The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| AKERO THERAPEUTICS INC | COM | 00973Y108 | 86 | 3,470 | SH | DFND | 1,2 | 3,470 | 0 | 0 | |
| ALX ONCOLOGY HLDGS INC | COM | 00166B105 | 1,911 | 34,950 | SH | DFND | 1,2 | 34,950 | 0 | 0 | |
| ARDELYX INC | COM | 039697107 | 2,465 | 325,233 | SH | DFND | 1,2 | 325,233 | 0 | 0 | |
| BEAM THERAPEUTICS INC | COM | 07373V105 | 6,263 | 48,660 | SH | DFND | 1,2 | 48,660 | 0 | 0 | |
| BOLT BIOTHERAPEUTICS INC | COM | 097702104 | 18,041 | 1,166,952 | SH | DFND | 1,2 | 1,166,952 | 0 | 0 | |
| DBV TECHNOLOGIES S A | SPONSORED ADR | 23306J101 | 1,559 | 285,500 | SH | DFND | 1,2 | 285,500 | 0 | 0 | |
| EARGO INC | COM | 270087109 | 115,209 | 2,886,724 | SH | DFND | 1,2 | 2,886,724 | 0 | 0 | |
| EXACT SCIENCES CORP | COM | 30063P105 | 2,171 | 17,464 | SH | DFND | 1,2 | 17,464 | 0 | 0 | |
| EXELIXIS INC | COM | 30161Q104 | 1,170 | 64,200 | SH | DFND | 1,2 | 64,200 | 0 | 0 | |
| FLUENT INC | COM | 34380C102 | 571 | 194,799 | SH | DFND | 1,2 | 194,799 | 0 | 0 | |
| GALERA THERAPEUTICS INC | COM | 36338D108 | 6,028 | 613,223 | SH | DFND | 1,2 | 613,223 | 0 | 0 | |
| HARMONY BIOSCIENCES HLDGS IN | COM | 413197104 | 21,701 | 768,708 | SH | DFND | 1,2 | 768,708 | 0 | 0 | |
| INVITAE CORP | COM | 46185L103 | 4,880 | 144,667 | SH | DFND | 1,2 | 144,667 | 0 | 0 | |
| KALVISTA PHARMACEUTICALS INC | COM | 483497103 | 1,886 | 78,720 | SH | DFND | 1,2 | 78,720 | 0 | 0 | |
| KARUNA THERAPEUTICS INC | COM | 48576A100 | 26,766 | 234,811 | SH | DFND | 1,2 | 234,811 | 0 | 0 | |
| NEW FRONTIER HEALTH CORP | ORD SHS | G6461G106 | 93,270 | 8,350,000 | SH | DFND | 1,2 | 8,350,000 | 0 | 0 | |
| NEW FRONTIER HEALTH CORP | *W EXP 11/30/202 | G6461G114 | 3,666 | 1,580,000 | SH | DFND | 1,2 | 1,580,000 | 0 | 0 | |
| OTONOMY INC | COM | 68906L105 | 1,898 | 851,000 | SH | DFND | 1,2 | 851,000 | 0 | 0 | |
| REATA PHARMACEUTICALS INC | CL A | 75615P103 | 1,170 | 8,265 | SH | DFND | 1,2 | 8,265 | 0 | 0 | |
| RUBIUS THERAPEUTICS INC | COM | 78116T103 | 1,386 | 56,768 | SH | DFND | 1,2 | 56,768 | 0 | 0 | |
| SIERRA ONCOLOGY INC | COM NEW | 82640U404 | 2,550 | 130,979 | SH | DFND | 1,2 | 130,979 | 0 | 0 | |
| SYNLOGIC INC | COM | 87166L100 | 267 | 68,634 | SH | DFND | 1,2 | 68,634 | 0 | 0 | |
| VIR BIOTECHNOLOGY INC | COM | 92764N102 | 3,246 | 68,663 | SH | DFND | 1,2 | 68,663 | 0 | 0 | |
| XENON PHARMACEUTICALS INC | COM | 98420N105 | 3,685 | 197,880 | SH | DFND | 1,2 | 197,880 | 0 | 0 | |