The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
1LIFE HEALTHCARE INC COM 68269G107 27,644 836,190 SH   DFND 2 836,190 0 0
10X GENOMICS INC CL A COM 88025U109 45,562 232,672 SH   DFND 2 232,672 0 0
ABBOTT LABS COM 002824100 159,693 1,377,499 SH   DFND 2 1,377,499 0 0
ABBVIE INC COM 00287Y109 36,518 324,200 SH   DFND 2 324,200 0 0
ABIOMED INC COM 003654100 47,184 151,178 SH   DFND 2 151,178 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 1,607 65,900 SH   DFND 2 65,900 0 0
ACCOLADE INC COM 00437E102 37,391 688,479 SH   DFND 2 688,479 0 0
ACCOLADE INC COM 00437E102 56,277 1,036,220 SH   DFND 3 1,036,220 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 39,322 962,352 SH   DFND 3 962,352 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 399 2,700 SH   DFND 2 2,700 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 2,645 48,000 SH   DFND 2 48,000 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 237,248 4,304,992 SH   DFND 1,2 4,304,992 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 2,627 14,300 SH   DFND 2 14,300 0 0
ALIGN TECHNOLOGY INC COM 016255101 95,786 156,770 SH   DFND 2 156,770 0 0
ALLAKOS INC COM 01671P100 1,579 18,500 SH   DFND 2 18,500 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 8,985 53,000 SH   DFND 2 53,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 188,167 1,110,000 SH   DFND 1,2 1,110,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 65,450 386,092 SH   DFND 3 386,092 0 0
AMEDISYS INC COM 023436108 14,815 60,487 SH   DFND 2 60,487 0 0
AMERICAN EXPRESS CO COM 025816109 430 2,600 SH   DFND 2 2,600 0 0
AMERICAN WELL CORP CL A 03044L105 26,943 2,141,758 SH   DFND 2 2,141,758 0 0
AMGEN INC COM 031162100 10,201 41,850 SH   DFND 2 41,850 0 0
AMGEN INC COM 031162100 21,384 87,730 SH   DFND 3 87,730 0 0
ANSYS INC COM 03662Q105 312 900 SH   DFND 2 900 0 0
ANTHEM INC COM 036752103 105,063 275,179 SH   DFND 2 275,179 0 0
ANTHEM INC COM 036752103 72,846 190,797 SH   DFND 3 190,797 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 3,034 48,000 SH   DFND 2 48,000 0 0
ARCUS BIOSCIENCES INC COM 03969F109 2,060 75,000 SH   DFND 2 75,000 0 0
ARGENX SE SPONSORED ADR 04016X101 5,570 18,500 SH   DFND 2 18,500 0 0
ARGENX SE SPONSORED ADR 04016X101 287,684 955,538 SH   DFND 1,2 955,538 0 0
ARVINAS INC COM 04335A105 4,659 60,500 SH   DFND 2 60,500 0 0
ARVINAS INC COM 04335A105 167,622 2,176,903 SH   DFND 1,2 2,176,903 0 0
ASPEN TECHNOLOGY INC COM 045327103 330 2,400 SH   DFND 2 2,400 0 0
ATRICURE INC COM 04963C209 29,703 374,418 SH   DFND 3 374,418 0 0
AVALARA INC COM 05338G106 372 2,300 SH   DFND 2 2,300 0 0
AVANTOR INC COM 05352A100 18,189 512,216 SH   DFND 2 512,216 0 0
AXONICS INC COM 05465P101 63,402 999,881 SH   DFND 2 999,881 0 0
AXONICS INC COM 05465P101 46,327 730,590 SH   DFND 3 730,590 0 0
AXSOME THERAPEUTICS INC COM 05464T104 23,747 352,021 SH   DFND 3 352,021 0 0
BAXTER INTL INC COM 071813109 72,500 900,623 SH   DFND 2 900,623 0 0
BEAM THERAPEUTICS INC COM 07373V105 772 6,000 SH   DFND 2 6,000 0 0
BEAM THERAPEUTICS INC COM 07373V105 78,104 606,821 SH   DFND 1,2 606,821 0 0
BECTON DICKINSON & CO COM 075887109 112,102 460,965 SH   DFND 2 460,965 0 0
BEIGENE LTD SPONSORED ADR 07725L102 28,931 84,300 SH   DFND 2 84,300 0 0
BERKELEY LTS INC COM 084310101 17,252 385,014 SH   DFND 2 385,014 0 0
BIOGEN INC COM 09062X103 9,730 28,100 SH   DFND 2 28,100 0 0
BIOGEN INC COM 09062X103 173,135 500,000 SH   DFND 1,2 500,000 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 3,495 36,000 SH   DFND 2 36,000 0 0
BIONTECH SE SPONSORED ADS 09075V102 5,060 22,600 SH   DFND 2 22,600 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 3,379 40,500 SH   DFND 2 40,500 0 0
BIO RAD LABS INC CL A 090572207 56,247 87,301 SH   DFND 3 87,301 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 280 23,000 SH   DFND 2 23,000 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 41,934 3,440,000 SH   DFND 1,2 3,440,000 0 0
BOOKING HOLDINGS INC COM 09857L108 350 160 SH   DFND 2 160 0 0
BOSTON SCIENTIFIC CORP COM 101137107 99,493 2,326,787 SH   DFND 2 2,326,787 0 0
BRIGHT HEALTH GROUP INC COM 10920V107 25,740 1,500,000 SH   DFND 2 1,500,000 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 4,510 67,500 SH   DFND 2 67,500 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 93,276 1,395,932 SH   DFND 3 1,395,932 0 0
BROWN FORMAN CORP CL B 115637209 345 4,600 SH   DFND 2 4,600 0 0
BURNING ROCK BIOTECH LTD SPONSORED ADR 12233L107 14,432 489,890 SH   DFND 2 489,890 0 0
C4 THERAPEUTICS INC COM STK 12529R107 1,173 31,000 SH   DFND 2 31,000 0 0
CAREDX INC COM 14167L103 13,625 148,871 SH   DFND 3 148,871 0 0
CARMAX INC COM 143130102 368 2,850 SH   DFND 2 2,850 0 0
CATALENT INC COM 148806102 292 2,700 SH   DFND 2 2,700 0 0
CELLECTIS S A SPON ADS 15117K103 1,292 83,500 SH   DFND 2 83,500 0 0
CENTENE CORP DEL COM 15135B101 101,103 1,386,297 SH   DFND 2 1,386,297 0 0
CHARLES RIV LABS INTL INC COM 159864107 65,946 178,270 SH   DFND 3 178,270 0 0
CIGNA CORP NEW COM 125523100 60,866 256,742 SH   DFND 2 256,742 0 0
CLOROX CO DEL COM 189054109 360 2,000 SH   DFND 2 2,000 0 0
CONSTELLATION BRANDS INC CL A 21036P108 341 1,459 SH   DFND 2 1,459 0 0
COOPER COS INC COM NEW 216648402 29,429 74,266 SH   DFND 2 74,266 0 0
COSTAR GROUP INC COM 22160N109 290 3,500 SH   DFND 2 3,500 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 2,801 17,300 SH   DFND 2 17,300 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 153,728 949,584 SH   DFND 1,2 949,584 0 0
CUREVAC N V COM N2451R105 39 70 SH Call DFND 2 70 0 0
CVS HEALTH CORP COM 126650100 13,363 160,148 SH   DFND 2 160,148 0 0
CYBERARK SOFTWARE LTD SHS M2682V108 274 2,100 SH   DFND 2 2,100 0 0
DANAHER CORPORATION COM 235851102 129,602 482,940 SH   DFND 2 482,940 0 0
DENTSPLY SIRONA INC COM 24906P109 10,067 159,129 SH   DFND 2 159,129 0 0
DEXCOM INC COM 252131107 104,519 244,776 SH   DFND 2 244,776 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 2,277 61,000 SH   DFND 2 61,000 0 0
DOLBY LABORATORIES INC COM CL A 25659T107 354 3,600 SH   DFND 2 3,600 0 0
DOMINOS PIZZA INC COM 25754A201 466 1,000 SH   DFND 2 1,000 0 0
DR REDDYS LABS LTD ADR 256135203 625 8,500 SH   DFND 2 8,500 0 0
EARGO INC COM 270087109 17,323 434,054 SH   DFND 2 434,054 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 92,204 890,256 SH   DFND 2 890,256 0 0
ELECTRONIC ARTS INC COM 285512109 326 2,270 SH   DFND 2 2,270 0 0
ENTEGRIS INC COM 29362U104 369 3,000 SH   DFND 2 3,000 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 871 41,200 SH   DFND 2 41,200 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 94,709 4,477,964 SH   DFND 1,2 4,477,964 0 0
ESSA PHARMA INC COM NEW 29668H708 543 19,000 SH   DFND 2 19,000 0 0
ESSA PHARMA INC COM NEW 29668H708 69,734 2,440,814 SH   DFND 1,2 2,440,814 0 0
EVOLENT HEALTH INC CL A 30050B101 34,927 1,653,761 SH   DFND 2 1,653,761 0 0
EVOLENT HEALTH INC CL A 30050B101 41,916 1,984,650 SH   DFND 3 1,984,650 0 0
EXACT SCIENCES CORP COM 30063P105 34,269 275,673 SH   DFND 3 275,673 0 0
EXELIXIS INC COM 30161Q104 1,767 97,000 SH   DFND 2 97,000 0 0
EXELIXIS INC COM 30161Q104 51,654 2,835,000 SH   DFND 1,2 2,835,000 0 0
FACTSET RESH SYS INC COM 303075105 352 1,050 SH   DFND 2 1,050 0 0
FASTENAL CO COM 311900104 364 7,000 SH   DFND 2 7,000 0 0
FATE THERAPEUTICS INC COM 31189P102 5,832 67,200 SH   DFND 2 67,200 0 0
FATE THERAPEUTICS INC COM 31189P102 220,997 2,546,336 SH   DFND 1,2 2,546,336 0 0
FORTINET INC COM 34959E109 524 2,200 SH   DFND 2 2,200 0 0
GARTNER INC COM 366651107 509 2,100 SH   DFND 2 2,100 0 0
GENERATION BIO CO COM 37148K100 673 25,000 SH   DFND 2 25,000 0 0
GENERATION BIO CO COM 37148K100 65,991 2,453,180 SH   DFND 1,2 2,453,180 0 0
GENETRON HLDGS LTD ADS 37186H100 14,564 723,137 SH   DFND 2 723,137 0 0
GILEAD SCIENCES INC COM 375558103 7,643 111,000 SH   DFND 2 111,000 0 0
GLAUKOS CORP COM 377322102 42,027 495,432 SH   DFND 2 495,432 0 0
GLOBUS MED INC CL A 379577208 56,552 729,420 SH   DFND 2 729,420 0 0
GRACO INC COM 384109104 341 4,500 SH   DFND 2 4,500 0 0
GUARDANT HEALTH INC COM 40131M109 47,144 379,609 SH   DFND 2 379,609 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 40,528 892,500 SH   DFND 2 892,500 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 60,485 1,331,966 SH   DFND 1,2 1,331,966 0 0
HCA HEALTHCARE INC COM 40412C101 69,108 334,273 SH   DFND 2 334,273 0 0
HEALTH CATALYST INC COM 42225T107 41,834 753,621 SH   DFND 2 753,621 0 0
HILL-ROM HLDGS INC COM 431475102 76,546 673,878 SH   DFND 3 673,878 0 0
HOLOGIC INC COM 436440101 26,006 389,779 SH   DFND 2 389,779 0 0
HOLOGIC INC COM 436440101 34,959 523,973 SH   DFND 3 523,973 0 0
HOMOLOGY MEDICINES INC COM 438083107 12,629 1,737,122 SH   DFND 1,2 1,737,122 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 39,113 417,700 SH   DFND 2 417,700 0 0
HUMANA INC COM 444859102 63,415 143,239 SH   DFND 2 143,239 0 0
HUMANA INC COM 444859102 61,767 139,516 SH   DFND 3 139,516 0 0
HUTCHMED CHINA LTD SPONSORED ADS 44842L103 33,959 864,760 SH   DFND 3 864,760 0 0
IDEXX LABS INC COM 45168D104 74,599 118,120 SH   DFND 2 118,120 0 0
ILLUMINA INC COM 452327109 35,647 75,330 SH   DFND 2 75,330 0 0
I MAB SPONSORED ADS 44975P103 15,401 183,457 SH   DFND 2 183,457 0 0
INCYTE CORP COM 45337C102 6,259 74,400 SH   DFND 2 74,400 0 0
INCYTE CORP COM 45337C102 243,725 2,897,000 SH   DFND 1,2 2,897,000 0 0
INOGEN INC COM 45780L104 18,304 280,863 SH   DFND 2 280,863 0 0
INSMED INC COM PAR $.01 457669307 88,821 3,120,901 SH   DFND 3 3,120,901 0 0
INSPIRE MED SYS INC COM 457730109 72,130 373,226 SH   DFND 2 373,226 0 0
INSULET CORP COM 45784P101 88,425 322,119 SH   DFND 2 322,119 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 356 3,000 SH   DFND 2 3,000 0 0
INTERSECT ENT INC COM 46071F103 10,561 617,968 SH   DFND 2 617,968 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101 4,960 121,500 SH   DFND 2 121,500 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101 142,397 3,488,419 SH   DFND 1,2 3,488,419 0 0
INTUIT COM 461202103 441 900 SH   DFND 2 900 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 185,855 202,095 SH   DFND 2 202,095 0 0
IONIS PHARMACEUTICALS INC COM 462222100 7,461 187,050 SH   DFND 2 187,050 0 0
IONIS PHARMACEUTICALS INC COM 462222100 363,516 9,112,973 SH   DFND 1,2 9,112,973 0 0
IONIS PHARMACEUTICALS INC COM 462222100 25,140 630,222 SH   DFND 3 630,222 0 0
IPG PHOTONICS CORP COM 44980X109 285 1,350 SH   DFND 2 1,350 0 0
IQVIA HLDGS INC COM 46266C105 42,988 177,400 SH   DFND 2 177,400 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 7,354 41,400 SH   DFND 2 41,400 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 89,415 503,350 SH   DFND 3 503,350 0 0
JD.COM INC SPON ADR CL A 47215P106 287 3,600 SH   DFND 2 3,600 0 0
JOHNSON & JOHNSON COM 478160104 5,107 31,000 SH   DFND 2 31,000 0 0
JUMIA TECHNOLOGIES AG SPONSORED ADS 48138M105 546 18,000 SH   DFND 2 18,000 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 24,615 4,533,148 SH   DFND 1,2 4,533,148 0 0
KOSMOS ENERGY LTD COM 500688106 1,010 292,000 SH   DFND 2 292,000 0 0
KURA ONCOLOGY INC COM 50127T109 1,209 58,000 SH   DFND 2 58,000 0 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409 9,986 36,200 SH   DFND 2 36,200 0 0
LAUDER ESTEE COS INC CL A 518439104 429 1,348 SH   DFND 2 1,348 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102 16,016 390,163 SH   DFND 2 390,163 0 0
LIVE NATION ENTERTAINMENT IN COM 538034109 412 4,700 SH   DFND 2 4,700 0 0
MACROGENICS INC COM 556099109 1,342 49,950 SH   DFND 2 49,950 0 0
MACROGENICS INC COM 556099109 168,562 6,275,564 SH   DFND 1,2 6,275,564 0 0
MACROGENICS INC COM 556099109 28,217 1,050,512 SH   DFND 3 1,050,512 0 0
MARKEL CORP COM 570535104 356 300 SH   DFND 2 300 0 0
MARKETAXESS HLDGS INC COM 57060D108 307 662 SH   DFND 2 662 0 0
MASIMO CORP COM 574795100 30,964 127,713 SH   DFND 2 127,713 0 0
MATCH GROUP INC NEW COM 57667L107 383 2,378 SH   DFND 2 2,378 0 0
MCCORMICK & CO INC COM NON VTG 579780206 353 4,000 SH   DFND 2 4,000 0 0
MCKESSON CORP COM 58155Q103 465 2,430 SH   DFND 2 2,430 0 0
MEDTRONIC PLC SHS G5960L103 44,640 359,625 SH   DFND 2 359,625 0 0
MERCADOLIBRE INC COM 58733R102 265 170 SH   DFND 2 170 0 0
MERSANA THERAPEUTICS INC COM 59045L106 1,100 81,000 SH   DFND 2 81,000 0 0
MERSANA THERAPEUTICS INC COM 59045L106 38,839 2,860,000 SH   DFND 1,2 2,860,000 0 0
METTLER TOLEDO INTERNATIONAL COM 592688105 374 270 SH   DFND 2 270 0 0
MIRATI THERAPEUTICS INC COM 60468T105 1,179 7,300 SH   DFND 2 7,300 0 0
MODERNA INC COM 60770K107 21,689 92,300 SH   DFND 2 92,300 0 0
MODERNA INC COM 60770K107 575,701 2,450,000 SH   DFND 1,2 2,450,000 0 0
MOLECULAR TEMPLATES INC COM 608550109 673 86,000 SH   DFND 2 86,000 0 0
MOLECULAR TEMPLATES INC COM 608550109 74,623 9,542,621 SH   DFND 1,2 9,542,621 0 0
MOLINA HEALTHCARE INC COM 60855R100 50,292 198,734 SH   DFND 2 198,734 0 0
MOODYS CORP COM 615369105 453 1,250 SH   DFND 2 1,250 0 0
MSCI INC COM 55354G100 435 816 SH   DFND 2 816 0 0
MYOVANT SCIENCES LTD COM G637AM102 1,070 47,000 SH   DFND 2 47,000 0 0
MYOVANT SCIENCES LTD COM G637AM102 118,906 5,222,039 SH   DFND 1,2 5,222,039 0 0
NEKTAR THERAPEUTICS COM 640268108 494 28,800 SH   DFND 2 28,800 0 0
NEKTAR THERAPEUTICS COM 640268108 44,971 2,620,676 SH   DFND 1,2 2,620,676 0 0
NEKTAR THERAPEUTICS COM 640268108 24,915 1,451,928 SH   DFND 3 1,451,928 0 0
NEOGENOMICS INC COM NEW 64049M209 36,963 818,313 SH   DFND 3 818,313 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 9,961 102,351 SH   DFND 2 102,351 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 283,727 2,915,400 SH   DFND 1,2 2,915,400 0 0
NEUROPACE INC COM 641288105 12,084 507,930 SH   DFND 2 507,930 0 0
NEVRO CORP COM 64157F103 30,373 183,201 SH   DFND 2 183,201 0 0
NEW YORK TIMES CO CL A 650111107 327 7,500 SH   DFND 2 7,500 0 0
OLINK HLDG AB SPONSORED ADS 680710100 6,799 197,527 SH   DFND 2 197,527 0 0
OMNICELL INC COM 68213N109 59,608 393,583 SH   DFND 2 393,583 0 0
OPTHEA LTD SPONSORED ADS 68386J208 397 50,000 SH   DFND 2 50,000 0 0
OPTION CARE HEALTH INC COM NEW 68404L201 39,151 1,790,192 SH   DFND 3 1,790,192 0 0
OSCAR HEALTH INC CL A 687793109 14,924 694,136 SH   DFND 2 694,136 0 0
OUTSET MED INC COM 690145107 22,844 457,060 SH   DFND 2 457,060 0 0
PACIFIC BIOSIENCES CALIF IN COM 69404D108 57,461 1,643,159 SH   DFND 2 1,643,159 0 0
PENUMBRA INC COM 70975L107 49,913 182,125 SH   DFND 2 182,125 0 0
PERKINELMER INC COM 714046109 340 2,200 SH   DFND 2 2,200 0 0
PHREESIA INC COM 71944F106 38,162 622,542 SH   DFND 2 622,542 0 0
POOL CORP COM 73278L105 413 900 SH   DFND 2 900 0 0
PRIVIA HEALTH GROUP INC COM 74276R102 23,294 525,000 SH   DFND 2 525,000 0 0
PULMONX CORP COM 745848101 7,788 176,510 SH   DFND 2 176,510 0 0
QUANTERIX CORP COM 74766Q101 37,414 637,815 SH   DFND 2 637,815 0 0
RADIUS HEALTH INC COM NEW 750469207 1,381 75,700 SH   DFND 2 75,700 0 0
RADIUS HEALTH INC COM NEW 750469207 135,992 7,455,714 SH   DFND 1,2 7,455,714 0 0
RECURSION PHARMACEUTICALS IN CL A 75629V104 730 20,000 SH   DFND 2 20,000 0 0
REGENERON PHARMACEUTICALS COM 75886F107 59,015 105,660 SH   DFND 2 105,660 0 0
RELAY THERAPEUTICS INC COM 75943R102 732 20,000 SH   DFND 2 20,000 0 0
RELAY THERAPEUTICS INC COM 75943R102 95,901 2,620,962 SH   DFND 1,2 2,620,962 0 0
RESMED INC COM 761152107 21,730 88,145 SH   DFND 2 88,145 0 0
REVOLUTION MEDICINES INC COM 76155X100 1,577 49,700 SH   DFND 2 49,700 0 0
REVOLUTION MEDICINES INC COM 76155X100 57,294 1,805,105 SH   DFND 1,2 1,805,105 0 0
S&P GLOBAL INC COM 78409V104 493 1,200 SH   DFND 2 1,200 0 0
SAGE THERAPEUTICS INC COM 78667J108 2,221 39,100 SH   DFND 2 39,100 0 0
SAGE THERAPEUTICS INC COM 78667J108 132,089 2,325,104 SH   DFND 1,2 2,325,104 0 0
SANOFI SPONSORED ADR 80105N105 3,581 68,000 SH   DFND 2 68,000 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 650 22,500 SH   DFND 2 22,500 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 65,751 2,275,125 SH   DFND 1,2 2,275,125 0 0
SEAGEN INC COM 81181C104 4,342 27,500 SH   DFND 2 27,500 0 0
SEER INC COM CL A 81578P106 4,462 136,133 SH   DFND 2 136,133 0 0
SENSATA TECHNOLOGIES HLDNG PL SHS G8060N102 342 5,900 SH   DFND 2 5,900 0 0
SERVICE CORP INTL COM 817565104 348 6,500 SH   DFND 2 6,500 0 0
SHOCKWAVE MED INC COM 82489T104 98,074 516,915 SH   DFND 2 516,915 0 0
SIGNIFY HEALTH INC CL A COM 82671G100 6,086 200,000 SH   DFND 2 200,000 0 0
SILK RD MED INC COM 82710M100 19,895 415,683 SH   DFND 2 415,683 0 0
SILK RD MED INC COM 82710M100 42,025 878,076 SH   DFND 3 878,076 0 0
SKYWORKS SOLUTIONS INC COM 83088M102 403 2,100 SH   DFND 2 2,100 0 0
SPOTIFY TECHNOLOGY SA SHS L8681T102 303 1,100 SH   DFND 2 1,100 0 0
STARBUCKS CORP COM 855244109 362 3,234 SH   DFND 2 3,234 0 0
STONECO LTD COM CL A G85158106 288 4,300 SH   DFND 2 4,300 0 0
STRYKER CORPORATION COM 863667101 89,481 344,514 SH   DFND 2 344,514 0 0
SYNEOS HEALTH INC CL A 87166B102 6,309 70,500 SH   DFND 2 70,500 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 53,392 548,173 SH   DFND 2 548,173 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 45,992 472,195 SH   DFND 3 472,195 0 0
TELADOC HEALTH INC COM 87918A105 42,894 257,948 SH   DFND 2 257,948 0 0
TELEFLEX INCORPORATED COM 879369106 40,244 100,161 SH   DFND 2 100,161 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 21,175 41,974 SH   DFND 2 41,974 0 0
TRADEWEB MKTS INC CL A 892672106 440 5,200 SH   DFND 2 5,200 0 0
TRANSMEDICS GROUP INC COM 89377M109 24,221 729,989 SH   DFND 2 729,989 0 0
TRANSUNION COM 89400J107 406 3,696 SH   DFND 2 3,696 0 0
TRIMBLE INC COM 896239100 393 4,800 SH   DFND 2 4,800 0 0
TRIP COM GROUP LTD ADS 89677Q107 355 10,000 SH   DFND 2 10,000 0 0
TYLER TECHNOLOGIES INC COM 902252105 362 800 SH   DFND 2 800 0 0
ULTA BEAUTY INC COM 90384S303 380 1,100 SH   DFND 2 1,100 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 2,040 21,400 SH   DFND 2 21,400 0 0
UNITEDHEALTH GROUP INC COM 91324P102 88,192 220,238 SH   DFND 2 220,238 0 0
UNITEDHEALTH GROUP INC COM 91324P102 49,179 122,813 SH   DFND 3 122,813 0 0
UNIVERSAL DISPLAY CORP COM 91347P105 303 1,365 SH   DFND 2 1,365 0 0
VEEVA SYS INC CL A COM 922475108 53,685 172,647 SH   DFND 2 172,647 0 0
VERISIGN INC COM 92343E102 387 1,700 SH   DFND 2 1,700 0 0
VERISK ANALYTICS INC COM 92345Y106 304 1,739 SH   DFND 2 1,739 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 48,230 239,200 SH   DFND 2 239,200 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 89,623 444,494 SH   DFND 3 444,494 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 211,712 1,050,000 SH   DFND 1,2 1,050,000 0 0
VOCERA COMMUNICATONS INC COM 92857F107 19,921 499,912 SH   DFND 2 499,912 0 0
VOCERA COMMUNICATONS INC COM 92857F107 6,094 152,920 SH   DFND 3 152,920 0 0
WABTEC COM 929740108 346 4,200 SH   DFND 2 4,200 0 0
WATSCO INC COM 942622200 373 1,300 SH   DFND 2 1,300 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 17,335 2,602,858 SH   DFND 1,2 2,602,858 0 0
XENCOR INC COM 98401F105 1,831 53,100 SH   DFND 2 53,100 0 0
ZAI LAB LTD ADR 98887Q104 21,593 122,000 SH   DFND 2 122,000 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 45,043 280,082 SH   DFND 2 280,082 0 0
ZOETIS INC CL A 98978V103 1,323 7,100 SH   DFND 2 7,100 0 0