The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CL A COM 88025U109 143,826 734,481 SH   SOLE 1,2,3 734,481 0 0
5 01 ACQUISITION CORP COM CL A 33836P105 3,908 392,000 SH   SOLE 1,2,3 392,000 0 0
908 DEVICES INC COM 65443P102 1,550 40,000 SH   SOLE 1,2,3 40,000 0 0
ACUTUS MED INC COM 005111109 7,672 451,834 SH   SOLE 1,2,3 451,834 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 25,753 7,357,917 SH   SOLE 1,2,3 7,357,917 0 0
AGENUS INC COM NEW 00847G705 62,790 11,437,238 SH   SOLE 1,2,3 11,437,238 0 0
AKOYA BIOSCIENCES INC COM 00974H104 1,934 100,000 SH   SOLE 1,2,3 100,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 285,364 1,683,362 SH   SOLE 1,2,3 1,683,362 0 0
APTEVO THERAPEUTICS INC COM NEW 03835L207 6,312 281,402 SH   SOLE 1,2,3 281,402 0 0
APYX MEDICAL CORPORATION COM 03837C106 34,964 3,391,279 SH   SOLE 1,2,3 3,391,279 0 0
ARBUTUS BIOPHARMA CORP COM 03879J100 18,114 5,978,355 SH   SOLE 1,2,3 5,978,355 0 0
ARGENX SE SPONSORED ADR 04016X101 9,560 31,752 SH   SOLE 1,2 31,752 0 0
ARYA SCIENCES ACQU CORP IV CL A G31659108 5,360 500,000 SH   SOLE 1,2,3 500,000 0 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 10,725 3,250,000 SH   SOLE 1,2,3 3,250,000 0 0
ATHIRA PHARMA INC COM 04746L104 19,523 1,906,557 SH   SOLE 1,2,3 1,906,557 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 38,643 5,741,939 SH   SOLE 1,2,3 5,741,939 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 98,716 3,995,000 SH   SOLE 1,2,3 3,995,000 0 0
AVITA MEDICAL INC COM 05380C102 5,746 280,000 SH   SOLE 1,2,3 280,000 0 0
AXONICS INC COM 05465P101 123,260 1,943,864 SH   SOLE 1,2,3 1,943,864 0 0
AXSOME THERAPEUTICS INC COM 05464T104 109,049 1,616,497 SH   SOLE 1,2,3 1,616,497 0 0
AZIYO BIOLOGICS INC COM CL A 05479K106 1,201 125,000 SH   SOLE 1,2,3 125,000 0 0
BCLS ACQUISITION CORP COM CL A G0904B105 6,450 612,500 SH   SOLE 1,2,3 612,500 0 0
BCTG ACQUISITION CORP COM 05492W103 6,828 600,000 SH   SOLE 1,2,3 600,000 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 15,441 4,968,017 SH   SOLE 1,2,3 4,968,017 0 0
BERKELEY LTS INC COM 084310101 11,541 257,546 SH   SOLE 1,2,3 257,546 0 0
BIODESIX INC COM 09075X108 1,651 125,000 SH   SOLE 1,2,3 125,000 0 0
BIOMEA FUSION INC COM 09077A106 12,270 830,794 SH   SOLE 1,2,3 830,794 0 0
BOLT BIOTHERAPEUTICS INC COM 097702104 1,954 126,365 SH   SOLE 1,2,3 126,365 0 0
BRAINSWAY LTD SPONSORED ADS 10501L106 16,342 1,602,181 SH   SOLE 1,2,3 1,602,181 0 0
BURNING ROCK BIOTECH LTD SPONSORED ADS 12233L107 884 30,000 SH   SOLE 1,2,3 30,000 0 0
C4 THERAPEUTICS INC COM STK 12529R107 81,327 2,149,228 SH   SOLE 1,2,3 2,149,228 0 0
CASTLE BIOSCIENCES INC COM 14843C105 58,591 799,009 SH   SOLE 1,2,3 799,009 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 130,715 3,908,947 SH   SOLE 1,2,3 3,908,947 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128 12,810 500,000 SH   SOLE 1,2,3 500,000 0 0
CEREVEL THERAPEUTICS HLDNG I *W EXP 06/09/202 15678U102 2,398 166,666 SH   SOLE 1,2,3 166,666 0 0
CHARDAN HEALTHCR ACQSTN 2 CO COM 15957T107 8,299 837,540 SH   SOLE 1,2,3 837,540 0 0
CHARDAN HEALTHCR ACQSTN 2 CO UNIT 99/99/9999 15957T206 3,644 350,000 SH   SOLE 1,2,3 350,000 0 0
CLEARSIDE BIOMEDICAL INC COM 185063104 20,487 4,206,765 SH   SOLE 1,2,3 4,206,765 0 0
CODEX DNA INC COM 192003101 4,400 200,000 SH   SOLE 1,2,3 200,000 0 0
CONNECT BIOPHARMA HLDGS LTD ADS 207523101 8,789 450,000 SH   SOLE 1,2,3 450,000 0 0
CUTERA INC COM 232109108 35,342 720,817 SH   SOLE 1,2,3 720,817 0 0
CVRX INC COM 126638105 4,200 150,000 SH   SOLE 1,2,3 150,000 0 0
CYTOKINETICS INC COM NEW 23282W605 39,580 2,000,000 SH   SOLE 1,2,3 2,000,000 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 8,868 1,400,939 SH   SOLE 1,2,3 1,400,939 0 0
DERMTECH INC COM 24984K105 129,643 3,118,665 SH   SOLE 1,2,3 3,118,665 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 280,716 7,521,859 SH   SOLE 1,2,3 7,521,859 0 0
ESSA PHARMA INC COM NEW 29668H708 87,250 3,053,919 SH   SOLE 1,2,3 3,053,919 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108 202,554 2,319,138 SH   SOLE 1,2,3 2,319,138 0 0
EXAGEN INC COM 30068X103 12,313 821,414 SH   SOLE 1,2,3 821,414 0 0
FULCRUM THERAPEUTICS INC COM 359616109 33,591 3,205,291 SH   SOLE 1,2,3 3,205,291 0 0
GENETRON HLDGS LTD ADS 37186H100 36,618 1,818,162 SH   SOLE 1,2,3 1,818,162 0 0
GH RESEARCH PLC ORDINARY SHARES G3855L106 42,661 2,168,957 SH   SOLE 1,2,3 2,168,957 0 0
GLOBUS MED INC CL A 379577208 129,538 1,670,811 SH   SOLE 1,2,3 1,670,811 0 0
GUARDANT HEALTH INC COM 40131M109 114,038 918,253 SH   SOLE 1,2,3 918,253 0 0
HELIX ACQUISITION CORP COM CL A G4444C102 7,763 750,000 SH   SOLE 1,2,3 750,000 0 0
IDEAYA BIOSCIENCES INC COM 45166A102 68,559 3,266,255 SH   SOLE 1,2,3 3,266,255 0 0
ILLUMINA INC COM 452327109 228,462 482,791 SH   SOLE 1,2,3 482,791 0 0
IMMATICS N.V SHS N44445109 4,064 350,000 SH   SOLE 1,2,3 350,000 0 0
IMMUNIC INC COM 4525EP101 11,289 920,814 SH   SOLE 1,2,3 920,814 0 0
IMMUNOCORE HLDGS PLC ADS 45258D105 47,888 1,245,532 SH   SOLE 1,2,3 1,245,532 0 0
INMODE LTD SHS M5425M103 11,835 124,999 SH   SOLE 1,2 124,999 0 0
ITAMAR MED LTD SPONSORED ADS 465437101 6,326 268,609 SH   SOLE 1,2,3 268,609 0 0
ITEOS THERAPEUTICS INC COM 46565G104 44,030 1,716,585 SH   SOLE 1,2,3 1,716,585 0 0
IVERIC BIO INC COM 46583P102 42,420 6,722,624 SH   SOLE 1,2,3 6,722,624 0 0
JOHNSON & JOHNSON COM 478160104 28,095 170,542 SH   SOLE 1,2,3 170,542 0 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 9,963 2,327,903 SH   SOLE 1,2,3 2,327,903 0 0
LANDOS BIOPHARMA INC COM 515069102 48,457 4,275,722 SH   SOLE 1,2,3 4,275,722 0 0
LIFESCI ACQUISITION II CORP COM 53229E103 9,750 975,000 SH   SOLE 1,2,3 975,000 0 0
MACROGENICS INC COM 556099109 68,410 2,546,925 SH   SOLE 1,2,3 2,546,925 0 0
MARAVAI LIFESCIENCES HLDGS I COM CL A 56600D107 2,921 70,000 SH   SOLE 1,2,3 70,000 0 0
MASIMO CORP COM 574795100 200,315 826,210 SH   SOLE 1,2,3 826,210 0 0
MEDICUS SCIENCES ACQUISITION *W EXP 02/12/202 G5960S124 34 33,331 SH   SOLE 1,2,3 33,331 0 0
MEDICUS SCIENCES ACQUISITION CL A SHS G5960S108 2,895 300,000 SH   SOLE 1,2,3 300,000 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 23,733 4,315,102 SH   SOLE 1,2,3 4,315,102 0 0
MIMEDX GROUP INC COM 602496101 33,781 2,700,320 SH   SOLE 1,2,3 2,700,320 0 0
MIRATI THERAPEUTICS INC COM 60468T105 235,435 1,457,532 SH   SOLE 1,2,3 1,457,532 0 0
MIROMATRIX MED INC COM 60471P108 3,262 280,000 SH   SOLE 1,2,3 280,000 0 0
MONTE ROSA THERAPEUTICS INC COM 61225M102 25,228 1,214,572 SH   SOLE 1,2,3 1,214,572 0 0
NANOSTRING TECHNOLOGIES INC COM 63009R109 52,093 804,029 SH   SOLE 1,2,3 804,029 0 0
NATERA INC COM 632307104 194,390 1,712,234 SH   SOLE 1,2,3 1,712,234 0 0
NAUTILUS BIOTECHNOLOGY INC COM 63909J108 10,383 1,100,000 SH   SOLE 1,2,3 1,100,000 0 0
NEOGENOMICS INC COM NEW 64049M209 13,139 311,111 SH   SOLE 1,2,3 311,111 0 0
OLINK HLDG AB SPONSORED ADS 680710100 42,963 1,248,188 SH   SOLE 1,2,3 1,248,188 0 0
OUTSET MED INC COM 690145107 36,843 737,152 SH   SOLE 1,2,3 737,152 0 0
OYSTER PT PHARMA INC COM 69242L106 31,994 1,861,209 SH   SOLE 1,2,3 1,861,209 0 0
PERSONALIS INC COM 71535D106 3,226 127,501 SH   SOLE 1,2 127,501 0 0
PMV PHARMACEUTICALS INC COM 69353Y103 16,538 484,133 SH   SOLE 1,2,3 484,133 0 0
PROFOUND MED CORP COM NEW 74319B502 1,998 122,098 SH   SOLE 1,2,3 122,098 0 0
PROGENITY INC COM 74319F107 357 100,000 SH   SOLE 1,2,3 100,000 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108 75,989 3,264,031 SH   SOLE 1,2,3 3,264,031 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 43,427 6,443,113 SH   SOLE 1,2,3 6,443,113 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 157,412 3,507,390 SH   SOLE 1,2,3 3,507,390 0 0
PTC THERAPEUTICS INC COM 69366J200 223,776 5,293,966 SH   SOLE 1,2,3 5,293,966 0 0
PULMONX CORP COM 745848101 49,838 1,129,600 SH   SOLE 1,2,3 1,129,600 0 0
QUIDEL CORP COM 74838J101 112,558 878,533 SH   SOLE 1,2,3 878,533 0 0
REGENXBIO INC COM 75901B107 68,288 1,757,743 SH   SOLE 1,2,3 1,757,743 0 0
RELMADA THERAPEUTICS INC COM 75955J402 49,232 1,538,026 SH   SOLE 1,2,3 1,538,026 0 0
RESEARCH ALLIANCE CORP II COM CL A 760873109 6,459 637,000 SH   SOLE 1,2,3 637,000 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 663,920 14,990,286 SH   SOLE 1,2,3 14,990,286 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 4,671 161,612 SH   SOLE 1,2,3 161,612 0 0
SINGULAR GENOMICS SYSTEMS IN COM 82933R100 2,748 100,000 SH   SOLE 1,2,3 100,000 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 426,457 996,255 SH   SOLE 1,2,3 996,255 0 0
STOKE THERAPEUTICS INC COM 86150R107 122,665 3,644,248 SH   SOLE 1,2,3 3,644,248 0 0
SUMMIT HEALTHCRE ACQUISTN CO UNIT 06/03/2026 G8566R128 5,005 500,000 SH   SOLE 1,2,3 500,000 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 111,758 1,147,408 SH   SOLE 1,2,3 1,147,408 0 0
TARSUS PHARMACEUTICALS INC COM 87650L103 58,354 2,013,601 SH   SOLE 1,2,3 2,013,601 0 0
TELA BIO INC COM 872381108 22,432 1,392,434 SH   SOLE 1,2,3 1,392,434 0 0
THERAPEUTICS ACQUISITION COR COM CL A 88339T103 5,034 490,000 SH   SOLE 1,2,3 490,000 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 20,286 2,091,389 SH   SOLE 1,2,3 2,091,389 0 0
TWIST BIOSCIENCE CORP COM 90184D100 2,462 18,473 SH   SOLE 1,2,3 18,473 0 0
VERICEL CORP COM 92346J108 237,172 4,517,570 SH   SOLE 1,2,3 4,517,570 0 0
VINCERX PHARMA INC COM NEW 92731L106 9,742 749,999 SH   SOLE 1,2,3 749,999 0 0
ZYMERGEN INC COM 98985X100 2,801 70,000 SH   SOLE 1,2,3 70,000 0 0