The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AbCellera Biologics Inc. COM 00288U106 354,888 10,450,180 SH   SOLE   10,450,180 0 0
ACADIA Pharmaceuticals Inc. COM 004225108 1,081,296 41,910,704 SH   SOLE   41,910,704 0 0
Acceleron Pharma Inc. COM 00434H108 3,042 22,430 SH   SOLE   22,430 0 0
Achilles Therapeutics plc SPONSORED ADS 00449L102 42,887 2,591,366 SH   SOLE   2,591,366 0 0
Adamas Pharmaceuticals, Inc. COM 00548A106 710 147,996 SH   SOLE   147,996 0 0
Adaptimmune Therapeutics plc SPONSORED ADR 00653A107 52,202 9,830,877 SH   SOLE   9,830,877 0 0
ADC Therapeutics SA SHS H0036K147 34,616 1,418,107 SH   SOLE   1,418,107 0 0
Aeglea BioTherapeutics, Inc. COM 00773J103 27,008 3,410,106 SH   SOLE   3,410,106 0 0
Affimed N.V. COM N01045108 1,302 164,605 SH   SOLE   164,605 0 0
Akero Therapeutics, Inc. COM 00973Y108 3,434 118,378 SH   SOLE   118,378 0 0
Albireo Pharma, Inc. COM 01345P106 14,539 412,466 SH   SOLE   412,466 0 0
Alector, Inc. COM 014442107 4,818 239,228 SH   SOLE   239,228 0 0
Alexion Pharmaceuticals, Inc. COM 015351109 610,617 3,993,312 SH   SOLE   3,993,312 0 0
Aligos Therapeutics, Inc. COM 01626L105 36,611 1,610,000 SH   SOLE   1,610,000 0 0
Alkermes plc SHS G01767105 22,942 1,228,170 SH   SOLE   1,228,170 0 0
Allakos Inc. COM 01671P100 80,696 703,050 SH   SOLE   703,050 0 0
Altimmune, Inc. COM 02155H200 38,978 2,758,518 SH   SOLE   2,758,518 0 0
Amarin Corporation plc SPONSORED ADR 023111206 164,276 26,453,422 SH   SOLE   26,453,422 0 0
AnaptysBio, Inc. COM 032724106 9,206 427,179 SH   SOLE   427,179 0 0
Apellis Pharmaceuticals, Inc. COM 03753U106 71,832 1,674,004 SH   SOLE   1,674,004 0 0
argenx SE SPONSORED ADR 04016X101 308,315 1,119,557 SH   SOLE   1,119,557 0 0
Ascendis Pharma A/S SPONSORED ADR 04351P101 456,270 3,540,270 SH   SOLE   3,540,270 0 0
Assembly Biosciences, Inc. COM 045396108 7,091 1,541,418 SH   SOLE   1,541,418 0 0
Atreca, Inc. CL A COM 04965G109 54,157 3,532,760 SH   SOLE   3,532,760 0 0
Athira Pharma, Inc. COM 04746L104 14,837 806,367 SH   SOLE   806,367 0 0
Aurinia Pharmaceuticals Inc. COM 05156V102 18,310 1,410,064 SH   SOLE   1,410,064 0 0
Autolus Therapeutics plc SPONSORED ADS 05280R100 2,646 461,726 SH   SOLE   461,726 0 0
Axsome Therapeutics, Inc. COM 05464T104 35,581 628,414 SH   SOLE   628,414 0 0
BeiGene, Ltd. SPONSORED ADR 07725L102 4,061,710 11,668,897 SH   SOLE   11,668,897 0 0
Bellicum Pharmaceuticals, Inc. COM 079481404 937 249,123 SH   SOLE   249,123 0 0
BioAtla, Inc. COM 09077B104 41,943 825,000 SH   SOLE   825,000 0 0
BioCryst Pharmaceuticals, Inc. COM 09058V103 129,269 12,710,818 SH   SOLE   12,710,818 0 0
BioMarin Pharmaceutical Inc. COM 09061G101 573,068 7,589,294 SH   SOLE   7,589,294 0 0
bluebird bio, Inc. COM 09609G100 6,844 226,988 SH   SOLE   226,988 0 0
Burning Rock Biotech Limited SPONSORED ADS 12233L107 5,630 209,131 SH   SOLE   209,131 0 0
Cabaletta Bio, Inc. COM 12674W109 7,064 636,363 SH   SOLE   636,363 0 0
Cerus Corporation COM 157085101 82,416 13,713,195 SH   SOLE   13,713,195 0 0
ChemoCentryx, Inc. COM 16383L106 33,650 656,710 SH   SOLE   656,710 0 0
Chiasma, Inc. COM 16706W102 2,323 742,133 SH   SOLE   742,133 0 0
Chinook Therapeutics, Inc. COM 16961L106 11,635 748,693 SH   SOLE   748,693 0 0
Constellation Pharmaceuticals, Inc. COM 210373106 2,684 114,735 SH   SOLE   114,735 0 0
Crinetics Pharmaceuticals, Inc. COM 22663K107 9,420 616,520 SH   SOLE   616,520 0 0
Cymabay Therapeutics, Inc. COM 23257D103 9,854 2,170,464 SH   SOLE   2,170,464 0 0
DBV Technologies S.A. SPONSORED ADR 23306J101 77,894 14,614,264 SH   SOLE   14,614,264 0 0
Denali Therapeutics Inc. COM 24823R105 5,067 88,738 SH   SOLE   88,738 0 0
Design Therapeutics, Inc. COM 25056L103 42,955 1,436,636 SH   SOLE   1,436,636 0 0
Edgewise Therapeutics, Inc. COM 28036F105 16,250 500,000 SH   SOLE   500,000 0 0
Evofem Biosciences, Inc. COM 30048L104 4,720 2,697,110 SH   SOLE   2,697,110 0 0
Frequency Therapeutics, Inc. COM 35803L108 528 55,555 SH   SOLE   55,555 0 0
Forma Therapeutics Holdings, Inc. SHS 34633R104 56,737 2,024,876 SH   SOLE   2,024,876 0 0
Fulgent Genetics, Inc. COM 359664109 38,746 401,016 SH   SOLE   401,016 0 0
Galapagos NV SPONSORED ADR 36315X101 862 11,180 SH   SOLE   11,180 0 0
Galmed Pharmaceuticals Ltd. SHS M47238106 634 184,927 SH   SOLE   184,927 0 0
Gamida Cell Ltd. SHS M47364100 8,391 1,037,226 SH   SOLE   1,037,226 0 0
Genetron Holdings Limited ADS 37186H100 9,771 455,306 SH   SOLE   455,306 0 0
Genfit SA ADS 372279109 68 14,720 SH   SOLE   14,720 0 0
Global Blood Therapeutics, Inc. COM 37890U108 131,111 3,217,441 SH   SOLE   3,217,441 0 0
Harmony Biosciences Holdings, Inc. COM 413197104 4,084 123,600 SH   SOLE   123,600 0 0
Heron Therapeutics, Inc. COM 427746102 97,174 5,994,704 SH   SOLE   5,994,704 0 0
HOOKIPA Pharma Inc. COM 43906K100 9,421 700,481 SH   SOLE   700,481 0 0
Horizon Therapeutics Public Ltd Co SHS G46188101 55,142 599,110 SH   SOLE   599,110 0 0
Idera Pharmaceuticals, Inc. COM PAR 45168K405 2,661 2,047,180 SH   SOLE   2,047,180 0 0
IGM Biosciences, Inc. COM 449585108 242,041 3,156,102 SH   SOLE   3,156,102 0 0
Immatics N.V. SHS N44445109 44,759 3,992,756 SH   SOLE   3,992,756 0 0
Immunocore Holdings plc ADS 45258D105 107,307 2,520,730 SH   SOLE   2,520,730 0 0
Incyte Corporation COM 45337C102 2,600,753 32,001,387 SH   SOLE   32,001,387 0 0
Inflarx N.V. COM N44821101 538 138,040 SH   SOLE   138,040 0 0
Instil Bio, Inc. COM 45783C101 97,654 3,893,700 SH   SOLE   3,893,700 0 0
Inozyme Pharma, Inc. COM 45790W108 2,119 106,999 SH   SOLE   106,999 0 0
Insmed Incorporated COM PAR $.01 457669307 73,433 2,156,001 SH   SOLE   2,156,001 0 0
Invitae Corporation COM 46185L103 601,776 15,749,182 SH   SOLE   15,749,182 0 0
Iteos Therapeutics, Inc. COM 46565G104 5,139 150,346 SH   SOLE   150,346 0 0
IVERIC bio, Inc. COM 46583P102 8,689 1,406,037 SH   SOLE   1,406,037 0 0
Karuna Therapeutics, Inc. COM 48576A100 8,412 69,966 SH   SOLE   69,966 0 0
Kezar Life Sciences, Inc. COM 49372L100 832 139,676 SH   SOLE   139,676 0 0
Kiniksa Pharmaceuticals, Ltd. COM CL A G5269C101 51,820 2,799,577 SH   SOLE   2,799,577 0 0
Kymera Therapeutics, Inc. COM 501575104 76,135 1,959,211 SH   SOLE   1,959,211 0 0
Kodiak Sciences Inc. COM 50015M109 1,573,848 13,879,952 SH   SOLE   13,879,952 0 0
Krystal Biotech, Inc. COM 501147102 58,582 760,412 SH   SOLE   760,412 0 0
Leap Therapeutics, Inc. COM 52187K101 1,063 559,705 SH   SOLE   559,705 0 0
Legend Biotech Corporation SPONSORED ADS 52490G102 3,355 115,626 SH   SOLE   115,626 0 0
LogicBio Therapeutics, Inc. COM 54142F102 3,287 451,478 SH   SOLE   451,478 0 0
MacroGenics, Inc. COM 556099109 6,392 200,679 SH   SOLE   200,679 0 0
Madrigal Pharmaceuticals, Inc. COM 558868105 175,363 1,499,213 SH   SOLE   1,499,213 0 0
Mereo BioPharma Group plc ADS 589492107 22,646 6,719,948 SH   SOLE   6,719,948 0 0
Merus N.V. COM N5749R100 42,563 2,037,469 SH   SOLE   2,037,469 0 0
Mirati Therapeutics, Inc. COM 60468T105 241,496 1,409,784 SH   SOLE   1,409,784 0 0
Mirum Pharmaceuticals, Inc. COM 604749101 12,830 647,313 SH   SOLE   647,313 0 0
Molecular Templates, Inc. COM 608550109 1,689 133,833 SH   SOLE   133,833 0 0
Neoleukin Therapeutics, Inc. COM 64049K104 47,046 3,821,740 SH   SOLE   3,821,740 0 0
NexImmune, Inc. COM 65344D109 5,612 294,117 SH   SOLE   294,117 0 0
Neurocrine Biosciences, Inc. COM 64125C109 65,836 676,975 SH   SOLE   676,975 0 0
NGM Biopharmaceuticals, Inc. COM 62921N105 8,483 291,801 SH   SOLE   291,801 0 0
Novavax, Inc. COM 670002401 26,064 143,756 SH   SOLE   143,756 0 0
Nurix Therapeutics, Inc. COM 67080M103 76,297 2,454,082 SH   SOLE   2,454,082 0 0
Opthea Limited SPONSORED ADS 68386J208 31,664 3,308,705 SH   SOLE   3,308,705 0 0
Otonomy, Inc. COM 68906L105 18,411 7,220,074 SH   SOLE   7,220,074 0 0
Orchard Therapeutics plc ADS 68570P101 5,332 734,431 SH   SOLE   734,431 0 0
Oyster Point Pharma, Inc. COM 69242L106 1,123 61,424 SH   SOLE   61,424 0 0
Pacific Biosciences of California, Inc. COM 69404D108 106,658 3,201,972 SH   SOLE   3,201,972 0 0
Passage Bio, Inc. COM 702712100 4,114 235,362 SH   SOLE   235,362 0 0
Prelude Therapeutics Incorporated COM 74065P101 438,665 10,123,824 SH   SOLE   10,123,824 0 0
Protagonist Therapeutics, Inc. COM 74366E102 37,197 1,436,192 SH   SOLE   1,436,192 0 0
Protara Therapeutics, Inc. COM STK 74365U107 3,143 199,671 SH   SOLE   199,671 0 0
Reata Pharmaceuticals, Inc. CL A 75615P103 22,330 223,976 SH   SOLE   223,976 0 0
Replimune Group, Inc. COM 76029N106 4,684 153,512 SH   SOLE   153,512 0 0
Revolution Medicines, Inc. COM 76155X100 10,196 222,222 SH   SOLE   222,222 0 0
Rhythm Pharmaceuticals, Inc. COM 76243J105 74,017 3,479,873 SH   SOLE   3,479,873 0 0
Sangamo Therapeutics, Inc. COM 800677106 5,376 429,063 SH   SOLE   429,063 0 0
Sarepta Therapeutics, Inc. COM 803607100 4,375 58,700 SH   SOLE   58,700 0 0
Seagen Inc. COM 81181C104 6,564,018 47,270,759 SH   SOLE   47,270,759 0 0
Silverback Therapeutics, Inc. COM 82835W108 10,388 238,095 SH   SOLE   238,095 0 0
Syros Pharmaceuticals, Inc. COM 87184Q107 5,162 690,167 SH   SOLE   690,167 0 0
Talis Biomedical Corporation COM 87424L108 97,337 7,574,835 SH   SOLE   7,574,835 0 0
TCR2 Therapeutics Inc. COM 87808K106 3,896 176,461 SH   SOLE   176,461 0 0
Travere Therapeutics, Inc. COM 89422G107 4,667 186,915 SH   SOLE   186,915 0 0
Tricida, Inc. COM 89610F101 3,858 729,300 SH   SOLE   729,300 0 0
Ultragenyx Pharmaceutical Inc. COM 90400D108 50,604 444,444 SH   SOLE   444,444 0 0
Verastem, Inc. COM 92337C104 42,038 17,019,294 SH   SOLE   17,019,294 0 0
Viking Therapeutics, Inc. COM 92686J106 2,302 363,980 SH   SOLE   363,980 0 0
Xencor, Inc. COM 98401F105 15,905 369,370 SH   SOLE   369,370 0 0
Xenon Pharmaceuticals Inc. COM 98420N105 13,454 751,639 SH   SOLE   751,639 0 0
Zymeworks Inc. COM 98985W102 53,954 1,708,472 SH   SOLE   1,708,472 0 0
BioMarin Pharmaceutical Inc. NOTE 0.599% 8/1/2024 09061GAH4 15,299 15,000,000 PRN   SOLE   15,000,000 0 0
Invitae Corporation NOTE 2.0% 9/1/2024 46185LAB9 15,557 10,300,000 PRN   SOLE   10,300,000 0 0
Sarepta Therapeutics, Inc. DBCV 1.5% 11/15/2024 803607AB6 11,970 9,174,000 PRN   SOLE   9,174,000 0 0