The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
1LIFE HEALTHCARE INC COM 68269G107 16,933 836,190 SH   DFND 2 836,190 0 0
10X GENOMICS INC CL A COM 88025U109 33,872 232,672 SH   DFND 2 232,672 0 0
ABBOTT LABS COM 002824100 163,905 1,387,499 SH   DFND 2 1,387,499 0 0
ABBVIE INC COM 00287Y109 30,516 282,900 SH   DFND 2 282,900 0 0
ABIOMED INC COM 003654100 49,211 151,178 SH   DFND 2 151,178 0 0
AC IMMUNE SA SHS H00263105 933 139,000 SH   DFND 2 139,000 0 0
ACCOLADE INC COM 00437E102 29,033 688,479 SH   DFND 2 688,479 0 0
ACCOLADE INC COM 00437E102 49,412 1,171,724 SH   DFND 3 1,171,724 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 45,411 1,336,023 SH   DFND 3 1,336,023 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 425 2,700 SH   DFND 2 2,700 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 1,708 37,000 SH   DFND 2 37,000 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 198,675 4,304,992 SH   DFND 1,2 4,304,992 0 0
ALIGN TECHNOLOGY INC COM 016255101 104,493 157,031 SH   DFND 2 157,031 0 0
ALLAKOS INC COM 01671P100 1,959 18,500 SH   DFND 2 18,500 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 8,610 45,600 SH   DFND 2 45,600 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 209,579 1,110,000 SH   DFND 1,2 1,110,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 47,735 252,818 SH   DFND 3 252,818 0 0
AMEDISYS INC COM 023436108 9,019 60,487 SH   DFND 2 60,487 0 0
AMEDISYS INC COM 023436108 36,129 242,311 SH   DFND 3 242,311 0 0
AMERICAN EXPRESS CO COM 025816109 436 2,600 SH   DFND 2 2,600 0 0
AMERICAN WELL CORP CL A 03044L105 19,385 2,127,838 SH   DFND 2 2,127,838 0 0
AMGEN INC COM 031162100 7,219 33,950 SH   DFND 2 33,950 0 0
ANSYS INC COM 03662Q105 306 900 SH   DFND 2 900 0 0
ANTHEM INC COM 036752103 101,649 272,664 SH   DFND 2 272,664 0 0
ANTHEM INC COM 036752103 75,509 202,546 SH   DFND 3 202,546 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 1,582 48,000 SH   DFND 2 48,000 0 0
ARCTURUS THERAPEUTICS HLDGS COM 03969T109 1,648 34,500 SH   DFND 2 34,500 0 0
ARCUS BIOSCIENCES INC COM 03969F109 3,302 94,700 SH   DFND 2 94,700 0 0
ARGENX SE SPONSORED ADR 04016X101 8,577 28,400 SH   DFND 2 28,400 0 0
ARGENX SE SPONSORED ADR 04016X101 288,572 955,538 SH   DFND 1,2 955,538 0 0
ARVINAS INC COM 04335A105 5,301 64,500 SH   DFND 2 64,500 0 0
ARVINAS INC COM 04335A105 178,898 2,176,903 SH   DFND 1,2 2,176,903 0 0
ASPEN TECHNOLOGY INC COM 045327103 295 2,400 SH   DFND 2 2,400 0 0
ATRICURE INC COM 04963C209 29,073 418,016 SH   DFND 3 418,016 0 0
AVALARA INC COM 05338G106 402 2,300 SH   DFND 2 2,300 0 0
AVANTOR INC COM 05352A100 20,950 512,216 SH   DFND 2 512,216 0 0
AXONICS INC COM 05465P101 64,973 998,204 SH   DFND 2 998,204 0 0
AXONICS INC COM 05465P101 39,743 610,590 SH   DFND 3 610,590 0 0
AXSOME THERAPEUTICS INC COM 05464T104 24,817 752,945 SH   DFND 3 752,945 0 0
BAXTER INTL INC COM 071813109 74,255 923,223 SH   DFND 2 923,223 0 0
BEAM THERAPEUTICS INC COM 07373V105 522 6,000 SH   DFND 2 6,000 0 0
BEAM THERAPEUTICS INC COM 07373V105 52,799 606,821 SH   DFND 1,2 606,821 0 0
BECTON DICKINSON & CO COM 075887109 111,989 455,572 SH   DFND 2 455,572 0 0
BEIGENE LTD SPONSORED ADR 07725L102 8,349 23,000 SH   DFND 2 23,000 0 0
BERKELEY LTS INC COM 084310101 7,531 385,014 SH   DFND 2 385,014 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108 2,732 65,700 SH   DFND 2 65,700 0 0
BIOGEN INC COM 09062X103 7,641 27,000 SH   DFND 2 27,000 0 0
BIOGEN INC COM 09062X103 141,495 500,000 SH   DFND 1,2 500,000 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 2,431 17,500 SH   DFND 2 17,500 0 0
BIONTECH SE SPONSORED ADS 09075V102 3,467 12,700 SH   DFND 2 12,700 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 3,996 51,700 SH   DFND 2 51,700 0 0
BIO RAD LABS INC CL A 090572207 34,325 46,015 SH   DFND 3 46,015 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 195 23,000 SH   DFND 2 23,000 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 29,102 3,440,000 SH   DFND 1,2 3,440,000 0 0
BOOKING HOLDINGS INC COM 09857L108 380 160 SH   DFND 2 160 0 0
BOSTON SCIENTIFIC CORP COM 101137107 128,744 2,967,127 SH   DFND 2 2,967,127 0 0
BRIGHT HEALTH GROUP INC COM 10920V107 12,240 1,500,000 SH   DFND 2 1,500,000 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 1,923 32,500 SH   DFND 2 32,500 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 75,172 1,270,434 SH   DFND 3 1,270,434 0 0
BROWN FORMAN CORP CL B 115637209 308 4,600 SH   DFND 2 4,600 0 0
BURNING ROCK BIOTECH LTD SPONSORED ADS 12233L107 8,759 489,890 SH   DFND 2 489,890 0 0
C4 THERAPEUTICS INC COM STK 12529R107 2,109 47,200 SH   DFND 2 47,200 0 0
CAREDX INC COM 14167L103 1,961 30,943 SH   DFND 3 30,943 0 0
CARMAX INC COM 143130102 365 2,850 SH   DFND 2 2,850 0 0
CATALENT INC COM 148806102 4,791 36,000 SH   DFND 2 36,000 0 0
CELLECTIS S A SPON ADS 15117K103 1,040 82,500 SH   DFND 2 82,500 0 0
CENTENE CORP DEL COM 15135B101 71,940 1,154,545 SH   DFND 2 1,154,545 0 0
CHARLES RIV LABS INTL INC COM 159864107 26,134 63,329 SH   DFND 3 63,329 0 0
CIGNA CORP NEW COM 125523100 43,597 217,812 SH   DFND 2 217,812 0 0
CLOROX CO DEL COM 189054109 331 2,000 SH   DFND 2 2,000 0 0
CONSTELLATION BRANDS INC CL A 21036P108 307 1,459 SH   DFND 2 1,459 0 0
COOPER COS INC COM NEW 216648402 30,695 74,266 SH   DFND 2 74,266 0 0
COSTAR GROUP INC COM 22160N109 301 3,500 SH   DFND 2 3,500 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 2,809 25,100 SH   DFND 2 25,100 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 106,287 949,584 SH   DFND 1,2 949,584 0 0
CUREVAC N V COM N2451R105 1 120 SH Call DFND 2 120 0 0
CUREVAC N V COM N2451R105 1,923 35,200 SH   DFND 2 35,200 0 0
CVS HEALTH CORP COM 126650100 13,454 158,548 SH   DFND 2 158,548 0 0
CYBERARK SOFTWARE LTD SHS M2682V108 331 2,100 SH   DFND 2 2,100 0 0
DANAHER CORPORATION COM 235851102 139,031 456,679 SH   DFND 2 456,679 0 0
DENTSPLY SIRONA INC COM 24906P109 9,237 159,129 SH   DFND 2 159,129 0 0
DEXCOM INC COM 252131107 144,283 263,839 SH   DFND 2 263,839 0 0
DOLBY LABORATORIES INC COM CL A 25659T107 317 3,600 SH   DFND 2 3,600 0 0
DOMINOS PIZZA INC COM 25754A201 477 1,000 SH   DFND 2 1,000 0 0
DR REDDYS LABS LTD ADR 256135203 554 8,500 SH   DFND 2 8,500 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 98,487 869,951 SH   DFND 2 869,951 0 0
ELECTRONIC ARTS INC COM 285512109 323 2,270 SH   DFND 2 2,270 0 0
ENTEGRIS INC COM 29362U104 378 3,000 SH   DFND 2 3,000 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 496 41,200 SH   DFND 2 41,200 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 53,959 4,477,964 SH   DFND 1,2 4,477,964 0 0
ESSA PHARMA INC COM NEW 29668H708 152 19,000 SH   DFND 2 19,000 0 0
ESSA PHARMA INC COM NEW 29668H708 40,127 5,015,814 SH   DFND 1,2 5,015,814 0 0
EVOLENT HEALTH INC CL A 30050B101 51,267 1,653,761 SH   DFND 2 1,653,761 0 0
EVOLENT HEALTH INC CL A 30050B101 42,746 1,378,917 SH   DFND 3 1,378,917 0 0
EXACT SCIENCES CORP COM 30063P105 40,974 429,273 SH   DFND 3 429,273 0 0
EXELIXIS INC COM 30161Q104 507 24,000 SH   DFND 2 24,000 0 0
EXELIXIS INC COM 30161Q104 59,932 2,835,000 SH   DFND 1,2 2,835,000 0 0
FACTSET RESH SYS INC COM 303075105 415 1,050 SH   DFND 2 1,050 0 0
FASTENAL CO COM 311900104 361 7,000 SH   DFND 2 7,000 0 0
FATE THERAPEUTICS INC COM 31189P102 3,064 51,700 SH   DFND 2 51,700 0 0
FATE THERAPEUTICS INC COM 31189P102 188,854 3,186,336 SH   DFND 1,2 3,186,336 0 0
FORTINET INC COM 34959E109 642 2,200 SH   DFND 2 2,200 0 0
GARTNER INC COM 366651107 638 2,100 SH   DFND 2 2,100 0 0
GENERATION BIO CO COM 37148K100 476 19,000 SH   DFND 2 19,000 0 0
GENERATION BIO CO COM 37148K100 61,501 2,453,180 SH   DFND 1,2 2,453,180 0 0
GENETRON HLDGS LTD ADS 37186H100 10,015 723,137 SH   DFND 2 723,137 0 0
GILEAD SCIENCES INC COM 375558103 10,966 157,000 SH   DFND 2 157,000 0 0
GLAUKOS CORP COM 377322102 6,930 143,870 SH   DFND 2 143,870 0 0
GLOBUS MED INC CL A 379577208 55,888 729,420 SH   DFND 2 729,420 0 0
GRACO INC COM 384109104 315 4,500 SH   DFND 2 4,500 0 0
GUARDANT HEALTH INC COM 40131M109 42,490 339,894 SH   DFND 2 339,894 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 37,487 921,500 SH   DFND 2 921,500 0 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104 4,956 129,289 SH   DFND 2 129,289 0 0
HCA HEALTHCARE INC COM 40412C101 82,882 341,473 SH   DFND 2 341,473 0 0
HEALTH CATALYST INC COM 42225T107 36,369 727,233 SH   DFND 2 727,233 0 0
HILL-ROM HLDGS INC COM 431475102 63,107 420,716 SH   DFND 3 420,716 0 0
HOLOGIC INC COM 436440101 28,770 389,779 SH   DFND 2 389,779 0 0
HOLOGIC INC COM 436440101 35,494 480,883 SH   DFND 3 480,883 0 0
HOMOLOGY MEDICINES INC COM 438083107 13,671 1,737,122 SH   DFND 1,2 1,737,122 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 45,591 416,200 SH   DFND 2 416,200 0 0
HUMANA INC COM 444859102 53,407 137,239 SH   DFND 2 137,239 0 0
HUMANA INC COM 444859102 68,305 175,523 SH   DFND 3 175,523 0 0
HUTCHMED CHINA LTD SPONSORED ADS 44842L103 36,835 1,006,147 SH   DFND 3 1,006,147 0 0
IDEXX LABS INC COM 45168D104 73,459 118,120 SH   DFND 2 118,120 0 0
ILLUMINA INC COM 452327109 28,445 70,130 SH   DFND 2 70,130 0 0
I MAB SPONSORED ADS 44975P103 11,813 162,957 SH   DFND 2 162,957 0 0
INCYTE CORP COM 45337C102 4,127 60,000 SH   DFND 2 60,000 0 0
INCYTE CORP COM 45337C102 199,256 2,897,000 SH   DFND 1,2 2,897,000 0 0
INOGEN INC COM 45780L104 10,435 242,174 SH   DFND 2 242,174 0 0
INSMED INC COM PAR $.01 457669307 93,241 3,385,645 SH   DFND 3 3,385,645 0 0
INSPIRE MED SYS INC COM 457730109 98,056 421,058 SH   DFND 2 421,058 0 0
INSULET CORP COM 45784P101 108,858 382,994 SH   DFND 2 382,994 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 2,226 16,594 SH   DFND 2 16,594 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 344 3,000 SH   DFND 2 3,000 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101 4,119 110,500 SH   DFND 2 110,500 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101 136,572 3,663,419 SH   DFND 1,2 3,663,419 0 0
INTUIT COM 461202103 486 900 SH   DFND 2 900 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 202,404 203,595 SH   DFND 2 203,595 0 0
IONIS PHARMACEUTICALS INC COM 462222100 4,097 122,150 SH   DFND 2 122,150 0 0
IONIS PHARMACEUTICALS INC COM 462222100 305,649 9,112,973 SH   DFND 1,2 9,112,973 0 0
IONIS PHARMACEUTICALS INC COM 462222100 3,783 112,803 SH   DFND 3 112,803 0 0
IPG PHOTONICS CORP COM 44980X109 214 1,350 SH   DFND 2 1,350 0 0
IQVIA HLDGS INC COM 46266C105 45,661 190,620 SH   DFND 2 190,620 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 100,162 769,238 SH   DFND 3 769,238 0 0
JD.COM INC SPON ADR CL A 47215P106 260 3,600 SH   DFND 2 3,600 0 0
JOHNSON & JOHNSON COM 478160104 4,926 30,500 SH   DFND 2 30,500 0 0
JUMIA TECHNOLOGIES AG SPONSORED ADS 48138M105 335 18,000 SH   DFND 2 18,000 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 39,166 4,533,148 SH   DFND 1,2 4,533,148 0 0
KOSMOS ENERGY LTD COM 500688106 864 292,000 SH   DFND 2 292,000 0 0
KURA ONCOLOGY INC COM 50127T109 1,077 57,500 SH   DFND 2 57,500 0 0
KYMERA THERAPEUTICS INC COM 501575104 2,085 35,500 SH   DFND 2 35,500 0 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409 12,412 44,100 SH   DFND 2 44,100 0 0
LAUDER ESTEE COS INC CL A 518439104 404 1,348 SH   DFND 2 1,348 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102 14,488 286,556 SH   DFND 2 286,556 0 0
LIVE NATION ENTERTAINMENT IN COM 538034109 428 4,700 SH   DFND 2 4,700 0 0
MACROGENICS INC COM 556099109 1,046 49,950 SH   DFND 2 49,950 0 0
MACROGENICS INC COM 556099109 148,162 7,075,564 SH   DFND 1,2 7,075,564 0 0
MACROGENICS INC COM 556099109 29,716 1,419,083 SH   DFND 3 1,419,083 0 0
MARKEL CORP COM 570535104 359 300 SH   DFND 2 300 0 0
MARKETAXESS HLDGS INC COM 57060D108 278 662 SH   DFND 2 662 0 0
MASIMO CORP COM 574795100 34,573 127,713 SH   DFND 2 127,713 0 0
MATCH GROUP INC NEW COM 57667L107 373 2,378 SH   DFND 2 2,378 0 0
MCCORMICK & CO INC COM NON VTG 579780206 324 4,000 SH   DFND 2 4,000 0 0
MCKESSON CORP COM 58155Q103 484 2,430 SH   DFND 2 2,430 0 0
MEDTRONIC PLC SHS G5960L103 42,509 339,125 SH   DFND 2 339,125 0 0
MERCADOLIBRE INC COM 58733R102 285 170 SH   DFND 2 170 0 0
MERSANA THERAPEUTICS INC COM 59045L106 1,188 126,000 SH   DFND 2 126,000 0 0
MERSANA THERAPEUTICS INC COM 59045L106 38,993 4,135,000 SH   DFND 1,2 4,135,000 0 0
METTLER TOLEDO INTERNATIONAL COM 592688105 372 270 SH   DFND 2 270 0 0
MIRATI THERAPEUTICS INC COM 60468T105 3,344 18,900 SH   DFND 2 18,900 0 0
MODERNA INC COM 60770K107 18,858 49,000 SH   DFND 2 49,000 0 0
MODERNA INC COM 60770K107 645,929 1,678,349 SH   DFND 1,2 1,678,349 0 0
MOLECULAR TEMPLATES INC COM 608550109 577 86,000 SH   DFND 2 86,000 0 0
MOLECULAR TEMPLATES INC COM 608550109 72,414 10,792,003 SH   DFND 1,2 10,792,003 0 0
MOLINA HEALTHCARE INC COM 60855R100 45,649 168,255 SH   DFND 2 168,255 0 0
MOODYS CORP COM 615369105 444 1,250 SH   DFND 2 1,250 0 0
MSCI INC COM 55354G100 496 816 SH   DFND 2 816 0 0
MYOVANT SCIENCES LTD COM G637AM102 1,055 47,000 SH   DFND 2 47,000 0 0
MYOVANT SCIENCES LTD COM G637AM102 128,403 5,722,039 SH   DFND 1,2 5,722,039 0 0
NEKTAR THERAPEUTICS COM 640268108 517 28,800 SH   DFND 2 28,800 0 0
NEKTAR THERAPEUTICS COM 640268108 47,067 2,620,676 SH   DFND 1,2 2,620,676 0 0
NEKTAR THERAPEUTICS COM 640268108 34,935 1,945,180 SH   DFND 3 1,945,180 0 0
NEOGENOMICS INC COM NEW 64049M209 27,096 561,683 SH   DFND 3 561,683 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 8,503 88,651 SH   DFND 2 88,651 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 279,616 2,915,400 SH   DFND 1,2 2,915,400 0 0
NEUROPACE INC COM 641288105 8,051 507,930 SH   DFND 2 507,930 0 0
NEVRO CORP COM 64157F103 25,017 214,956 SH   DFND 2 214,956 0 0
NEW YORK TIMES CO CL A 650111107 370 7,500 SH   DFND 2 7,500 0 0
NOVAVAX INC COM NEW 670002401 3,317 16,000 SH   DFND 2 16,000 0 0
OLINK HLDG AB SPONSORED ADS 680710100 4,790 197,527 SH   DFND 2 197,527 0 0
OMNICELL INC COM 68213N109 58,420 393,583 SH   DFND 2 393,583 0 0
OPTHEA LTD SPONSORED ADS 68386J208 392 49,000 SH   DFND 2 49,000 0 0
OPTION CARE HEALTH INC COM NEW 68404L201 62,974 2,595,814 SH   DFND 3 2,595,814 0 0
OSCAR HEALTH INC CL A 687793109 11,824 679,952 SH   DFND 2 679,952 0 0
OUTSET MED INC COM 690145107 22,597 457,060 SH   DFND 2 457,060 0 0
PACIFIC BIOSIENCES CALIF IN COM 69404D108 41,983 1,643,159 SH   DFND 2 1,643,159 0 0
PENUMBRA INC COM 70975L107 54,817 205,692 SH   DFND 2 205,692 0 0
PERKINELMER INC COM 714046109 381 2,200 SH   DFND 2 2,200 0 0
PFIZER INC COM 717081103 4,284 99,600 SH   DFND 2 99,600 0 0
PHREESIA INC COM 71944F106 38,411 622,542 SH   DFND 2 622,542 0 0
POOL CORP COM 73278L105 391 900 SH   DFND 2 900 0 0
PRIVIA HEALTH GROUP INC COM 74276R102 12,369 525,000 SH   DFND 2 525,000 0 0
PROCEPT BIOROBOTICS CORP COM 74276L105 5,723 150,000 SH   DFND 2 150,000 0 0
PULMONX CORP COM 745848101 6,351 176,510 SH   DFND 2 176,510 0 0
QUANTERIX CORP COM 74766Q101 29,566 593,819 SH   DFND 2 593,819 0 0
QUEST DIAGNOSTICS INC COM 74834L100 1,889 13,000 SH   DFND 2 13,000 0 0
RADIUS HEALTH INC COM NEW 750469207 782 63,000 SH   DFND 2 63,000 0 0
RADIUS HEALTH INC COM NEW 750469207 95,628 7,705,714 SH   DFND 1,2 7,705,714 0 0
REGENERON PHARMACEUTICALS COM 75886F107 64,397 106,410 SH   DFND 2 106,410 0 0
RELAY THERAPEUTICS INC COM 75943R102 631 20,000 SH   DFND 2 20,000 0 0
RELAY THERAPEUTICS INC COM 75943R102 117,795 3,735,962 SH   DFND 1,2 3,735,962 0 0
RESMED INC COM 761152107 23,231 88,145 SH   DFND 2 88,145 0 0
REVOLUTION MEDICINES INC COM 76155X100 1,340 48,700 SH   DFND 2 48,700 0 0
REVOLUTION MEDICINES INC COM 76155X100 93,812 3,410,105 SH   DFND 1,2 3,410,105 0 0
S&P GLOBAL INC COM 78409V104 510 1,200 SH   DFND 2 1,200 0 0
SAGE THERAPEUTICS INC COM 78667J108 1,724 38,900 SH   DFND 2 38,900 0 0
SAGE THERAPEUTICS INC COM 78667J108 140,467 3,170,104 SH   DFND 1,2 3,170,104 0 0
SANOFI SPONSORED ADR 80105N105 3,230 67,000 SH   DFND 2 67,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 52,637 569,168 SH   DFND 3 569,168 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 637 19,300 SH   DFND 2 19,300 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 75,125 2,275,125 SH   DFND 1,2 2,275,125 0 0
SEAGEN INC COM 81181C104 9,067 53,400 SH   DFND 2 53,400 0 0
SEER INC COM CL A 81578P106 4,701 136,133 SH   DFND 2 136,133 0 0
SENSATA TECHNOLOGIES HLDNG PL SHS G8060N102 323 5,900 SH   DFND 2 5,900 0 0
SERVICE CORP INTL COM 817565104 392 6,500 SH   DFND 2 6,500 0 0
SHOCKWAVE MED INC COM 82489T104 95,579 464,247 SH   DFND 2 464,247 0 0
SIGHT SCIENCES INC COM 82657M105 6,810 300,000 SH   DFND 2 300,000 0 0
SILK RD MED INC COM 82710M100 43,015 781,660 SH   DFND 3 781,660 0 0
SKYWORKS SOLUTIONS INC COM 83088M102 346 2,100 SH   DFND 2 2,100 0 0
SPOTIFY TECHNOLOGY SA SHS L8681T102 248 1,100 SH   DFND 2 1,100 0 0
STARBUCKS CORP COM 855244109 357 3,234 SH   DFND 2 3,234 0 0
STONECO LTD COM CL A G85158106 149 4,300 SH   DFND 2 4,300 0 0
STRYKER CORPORATION COM 863667101 111,377 422,332 SH   DFND 2 422,332 0 0
SYNEOS HEALTH INC CL A 87166B102 4,986 57,000 SH   DFND 2 57,000 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 66,023 553,053 SH   DFND 2 553,053 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 57,477 481,466 SH   DFND 3 481,466 0 0
TELADOC HEALTH INC COM 87918A105 27,379 215,906 SH   DFND 2 215,906 0 0
TELEFLEX INCORPORATED COM 879369106 36,833 97,818 SH   DFND 2 97,818 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 49,637 86,879 SH   DFND 2 86,879 0 0
TRADEWEB MKTS INC CL A 892672106 420 5,200 SH   DFND 2 5,200 0 0
TRANSMEDICS GROUP INC COM 89377M109 19,226 581,029 SH   DFND 2 581,029 0 0
TRANSUNION COM 89400J107 415 3,696 SH   DFND 2 3,696 0 0
TRIMBLE INC COM 896239100 395 4,800 SH   DFND 2 4,800 0 0
TRIP COM GROUP LTD ADS 89677Q107 308 10,000 SH   DFND 2 10,000 0 0
TYLER TECHNOLOGIES INC COM 902252105 367 800 SH   DFND 2 800 0 0
ULTA BEAUTY INC COM 90384S303 397 1,100 SH   DFND 2 1,100 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 2,516 27,900 SH   DFND 2 27,900 0 0
UNITEDHEALTH GROUP INC COM 91324P102 79,523 203,518 SH   DFND 2 203,518 0 0
UNITEDHEALTH GROUP INC COM 91324P102 52,540 134,464 SH   DFND 3 134,464 0 0
UNIVERSAL DISPLAY CORP COM 91347P105 233 1,365 SH   DFND 2 1,365 0 0
VEEVA SYS INC CL A COM 922475108 50,300 174,551 SH   DFND 2 174,551 0 0
VERISIGN INC COM 92343E102 349 1,700 SH   DFND 2 1,700 0 0
VERISK ANALYTICS INC COM 92345Y106 348 1,739 SH   DFND 2 1,739 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 44,041 242,800 SH   DFND 2 242,800 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 85,039 468,816 SH   DFND 3 468,816 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 190,460 1,050,000 SH   DFND 1,2 1,050,000 0 0
VOCERA COMMUNICATONS INC COM 92857F107 22,876 499,912 SH   DFND 2 499,912 0 0
VOCERA COMMUNICATONS INC COM 92857F107 29,933 654,129 SH   DFND 3 654,129 0 0
WABTEC COM 929740108 362 4,200 SH   DFND 2 4,200 0 0
WATSCO INC COM 942622200 344 1,300 SH   DFND 2 1,300 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 12,754 2,602,858 SH   DFND 1,2 2,602,858 0 0
XENCOR INC COM 98401F105 1,702 52,100 SH   DFND 2 52,100 0 0
ZAI LAB LTD ADR 98887Q104 13,174 125,000 SH   DFND 2 125,000 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 40,993 280,082 SH   DFND 2 280,082 0 0
ZOETIS INC CL A 98978V103 1,378 7,100 SH   DFND 2 7,100 0 0