2,3 3,205,291 0 0
Genetron Hldgs Ltd ADS 37186H100 39,018 1,818,162 SH   SOLE 1,2,3 1,818,162 0 0
Globus Med Inc CL A 379577208 103,039 1,670,811 SH   SOLE 1,2,3 1,670,811 0 0
Guardant Health Inc COM 40131M109 93,082 609,774 SH   SOLE 1,2,3 609,774 0 0
Helix Acquisition Corp COM CL A G4444C102 7,658 750,000 SH   SOLE 1,2,3 750,000 0 0
Ideaya Biosciences Inc COM 45166A102 57,957 2,466,255 SH   SOLE 1,2,3 2,466,255 0 0
Illumina Inc COM 452327109 185,100 481,956 SH   SOLE 1,2,3 481,956 0 0
Immatics N.V SHS N44445109 3,924 350,000 SH   SOLE 1,2,3 350,000 0 0
Immunic Inc COM 4525EP101 14,678 920,814 SH   SOLE 1,2,3 920,814 0 0
Immunocore Hldgs PLC ADS 45258D105 50,142 1,245,532 SH   SOLE 1,2,3 1,245,532 0 0
Immunovant Inc COM 45258J102 101,962 6,356,743 SH   SOLE 1,2,3 6,356,743 0 0
Inmode Ltd SHS M5425M103 9,046 124,999 SH   SOLE 1,2 124,999 0 0
Itamar Med Ltd SPONSORED ADS 465437101 6,433 268,609 SH   SOLE 1,2,3 268,609 0 0
Iteos Therapeutics Inc COM 46565G104 94,432 2,762,791 SH   SOLE 1,2,3 2,762,791 0 0
IVERIC bio Inc COM 46583P102 41,546 6,722,624 SH   SOLE 1,2,3 6,722,624 0 0
Johnson & Johnson COM 478160104 28,029 170,542 SH   SOLE 1,2,3 170,542 0 0
Kura Oncology Inc COM 50127T109 30,586 1,081,912 SH   SOLE 1,2,3 1,081,912 0 0
La Jolla Pharmaceutical Co COM PAR $.0001 2 503459604 9,870 2,327,903 SH   SOLE 1,2,3 2,327,903 0 0
Landos Biopharma Inc COM 515069102 38,328 4,275,722 SH   SOLE 1,2,3 4,275,722 0 0
Lifesci Acquisition Ii Corp COM 53229E103 6,591 650,000 SH   SOLE 1,2,3 650,000 0 0
MacroGenics Inc COM 556099109 64,159 2,014,400 SH   SOLE 1,2,3 2,014,400 0 0
Maravai Lifesciences Hldgs I COM CL A 56600D107 2,495 70,000 SH   SOLE 1,2,3 70,000 0 0
Masimo Corp COM 574795100 136,638 594,956 SH   SOLE 1,2,3 594,956 0 0
Medicus Sciences Acquisition UNIT 99/99/9999 G5960S116 2,955 300,000 SH   SOLE 1,2,3 300,000 0 0
Milestone Pharmaceuticals In COM 59935V107 24,984 4,315,102 SH   SOLE 1,2,3 4,315,102 0 0
MiMedx Group Inc COM 602496101 27,813 2,700,320 SH   SOLE 1,2,3 2,700,320 0 0
Mirati Therapeutics Inc COM 60468T105 228,383 1,333,232 SH   SOLE 1,2,3 1,333,232 0 0
NanoString Technologies Inc COM 63009R109 52,833 804,029 SH   SOLE 1,2,3 804,029 0 0
Natera Inc COM 632307104 173,860 1,712,234 SH   SOLE 1,2,3 1,712,234 0 0
Nuvation Bio Inc COM CL A 67080N101 3,135 300,000 SH   SOLE 1,2,3 300,000 0 0
Nuvation Bio Inc *W EXP 07/07/202 67080N119 267 100,000 SH   SOLE 1,2,3 100,000 0 0
Olink Hldg AB SPONSORED ADS 680710100 6,690 185,838 SH   SOLE 1,2,3 185,838 0 0
Outset Med Inc COM 690145107 37,374 687,152 SH   SOLE 1,2,3 687,152 0 0
Oyster Pt Pharma Inc COM 69242L106 34,023 1,861,209 SH   SOLE 1,2,3 1,861,209 0 0
Personalis Inc COM 71535D106 3,138 127,501 SH   SOLE 1,2 127,501 0 0
Pmv Pharmaceuticals Inc COM 69353Y103 15,923 484,133 SH   SOLE 1,2,3 484,133 0 0
Profound Med Corp COM NEW 74319B502 2,459 122,098 SH   SOLE 1,2,3 122,098 0 0
Progenity Inc COM 74319F107 476 100,000 SH   SOLE 1,2,3 100,000 0 0
Prometheus Biosciences Inc COM 74349U108 51,727 3,264,031 SH   SOLE 1,2,3 3,264,031 0 0
ProQR Thrapeutics N V SHS EURO N71542109 42,463 6,424,078 SH   SOLE 1,2,3 6,424,078 0 0
Protagonist Therapeutics Inc COM 74366E102 90,841 3,507,390 SH   SOLE 1,2,3 3,507,390 0 0
PTC Therapeutics Inc COM 69366J200 250,669 5,293,966 SH   SOLE 1,2,3 5,293,966 0 0
Pulmonx Corp COM 745848101 51,668 1,129,600 SH   SOLE 1,2,3 1,129,600 0 0
Quidel Corp COM 74838J101 112,391 878,533 SH   SOLE 1,2,3 878,533 0 0
Regenxbio Inc COM 75901B107 14,209 416,577 SH   SOLE 1,2,3 416,577 0 0
Relmada Therapeutics Inc COM 75955J402 53,897 1,530,717 SH   SOLE 1,2,3 1,530,717 0 0
Research Alliance Corp II COM CL A 760873109 6,529 637,000 SH   SOLE 1,2,3 637,000 0 0
Rocket Pharmaceuticals Inc COM 77313F106 697,287 15,715,286 SH   SOLE 1,2,3 15,715,286 0 0
Scholar Rock Holding Corp COM 80706P103 8,187 161,612 SH   SOLE 1,2,3 161,612 0 0
Seer Inc COM CL A 81578P106 200 4,000 SH   SOLE 1,2,3 4,000 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 375,029 946,255 SH   SOLE 1,2,3 946,255 0 0
Stoke Therapeutics Inc COM 86150R107 141,543 3,644,248 SH   SOLE 1,2,3 3,644,248 0 0
Tandem Diabetes Care Inc COM NEW 875372203 100,537 1,139,230 SH   SOLE 1,2,3 1,139,230 0 0
Tarsus Pharmaceuticals Inc. COM 87650L103 79,091 2,463,601 SH   SOLE 1,2,3 2,463,601 0 0
Tela Bio Inc COM 872381108 20,597 1,382,343 SH   SOLE 1,2,3 1,382,343 0 0
Therapeutics Acquisition Corp COM CL A 88339T103 5,150 490,000 SH   SOLE 1,2,3 490,000 0 0
Translate Bio Inc COM 89374L104 72,262 4,382,199 SH   SOLE 1,2,3 4,382,199 0 0
Trillium Therapeutics Inc COM NEW 89620X506 22,462 2,091,389 SH   SOLE 1,2,3 2,091,389 0 0
Twist Bioscience Corp COM 90184D100 2,288 18,473 SH   SOLE 1,2,3 18,473 0 0
Vericel Corp COM 92346J108 250,951 4,517,570 SH   SOLE 1,2,3 4,517,570 0 0
Vincerx Pharma Inc COM NEW 92731L106 9,650 500,000 SH   SOLE 1,2,3 500,000 0 0
Vincerx Pharma Inc wts $11.5 Exp. 12/24/2025 *W EXP 12/24/202 92731L114 2,020 500,000 SH   SOLE 1,2,3 500,000 0 0