The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AERIE PHARMACEUTICALS INC COM 00771V108 18,510 1,156,142 SH   DFND 2 1,156,142 0 0
ALIGN TECHNOLOGY INC COM 016255101 20,425 33,428 SH   DFND 2 33,428 0 0
ALLEGION PLC ORD SHS G0176J109 4,995 35,856 SH   DFND 2 4,241 0 31,615
ALPHABET INC CAP STK CL C 02079K107 939,116 374,699 SH   DFND 2 189,752 0 184,947
ALPHABET INC CAP STK CL C 02079K107 66,844 26,670 SH   DFND 1 26,670 0 0
ALPHABET INC CAP STK CL A 02079K305 2,122 869 SH   DFND 2 0 0 869
AMAZON INC COM 023135106 773,499 224,844 SH   DFND 2 113,734 0 111,110
AMAZON INC COM 023135106 55,290 16,072 SH   DFND 1 16,072 0 0
AMDOCS LTD SHS G02602103 868 11,219 SH   DFND 1 11,219 0 0
AMDOCS LTD SHS G02602103 338 4,370 SH   DFND 2 4,370 0 0
AMERICAN TOWER CORP NEW COM 03027X100 405,611 1,501,485 SH   DFND 2 751,462 0 750,023
AMERICAN TOWER CORP NEW COM 03027X100 29,610 109,611 SH   DFND 1 109,611 0 0
ANTHEM INC COM 036752103 38,562 101,000 SH   DFND 2 101,000 0 0
ARCO PLATFORM LTD COM CL A G04553106 350 11,427 SH   DFND 2 11,427 0 0
ARCO PLATFORM LTD COM CL A G04553106 243 7,933 SH   DFND 1 7,933 0 0
AUTOMATIC DATA PROCESSING IN COM 053015103 1,705 8,582 SH   DFND 1 8,582 0 0
AUTOMATIC DATA PROCESSING IN COM 053015103 615 3,095 SH   DFND 2 3,095 0 0
AXONICS INC COM 05465P101 20,291 320,000 SH   DFND 2 320,000 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 24,027 247,498 SH   DFND 2 247,498 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 17,844 213,851 SH   DFND 2 213,851 0 0
CARA THERAPEUTICS INC COM 140755109 8,326 583,460 SH   DFND 2 583,460 0 0
CENTENE CORP DEL COM 15135B101 30,248 414,756 SH   DFND 2 414,756 0 0
COGNEX CORP COM 192422103 4,661 55,460 SH   DFND 2 6,548 0 48,912
COHERUS BIOSCIENCES INC COM 19249H103 14,639 1,058,464 SH   DFND 2 1,058,464 0 0
COOPER COS INC COM NEW 216648402 6,147 15,512 SH   DFND 2 1,833 0 13,679
DEX INC COM 252131107 41,419 97,000 SH   DFND 2 97,000 0 0
DOLLAR GEN CORP NEW COM 256677105 626 2,891 SH   DFND 2 2,891 0 0
DOLLAR GEN CORP NEW COM 256677105 1,659 7,669 SH   DFND 1 7,669 0 0
DROPBOX INC CL A 26210C104 7,406 244,333 SH   DFND 2 28,908 0 215,425
ECOLAB INC COM 278865100 359,643 1,746,093 SH   DFND 2 888,119 0 857,974
ECOLAB INC COM 278865100 26,001 126,238 SH   DFND 1 126,238 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 36,101 348,564 SH   DFND 2 294,494 0 54,070
ELECTRONIC ARTS INC COM 285512109 5,098 35,443 SH   DFND 2 7,062 0 28,381
ELECTRONIC ARTS INC COM 285512109 1,198 8,328 SH   DFND 1 8,328 0 0
EXACT SCIENCES CORP COM 30063P105 32,636 262,541 SH   DFND 2 220,307 0 42,234
FIDELITY NATL INFORMATION SV COM 31620M106 1,292 9,119 SH   DFND 1 9,119 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 504 3,556 SH   DFND 2 3,556 0 0
FIRST REP BK SAN FRANCISCO C COM 33616C100 402,751 2,151,791 SH   DFND 2 1,112,580 0 1,039,211
FIRST REP BK SAN FRANCISCO C COM 33616C100 29,860 159,533 SH   DFND 1 159,533 0 0
FISERV INC COM 337738108 276,290 2,584,811 SH   DFND 2 1,359,249 0 1,225,562
FISERV INC COM 337738108 22,020 206,008 SH   DFND 1 206,008 0 0
GLAUKOS CORP COM 377322102 16,729 197,212 SH   DFND 2 197,212 0 0
GLOBAL PMTS INC COM 37940X102 5,690 30,341 SH   DFND 2 3,592 0 26,749
GLOBANT S A COM L44385109 679 3,100 SH   DFND 2 3,100 0 0
GLOBANT S A COM L44385109 460 2,100 SH   DFND 1 2,100 0 0
HDFC BANK LTD SPONSORED ADS 40415F101 20,323 277,946 SH   DFND 1 277,946 0 0
HDFC BANK LTD SPONSORED ADS 40415F101 212,379 2,904,526 SH   DFND 2 1,423,089 0 1,481,437
HERON THERAPEUTICS INC COM 427746102 18,656 1,202,069 SH   DFND 2 1,202,069 0 0
HOME DEPOT INC COM 437076102 719,832 2,257,305 SH   DFND 2 1,150,660 0 1,106,645
HOME DEPOT INC COM 437076102 52,218 163,749 SH   DFND 1 163,749 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 30,578 326,544 SH   DFND 2 326,544 0 0
HUMANA INC COM 444859102 34,293 77,459 SH   DFND 2 77,459 0 0
ICICI BANK LIMITED ADR 45104G104 115,995 6,783,307 SH   DFND 2 2,370,933 0 4,412,374
ICICI BANK LIMITED ADR 45104G104 9,231 539,800 SH   DFND 1 539,800 0 0
ILLUMINA INC COM 452327109 27,436 57,978 SH   DFND 2 57,978 0 0
INFOSYS LTD SPONSORED ADR 456788108 12,720 600,277 SH   DFND 2 331,715 0 268,562
INFOSYS LTD SPONSORED ADR 456788108 1,261 59,506 SH   DFND 1 59,506 0 0
INSMED INC COM PAR $.01 457669307 9,765 343,110 SH   DFND 2 343,110 0 0
INSULET CORP COM 45784P101 20,014 72,908 SH   DFND 2 72,908 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 1,251 10,542 SH   DFND 1 10,542 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 478 4,023 SH   DFND 2 4,023 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 38,567 41,937 SH   DFND 2 41,937 0 0
IRHYTHM TECHNOLOGIES INC COM 450056106 5,308 80,000 SH   DFND 2 80,000 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 12,384 1,200,000 SH   DFND 2 1,200,000 0 0
KRYSTAL BIOTECH INC COM 501147102 12,635 185,809 SH   DFND 2 185,809 0 0
LHC GROUP INC COM 50187A107 22,160 110,657 SH   DFND 2 110,657 0 0
MCCORMICK & CO INC COM NON VTG 579780206 2,970 33,624 SH   DFND 2 3,998 0 29,626
MCDONALDS CORP COM 580135101 948 4,104 SH   DFND 1 4,104 0 0
MCDONALDS CORP COM 580135101 371 1,605 SH   DFND 2 1,605 0 0
MERCADOLIBRE INC COM 58733R102 4,536 2,912 SH   DFND 2 703 0 2,209
MERCADOLIBRE INC COM 58733R102 433 278 SH   DFND 1 278 0 0
MICROSOFT CORP COM 594918104 732,804 2,705,071 SH   DFND 2 1,353,483 0 1,351,588
MICROSOFT CORP COM 594918104 51,904 191,600 SH   DFND 1 191,600 0 0
MSCI INC COM 55354G100 4,074 7,642 SH   DFND 2 910 0 6,732
NEXTERA ENERGY INC COM 65339F101 375,175 5,119,750 SH   DFND 2 2,392,762 0 2,726,988
NEXTERA ENERGY INC COM 65339F101 24,828 338,806 SH   DFND 1 338,806 0 0
NOVOCURE LTD ORD SHS G6674U108 24,796 111,784 SH   DFND 2 111,784 0 0
OAK STR HEALTH INC COM 67181A107 13,350 227,933 SH   DFND 2 227,933 0 0
PAGSEGURO DIGITAL LTD COM CL A G68707101 390 6,971 SH   DFND 1 6,971 0 0
PAGSEGURO DIGITAL LTD COM CL A G68707101 524 9,366 SH   DFND 2 9,366 0 0
PROCTER AND GAMBLE CO COM 742718109 29,391 217,823 SH   DFND 1 217,823 0 0
PROCTER AND GAMBLE CO COM 742718109 407,533 3,020,332 SH   DFND 2 1,538,209 0 1,482,123
PTC INC COM 69370C100 5,178 36,659 SH   DFND 2 4,336 0 32,323
QUIDEL CORP COM 74838J101 20,499 160,000 SH   DFND 2 160,000 0 0
REPUBLIC SVCS INC COM 760759100 765 6,955 SH   DFND 1 6,955 0 0
REPUBLIC SVCS INC COM 760759100 299 2,714 SH   DFND 2 2,714 0 0
RESMED INC COM 761152107 5,382 21,830 SH   DFND 2 2,583 0 19,247
ROBERT HALF INTL INC COM 770323103 716 8,043 SH   DFND 1 8,043 0 0
ROBERT HALF INTL INC COM 770323103 218 2,453 SH   DFND 2 2,453 0 0
S&P GLOBAL INC COM 78409V104 419,259 1,021,462 SH   DFND 2 520,358 0 501,104
S&P GLOBAL INC COM 78409V104 31,618 77,033 SH   DFND 1 77,033 0 0
SAREPTA THERAPEUTICS INC COM 803607100 9,354 120,329 SH   DFND 2 120,329 0 0
SEA LTD SPONSORD ADS 81141R100 197,695 719,939 SH   DFND 2 232,955 0 486,984
SEA LTD SPONSORD ADS 81141R100 16,929 61,651 SH   DFND 1 61,651 0 0
SERVICE CORP INTL COM 817565104 6,325 118,032 SH   DFND 2 17,627 0 100,405
SERVICE CORP INTL COM 817565104 453 8,460 SH   DFND 1 8,460 0 0
SMITH A O CORP COM 831865209 6,225 86,386 SH   DFND 2 10,228 0 76,158
STONECO LTD COM CL A G85158106 411 6,122 SH   DFND 2 6,122 0 0
STONECO LTD COM CL A G85158106 319 4,753 SH   DFND 1 4,753 0 0
SYNOPSYS INC COM 871607107 6,106 22,140 SH   DFND 2 2,622 0 19,518
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 40,157 334,196 SH   DFND 1 334,196 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 57,123 475,387 SH   DFND 2 383,001 0 92,386
TELADOC HEALTH INC COM 87918A105 19,123 115,000 SH   DFND 2 115,000 0 0
TELEFLEX INCORPORATED COM 879369106 23,304 58,000 SH   DFND 2 58,000 0 0
THERAPEUTICSMD INC COM 88338N107 7,366 6,189,834 SH   DFND 2 6,189,834 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 783,510 1,553,134 SH   DFND 2 839,468 0 713,666
THERMO FISHER SCIENTIFIC INC COM 883556102 54,335 107,708 SH   DFND 1 107,708 0 0
TRANSUNION COM 89400J107 6,431 58,565 SH   DFND 2 9,161 0 49,404
TRANSUNION COM 89400J107 729 6,637 SH   DFND 1 6,637 0 0
TREACE MED CONCEPTS INC COM ADDED 89455T109 156 5,000 SH   DFND 2 5,000 0 0
TRIP COM GROUP LTD ADS 89677Q107 61,480 1,733,774 SH   DFND 2 563,089 0 1,170,685
TRIP COM GROUP LTD ADS 89677Q107 5,271 148,650 SH   DFND 1 148,650 0 0
TYLER TECHNOLOGIES INC COM 902252105 2,970 6,566 SH   DFND 2 780 0 5,786
VERTEX PHARMACEUTICALS INC COM 92532F100 21,888 108,557 SH   DFND 2 108,557 0 0
VISA INC COM CL A 92826C839 990,744 4,237,207 SH   DFND 2 2,166,718 0 2,070,489
VISA INC COM CL A 92826C839 73,266 313,345 SH   DFND 1 313,345 0 0
VOCERA MUNICATIONS INC COM 92857F107 7,574 190,058 SH   DFND 2 190,058 0 0
WASTE MGMT INC DEL COM 94106L109 676 4,828 SH   DFND 2 4,828 0 0
WASTE MGMT INC DEL COM 94106L109 1,734 12,376 SH   DFND 1 12,376 0 0
WATERS CORP COM 941848103 7,272 21,040 SH   DFND 2 2,491 0 18,549
WILLIS TOWERS WATSON PLC LTD SHS G96629103 1,142 4,963 SH   DFND 1 4,963 0 0
WILLIS TOWERS WATSON PLC LTD SHS G96629103 445 1,936 SH   DFND 2 1,936 0 0
XYLEM INC COM 98419M100 6,052 50,454 SH   DFND 2 5,978 0 44,476