The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
111 INC ADS 68247Q102 1,173 85,000 SH   DFND 2 85,000 0 0
1LIFE HEALTHCARE INC COM 68269G107 32,168 823,135 SH   DFND 2 823,135 0 0
10X GENOMICS INC CL A COM 88025U109 41,456 229,039 SH   DFND 2 229,039 0 0
ABBOTT LABS COM 002824100 166,937 1,392,999 SH   DFND 2 1,392,999 0 0
ABBVIE INC COM 00287Y109 41,567 384,100 SH   DFND 2 384,100 0 0
ABIOMED INC COM 003654100 45,478 142,684 SH   DFND 2 142,684 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 1,700 65,900 SH   DFND 2 65,900 0 0
ACCOLADE INC COM 00437E102 29,509 650,401 SH   DFND 2 650,401 0 0
ACCOLADE INC COM 00437E102 41,319 910,720 SH   DFND 3 910,720 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 343 2,700 SH   DFND 2 2,700 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 2,174 42,100 SH   DFND 2 42,100 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 232,121 4,494,992 SH   DFND 1,2 4,494,992 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 2,187 14,300 SH   DFND 2 14,300 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 197,931 1,294,428 SH   DFND 1,2 1,294,428 0 0
ALIGN TECHNOLOGY INC COM 016255101 77,959 143,960 SH   DFND 2 143,960 0 0
ALLAKOS INC COM 01671P100 2,123 18,500 SH   DFND 2 18,500 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 9,248 65,500 SH   DFND 2 65,500 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 159,545 1,130,000 SH   DFND 1,2 1,130,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 60,940 431,614 SH   DFND 3 431,614 0 0
AMEDISYS INC COM 023436108 16,016 60,487 SH   DFND 2 60,487 0 0
AMERICAN EXPRESS CO COM 025816109 368 2,600 SH   DFND 2 2,600 0 0
AMERICAN WELL CORP CL A 03044L105 32,455 1,868,433 SH   DFND 2 1,868,433 0 0
AMGEN INC COM 031162100 12,154 48,850 SH   DFND 2 48,850 0 0
AMGEN INC COM 031162100 31,746 127,590 SH   DFND 3 127,590 0 0
ANSYS INC COM 03662Q105 306 900 SH   DFND 2 900 0 0
ANTHEM INC COM 036752103 63,825 177,809 SH   DFND 2 177,809 0 0
ANTHEM INC COM 036752103 74,568 207,739 SH   DFND 3 207,739 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 2,060 48,000 SH   DFND 2 48,000 0 0
ARCUS BIOSCIENCES INC COM 03969F109 2,106 75,000 SH   DFND 2 75,000 0 0
ARGENX SE SPONSORED ADR 04016X101 6,614 24,016 SH   DFND 2 24,016 0 0
ARGENX SE SPONSORED ADR 04016X101 256,261 930,538 SH   DFND 1,2 930,538 0 0
ARVINAS INC COM 04335A105 965 14,600 SH   DFND 2 14,600 0 0
ARVINAS INC COM 04335A105 135,961 2,056,903 SH   DFND 1,2 2,056,903 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 1,998 15,500 SH   DFND 2 15,500 0 0
ASPEN TECHNOLOGY INC COM 045327103 346 2,400 SH   DFND 2 2,400 0 0
ATRICURE INC COM 04963C209 32,610 497,712 SH   DFND 3 497,712 0 0
AVANTOR INC COM 05352A100 14,818 512,216 SH   DFND 2 512,216 0 0
AXONICS MODULATION TECHNOLOG COM 05465P101 50,849 849,034 SH   DFND 2 849,034 0 0
AXONICS MODULATION TECHNOLOG COM 05465P101 36,368 607,240 SH   DFND 3 607,240 0 0
BAXTER INTL INC COM 071813109 40,030 474,623 SH   DFND 2 474,623 0 0
BEAM THERAPEUTICS INC COM 07373V105 45,368 566,821 SH   DFND 1,2 566,821 0 0
BECTON DICKINSON & CO COM 075887109 112,084 460,965 SH   DFND 2 460,965 0 0
BEIGENE LTD SPONSORED ADR 07725L102 20,780 59,700 SH   DFND 2 59,700 0 0
BERKELEY LTS INC COM 084310101 19,037 379,003 SH   DFND 2 379,003 0 0
BIOGEN INC COM 09062X103 5,987 21,400 SH   DFND 2 21,400 0 0
BIOGEN INC COM 09062X103 150,226 537,000 SH   DFND 1,2 537,000 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 2,461 36,000 SH   DFND 2 36,000 0 0
BIONTECH SE SPONSORED ADS 09075V102 4,968 45,500 SH   DFND 2 45,500 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 2,794 37,000 SH   DFND 2 37,000 0 0
BIO RAD LABS INC CL A 090572207 57,232 100,202 SH   DFND 3 100,202 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 315 13,000 SH   DFND 2 13,000 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 54,100 2,230,000 SH   DFND 1,2 2,230,000 0 0
BOOKING HOLDINGS INC COM 09857L108 373 160 SH   DFND 2 160 0 0
BOSTON SCIENTIFIC CORP COM 101137107 89,930 2,326,787 SH   DFND 2 2,326,787 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 38,364 607,700 SH   DFND 2 607,700 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 93,272 1,477,452 SH   DFND 3 1,477,452 0 0
BROWN FORMAN CORP CL B 115637209 317 4,600 SH   DFND 2 4,600 0 0
BURNING ROCK BIOTECH LTD SPONSORED ADR 12233L107 11,654 432,926 SH   DFND 2 432,926 0 0
CARDINAL HEALTH INC COM 14149Y108 1,458 24,000 SH   DFND 2 24,000 0 0
CAREDX INC COM 14167L103 12,962 190,371 SH   DFND 3 190,371 0 0
CARMAX INC COM 143130102 378 2,850 SH   DFND 2 2,850 0 0
CATALENT INC COM 148806102 284 2,700 SH   DFND 2 2,700 0 0
CELLECTIS S A SPON ADS 15117K103 1,688 83,500 SH   DFND 2 83,500 0 0
CENTENE CORP DEL COM 15135B101 82,482 1,290,597 SH   DFND 2 1,290,597 0 0
CHARLES RIV LABS INTL INC COM 159864107 54,600 188,385 SH   DFND 3 188,385 0 0
CIGNA CORP NEW COM 125523100 108,339 448,162 SH   DFND 2 448,162 0 0
CLOROX CO DEL COM 189054109 386 2,000 SH   DFND 2 2,000 0 0
CONSTELLATION BRANDS INC CL A 21036P108 333 1,459 SH   DFND 2 1,459 0 0
COOPER COS INC COM NEW 216648402 26,643 69,367 SH   DFND 2 69,367 0 0
COSTAR GROUP INC COM 22160N109 288 350 SH   DFND 2 350 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 1,072 8,800 SH   DFND 2 8,800 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 118,144 969,584 SH   DFND 1,2 969,584 0 0
CUREVAC NV COM N2451R105 2,643 28,900 SH   DFND 2 28,900 0 0
CVS HEALTH CORP COM 126650100 9,370 124,548 SH   DFND 2 124,548 0 0
CYBERARK SOFTWARE LTD SHS M2682V108 272 2,100 SH   DFND 2 2,100 0 0
DANAHER CORPORATION COM 235851102 106,494 473,140 SH   DFND 2 473,140 0 0
DAVITA INC COM 23918K108 39,616 367,600 SH   DFND 2 367,600 0 0
DENTSPLY SIRONA INC COM 24906P109 10,154 159,129 SH   DFND 2 159,129 0 0
DEXCOM INC COM 252131107 77,698 216,193 SH   DFND 2 216,193 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 1,739 68,000 SH   DFND 2 68,000 0 0
DOLBY LABORATORIES INC COM CL A 25659T107 355 3,600 SH   DFND 2 3,600 0 0
DOMINOS PIZZA INC COM 25754A201 368 1,000 SH   DFND 2 1,000 0 0
DR REDDYS LABS LTD ADR 256135203 522 8,500 SH   DFND 2 8,500 0 0
EARGO INC COM 270087109 19,373 387,857 SH   DFND 2 387,857 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 74,461 890,256 SH   DFND 2 890,256 0 0
ELECTRONIC ARTS INC COM 285512109 307 2,270 SH   DFND 2 2,270 0 0
ENTEGRIS INC COM 29362U104 335 3,000 SH   DFND 2 3,000 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 1,156 41,200 SH   DFND 2 41,200 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 110,740 3,947,964 SH   DFND 1,2 3,947,964 0 0
ESSA PHARMA INC COM NEW 29668H708 53,040 1,825,814 SH   DFND 1,2 1,825,814 0 0
EVOLENT HEALTH INC CL A 30050B101 32,884 1,627,942 SH   DFND 2 1,627,942 0 0
EVOLENT HEALTH INC CL A 30050B101 38,392 1,900,605 SH   DFND 3 1,900,605 0 0
EXACT SCIENCES CORP COM 30063P105 28,746 218,140 SH   DFND 3 218,140 0 0
EXELIXIS INC COM 30161Q104 2,474 109,500 SH   DFND 2 109,500 0 0
EXELIXIS INC COM 30161Q104 64,043 2,835,000 SH   DFND 1,2 2,835,000 0 0
FACTSET RESH SYS INC COM 303075105 324 1,050 SH   DFND 2 1,050 0 0
FASTENAL CO COM 311900104 352 7,000 SH   DFND 2 7,000 0 0
FATE THERAPEUTICS INC COM 31189P102 3,958 48,000 SH   DFND 2 48,000 0 0
FATE THERAPEUTICS INC COM 31189P102 178,202 2,161,336 SH   DFND 1,2 2,161,336 0 0
FIBROGEN INC COM 31572Q808 2,083 60,000 SH   DFND 2 60,000 0 0
FORTINET INC COM 34959E109 406 2,200 SH   DFND 2 2,200 0 0
GARTNER INC COM 366651107 383 2,100 SH   DFND 2 2,100 0 0
GENERATION BIO CO COM 37148K100 68,110 2,393,180 SH   DFND 1,2 2,393,180 0 0
GENETRON HLDGS LTD ADS 37186H100 13,565 632,087 SH   DFND 2 632,087 0 0
GILEAD SCIENCES INC COM 375558103 7,174 111,000 SH   DFND 2 111,000 0 0
GLAUKOS CORP COM 377322102 41,070 489,342 SH   DFND 2 489,342 0 0
GLOBUS MED INC CL A 379577208 39,932 647,509 SH   DFND 2 647,509 0 0
GRACO INC COM 384109104 322 4,500 SH   DFND 2 4,500 0 0
GUARDANT HEALTH INC COM 40131M109 46,232 302,866 SH   DFND 2 302,866 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 2,169 10,000 SH   DFND 2 10,000 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 3,127 75,000 SH   DFND 2 75,000 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 122,442 2,936,966 SH   DFND 1,2 2,936,966 0 0
HCA HEALTHCARE INC COM 40412C101 70,545 374,563 SH   DFND 2 374,563 0 0
HEALTH CATALYST INC COM 42225T107 34,697 741,855 SH   DFND 2 741,855 0 0
HILL ROM HLDGS INC COM 431475102 72,986 660,628 SH   DFND 3 660,628 0 0
HOLOGIC INC COM 436440101 28,992 389,779 SH   DFND 2 389,779 0 0
HOLOGIC INC COM 436440101 38,973 523,973 SH   DFND 3 523,973 0 0
HOMOLOGY MEDICINES INC COM 438083107 16,346 1,737,122 SH   DFND 1,2 1,737,122 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 37,598 408,500 SH   DFND 2 408,500 0 0
HUMANA INC COM 444859102 60,682 144,739 SH   DFND 2 144,739 0 0
HUMANA INC COM 444859102 60,364 143,980 SH   DFND 3 143,980 0 0
HUTCHISON CHINA MEDITECH LTD SPONSORED ADR 44842L103 27,558 975,488 SH   DFND 3 975,488 0 0
IDEXX LABS INC COM 45168D104 44,649 91,249 SH   DFND 2 91,249 0 0
ILLUMINA INC COM 452327109 23,396 60,918 SH   DFND 2 60,918 0 0
I MAB SPONSORED ADS 44975P103 9,619 198,457 SH   DFND 2 198,457 0 0
INCYTE CORP COM 45337C102 8,834 108,700 SH   DFND 2 108,700 0 0
INCYTE CORP COM 45337C102 235,439 2,897,000 SH   DFND 1,2 2,897,000 0 0
INOGEN INC COM 45780L104 14,751 280,863 SH   DFND 2 280,863 0 0
INSMED INC COM PAR $.01 457669307 84,372 2,477,166 SH   DFND 3 2,477,166 0 0
INSPIRE MED SYS INC COM 457730109 66,276 320,188 SH   DFND 2 320,188 0 0
INSULET CORP COM 45784P101 113,288 434,188 SH   DFND 2 434,188 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 185 8,000 SH   DFND 2 8,000 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 335 3,000 SH   DFND 2 3,000 0 0
INTERSECT ENT INC COM 46071F103 12,903 617,968 SH   DFND 2 617,968 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 4,122 121,500 SH   DFND 2 121,500 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 120,059 3,538,419 SH   DFND 1,2 3,538,419 0 0
INTUIT COM 461202103 345 900 SH   DFND 2 900 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 163,139 220,775 SH   DFND 2 220,775 0 0
IONIS PHARMACEUTICALS INC COM 462222100 8,410 187,050 SH   DFND 2 187,050 0 0
IONIS PHARMACEUTICALS INC COM 462222100 367,187 8,166,962 SH   DFND 1,2 8,166,962 0 0
IONIS PHARMACEUTICALS INC COM 462222100 28,335 630,222 SH   DFND 3 630,222 0 0
IPG PHOTONICS CORP COM 44980X109 285 1,350 SH   DFND 2 1,350 0 0
IQVIA HLDGS INC COM 46266C105 348 1,800 SH   DFND 2 1,800 0 0
IRHYTHM TECHNOLOGIES INC COM 450056106 12,168 87,631 SH   DFND 2 87,631 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 7,775 47,300 SH   DFND 2 47,300 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 82,736 503,350 SH   DFND 3 503,350 0 0
JD.COM INC SPON ADR CL A 47215P106 304 3,600 SH   DFND 2 3,600 0 0
JOHNSON & JOHNSON COM 478160104 6,755 41,100 SH   DFND 2 41,100 0 0
JUMIA TECHNOLOGIES AG SPONSORED ADS 48138M105 638 18,000 SH   DFND 2 18,000 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 27,018 4,533,148 SH   DFND 1,2 4,533,148 0 0
KOSMOS ENERGY LTD COM 500688106 599 195,000 SH   DFND 2 195,000 0 0
KURA ONCOLOGY INC COM 50127T109 1,640 58,000 SH   DFND 2 58,000 0 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409 3,621 14,200 SH   DFND 2 14,200 0 0
LAUDER ESTEE COS INC CL A 518439104 392 1,348 SH   DFND 2 1,348 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102 17,506 603,243 SH   DFND 2 603,243 0 0
LIVE NATION ENTERTAINMENT IN COM 538034109 398 4,700 SH   DFND 2 4,700 0 0
MACROGENICS INC COM 556099109 1,591 49,950 SH   DFND 2 49,950 0 0
MACROGENICS INC COM 556099109 161,497 5,070,564 SH   DFND 1,2 5,070,564 0 0
MACROGENICS INC COM 556099109 28,901 907,412 SH   DFND 3 907,412 0 0
MARKEL CORP COM 570535104 456 400 SH   DFND 2 400 0 0
MARKETAXESS HLDGS INC COM 57060D108 330 662 SH   DFND 2 662 0 0
MASIMO CORP COM 574795100 28,982 126,196 SH   DFND 2 126,196 0 0
MATCH GROUP INC NEW COM 57667L107 327 2,378 SH   DFND 2 2,378 0 0
MCCORMICK & CO INC COM NON VTG 579780206 526 5,900 SH   DFND 2 5,900 0 0
MCKESSON CORP COM 58155Q103 474 2,430 SH   DFND 2 2,430 0 0
MEDTRONIC PLC SHS G5960L103 39,281 332,522 SH   DFND 2 332,522 0 0
MERCADOLIBRE INC COM 58733R102 250 170 SH   DFND 2 170 0 0
MERSANA THERAPEUTICS INC COM 59045L106 1,456 90,010 SH   DFND 2 90,010 0 0
MERSANA THERAPEUTICS INC COM 59045L106 44,657 2,760,000 SH   DFND 1,2 2,760,000 0 0
METTLER TOLEDO INTERNATIONAL COM 592688105 312 270 SH   DFND 2 270 0 0
MIRATI THERAPEUTICS INC COM 60468T105 1,679 9,800 SH   DFND 2 9,800 0 0
MODERNA INC COM 60770K107 14,398 109,950 SH   DFND 2 109,950 0 0
MODERNA INC COM 60770K107 353,565 2,700,000 SH   DFND 1,2 2,700,000 0 0
MOLECULAR TEMPLATES INC COM 608550109 404 32,000 SH   DFND 2 32,000 0 0
MOLECULAR TEMPLATES INC COM 608550109 102,425 8,116,105 SH   DFND 1,2 8,116,105 0 0
MOLINA HEALTHCARE INC COM 60855R100 47,976 205,234 SH   DFND 2 205,234 0 0
MOODYS CORP COM 615369105 373 1,250 SH   DFND 2 1,250 0 0
MSCI INC COM 55354G100 342 816 SH   DFND 2 816 0 0
MYOVANT SCIENCES LTD COM G637AM102 967 47,000 SH   DFND 2 47,000 0 0
MYOVANT SCIENCES LTD COM G637AM102 105,926 5,147,039 SH   DFND 1,2 5,147,039 0 0
NEKTAR THERAPEUTICS COM 640268108 576 28,800 SH   DFND 2 28,800 0 0
NEKTAR THERAPEUTICS COM 640268108 52,414 2,620,676 SH   DFND 1,2 2,620,676 0 0
NEKTAR THERAPEUTICS COM 640268108 26,103 1,305,128 SH   DFND 3 1,305,128 0 0
NEOGENOMICS INC COM NEW 64049M209 38,003 787,953 SH   DFND 3 787,953 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 34,927 359,151 SH   DFND 2 359,151 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 283,523 2,915,400 SH   DFND 1,2 2,915,400 0 0
NEVRO CORP COM 64157F103 25,251 181,013 SH   DFND 2 181,013 0 0
NUANCE COMMUNICATIONS INC COM 67020Y100 20,462 468,885 SH   DFND 2 468,885 0 0
OLINK HLDG AB SPONSORED ADS 680710100 5,477 152,137 SH   DFND 2 152,137 0 0
OMNICELL INC COM 68213N109 42,587 327,919 SH   DFND 2 327,919 0 0
OPTHEA LTD SPONSORED ADS 68386J208 483 50,000 SH   DFND 2 50,000 0 0
OPTION CARE HEALTH INC COM NEW 68404L201 26,758 1,508,320 SH   DFND 3 1,508,320 0 0
OSCAR HEALTH INC CL A 687793109 12,219 454,574 SH   DFND 2 454,574 0 0
OUTSET MED INC COM 690145107 13,908 255,714 SH   DFND 2 255,714 0 0
PACIFIC BIOSIENCES CALIF IN COM 69404D108 53,879 1,617,505 SH   DFND 2 1,617,505 0 0
PAYCHEX INC COM 704326107 382 3,900 SH   DFND 2 3,900 0 0
PENUMBRA INC COM 70975L107 48,671 179,875 SH   DFND 2 179,875 0 0
PERKINELMER INC COM 714046109 282 2,200 SH   DFND 2 2,200 0 0
PHREESIA INC COM 71944F106 31,938 613,013 SH   DFND 2 613,013 0 0
POOL CORP COM 73278L105 311 900 SH   DFND 2 900 0 0
PULMONX CORP COM 745848101 8,074 176,510 SH   DFND 2 176,510 0 0
QUANTERIX CORP COM 74766Q101 40,779 697,432 SH   DFND 2 697,432 0 0
RADIUS HEALTH INC COM NEW 750469207 1,579 75,700 SH   DFND 2 75,700 0 0
RADIUS HEALTH INC COM NEW 750469207 155,526 7,455,714 SH   DFND 1,2 7,455,714 0 0
REGENERON PHARMACEUTICALS COM 75886F107 16,938 35,800 SH   DFND 2 35,800 0 0
RELAY THERAPEUTICS INC COM 75943R102 66,767 1,931,344 SH   DFND 1,2 1,931,344 0 0
RESMED INC COM 761152107 17,102 88,145 SH   DFND 2 88,145 0 0
REVOLUTION MEDICINES INC COM 76155X100 2,661 58,000 SH   DFND 2 58,000 0 0
REVOLUTION MEDICINES INC COM 76155X100 46,236 1,007,770 SH   DFND 1,2 1,007,770 0 0
S&P GLOBAL INC COM 78409V104 423 1,200 SH   DFND 2 1,200 0 0
SAGE THERAPEUTICS INC COM 78667J108 2,665 35,600 SH   DFND 2 35,600 0 0
SAGE THERAPEUTICS INC COM 78667J108 132,867 1,775,104 SH   DFND 1,2 1,775,104 0 0
SAREPTA THERAPEUTICS INC COM 803607100 1,513 20,300 SH   DFND 2 20,300 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 1,570 31,000 SH   DFND 2 31,000 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 106,392 2,100,125 SH   DFND 1,2 2,100,125 0 0
SEAGEN INC COM 81181C104 4,902 35,300 SH   DFND 2 35,300 0 0
SEER INC COM CL A 81578P106 5,514 110,228 SH   DFND 2 110,228 0 0
SENSATA TECHNOLOGIES HLDNG PL SHS G8060N102 342 5,900 SH   DFND 2 5,900 0 0
SERVICE CORP INTL COM 817565104 332 6,500 SH   DFND 2 6,500 0 0
SHOCKWAVE MED INC COM 82489T104 63,119 484,564 SH   DFND 2 484,564 0 0
SIGNIFY HEALTH INC CL A COM 82671G100 5,852 200,000 SH   DFND 2 200,000 0 0
SILK RD MED INC COM 82710M100 24,560 484,893 SH   DFND 2 484,893 0 0
SILK RD MED INC COM 82710M100 34,140 674,031 SH   DFND 3 674,031 0 0
SKYWORKS SOLUTIONS INC COM 83088M102 385 2,100 SH   DFND 2 2,100 0 0
STARBUCKS CORP COM 855244109 353 3,234 SH   DFND 2 3,234 0 0
STONECO LTD COM CL A G85158106 263 4,300 SH   DFND 2 4,300 0 0
STRYKER CORPORATION COM 863667101 83,917 344,514 SH   DFND 2 344,514 0 0
SYNEOS HEALTH INC CL A 87166B102 1,441 19,000 SH   DFND 2 19,000 0 0
TABULA RASA HEALTHCARE INC COM 873379101 10,462 227,178 SH   DFND 2 227,178 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 41,130 466,063 SH   DFND 2 466,063 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 5,390 61,071 SH   DFND 3 61,071 0 0
TELADOC HEALTH INC COM 87918A105 46,269 254,577 SH   DFND 2 254,577 0 0
TELEFLEX INCORPORATED COM 879369106 50,421 121,361 SH   DFND 2 121,361 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 16,692 36,574 SH   DFND 2 36,574 0 0
TRADEWEB MKTS INC CL A 892672106 385 5,200 SH   DFND 2 5,200 0 0
TRANSMEDICS GROUP INC COM 89377M109 30,794 742,200 SH   DFND 2 742,200 0 0
TRANSUNION COM 89400J107 333 3,696 SH   DFND 2 3,696 0 0
TRIMBLE INC COM 896239100 373 4,800 SH   DFND 2 4,800 0 0
TRIP COM GROUP LTD ADS 89677Q107 396 10,000 SH   DFND 2 10,000 0 0
TYLER TECHNOLOGIES INC COM 902252105 340 800 SH   DFND 2 800 0 0
ULTA BEAUTY INC COM 90384S303 340 1,100 SH   DFND 2 1,100 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 4,668 41,000 SH   DFND 2 41,000 0 0
UNIQURE NV SHS N90064101 1,162 34,500 SH   DFND 2 34,500 0 0
UNITEDHEALTH GROUP INC COM 91324P102 83,693 224,938 SH   DFND 2 224,938 0 0
UNITEDHEALTH GROUP INC COM 91324P102 49,278 132,443 SH   DFND 3 132,443 0 0
UNIVERSAL DISPLAY CORP COM 91347P105 323 1,365 SH   DFND 2 1,365 0 0
VEEVA SYS INC CL A COM 922475108 39,917 152,800 SH   DFND 2 152,800 0 0
VERISIGN INC COM 92343E102 338 1,700 SH   DFND 2 1,700 0 0
VERISK ANALYTICS INC COM 92345Y106 307 1,739 SH   DFND 2 1,739 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 18,824 87,600 SH   DFND 2 87,600 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 83,615 389,104 SH   DFND 3 389,104 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 193,401 900,000 SH   DFND 1,2 900,000 0 0
VOCERA COMMUNICATONS INC COM 92857F107 18,926 492,107 SH   DFND 2 492,107 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 150 31,800 SH   DFND 2 31,800 0 0
WABTEC COM 929740108 332 4,200 SH   DFND 2 4,200 0 0
WATSCO INC COM 942622200 339 1,300 SH   DFND 2 1,300 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 14,602 2,602,858 SH   DFND 1,2 2,602,858 0 0
XENCOR INC COM 98401F105 2,286 53,100 SH   DFND 2 53,100 0 0
ZAI LAB LTD ADR 98887Q104 11,542 86,500 SH   DFND 2 86,500 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 44,836 280,082 SH   DFND 2 280,082 0 0