The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
1Life Healthcare, Inc. Common 68269G107 1,034 31,266 SH   SOLE   31,266 0 0
Abbott Laboratories Common 002824100 87,063 750,997 SH   SOLE   750,997 0 0
AbbVie Inc. Common 00287Y109 69,533 617,303 SH   SOLE   617,303 0 0
ACADIA Pharmaceuticals Inc. Common 004225108 8,092 331,789 SH   SOLE   331,789 0 0
Adaptive Biotechnologies Corp. Common 00650F109 13,799 337,722 SH   SOLE   337,722 0 0
Addus HomeCare Corp. Common 006739106 4,732 54,237 SH   SOLE   54,237 0 0
Affimed N.V. Common N01045108 7,724 908,736 SH   SOLE   908,736 0 0
Agilent Technologies, Inc. Common 00846U101 7,764 52,525 SH   SOLE   52,525 0 0
Alexion Pharmaceuticals, Inc. Common 015351109 11,841 64,453 SH   SOLE   64,453 0 0
Align Technology, Inc. Common 016255101 6,064 9,925 SH   SOLE   9,925 0 0
Allakos Inc. Common 01671P100 11,358 133,045 SH   SOLE   133,045 0 0
Alnylam Pharmaceuticals, Inc. Common 02043Q107 22,800 134,495 SH   SOLE   134,495 0 0
Amedisys, Inc. Common 023436108 11,774 48,070 SH   SOLE   48,070 0 0
Amgen Inc. Common 031162100 112,955 463,405 SH   SOLE   463,405 0 0
Amicus Therapeutics, Inc. Common 03152W109 5,993 621,659 SH   SOLE   621,659 0 0
Anthem, Inc. Common 036752103 41,133 107,734 SH   SOLE   107,734 0 0
Apellis Pharmaceuticals, Inc. Common 03753U106 9,640 152,538 SH   SOLE   152,538 0 0
ARCA biopharma, Inc. Common 00211Y506 113 32,461 SH   SOLE   32,461 0 0
Arcutis Biotherapeutics, Inc. Common 03969K108 3,592 131,633 SH   SOLE   131,633 0 0
Ardelyx, Inc. Common 039697107 4,089 539,408 SH   SOLE   539,408 0 0
Arena Pharmaceuticals, Inc. Common 040047607 13,393 196,385 SH   SOLE   196,385 0 0
argenx SE Sponsored ADR 04016X101 22,403 74,410 SH   SOLE   74,410 0 0
Arrowhead Pharmaceuticals, Inc. Common 04280A100 11,006 132,886 SH   SOLE   132,886 0 0
Arvinas, Inc. Common 04335A105 6,622 85,997 SH   SOLE   85,997 0 0
Ascendis Pharma A/S Sponsored ADR 04351P101 20,211 153,636 SH   SOLE   153,636 0 0
Assertio Holdings, Inc. Common 04546C205 640 410,575 SH   SOLE   410,575 0 0
AstraZeneca PLC Sponsored ADR 046353108 26,853 448,298 SH   SOLE   448,298 0 0
Atreca, Inc. Class A Common 04965G109 3,003 352,424 SH   SOLE   352,424 0 0
Aurinia Pharmaceuticals Inc. Common 05156V102 5,157 397,920 SH   SOLE   397,920 0 0
Becton, Dickinson and Co. Common 075887109 10,532 43,307 SH   SOLE   43,307 0 0
BeiGene, Ltd. Sponsored ADR 07725L102 15,781 45,983 SH   SOLE   45,983 0 0
Bellicum Pharmaceuticals, Inc. Common 079481404 20 6,000 SH   SOLE   6,000 0 0
Bio-Techne Corp. Common 09073M104 3,422 7,600 SH   SOLE   7,600 0 0
Biogen Inc. Common 09062X103 72,413 209,124 SH   SOLE   209,124 0 0
BioMarin Pharmaceutical Inc. Common 09061G101 10,681 128,004 SH   SOLE   128,004 0 0
BioNTech SE Sponsored ADS 09075V102 12,778 57,073 SH   SOLE   57,073 0 0
Black Diamond Therapeutics, Inc. Common 09203E105 1,609 131,990 SH   SOLE   131,990 0 0
Blueprint Medicines Corp. Common 09627Y109 10,793 122,699 SH   SOLE   122,699 0 0
Boston Scientific Corp. Common 101137107 7,950 185,931 SH   SOLE   185,931 0 0
BridgeBio Pharma, Inc. Common 10806X102 11,507 188,767 SH   SOLE   188,767 0 0
Bristol-Myers Squibb Co. Common 110122108 43,832 655,973 SH   SOLE   655,973 0 0
Catalent, Inc. Common 148806102 8,652 80,025 SH   SOLE   80,025 0 0
Celldex Therapeutics, Inc. Common 15117B202 236 7,053 SH   SOLE   7,053 0 0
Centene Corp. Common 15135B101 4,907 67,290 SH   SOLE   67,290 0 0
Charles River Laboratories International, Inc. Common 159864107 20,225 54,674 SH   SOLE   54,674 0 0
ChemoCentryx, Inc. Common 16383L106 1,047 78,197 SH   SOLE   78,197 0 0
Cigna Corp. Common 125523100 50,026 211,018 SH   SOLE   211,018 0 0
Cogent Biosciences, Inc. Common 19240Q201 4,361 537,742 SH   SOLE   537,742 0 0
Community Health Systems, Inc. Common 203668108 1,568 101,535 SH   SOLE   101,535 0 0
Community Healthcare Trust Inc. Common 20369C106 707 14,900 SH   SOLE   14,900 0 0
Corbus Pharmaceuticals Holdings, Inc. Common 21833P103 757 413,481 SH   SOLE   413,481 0 0
CRISPR Therapeutics AG Namen AKT H17182108 26,281 162,337 SH   SOLE   162,337 0 0
CVS Health Corp. Common 126650100 12,303 147,453 SH   SOLE   147,453 0 0
CymaBay Therapeutics, Inc. Common 23257D103 384 88,102 SH   SOLE   88,102 0 0
Danaher Corp. Common 235851102 44,612 166,240 SH   SOLE   166,240 0 0
Deciphera Pharmaceuticals, Inc. Common 24344T101 11,265 307,703 SH   SOLE   307,703 0 0
Denali Therapeutics Inc. Common 24823R105 11,773 150,086 SH   SOLE   150,086 0 0
DENTSPLY SIRONA Inc. Common 24906P109 24,187 382,344 SH   SOLE   382,344 0 0
Dexcom, Inc. Common 252131107 35,336 82,755 SH   SOLE   82,755 0 0
Dicerna Pharmaceuticals, Inc. Common 253031108 2,543 68,150 SH   SOLE   68,150 0 0
Diversified Healthcare Trust Common 25525P107 1,495 357,720 SH   SOLE   357,720 0 0
Editas Medicine, Inc. Common 28106W103 860 15,190 SH   SOLE   15,190 0 0
Edwards Lifesciences Corp. Common 28176E108 22,946 221,555 SH   SOLE   221,555 0 0
Eli Lilly and Co. Common 532457108 58,886 256,561 SH   SOLE   256,561 0 0
Endo International plc Shares G30401106 2,488 531,570 SH   SOLE   531,570 0 0
Exact Sciences Corp. Common 30063P105 24,819 199,654 SH   SOLE   199,654 0 0
Exelixis, Inc. Common 30161Q104 9,104 499,657 SH   SOLE   499,657 0 0
Fate Therapeutics, Inc. Common 31189P102 6,312 72,727 SH   SOLE   72,727 0 0
Five Star Senior Living Inc. Common 33832D205 140 24,237 SH   SOLE   24,237 0 0
Forma Therapeutics Holdings, Inc. Shares 34633R104 3,729 149,825 SH   SOLE   149,825 0 0
G1 Therapeutics, Inc. Common 3621LQ109 13,699 624,369 SH   SOLE   624,369 0 0
Galera Therapeutics, Inc. Common 36338D108 10,241 1,041,845 SH   SOLE   1,041,845 0 0
Gamida Cell Ltd. Shares M47364100 757 118,142 SH   SOLE   118,142 0 0
Gilead Sciences, Inc. Common 375558103 112,571 1,634,785 SH   SOLE   1,634,785 0 0
Global Medical REIT Inc. Common 37954A204 2,581 174,897 SH   SOLE   174,897 0 0
Grifols, S.A. Sponsored ADR 398438408 822 47,373 SH   SOLE   47,373 0 0
Guardant Health, Inc. Common 40131M109 19,712 158,727 SH   SOLE   158,727 0 0
HCA Healthcare, Inc. Common 40412C101 25,789 124,743 SH   SOLE   124,743 0 0
Health Care Select Sector SPDR Fund SBI Healthcare 81369Y209 23,796 188,930 SH   SOLE   188,930 0 0
Healthcare Realty Trust Inc. Common 421946104 3,142 104,024 SH   SOLE   104,024 0 0
Healthcare Trust of America, Inc. Common 42225P501 1,887 70,662 SH   SOLE   70,662 0 0
Healthpeak Properties, Inc. Common 42250P103 5,007 150,392 SH   SOLE   150,392 0 0
Helix Acquisition Corp. Class A Common G4444C102 2,583 250,000 SH   SOLE   250,000 0 0
Hologic, Inc. Common 436440101 2,173 32,564 SH   SOLE   32,564 0 0
Horizon Therapeutics plc Shares G46188101 87,679 936,340 SH   SOLE   936,340 0 0
Humana Inc. Common 444859102 25,738 58,135 SH   SOLE   58,135 0 0
I-Mab Sponsored ADS 44975P103 13,649 162,580 SH   SOLE   162,580 0 0
Icon plc Shares G4705A100 7,515 36,357 SH   SOLE   36,357 0 0
IDEXX Laboratories, Inc. Common 45168D104 21,987 34,814 SH   SOLE   34,814 0 0
Illumina, Inc. Common 452327109 95,498 201,809 SH   SOLE   201,809 0 0
Incyte Corp. Common 45337C102 9,060 107,687 SH   SOLE   107,687 0 0
Insmed Inc. Common 457669307 2,800 98,387 SH   SOLE   98,387 0 0
Intellia Therapeutics, Inc. Common 45826J105 9,420 58,180 SH   SOLE   58,180 0 0
Intercept Pharmaceuticals, Inc. Common 45845P108 1,539 77,067 SH   SOLE   77,067 0 0
Intra-Cellular Therapies, Inc. Common 46116X101 8,276 202,756 SH   SOLE   202,756 0 0
Intuitive Surgical, Inc. Common 46120E602 19,585 21,296 SH   SOLE   21,296 0 0
Ionis Pharmaceuticals, Inc. Common 462222100 12,865 322,521 SH   SOLE   322,521 0 0
Iovance Biotherapeutics, Inc. Common 462260100 12,191 468,538 SH   SOLE   468,538 0 0
IQVIA Holdings Inc. Common 46266C105 13,756 56,766 SH   SOLE   56,766 0 0
Jazz Pharmaceuticals plc Shares G50871105 11,983 67,456 SH   SOLE   67,456 0 0
Johnson & Johnson Common 478160104 85,113 516,652 SH   SOLE   516,652 0 0
Jounce Therapeutics, Inc. Common 481116101 2,599 382,237 SH   SOLE   382,237 0 0
KalVista Pharmaceuticals, Inc. Common 483497103 2,396 100,000 SH   SOLE   100,000 0 0
Karuna Therapeutics, Inc. Common 48576A100 11,451 100,458 SH   SOLE   100,458 0 0
Koninklijke Philips N.V. NY Reg Sh 500472303 2,829 56,927 SH   SOLE   56,927 0 0
Kura Oncology, Inc. Common 50127T109 5,702 273,463 SH   SOLE   273,463 0 0
Laboratory Corp. of America Holdings Sponsored ADR 50540R409 19,413 70,374 SH   SOLE   70,374 0 0
LTC Properties, Inc. Common 502175102 6,998 182,293 SH   SOLE   182,293 0 0
Madrigal Pharmaceuticals, Inc. Common 558868105 1,299 13,340 SH   SOLE   13,340 0 0
McKesson Corp. Common 58155Q103 28,823 150,715 SH   SOLE   150,715 0 0
Medical Properties Trust, Inc. Common 58463J304 8,276 411,743 SH   SOLE   411,743 0 0
Medpace Holdings, Inc. Common 58506Q109 3,333 18,871 SH   SOLE   18,871 0 0
Medtronic Plc Shares G5960L103 67,865 546,722 SH   SOLE   546,722 0 0
Merck & Co., Inc. Common 58933Y105 42,128 541,703 SH   SOLE   541,703 0 0
Mereo BioPharma Group plc ADS 589492107 3,312 1,044,790 SH   SOLE   1,044,790 0 0
Mettler-Toledo International Inc. Common 592688105 13,576 9,800 SH   SOLE   9,800 0 0
Mirati Therapeutics, Inc. Common 60468T105 13,534 83,784 SH   SOLE   83,784 0 0
Moderna, Inc. Common 60770K107 109,448 465,777 SH   SOLE   465,777 0 0
Molecular Templates, Inc. Common 608550109 1,559 199,420 SH   SOLE   199,420 0 0
Molina Healthcare, Inc. Common 60855R100 16,097 63,610 SH   SOLE   63,610 0 0
MorphoSys AG Sponsored ADS 617760202 1,576 81,867 SH   SOLE   81,867 0 0
National Health Investors, Inc. Common 63633D104 673 10,038 SH   SOLE   10,038 0 0
Nektar Therapeutics Common 640268108 3,096 180,438 SH   SOLE   180,438 0 0
Neurocrine Biosciences, Inc. Common 64125C109 20,719 212,891 SH   SOLE   212,891 0 0
New Senior Investment Group Inc. Common 648691103 2,251 256,398 SH   SOLE   256,398 0 0
Nkarta, Inc. Common 65487U108 919 28,988 SH   SOLE   28,988 0 0
Novartis AG Sponsored ADR 66987V109 12,429 136,225 SH   SOLE   136,225 0 0
Novavax, Inc. Common 670002401 18,598 87,596 SH   SOLE   87,596 0 0
Novo Nordisk A/S Sponsored ADR 670100205 4,055 48,406 SH   SOLE   48,406 0 0
Omega Healthcare Investors, Inc. Common 681936100 11,120 306,433 SH   SOLE   306,433 0 0
Organon & Co. Common 68622V106 1,639 54,169 SH   SOLE   54,169 0 0
Ovid Therapeutics Inc. Sponsored ADR 690469101 1,457 372,733 SH   SOLE   372,733 0 0
Owens & Minor, Inc. Common 690732102 11,261 266,023 SH   SOLE   266,023 0 0
PerkinElmer, Inc. Common 714046109 5,728 37,094 SH   SOLE   37,094 0 0
Perrigo Co. plc Shares G97822103 2,349 51,224 SH   SOLE   51,224 0 0
Personalis, Inc. Common 71535D106 4,547 179,731 SH   SOLE   179,731 0 0
Pfizer Inc. Common 717081103 17,637 450,379 SH   SOLE   450,379 0 0
Physicians Realty Trust Common 71943U104 9,156 495,733 SH   SOLE   495,733 0 0
PRA Health Sciences, Inc. Common 69354M108 4,141 25,068 SH   SOLE   25,068 0 0
Praxis Precision Medicines, Inc. Common 74006W108 1,371 75,000 SH   SOLE   75,000 0 0
Precision BioSciences, Inc. Common 74019P108 789 63,001 SH   SOLE   63,001 0 0
R1 RCM Inc. Common 749397105 4,500 202,351 SH   SOLE   202,351 0 0
Reata Pharmaceuticals, Inc. Class A 75615P103 5,409 38,219 SH   SOLE   38,219 0 0
Regeneron Pharmaceuticals, Inc. Common 75886F107 77,152 138,132 SH   SOLE   138,132 0 0
REGENXBIO Inc. Common 75901B107 843 21,700 SH   SOLE   21,700 0 0
Replimune Group, Inc. Common 76029N106 8,416 219,060 SH   SOLE   219,060 0 0
ResMed Inc. Common 761152107 33,972 137,807 SH   SOLE   137,807 0 0
Sabra Health Care REIT, Inc. Common 78573L106 9,294 510,660 SH   SOLE   510,660 0 0
Sage Therapeutics, Inc. Common 78667J108 6,483 114,119 SH   SOLE   114,119 0 0
Sanofi Sponsored ADR 80105N105 4,295 81,554 SH   SOLE   81,554 0 0
Sarepta Therapeutics, Inc. Common 803607100 15,021 193,224 SH   SOLE   193,224 0 0
Scholar Rock Holding Corp. Common 80706P103 3,145 108,833 SH   SOLE   108,833 0 0
Seagen Inc. Common 81181C104 33,275 210,759 SH   SOLE   210,759 0 0
Smith & Nephew plc Shares 83175M205 4,677 107,670 SH   SOLE   107,670 0 0
Spectrum Pharmaceuticals, Inc. Common 84763A108 430 114,670 SH   SOLE   114,670 0 0
STERIS plc Shares G8473T100 5,705 27,655 SH   SOLE   27,655 0 0
Stryker Corp. Common 863667101 39,089 150,500 SH   SOLE   150,500 0 0
Sutro Biopharma, Inc. Common 869367102 7,439 400,147 SH   SOLE   400,147 0 0
Syneos Health, Inc. Class A 87166B102 21,803 243,633 SH   SOLE   243,633 0 0
Takeda Pharmaceutical Company Ltd. Sponsored ADS 874060205 3,537 210,146 SH   SOLE   210,146 0 0
TCR2 Therapeutics Inc. Common 87808K106 3,870 235,808 SH   SOLE   235,808 0 0
Teleflex Inc. Common 879369106 884 2,200 SH   SOLE   2,200 0 0
Tetraphase Pharmaceuticals, Inc. Common 881CVR013 5 42,965 SH   SOLE   42,965 0 0
Teva Pharmaceutical Industries Ltd. Sponsored ADR 881624209 6,016 607,651 SH   SOLE   607,651 0 0
Theravance Biopharma, Inc. Common G8807B106 9,529 656,296 SH   SOLE   656,296 0 0
Thermo Fisher Scientific Inc. Common 883556102 70,691 140,130 SH   SOLE   140,130 0 0
Travere Therapeutics, Inc. Common 89422G107 3,106 212,869 SH   SOLE   212,869 0 0
Trillium Therapeutics Inc. Common 89620X506 5,133 529,226 SH   SOLE   529,226 0 0
Turning Point Therapeutics, Inc. Common 90041T108 9,310 119,324 SH   SOLE   119,324 0 0
Ultragenyx Pharmaceutical Inc. Common 90400D108 12,833 134,590 SH   SOLE   134,590 0 0
uniQure N.V. Shares N90064101 6,958 225,921 SH   SOLE   225,921 0 0
United Therapeutics Corp. Class B 91307C102 25,017 139,438 SH   SOLE   139,438 0 0
Unitedhealth Group Inc. Common 91324P102 126,358 315,548 SH   SOLE   315,548 0 0
Universal Health Realty Income Trust Shares 91359E105 693 11,258 SH   SOLE   11,258 0 0
Universal Health Services, Inc. Class B 913903100 8,789 60,023 SH   SOLE   60,023 0 0
Vectivbio Holding AG Ord Shares H9060V101 1,691 145,000 SH   SOLE   145,000 0 0
Ventas, Inc. Common 92276F100 11,883 208,108 SH   SOLE   208,108 0 0
Verona Pharma plc Sponsored ADR 925050106 4,917 751,905 SH   SOLE   751,905 0 0
Vertex Pharmaceuticals Inc. Common 92532F100 79,702 395,288 SH   SOLE   395,288 0 0
Vir Biotechnology, Inc. Common 92764N102 3,849 81,400 SH   SOLE   81,400 0 0
VYNE Therapeutics Inc. Common 92941V209 475 135,395 SH   SOLE   135,395 0 0
Waters Corp. Common 941848103 16,695 48,306 SH   SOLE   48,306 0 0
Welltower Inc. Common 95040Q104 16,876 203,083 SH   SOLE   203,083 0 0
Xenon Pharmaceuticals Inc. Common 98420N105 3,147 169,030 SH   SOLE   169,030 0 0
Y-mAbs Therapeutics, Inc. Common 984241109 6,686 197,820 SH   SOLE   197,820 0 0
Zai Lab Ltd. ADR 98887Q104 6,641 37,523 SH   SOLE   37,523 0 0
Zimmer Biomet Holdings, Inc. Common 98956P102 35,815 222,703 SH   SOLE   222,703 0 0
Zoetis Inc. Class A 98978V103 10,533 56,521 SH   SOLE   56,521 0 0
Zogenix, Inc. Common 98978L204 1,538 88,977 SH   SOLE   88,977 0 0