The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
|
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
|
||||||||||||||||
| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ADAMAS PHARMACEUTICALS INC | COM | 00548A106 | 18,509 | 3,856,000 | SH | DFND | 1 | 3,856,000 | 0 | 0 | |
| ADOBE SYSTEMS INCORPORATED | COM | 00724F101 | 25,670 | 54,000 | SH | DFND | 1 | 54,000 | 0 | 0 | |
| ADVANCE AUTO PARTS INC | COM | 00751Y106 | 50,179 | 273,469 | SH | DFND | 1 | 273,469 | 0 | 0 | |
| ADVANTAGE SOLUTIONS INC | COM CL A | 00791N102 | 10,629 | 900,000 | SH | DFND | 1 | 900,000 | 0 | 0 | |
| ALIBABA GROUP HLDG LTD | SPONSORED ADS | 01609W102 | 34,916 | 154,000 | SH | DFND | 1 | 154,000 | 0 | 0 | |
| ALKERMES PLC | SHS | G01767105 | 65,828 | 3,524,000 | SH | DFND | 1 | 3,524,000 | 0 | 0 | |
| ALPHATEC HLDGS INC | COM NEW | 02081G201 | 10,042 | 636,000 | SH | DFND | 1 | 636,000 | 0 | 0 | |
| ALTIMMUNE INC | COM NEW | 02155H200 | 7,574 | 536,000 | SH | DFND | 1 | 536,000 | 0 | 0 | |
| AMAZON COM INC | COM | 023135106 | 77,352 | 25,000 | SH | DFND | 1 | 25,000 | 0 | 0 | |
| AMERICAN EAGLE OUTFITTERS IN | COM | 02553E106 | 11,345 | 387,995 | SH | DFND | 1 | 387,995 | 0 | 0 | |
| AMRYT PHARMA PLC | SPONSORED ADS | 03217L106 | 2,786 | 200,000 | SH | DFND | 1 | 200,000 | 0 | 0 | |
| ANAPLAN INC | COM | 03272L108 | 7,108 | 132,000 | SH | DFND | 1 | 132,000 | 0 | 0 | |
| ANHEUSER BUSCH INBEV SA/NV | SPONSORED ADR | 03524A108 | 43,995 | 700,000 | SH | DFND | 1 | 700,000 | 0 | 0 | |
| ARGENX SE | SPONSORED ADR | 04016X101 | 41,309 | 150,000 | SH | DFND | 1 | 150,000 | 0 | 0 | |
| ASSEMBLY BIOSCIENCES INC | COM | 045396108 | 10,286 | 2,236,000 | SH | DFND | 1 | 2,236,000 | 0 | 0 | |
| AUDDIA INC | *W EXP 10/17/202 | 05072K115 | 21 | 30,400 | SH | DFND | 1 | 30,400 | 0 | 0 | |
| AVANTOR INC | COM | 05352A100 | 18,399 | 636,000 | SH | DFND | 1 | 636,000 | 0 | 0 | |
| AXONICS MODULATION TECHNOLOG | COM | 05465P101 | 25,034 | 418,000 | SH | DFND | 1 | 418,000 | 0 | 0 | |
| AYTU BIOPHARMA INC | COM NEW | 054754874 | 10,202 | 1,342,378 | SH | DFND | 1 | 1,342,378 | 0 | 0 | |
| AZURRX BIOPHARMA INC | COM | 05502L105 | 80 | 59,863 | SH | DFND | 1 | 59,863 | 0 | 0 | |
| B & G FOODS INC NEW | COM | 05508R106 | 8,945 | 288,000 | SH | DFND | 1 | 288,000 | 0 | 0 | |
| BIO RAD LABS INC | CL A | 090572207 | 21,704 | 38,000 | SH | DFND | 1 | 38,000 | 0 | 0 | |
| BIOGEN INC | COM | 09062X103 | 80,568 | 288,000 | SH | DFND | 1 | 288,000 | 0 | 0 | |
| BIOHAVEN PHARMACTL HLDG CO L | COM | G11196105 | 68,350 | 1,000,000 | SH | DFND | 1 | 1,000,000 | 0 | 0 | |
| BIONTECH SE | SPONSORED ADS | 09075V102 | 30,136 | 276,000 | SH | DFND | 1 | 276,000 | 0 | 0 | |
| BLUEBIRD BIO INC | COM | 09609G100 | 59,215 | 1,964,000 | SH | DFND | 1 | 1,964,000 | 0 | 0 | |
| BRIACELL THERAPEUTICS CORP | *W EXP 02/24/202 | 10778Y112 | 450 | 420,536 | SH | DFND | 1 | 420,536 | 0 | 0 | |
| BRISTOL-MYERS SQUIBB CO | COM | 110122108 | 94,695 | 1,500,000 | SH | DFND | 1 | 1,500,000 | 0 | 0 | |
| CAMPBELL SOUP CO | COM | 134429109 | 46,449 | 924,000 | SH | DFND | 1 | 924,000 | 0 | 0 | |
| CATALYST PHARMACEUTICALS INC | COM | 14888U101 | 46,100 | 10,000,000 | SH | DFND | 1 | 10,000,000 | 0 | 0 | |
| CENTRAL GARDEN & PET CO | CL A NON-VTG | 153527205 | 41,097 | 792,000 | SH | DFND | 1 | 792,000 | 0 | 0 | |
| CERECOR INC | COM | 15671L109 | 98,556 | 32,634,285 | SH | DFND | 1 | 32,634,285 | 0 | 0 | |
| CLOROX CO DEL | COM | 189054109 | 48,220 | 250,000 | SH | DFND | 1 | 250,000 | 0 | 0 | |
| COCA COLA CO | COM | 191216100 | 48,282 | 916,000 | SH | DFND | 1 | 916,000 | 0 | 0 | |
| COCA-COLA FEMSA SAB DE CV | SPONSORD ADR REP | 191241108 | 20,143 | 436,000 | SH | DFND | 1 | 436,000 | 0 | 0 | |
| COLGATE PALMOLIVE CO | COM | 194162103 | 18,604 | 236,000 | SH | DFND | 1 | 236,000 | 0 | 0 | |
| CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 19,009 | 156,000 | SH | DFND | 1 | 156,000 | 0 | 0 | |
| CUENTAS INC | *W EXP 99/99/999 | 229794110 | 46 | 50,000 | SH | DFND | 1 | 50,000 | 0 | 0 | |
| DEXCOM INC | COM | 252131107 | 29,470 | 82,000 | SH | DFND | 1 | 82,000 | 0 | 0 | |
| DYNATRACE INC | COM NEW | 268150109 | 7,236 | 150,000 | SH | DFND | 1 | 150,000 | 0 | 0 | |
| EAGLE PHARMACEUTICALS INC | COM | 269796108 | 8,014 | 192,000 | SH | DFND | 1 | 192,000 | 0 | 0 | |
| ENANTA PHARMACEUTICALS INC | COM | 29251M106 | 81,279 | 1,648,000 | SH | DFND | 1 | 1,648,000 | 0 | 0 | |
| ENERGIZER HLDGS INC NEW | COM | 29272W109 | 49,738 | 1,048,000 | SH | DFND | 1 | 1,048,000 | 0 | 0 | |
| EXELA TECHNOLOGIES INC | COM NEW | 30162V409 | 3,964 | 1,818,182 | SH | DFND | 1 | 1,818,182 | 0 | 0 | |
| EYEGATE PHARMACEUTICALS INC | COM NEW | 30233M503 | 16,666 | 3,346,601 | SH | DFND | 1 | 3,346,601 | 0 | 0 | |
| FIVE BELOW INC | COM | 33829M101 | 12,745 | 66,800 | SH | DFND | 1 | 66,800 | 0 | 0 | |
| FUEL TECH INC | COM | 359523107 | 2,669 | 850,000 | SH | DFND | 1 | 850,000 | 0 | 0 | |
| GAP INC | COM | 364760108 | 15,355 | 515,617 | SH | DFND | 1 | 515,617 | 0 | 0 | |
| GOLD ROYALTY CORP | *W EXP 99/99/999 | 38071H114 | 470 | 448,000 | SH | DFND | 1 | 448,000 | 0 | 0 | |
| HOSTESS BRANDS INC | CL A | 44109J106 | 18,327 | 1,278,000 | SH | DFND | 1 | 1,278,000 | 0 | 0 | |
| HOTH THERAPEUTICS INC | COM | 44148G105 | 4,472 | 2,270,000 | SH | DFND | 1 | 2,270,000 | 0 | 0 | |
| ILLUMINA INC | COM | 452327109 | 18,435 | 48,000 | SH | DFND | 1 | 48,000 | 0 | 0 | |
| INCYTE CORP | COM | 45337C102 | 83,871 | 1,032,000 | SH | DFND | 1 | 1,032,000 | 0 | 0 | |
| INMED PHARMACEUTICALS INC | COM NEW | 457637502 | 776 | 235,000 | SH | DFND | 1 | 235,000 | 0 | 0 | |
| ISHARES TR | RUSSELL 2000 ETF | 464287655 | 441,880 | 2,000,000 | SH | Put | DFND | 1 | 2,000,000 | 0 | 0 |
| LAMB WESTON HLDGS INC | COM | 513272104 | 21,539 | 278,000 | SH | DFND | 1 | 278,000 | 0 | 0 | |
| LANTHEUS HLDGS INC | COM | 516544103 | 57,699 | 2,700,000 | SH | DFND | 1 | 2,700,000 | 0 | 0 | |
| LEXARIA BIOSCIENCE CORP | *W EXP 01/11/202 | 52886N117 | 865 | 361,905 | SH | DFND | 1 | 361,905 | 0 | 0 | |
| LULULEMON ATHLETICA INC | COM | 550021109 | 10,236 | 33,373 | SH | DFND | 1 | 33,373 | 0 | 0 | |
| MADRIGAL PHARMACEUTICALS INC | COM | 558868105 | 40,940 | 350,000 | SH | DFND | 1 | 350,000 | 0 | 0 | |
| MEDIGUS LTD | *W EXP 07/23/202 | 58471G128 | 1,106 | 1,285,715 | SH | DFND | 1 | 1,285,715 | 0 | 0 | |
| MEDTRONIC PLC | SHS | G5960L103 | 63,318 | 536,000 | SH | DFND | 1 | 536,000 | 0 | 0 | |
| MICROSOFT CORP | COM | 594918104 | 25,463 | 108,000 | SH | DFND | 1 | 108,000 | 0 | 0 | |
| MINERVA NEUROSCIENCES INC | COM | 603380106 | 2,663 | 912,000 | SH | DFND | 1 | 912,000 | 0 | 0 | |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 91,817 | 536,000 | SH | DFND | 1 | 536,000 | 0 | 0 | |
| MONDELEZ INTL INC | CL A | 609207105 | 31,372 | 536,000 | SH | DFND | 1 | 536,000 | 0 | 0 | |
| NATERA INC | COM | 632307104 | 25,182 | 248,000 | SH | DFND | 1 | 248,000 | 0 | 0 | |
| NIKE INC | CL B | 654106103 | 42,856 | 322,491 | SH | DFND | 1 | 322,491 | 0 | 0 | |
| NLS PHARMACEUTICS LTD | *W EXP 09/25/202 | H57830111 | 475 | 500,000 | SH | DFND | 1 | 500,000 | 0 | 0 | |
| NUVASIVE INC | COM | 670704105 | 26,224 | 400,000 | SH | DFND | 1 | 400,000 | 0 | 0 | |
| OBALON THERAPEUTICS INC | COM NEW | 67424L209 | 3,102 | 1,100,000 | SH | DFND | 1 | 1,100,000 | 0 | 0 | |
| ORTHO CLINICAL DIAGNOSTICS H | ORD SHS | G6829J107 | 42,372 | 2,196,000 | SH | DFND | 1 | 2,196,000 | 0 | 0 | |
| PAINREFORM LTD | SHS | M77798102 | 3,710 | 839,346 | SH | DFND | 1 | 839,346 | 0 | 0 | |
| PFIZER INC | COM | 717081103 | 43,476 | 1,200,000 | SH | DFND | 1 | 1,200,000 | 0 | 0 | |
| POOL CORP | COM | 73278L105 | 12,731 | 36,875 | SH | DFND | 1 | 36,875 | 0 | 0 | |
| POST HLDGS INC | COM | 737446104 | 19,875 | 188,000 | SH | DFND | 1 | 188,000 | 0 | 0 | |
| POTBELLY CORP | COM | 73754Y100 | 2,406 | 407,099 | SH | DFND | 1 | 407,099 | 0 | 0 | |
| PREDICTIVE ONCOLOGY INC | COM NEW | 74039M200 | 2,482 | 2,051,284 | SH | DFND | 1 | 2,051,284 | 0 | 0 | |
| PROGENITY INC | COM | 74319F107 | 12,483 | 2,622,377 | SH | DFND | 1 | 2,622,377 | 0 | 0 | |
| PTC THERAPEUTICS INC | COM | 69366J200 | 66,101 | 1,396,000 | SH | DFND | 1 | 1,396,000 | 0 | 0 | |
| RALPH LAUREN CORP | CL A | 751212101 | 35,780 | 290,517 | SH | DFND | 1 | 290,517 | 0 | 0 | |
| REGENERON PHARMACEUTICALS | COM | 75886F107 | 82,800 | 175,000 | SH | DFND | 1 | 175,000 | 0 | 0 | |
| REWALK ROBOTICS LTD | SHS | M8216Q200 | 4,625 | 1,911,264 | SH | DFND | 1 | 1,911,264 | 0 | 0 | |
| REZOLUTE INC | COM NEW | 76200L309 | 2,033 | 288,000 | SH | DFND | 1 | 288,000 | 0 | 0 | |
| SI BONE INC | COM | 825704109 | 11,579 | 364,000 | SH | DFND | 1 | 364,000 | 0 | 0 | |
| SIENTRA INC | COM | 82621J105 | 5,774 | 792,000 | SH | DFND | 1 | 792,000 | 0 | 0 | |
| SILK RD MED INC | COM | 82710M100 | 7,598 | 150,000 | SH | DFND | 1 | 150,000 | 0 | 0 | |
| SIYATA MOBILE INC | *W EXP 09/24/202 | 83013Q152 | 755 | 150,000 | SH | DFND | 1 | 150,000 | 0 | 0 | |
| SPDR S&P 500 ETF TR | TR UNIT | 78462F103 | 792,660 | 2,000,000 | SH | Put | DFND | 1 | 2,000,000 | 0 | 0 |
| SPECTRUM PHARMACEUTICALS INC | COM | 84763A108 | 34,882 | 10,700,000 | SH | DFND | 1 | 10,700,000 | 0 | 0 | |
| SUPERNUS PHARMACEUTICALS INC | COM | 868459108 | 89,326 | 3,412,000 | SH | DFND | 1 | 3,412,000 | 0 | 0 | |
| TANDEM DIABETES CARE INC | COM NEW | 875372203 | 8,825 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| TELA BIO INC | COM | 872381108 | 3,725 | 250,000 | SH | DFND | 1 | 250,000 | 0 | 0 | |
| TENAX THERAPEUTICS INC | COM NEW | 88032L209 | 3,838 | 2,019,995 | SH | DFND | 1 | 2,019,995 | 0 | 0 | |
| THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 26,470 | 58,000 | SH | DFND | 1 | 58,000 | 0 | 0 | |
| TJX COS INC NEW | COM | 872540109 | 74,625 | 1,128,122 | SH | DFND | 1 | 1,128,122 | 0 | 0 | |
| TRACTOR SUPPLY CO | COM | 892356106 | 23,505 | 132,737 | SH | DFND | 1 | 132,737 | 0 | 0 | |
| TRAVERE THERAPEUTICS INC | COM | 89422G107 | 58,829 | 2,356,000 | SH | DFND | 1 | 2,356,000 | 0 | 0 | |
| TRIPADVISOR INC | COM | 896945201 | 8,606 | 160,000 | SH | DFND | 1 | 160,000 | 0 | 0 | |
| UBER TECHNOLOGIES INC | COM | 90353T100 | 19,624 | 360,000 | SH | DFND | 1 | 360,000 | 0 | 0 | |
| UNDER ARMOUR INC | CL A | 904311107 | 12,562 | 566,881 | SH | DFND | 1 | 566,881 | 0 | 0 | |
| UNITEDHEALTH GROUP INC | COM | 91324P102 | 50,602 | 136,000 | SH | DFND | 1 | 136,000 | 0 | 0 | |
| VANDA PHARMACEUTICALS INC | COM | 921659108 | 57,016 | 3,796,000 | SH | DFND | 1 | 3,796,000 | 0 | 0 | |
| VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 84,237 | 392,000 | SH | DFND | 1 | 392,000 | 0 | 0 | |
| VIACOMCBS INC | CL B | 92556H206 | 28,142 | 624,000 | SH | DFND | 1 | 624,000 | 0 | 0 | |
| VOYAGER THERAPEUTICS INC | COM | 92915B106 | 17,502 | 3,716,000 | SH | DFND | 1 | 3,716,000 | 0 | 0 | |
| WALMART INC | COM | 931142103 | 57,357 | 422,268 | SH | DFND | 1 | 422,268 | 0 | 0 | |
| WHOLE EARTH BRANDS INC | COM CL A | 96684W100 | 15,648 | 1,200,000 | SH | DFND | 1 | 1,200,000 | 0 | 0 | |
| WORKDAY INC | CL A | 98138H101 | 8,695 | 35,000 | SH | DFND | 1 | 35,000 | 0 | 0 | |
| WYNN RESORTS LTD | COM | 983134107 | 8,024 | 64,000 | SH | DFND | 1 | 64,000 | 0 | 0 | |
| ZYMEWORKS INC | COM | 98985W102 | 52,107 | 1,650,000 | SH | DFND | 1 | 1,650,000 | 0 | 0 | |