The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
1LIFE HEALTHCARE INC COM 68269G107 12,251 605,000 SH   DFND 2 605,000 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 13,180 1,156,142 SH   DFND 2 1,156,142 0 0
ALIGN TECHNOLOGY INC COM 016255101 22,244 33,428 SH   DFND 2 33,428 0 0
ALLEGION PLC ORD SHS G0176J109 4,830 36,544 SH   DFND 2 4,929 0 31,615
ALPHABET INC CAP STK CL C 02079K107 982,399 368,587 SH   DFND 2 183,152 0 185,435
ALPHABET INC CAP STK CL C 02079K107 71,819 26,946 SH   DFND 1 26,946 0 0
ALPHABET INC CAP STK CL A 02079K305 2,323 869 SH   DFND 2 0 0 869
AMAZON INC COM 023135106 726,881 221,270 SH   DFND 2 109,980 0 111,290
AMAZON INC COM 023135106 53,356 16,242 SH   DFND 1 16,242 0 0
AMDOCS LTD SHS G02602103 849 11,219 SH   DFND 1 11,219 0 0
AMDOCS LTD SHS G02602103 331 4,370 SH   DFND 2 4,370 0 0
AMERICAN TOWER CORP NEW COM 03027X100 29,236 110,154 SH   DFND 1 110,154 0 0
AMERICAN TOWER CORP NEW COM 03027X100 392,710 1,479,636 SH   DFND 2 727,683 0 751,953
ANTHEM INC COM 036752103 33,925 91,000 SH   DFND 2 91,000 0 0
ARCO PLATFORM LTD COM CL A G04553106 248 11,427 SH   DFND 2 11,427 0 0
ARCO PLATFORM LTD COM CL A G04553106 280 12,883 SH   DFND 1 12,883 0 0
AUTOMATIC DATA PROCESSING IN COM 053015103 828 4,143 SH   DFND 1 4,143 0 0
AUTOMATIC DATA PROCESSING IN COM 053015103 315 1,577 SH   DFND 2 1,577 0 0
AXONICS INC COM 05465P101 16,272 250,000 SH   DFND 2 250,000 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 32,296 232,498 SH   DFND 2 232,498 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 16,529 213,851 SH   DFND 2 213,851 0 0
CARA THERAPEUTICS INC COM 140755109 9,014 583,460 SH   DFND 2 583,460 0 0
CENTENE CORP DEL COM 15135B101 25,843 414,756 SH   DFND 2 414,756 0 0
COGNEX CORP COM 192422103 4,534 56,521 SH   DFND 2 7,609 0 48,912
COHERUS BIOSCIENCES INC COM 19249H103 14,920 928,464 SH   DFND 2 928,464 0 0
COOPER COS INC COM NEW 216648402 6,534 15,809 SH   DFND 2 2,130 0 13,679
DEX INC COM 252131107 37,733 69,000 SH   DFND 2 69,000 0 0
DLOCAL LTD CLASS A COM G29018101 333 6,100 SH   DFND 1 6,100 0 0
DLOCAL LTD CLASS A COM G29018101 371 6,800 SH   DFND 2 6,800 0 0
DOLLAR GEN CORP NEW COM 256677105 613 2,891 SH   DFND 2 2,891 0 0
DOLLAR GEN CORP NEW COM 256677105 1,627 7,669 SH   DFND 1 7,669 0 0
DROPBOX INC CL A 26210C104 7,275 248,973 SH   DFND 2 33,548 0 215,425
ECOLAB INC COM 278865100 358,704 1,719,411 SH   DFND 2 859,990 0 859,421
ECOLAB INC COM 278865100 26,449 126,780 SH   DFND 1 126,780 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 39,593 349,729 SH   DFND 2 295,659 0 54,070
ELECTRONIC ARTS INC COM 285512109 5,328 37,458 SH   DFND 2 9,077 0 28,381
ELECTRONIC ARTS INC COM 285512109 1,737 12,212 SH   DFND 1 12,212 0 0
EXACT SCIENCES CORP COM 30063P105 25,146 263,452 SH   DFND 2 221,218 0 42,234
FIDELITY NATL INFORMATION SV COM 31620M106 1,608 13,214 SH   DFND 1 13,214 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 433 3,556 SH   DFND 2 3,556 0 0
FIRST REP BK SAN FRANCISCO C COM 33616C100 408,983 2,120,400 SH   DFND 2 1,078,456 0 1,041,944
FIRST REP BK SAN FRANCISCO C COM 33616C100 30,901 160,210 SH   DFND 1 160,210 0 0
FISERV INC COM 337738108 276,387 2,547,350 SH   DFND 2 1,319,668 0 1,227,682
FISERV INC COM 337738108 22,619 208,467 SH   DFND 1 208,467 0 0
GLAUKOS CORP COM 377322102 9,500 197,212 SH   DFND 2 197,212 0 0
GLOBAL PMTS INC COM 37940X102 4,872 30,918 SH   DFND 2 4,169 0 26,749
GLOBANT S A COM L44385109 703 2,500 SH   DFND 2 2,500 0 0
GLOBANT S A COM L44385109 618 2,200 SH   DFND 1 2,200 0 0
HDFC BANK LTD SPONSORED ADS 40415F101 220,339 3,014,627 SH   DFND 2 1,491,366 0 1,523,261
HDFC BANK LTD SPONSORED ADS 40415F101 20,336 278,226 SH   DFND 1 278,226 0 0
HERON THERAPEUTICS INC COM 427746102 12,850 1,202,069 SH   DFND 2 1,202,069 0 0
HOME DEPOT INC COM 437076102 729,226 2,221,490 SH   DFND 2 1,113,077 0 1,108,413
HOME DEPOT INC COM 437076102 54,619 166,389 SH   DFND 1 166,389 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 32,483 296,544 SH   DFND 2 296,544 0 0
HUMANA INC COM 444859102 30,143 77,459 SH   DFND 2 77,459 0 0
ICICI BANK LIMITED ADR 45104G104 128,181 6,792,835 SH   DFND 2 2,380,461 0 4,412,374
ICICI BANK LIMITED ADR 45104G104 9,618 509,703 SH   DFND 1 509,703 0 0
ILLUMINA INC COM 452327109 23,516 57,978 SH   DFND 2 57,978 0 0
INFOSYS LTD SPONSORED ADR 456788108 13,175 592,144 SH   DFND 2 346,995 0 245,149
INFOSYS LTD SPONSORED ADR 456788108 466 20,950 SH   DFND 1 20,950 0 0
INSMED INC COM PAR $.01 457669307 9,449 343,110 SH   DFND 2 343,110 0 0
INSULET CORP COM 45784P101 20,723 72,908 SH   DFND 2 72,908 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 1,210 10,542 SH   DFND 1 10,542 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 462 4,023 SH   DFND 2 4,023 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 41,692 41,937 SH   DFND 2 41,937 0 0
IRHYTHM TECHNOLOGIES INC COM 450056106 4,685 80,000 SH   DFND 2 80,000 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 6,984 1,200,000 SH   DFND 2 1,200,000 0 0
KRYSTAL BIOTECH INC COM 501147102 9,701 185,809 SH   DFND 2 185,809 0 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409 913 3,244 SH   DFND 1 3,244 0 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409 350 1,242 SH   DFND 2 1,242 0 0
LHC GROUP INC COM 50187A107 17,363 110,657 SH   DFND 2 110,657 0 0
MCCORMICK & CO INC COM NON VTG 579780206 342 4,221 SH   DFND 2 4,221 0 0
MCDONALDS CORP COM 580135101 990 4,104 SH   DFND 1 4,104 0 0
MCDONALDS CORP COM 580135101 387 1,605 SH   DFND 2 1,605 0 0
MERCADOLIBRE INC COM 58733R102 4,968 2,958 SH   DFND 2 749 0 2,209
MERCADOLIBRE INC COM 58733R102 635 378 SH   DFND 1 378 0 0
MICROSOFT CORP COM 594918104 750,320 2,661,463 SH   DFND 2 1,306,465 0 1,354,998
MICROSOFT CORP COM 594918104 54,062 191,762 SH   DFND 1 191,762 0 0
MSCI INC COM 55354G100 4,734 7,782 SH   DFND 2 1,050 0 6,732
NEXTERA ENERGY INC COM 65339F101 395,726 5,039,809 SH   DFND 2 2,308,236 0 2,731,573
NEXTERA ENERGY INC COM 65339F101 26,762 340,825 SH   DFND 1 340,825 0 0
NOMAD FOODS LTD USD ORD SHS G6564A105 526 19,070 SH   DFND 2 19,070 0 0
NOMAD FOODS LTD USD ORD SHS G6564A105 1,524 55,284 SH   DFND 1 55,284 0 0
NOVOCURE LTD ORD SHS G6674U108 12,986 111,784 SH   DFND 2 111,784 0 0
OAK STR HEALTH INC COM 67181A107 15,946 374,933 SH   DFND 2 374,933 0 0
PAGSEGURO DIGITAL LTD COM CL A G68707101 484 9,366 SH   DFND 2 9,366 0 0
PAGSEGURO DIGITAL LTD COM CL A G68707101 348 6,726 SH   DFND 1 6,726 0 0
PRIVIA HEALTH GROUP INC COM 74276R102 12,251 520,000 SH   DFND 2 520,000 0 0
PROCTER AND GAMBLE CO COM 742718109 415,312 2,970,757 SH   DFND 2 1,486,001 0 1,484,756
PROCTER AND GAMBLE CO COM 742718109 30,595 218,848 SH   DFND 1 218,848 0 0
PTC INC COM 69370C100 4,475 37,355 SH   DFND 2 5,032 0 32,323
QUIDEL CORP COM 74838J101 19,761 140,000 SH   DFND 2 140,000 0 0
REPUBLIC SVCS INC COM 760759100 326 2,714 SH   DFND 2 2,714 0 0
REPUBLIC SVCS INC COM 760759100 835 6,955 SH   DFND 1 6,955 0 0
RESMED INC COM 761152107 5,862 22,244 SH   DFND 2 2,997 0 19,247
ROBERT HALF INTL INC COM 770323103 807 8,043 SH   DFND 1 8,043 0 0
ROBERT HALF INTL INC COM 770323103 246 2,453 SH   DFND 2 2,453 0 0
S&P GLOBAL INC COM 78409V104 427,595 1,006,366 SH   DFND 2 504,433 0 501,933
S&P GLOBAL INC COM 78409V104 32,868 77,356 SH   DFND 1 77,356 0 0
SAREPTA THERAPEUTICS INC COM 803607100 11,128 120,329 SH   DFND 2 120,329 0 0
SEA LTD SPONSORD ADS 81141R100 172,877 542,394 SH   DFND 2 173,556 0 368,838
SEA LTD SPONSORD ADS 81141R100 14,170 44,459 SH   DFND 1 44,459 0 0
SERVICE CORP INTL COM 817565104 7,243 120,194 SH   DFND 2 19,789 0 100,405
SERVICE CORP INTL COM 817565104 510 8,460 SH   DFND 1 8,460 0 0
SMITH A O CORP COM 831865209 5,376 88,027 SH   DFND 2 11,869 0 76,158
SYNOPSYS INC COM 871607107 6,755 22,561 SH   DFND 2 3,043 0 19,518
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 56,248 503,792 SH   DFND 2 411,406 0 92,386
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 37,201 333,192 SH   DFND 1 333,192 0 0
TELADOC HEALTH INC COM 87918A105 11,159 88,000 SH   DFND 2 88,000 0 0
TELEFLEX INCORPORATED COM 879369106 21,840 58,000 SH   DFND 2 58,000 0 0
THERAPEUTICSMD INC COM 88338N107 4,589 6,189,834 SH   DFND 2 6,189,834 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 873,710 1,529,257 SH   DFND 2 814,063 0 715,194
THERMO FISHER SCIENTIFIC INC COM 883556102 62,164 108,805 SH   DFND 1 108,805 0 0
TRANSUNION COM 89400J107 745 6,637 SH   DFND 1 6,637 0 0
TRANSUNION COM 89400J107 6,697 59,626 SH   DFND 2 10,222 0 49,404
TREACE MED CONCEPTS INC COM 89455T109 134 5,000 SH   DFND 2 5,000 0 0
TRIP COM GROUP LTD ADS 89677Q107 4,389 142,735 SH   DFND 1 142,735 0 0
TRIP COM GROUP LTD ADS 89677Q107 53,228 1,731,003 SH   DFND 2 560,318 0 1,170,685
TYLER TECHNOLOGIES INC COM 902252105 3,067 6,686 SH   DFND 2 900 0 5,786
VERTEX PHARMACEUTICALS INC COM 92532F100 19,691 108,557 SH   DFND 2 108,557 0 0
VISA INC COM CL A 92826C839 928,494 4,168,323 SH   DFND 2 2,093,125 0 2,075,198
VISA INC COM CL A 92826C839 70,516 316,572 SH   DFND 1 316,572 0 0
VOCERA MUNICATIONS INC COM 92857F107 8,697 190,058 SH   DFND 2 190,058 0 0
WASTE MGMT INC DEL COM 94106L109 357 2,390 SH   DFND 2 2,390 0 0
WASTE MGMT INC DEL COM 94106L109 934 6,251 SH   DFND 1 6,251 0 0
WATERS CORP COM 941848103 7,661 21,440 SH   DFND 2 2,891 0 18,549
WILLIS TOWERS WATSON PLC LTD SHS G96629103 1,154 4,963 SH   DFND 1 4,963 0 0
WILLIS TOWERS WATSON PLC LTD SHS G96629103 450 1,936 SH   DFND 2 1,936 0 0
XYLEM INC COM 98419M100 6,359 51,414 SH   DFND 2 6,938 0 44,476