The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABCAM PLC ADS 000380204 20,551 1,069,236 SH   SOLE   1,069,236 0 0
ACADIA HEALTHCARE COMPANY IN COM 00404A109 39,998 700,000 SH   SOLE   700,000 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 27,766 1,076,200 SH   SOLE   1,076,200 0 0
ACCOLADE INC COM 00437E102 28,356 625,000 SH   SOLE   625,000 0 0
ACELRX PHARMACEUTICALS INC COM 00444T100 6,435 3,785,457 SH   SOLE   3,785,457 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 89,944 3,569,192 SH   SOLE   3,569,192 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 8,204 1,545,000 SH   SOLE   1,545,000 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 26,169 650,000 SH   SOLE   650,000 0 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 12,492 1,577,296 SH   SOLE   1,577,296 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 131,352 2,543,600 SH   SOLE   2,543,600 0 0
AKERO THERAPEUTICS INC COM 00973Y108 15,119 521,171 SH   SOLE   521,171 0 0
ALIGN TECHNOLOGY INC COM 016255101 96,122 177,500 SH   SOLE   177,500 0 0
ALLAKOS INC COM 01671P100 35,089 305,706 SH   SOLE   305,706 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 42,357 300,000 SH   SOLE   300,000 0 0
AMARIN CORP PLC SPONS ADR NEW 023111206 26,051 4,195,000 SH   SOLE   4,195,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 10,004 1,012,506 SH   SOLE   1,012,506 0 0
ANAPTYSBIO INC COM 032724106 11,534 535,232 SH   SOLE   535,232 0 0
APPLIED THERAPEUTICS INC COM 03828A101 13,160 701,680 SH   SOLE   701,680 0 0
ARDELYX INC COM 039697107 34,269 5,176,561 SH   SOLE   5,176,561 0 0
ARGENX SE SPONSORED ADR 04016X101 82,617 300,000 SH   SOLE   300,000 0 0
ARVINAS INC COM 04335A105 41,101 621,800 SH   SOLE   621,800 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 30,093 233,500 SH   SOLE   233,500 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 32,318 650,000 SH   SOLE   650,000 0 0
ATEA PHARMACEUTICALS INC COM 04683R106 104,660 1,694,903 SH   SOLE   1,694,903 0 0
ATHIRA PHARMA INC COM 04746L104 14,503 788,202 SH   SOLE   788,202 0 0
ATRECA INC CL A COM 04965G109 6,959 453,930 SH   SOLE   453,930 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 10,149 781,569 SH   SOLE   781,569 0 0
BAXTER INTL INC COM 071813109 11,808 140,000 SH   SOLE   140,000 0 0
BCLS ACQUISITION CORP COM CL A G0904B105 3,266 309,000 SH   SOLE   309,000 0 0
BEIGENE LTD SPONSORED ADR 07725L102 69,616 200,000 SH   SOLE   200,000 0 0
BIOGEN INC COM 09062X103 31,752 113,500 SH   SOLE   113,500 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 19,142 253,500 SH   SOLE   253,500 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 72,605 746,732 SH   SOLE   746,732 0 0
BOLT BIOTHERAPEUTICS INC COM 097702104 51,315 1,559,248 SH   SOLE   1,559,248 0 0
BOSTON SCIENTIFIC CORP COM 101137107 30,920 800,000 SH   SOLE   800,000 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128 13,800 1,005,100 SH   SOLE   1,005,100 0 0
CHIASMA INC COM 16706W102 6,806 2,174,583 SH   SOLE   2,174,583 0 0
CHINOOK THERAPEUTICS INC COM 16961L106 10,459 673,049 SH   SOLE   673,049 0 0
COLLEGIUM PHARMACEUTICAL INC COM 19459J104 21,804 920,000 SH   SOLE   920,000 0 0
COMPUGEN LTD ORD M25722105 10,475 1,219,488 SH   SOLE   1,219,488 0 0
CONMED CORP COM 207410101 11,111 85,085 SH   SOLE   85,085 0 0
CONNECT BIOPHARMA HLDGS LTD ADS 207523101 2,204 119,114 SH   SOLE   119,114 0 0
CONSTELLATION PHARMCETICLS I COM 210373106 5,426 232,000 SH   SOLE   232,000 0 0
COVETRUS INC COM 22304C100 41,958 1,400,000 SH   SOLE   1,400,000 0 0
CULLINAN ONCOLOGY INC COM 230031106 44,833 1,075,912 SH   SOLE   1,075,912 0 0
CYTOKINETICS INC NOTE 4.000%11/1 23282WAA8 19,094 8,000,000 PRN   SOLE   8,000,000 0 0
DESIGN THERAPEUTICS INC COM 25056L103 9,785 327,250 SH   SOLE   327,250 0 0
DEXCOM INC COM 252131107 5,391 15,000 SH   SOLE   15,000 0 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 16,303 1,658,520 SH   SOLE   1,658,520 0 0
EARGO INC COM 270087109 42,541 851,671 SH   SOLE   851,671 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 48,678 582,000 SH   SOLE   582,000 0 0
ENCOMPASS HEALTH CORP COM 29261A100 40,950 500,000 SH   SOLE   500,000 0 0
EPIZYME INC COM 29428V104 24,414 2,802,954 SH   SOLE   2,802,954 0 0
ESSA PHARMA INC COM NEW 29668H708 14,613 503,035 SH   SOLE   503,035 0 0
EUCRATES BIOMEDICAL ACQU COR UNIT 10/23/2027 G3141W114 2,063 206,000 SH   SOLE   206,000 0 0
EVOLENT HEALTH INC CL A 30050B101 29,189 1,445,000 SH   SOLE   1,445,000 0 0
EXACT SCIENCES CORP COM 30063P105 75,115 570,000 SH   SOLE   570,000 0 0
FATE THERAPEUTICS INC COM 31189P102 5,772 70,000 SH   SOLE   70,000 0 0
FIBROGEN INC COM 31572Q808 10,853 312,687 SH   SOLE   312,687 0 0
FIVE PRIME THERAPEUTICS INC COM 33830X104 100,233 2,660,822 SH   SOLE   2,660,822 0 0
FRESHPET INC COM 358039105 80,437 506,500 SH   SOLE   506,500 0 0
FS DEVELOPMENT CORP II COM CL A 30318F100 2,085 209,332 SH   SOLE   209,332 0 0
FUSION PHARMACEUTICALS INC COM 36118A100 10,166 948,327 SH   SOLE   948,327 0 0
GALAPAGOS NV SPON ADR 36315X101 12,720 165,000 SH   SOLE   165,000 0 0
GALERA THERAPEUTICS INC COM 36338D108 5,012 568,252 SH   SOLE   568,252 0 0
GAMIDA CELL LTD SHS M47364100 16,991 2,100,300 SH   SOLE   2,100,300 0 0
GOSSAMER BIO INC NOTE 5.000% 6/0 38341PAA0 13,977 15,573,000 PRN   SOLE   15,573,000 0 0
GUARDANT HEALTH INC COM 40131M109 30,530 200,000 SH   SOLE   200,000 0 0
HCA HEALTHCARE INC COM 40412C101 84,753 450,000 SH   SOLE   450,000 0 0
HEALTH CATALYST INC COM 42225T107 36,714 785,000 SH   SOLE   785,000 0 0
HELIX ACQUISITION CORP COM CL A G4444C102 1,576 154,500 SH   SOLE   154,500 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 57,525 625,000 SH   SOLE   625,000 0 0
HUMANA INC COM 444859102 126,194 301,000 SH   SOLE   301,000 0 0
IDEXX LABS INC COM 45168D104 88,076 180,000 SH   SOLE   180,000 0 0
IMMUNOCORE HLDGS PLC ADS 45258D105 97,583 2,292,285 SH   SOLE   2,292,285 0 0
INNOVAGE HLDG CORP COM 45784A104 12,250 475,000 SH   SOLE   475,000 0 0
INOZYME PHARMA INC COM 45790W108 16,392 827,900 SH   SOLE   827,900 0 0
INSPIRE MED SYS INC COM 457730109 20,699 100,000 SH   SOLE   100,000 0 0
INSULET CORP COM 45784P101 96,801 371,000 SH   SOLE   371,000 0 0
INTERSECT ENT INC COM 46071F103 22,555 1,080,200 SH   SOLE   1,080,200 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 88,673 120,000 SH   SOLE   120,000 0 0
INVITAE CORP COM 46185L103 84,596 2,213,977 SH   SOLE   2,213,977 0 0
IRHYTHM TECHNOLOGIES INC COM 450056106 60,056 432,496 SH   SOLE   432,496 0 0
JIYA ACQUISITION CORP COM CL A 47760M102 2,029 206,200 SH   SOLE   206,200 0 0
KARUNA THERAPEUTICS INC COM 48576A100 44,336 368,764 SH   SOLE   368,764 0 0
KINNATE BIOPHARMA INC COM 49705R105 10,170 326,386 SH   SOLE   326,386 0 0
KURA ONCOLOGY INC COM 50127T109 20,073 710,035 SH   SOLE   710,035 0 0
KYMERA THERAPEUTICS INC COM 501575104 24,162 621,777 SH   SOLE   621,777 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102 9,072 312,618 SH   SOLE   312,618 0 0
LIFESCI ACQUISITION II CORP COM 53229E103 2,091 206,200 SH   SOLE   206,200 0 0
MACROGENICS INC COM 556099109 12,532 393,479 SH   SOLE   393,479 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 30,237 258,500 SH   SOLE   258,500 0 0
MEREO BIOPHARMA GROUP PLC ADS 589492107 15,148 4,494,869 SH   SOLE   4,494,869 0 0
MERSANA THERAPEUTICS INC COM 59045L106 44,902 2,775,127 SH   SOLE   2,775,127 0 0
MIRATI THERAPEUTICS INC COM 60468T105 55,441 323,647 SH   SOLE   323,647 0 0
MIRUM PHARMACEUTICALS INC COM 604749101 29,785 1,502,800 SH   SOLE   1,502,800 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 98,709 1,015,000 SH   SOLE   1,015,000 0 0
NEUROCRINE BIOSCIENCES INC NOTE 2.250% 5/1 64125CAD1 1,354 1,000,000 PRN   SOLE   1,000,000 0 0
NEVRO CORP COM 64157F103 67,658 485,000 SH   SOLE   485,000 0 0
NEVRO CORP NOTE 2.750% 4/0 64157FAC7 771 500,000 PRN   SOLE   500,000 0 0
NGM BIOPHARMACEUTICALS INC COM 62921N105 10,605 364,800 SH   SOLE   364,800 0 0
NKARTA INC COM 65487U108 16,182 491,848 SH   SOLE   491,848 0 0
NOVAVAX INC COM NEW 670002401 83,584 461,000 SH   SOLE   461,000 0 0
NOVOCURE LTD ORD SHS G6674U108 23,132 175,000 SH   SOLE   175,000 0 0
NURIX THERAPEUTICS INC COM 67080M103 9,667 310,950 SH   SOLE   310,950 0 0
NUVATION BIO INC *W EXP 07/07/202 67080N119 358 134,028 SH   SOLE   134,028 0 0
NUVATION BIO INC COM CL A 67080N101 4,202 402,088 SH   SOLE   402,088 0 0
OAK STR HEALTH INC COM 67181A107 20,351 375,000 SH   SOLE   375,000 0 0
OLINK HLDG AB SPONSORED ADS 680710100 14,400 400,000 SH   SOLE   400,000 0 0
ORION ACQUISITION CORP UNIT 02/19/2026 68626A207 10,000 1,000,000 SH   SOLE   1,000,000 0 0
PACIRA BIOSCIENCES INC COM 695127100 71,842 1,025,000 SH   SOLE   1,025,000 0 0
PACIRA BIOSCIENCES INC NOTE 2.375% 4/0 695127AD2 1,211 1,000,000 PRN   SOLE   1,000,000 0 0
PARATEK PHARMACEUTICALS INC COM 699374302 11,894 1,684,714 SH   SOLE   1,684,714 0 0
PENUMBRA INC COM 70975L107 39,911 147,500 SH   SOLE   147,500 0 0
PHASEBIO PHARMACEUTICALS INC COM 717224109 5,377 1,553,974 SH   SOLE   1,553,974 0 0
PHREESIA INC COM 71944F106 44,285 850,000 SH   SOLE   850,000 0 0
POPULATION HEALTH INVS CO IN UNIT 99/99/9999 G71716123 2,020 201,044 SH   SOLE   201,044 0 0
POSEIDA THERAPEUTICS INC COM 73730P108 2,767 289,754 SH   SOLE   289,754 0 0
PPD INC COM 69355F102 25,542 675,000 SH   SOLE   675,000 0 0
PRELUDE THERAPEUTICS INC COM 74065P101 16,387 378,195 SH   SOLE   378,195 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108 10,497 574,858 SH   SOLE   574,858 0 0
PROTARA THERAPEUTICS INC COM STK 74365U107 10,860 689,942 SH   SOLE   689,942 0 0
PROTHENA CORP PLC SHS G72800108 29,061 1,156,900 SH   SOLE   1,156,900 0 0
PULMONX CORP COM 745848101 27,101 592,500 SH   SOLE   592,500 0 0
RADIUS HEALTH INC NOTE 3.000% 9/0 750469AA6 1,401 1,500,000 PRN   SOLE   1,500,000 0 0
RELAY THERAPEUTICS INC COM 75943R102 8,716 252,127 SH   SOLE   252,127 0 0
RETROPHIN INC NOTE 2.500% 9/1 761299AB2 3,360 3,250,000 PRN   SOLE   3,250,000 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 12,747 599,280 SH   SOLE   599,280 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 16,218 4,742,000 SH   SOLE   4,742,000 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 17,884 403,070 SH   SOLE   403,070 0 0
ROYALTY PHARMA PLC SHS CLASS A G7709Q104 3,490 80,000 SH   SOLE   80,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 24,502 328,750 SH   SOLE   328,750 0 0
SEAGEN INC COM 81181C104 34,715 250,000 SH   SOLE   250,000 0 0
SHATTUCK LABS INC COM 82024L103 11,360 388,499 SH   SOLE   388,499 0 0
SHOCKWAVE MED INC COM 82489T104 28,657 220,000 SH   SOLE   220,000 0 0
SIERRA ONCOLOGY INC COM NEW 82640U404 17,529 1,017,358 SH   SOLE   1,017,358 0 0
SPERO THERAPEUTICS INC COM 84833T103 14,218 965,928 SH   SOLE   965,928 0 0
SPRUCE BIOSCIENCES INC COM 85209E109 26,216 1,579,301 SH   SOLE   1,579,301 0 0
TELEFLEX INCORPORATED COM 879369106 54,010 130,000 SH   SOLE   130,000 0 0
TG THERAPEUTICS INC COM 88322Q108 12,846 266,520 SH   SOLE   266,520 0 0
THERAVANCE BIOPHARMA INC COM G8807B106 13,932 682,600 SH   SOLE   682,600 0 0
THERAVANCE BIOPHARMA INC NOTE 3.250%11/0 88339KAA0 1,526 1,500,000 PRN   SOLE   1,500,000 0 0
TRANSLATE BIO INC COM 89374L104 10,717 649,900 SH   SOLE   649,900 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 36,845 1,475,564 SH   SOLE   1,475,564 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 6,667 620,800 SH   SOLE   620,800 0 0
TURMERIC ACQUISITION CORP UNIT 10/08/2025 G9127T116 2,060 206,000 SH   SOLE   206,000 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 51,237 450,000 SH   SOLE   450,000 0 0
UNITEDHEALTH GROUP INC COM 91324P102 102,319 275,000 SH   SOLE   275,000 0 0
WEST PHARMACEUTICAL SVSC INC COM 955306105 8,031 28,500 SH   SOLE   28,500 0 0
XENON PHARMACEUTICALS INC COM 98420N105 10,248 572,500 SH   SOLE   572,500 0 0
ZAI LAB LTD ADR 98887Q104 124,557 933,500 SH   SOLE   933,500 0 0