The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CL A COM 88025U109 7,544 51,822 SH   DFND 1 51,822 0 0
2U INC COM 90214J101 7,215 214,929 SH   DFND 1 214,929 0 0
2U INC NOTE 2.250% 5/0 90214JAB7 11,357 8,150,000 SH   DFND 1 8,150,000 0 0
51JOB INC SPONSORED ADS 316827104 779 11,207 SH   DFND 1 11,207 0 0
ABBVIE INC COM 00287Y109 5,003 46,376 SH   DFND 1 46,376 0 0
ACADIA HEALTHCARE COMPANY IN COM 00404A109 85,628 1,342,545 SH   DFND 1 1,342,545 0 0
ACCELERON PHARMA INC COM 00434H108 67,203 390,488 SH   DFND 1 390,488 0 0
ACCENTURE PLC IRELAND SHS CLASS A G1151C101 13,074 40,867 SH   DFND 1,2 40,867 0 0
ACTIVISION BLIZZARD INC COM 00507V109 10,391 134,265 SH   DFND 1 134,265 0 0
ADDUS HOMECARE CORP COM 006739106 26,125 327,584 SH   DFND 1 327,584 0 0
ADOBE SYSTEMS INCORPORATED COM 00724F101 294,350 511,272 SH   DFND 1 511,272 0 0
ADVANCED MICRO DEVICES INC COM 007903107 362,231 3,520,222 SH   DFND 1 3,520,222 0 0
AFFILIATED MANAGERS GROUP IN COM 008252108 21,608 143,012 SH   DFND 1 143,012 0 0
AFFIRM HLDGS INC COM CL A 00827B106 9,925 83,315 SH   DFND 1 83,315 0 0
AFLAC INC COM 001055102 22,286 427,500 SH   DFND 1 427,500 0 0
AIR TRANS SVCS GROUP INC NOTE 1.125%10/1 00922RAB1 21,215 19,615,000 SH   DFND 1 19,615,000 0 0
AIRBNB INC COM CL A 009066101 143,623 856,172 SH   DFND 1 856,172 0 0
AKOYA BIOSCIENCES INC COM 00974H104 14,874 1,065,470 SH   DFND 1 1,065,470 0 0
ALBEMARLE CORP COM 012653101 296 1,350 SH   DFND 1 1,350 0 0
ALCON AG ORD SHS H01301128 82,025 1,029,893 SH   DFND 1,2 1,029,893 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 1,303 8,798 SH   DFND 1 8,798 0 0
ALIGN TECHNOLOGY INC COM 016255101 9,649 14,500 SH   DFND 1 14,500 0 0
ALLEGHANY CORP MD COM 017175100 111,020 177,800 SH   DFND 1 177,800 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 98,882 523,712 SH   DFND 1 523,712 0 0
ALPHABET INC CAP STK CL A 02079K305 553,892 207,177 SH   DFND 1 207,177 0 0
ALPHABET INC CAP STK CL A 02079K305 477,223 178,500 SH Call DFND 1 178,500 0 0
ALPHABET INC CAP STK CL C 02079K107 584,359 219,246 SH   DFND 1,2 219,246 0 0
AMAZON COM INC COM 023135106 256,141 77,972 SH   DFND 1 77,972 0 0
AMBARELLA INC SHS G037AX101 55,713 357,728 SH   DFND 1 357,728 0 0
AMEDISYS INC COM 023436108 44,604 299,157 SH   DFND 1 299,157 0 0
AMERICAN EXPRESS CO COM 025816109 5,514 32,916 SH   DFND 1 32,916 0 0
AMERISOURCEBERGEN CORP COM 03073E105 17,440 146,000 SH   DFND 1 146,000 0 0
AMETEK INC COM 031100100 13,935 112,369 SH   DFND 1 112,369 0 0
AMGEN INC COM 031162100 5,576 26,222 SH   DFND 1 26,222 0 0
AMYRIS INC COM NEW 03236M200 1,005 73,202 SH   DFND 1 73,202 0 0
ANALOG DEVICES INC COM 032654105 31,830 190,053 SH   DFND 1 190,053 0 0
ANGIODYNAMICS INC COM 03475V101 34,384 1,325,508 SH   DFND 1 1,325,508 0 0
ANSYS INC COM 03662Q105 3,536 10,387 SH   DFND 1 10,387 0 0
ANTHEM INC COM 036752103 37,369 100,240 SH   DFND 1 100,240 0 0
AON PLC SHS CL A G0403H108 107,521 376,250 SH   DFND 1 376,250 0 0
APPLE INC COM 037833100 729,687 5,156,800 SH   DFND 1 5,156,800 0 0
APPLE INC COM 037833100 573,075 4,050,000 SH Call DFND 1 4,050,000 0 0
APPLIED MATLS INC COM 038222105 183,541 1,425,786 SH   DFND 1 1,425,786 0 0
APTARGROUP INC COM 038336103 66,659 558,517 SH   DFND 1 558,517 0 0
APTIV PLC SHS G6095L109 95,431 640,608 SH   DFND 1 640,608 0 0
ARCH CAP GROUP LTD ORD G0450A105 223,862 5,863,323 SH   DFND 1 5,863,323 0 0
ARCO PLATFORM LTD COM CL A G04553106 6,712 309,315 SH   DFND 1 309,315 0 0
ARCUTIS BIOTHERAPEUTICS INC COM 03969K108 37,003 1,548,901 SH   DFND 1 1,548,901 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 2,533 42,530 SH   DFND 1 42,530 0 0
ARES CAPITAL CORP COM 04010L103 5,306 260,972 SH   DFND 1 260,972 0 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100 899 14,407 SH   DFND 1 14,407 0 0
ATLASSIAN CORP PLC CL A G06242104 19,551 49,948 SH   DFND 1 49,948 0 0
ATRICURE INC COM 04963C209 35,882 515,910 SH   DFND 1 515,910 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 27,388 2,794,673 SH   DFND 1 2,794,673 0 0
AVANTOR INC COM 05352A100 69,645 1,702,800 SH   DFND 1 1,702,800 0 0
AXON ENTERPRISE INC COM 05464C101 25,081 143,304 SH   DFND 1 143,304 0 0
AXONICS INC COM 05465P101 36,549 561,516 SH   DFND 1 561,516 0 0
BALLARD PWR SYS INC NEW COM 058586108 159 10,020 SH   DFND 1 10,020 0 0
BANDWIDTH INC NOTE 0.250% 3/0 05988JAB9 1,202 1,000,000 SH   DFND 1 1,000,000 0 0
BANK OF NT BUTTERFIELD&SON L SHS NEW G0772R208 7,960 224,156 SH   DFND 1 224,156 0 0
BAXTER INTL INC COM 071813109 22,124 275,071 SH   DFND 1 275,071 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 16,106 2,623,109 SH   DFND 1 2,623,109 0 0
BERKLEY W R CORP COM 084423102 92,847 1,268,750 SH   DFND 1 1,268,750 0 0
BERKSHIRE HATHAWAY INC DEL CL B NEW 084670702 71,988 263,750 SH   DFND 1 263,750 0 0
BILIBILI INC SPONS ADS REP Z 090040106 214 3,234 SH   DFND 1 3,234 0 0
BIO RAD LABS INC CL A 090572207 76,047 101,946 SH   DFND 1 101,946 0 0
BIOGEN INC COM 09062X103 35,374 125,000 SH   DFND 1 125,000 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 174,537 1,256,472 SH   DFND 1 1,256,472 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 9,661 125,000 SH   DFND 1 125,000 0 0
BK OF AMERICA CORP COM 060505104 22,232 523,727 SH   DFND 1 523,727 0 0
BLACKLINE INC COM 09239B109 20,536 173,947 SH   DFND 1 173,947 0 0
BLACKSTONE INC COM 09260D107 9,637 82,831 SH   DFND 1 82,831 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 10,281 100,000 SH   DFND 1 100,000 0 0
BOOKING HOLDINGS INC COM 09857L108 13,023 5,486 SH   DFND 1 5,486 0 0
BOSTON SCIENTIFIC CORP COM 101137107 85,282 1,965,487 SH   DFND 1 1,965,487 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 105,102 1,776,268 SH   DFND 1 1,776,268 0 0
CANADIAN NAT RES LTD COM 136385101 30,279 732,919 SH   DFND 1 732,919 0 0
CANNAE HLDGS INC COM 13765N107 15,651 503,086 SH   DFND 1 503,086 0 0
CASTLE BIOSCIENCES INC COM 14843C105 2,452 36,878 SH   DFND 1 36,878 0 0
CATALENT INC COM 148806102 6,030 45,316 SH   DFND 1 45,316 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 39,026 722,843 SH   DFND 1 722,843 0 0
CENTENE CORP DEL COM 15135B101 71,748 1,151,468 SH   DFND 1 1,151,468 0 0
CERENCE INC COM 156727109 7,382 76,809 SH   DFND 1 76,809 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128 22,125 750,000 SH   DFND 1 750,000 0 0
CERUS CORP COM 157085101 12,114 1,989,199 SH   DFND 1 1,989,199 0 0
CHANGE HEALTHCARE INC UNIT 99/99/9999 15912K209 73,995 1,063,452 SH   DFND 1 1,063,452 0 0
CHEGG INC COM 163092109 67,960 999,122 SH   DFND 1 999,122 0 0
CHEGG INC NOTE 9/0 163092AF6 31,201 31,500,000 SH   DFND 1 31,500,000 0 0
CHEMED CORP NEW COM 16359R103 6,048 13,003 SH   DFND 1 13,003 0 0
CHUBB LIMITED COM H1467J104 194,193 1,119,396 SH   DFND 1 1,119,396 0 0
CITIGROUP INC COM NEW 172967424 17,188 244,915 SH   DFND 1 244,915 0 0
CITIZENS FINL GROUP INC COM 174610105 15,223 324,036 SH   DFND 1 324,036 0 0
CLOUDFLARE INC CL A COM 18915M107 5,638 50,053 SH   DFND 1 50,053 0 0
COGENT BIOSCIENCES INC COM 19240Q201 10,334 1,228,828 SH   DFND 1 1,228,828 0 0
COGNEX CORP COM 192422103 6,929 86,380 SH   DFND 1 86,380 0 0
COLFAX CORP COM 194014106 19,977 435,231 SH   DFND 1 435,231 0 0
CONMED CORP COM 207410101 1,480 11,314 SH   DFND 1 11,314 0 0
COOPER COS INC COM NEW 216648402 58,351 141,180 SH   DFND 1 141,180 0 0
COUPA SOFTWARE INC COM 22266L106 92,900 423,854 SH   DFND 1 423,854 0 0
COUPA SOFTWARE INC NOTE 0.375% 6/1 22266LAF3 19,736 18,200,000 SH   DFND 1 18,200,000 0 0
CRITEO S A SPONS ADS 226718104 5,965 162,766 SH   DFND 1 162,766 0 0
CROWDSTRIKE HLDGS INC CL A 22788C105 140,830 572,994 SH   DFND 1 572,994 0 0
CS DISCO INC COM 126327105 4,858 101,335 SH   DFND 1 101,335 0 0
CSG SYS INTL INC NOTE 4.250% 3/1 126349AF6 20,677 20,000,000 SH   DFND 1 20,000,000 0 0
CURIS INC COM NEW 231269200 25,171 3,214,700 SH   DFND 1 3,214,700 0 0
CVS HEALTH CORP COM 126650100 7,202 84,875 SH   DFND 1 84,875 0 0
CYBERARK SOFTWARE LTD SHS M2682V108 86,661 549,110 SH   DFND 1 549,110 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 298 81,630 SH   DFND 1 81,630 0 0
CYTOKINETICS INC COM NEW 23282W605 107,752 3,014,882 SH   DFND 1 3,014,882 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 19,134 563,100 SH   DFND 1 563,100 0 0
DENALI THERAPEUTICS INC COM 24823R105 2,716 53,835 SH   DFND 1 53,835 0 0
DEXCOM INC COM 252131107 29,849 54,583 SH   DFND 1 54,583 0 0
DEXCOM INC NOTE 0.250%11/1 252131AK3 7,140 6,000,000 SH   DFND 1 6,000,000 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 26,195 1,299,372 SH   DFND 1 1,299,372 0 0
DOCUSIGN INC COM 256163106 80,513 312,757 SH   DFND 1 312,757 0 0
DOLBY LABORATORIES INC COM CL A 25659T107 93,863 1,066,626 SH   DFND 1 1,066,626 0 0
DOLLAR GEN CORP NEW COM 256677105 4,212 19,853 SH   DFND 2 19,853 0 0
DUN & BRADSTREET HLDGS INC COM 26484T106 4,759 283,135 SH   DFND 2 283,135 0 0
EAST WEST BANCORP INC COM 27579R104 11,793 152,091 SH   DFND 1 152,091 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 9,651 85,245 SH   DFND 1 85,245 0 0
EMERSON ELEC CO COM 291011104 17,005 180,522 SH   DFND 1 180,522 0 0
ENCOMPASS HEALTH CORP COM 29261A100 74,448 992,110 SH   DFND 1 992,110 0 0
ENTERPRISE FINL SVCS CORP COM 293712105 9,993 220,697 SH   DFND 1 220,697 0 0
ENVISTA HOLDINGS CORPORATION COM 29415F104 92,640 2,215,735 SH   DFND 1 2,215,735 0 0
EPAM SYS INC COM 29414B104 17,256 30,248 SH   DFND 1 30,248 0 0
EQUIFAX INC COM 294429105 4,982 19,658 SH   DFND 1 19,658 0 0
ESQUIRE FINL HLDGS INC COM 29667J101 681 23,744 SH   DFND 1 23,744 0 0
ESSENT GROUP LTD COM G3198U102 101,025 2,295,500 SH   DFND 1 2,295,500 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108 705 9,847 SH   DFND 1 9,847 0 0
ETSY INC COM 29786A106 78,138 375,737 SH   DFND 1 375,737 0 0
ETSY INC NOTE 0.125% 9/0 29786AAL0 9,237 7,000,000 SH   DFND 1 7,000,000 0 0
EURONET WORLDWIDE INC COM 298736109 1,336 10,500 SH   DFND 2 10,500 0 0
EVERBRIDGE INC COM 29978A104 204,971 1,357,062 SH   DFND 1 1,357,062 0 0
EVEREST RE GROUP LTD COM G3223R108 63,510 253,250 SH   DFND 1 253,250 0 0
EVOLENT HEALTH INC CL A 30050B101 565 18,210 SH   DFND 1 18,210 0 0
EXACT SCIENCES CORP NOTE 0.375% 3/0 30063PAC9 11,325 10,500,000 SH   DFND 1 10,500,000 0 0
EXELIXIS INC COM 30161Q104 86,081 4,071,968 SH   DFND 1 4,071,968 0 0
FACEBOOK INC CL A 30303M102 608,337 1,792,442 SH   DFND 1 1,792,442 0 0
FERGUSON PLC NEW SHS G3421J106 4,558,132 271,927 SH   DFND 1 271,927 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 5,501 45,212 SH   DFND 2 45,212 0 0
FIRST AMERN FINL CORP COM 31847R102 37,716 562,500 SH   DFND 1 562,500 0 0
FIRST REP BK SAN FRANCISCO C COM 33616C100 6,627 34,356 SH   DFND 1 34,356 0 0
FISERV INC COM 337738108 20,402 188,040 SH   DFND 1 188,040 0 0
FIVE9 INC COM 338307101 121,058 757,842 SH   DFND 1 757,842 0 0
FULCRUM THERAPEUTICS INC COM 359616109 21,158 750,000 SH   DFND 1 750,000 0 0
GENERAL DYNAMICS CORP COM 369550108 2,294 11,700 SH   DFND 2 11,700 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 29,580 1,160,900 SH   DFND 1 1,160,900 0 0
GLOBUS MED INC CL A 379577208 54,710 714,037 SH   DFND 1 714,037 0 0
GOLUB CAP BDC INC COM 38173M102 1,389 87,850 SH   DFND 1 87,850 0 0
GUARDANT HEALTH INC COM 40131M109 71,057 568,409 SH   DFND 1 568,409 0 0
HDFC BANK LTD SPONSORED ADS 40415F101 563 7,698 SH   DFND 1 7,698 0 0
HEALTH CATALYST INC COM 42225T107 350 7,000 SH   DFND 1 7,000 0 0
HEALTHEQUITY INC COM 42226A107 697 10,770 SH   DFND 1 10,770 0 0
HOLOGIC INC COM 436440101 16,976 230,000 SH   DFND 1 230,000 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 163,202 1,489,882 SH   DFND 1 1,489,882 0 0
HUBSPOT INC COM 443573100 252,797 373,910 SH   DFND 1 373,910 0 0
HUBSPOT INC NOTE 0.375% 6/0 443573AD2 2,425 1,000,000 SH   DFND 1 1,000,000 0 0
IAC INTERACTIVECORP NEW COM NEW 44891N208 11,708 89,858 SH   DFND 1 89,858 0 0
ICON PLC SHS G4705A100 27,260 104,039 SH   DFND 1 104,039 0 0
IGM BIOSCIENCES INC COM 449585108 5,731 87,151 SH   DFND 1 87,151 0 0
ILLUMINA INC COM 452327109 853 2,104 SH   DFND 1 2,104 0 0
IMPINJ INC COM 453204109 5,201 91,039 SH   DFND 1 91,039 0 0
INCYTE CORP COM 45337C102 34,501 501,618 SH   DFND 1 501,618 0 0
INFINITY PHARMACEUTICALS INC COM 45665G303 8,550 2,500,000 SH   DFND 1 2,500,000 0 0
INSMED INC COM PAR $.01 457669307 49,523 1,798,209 SH   DFND 1 1,798,209 0 0
INSPIRE MED SYS INC COM 457730109 699 3,001 SH   DFND 1 3,001 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 17,628 153,523 SH   DFND 1 153,523 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101 3,420 91,735 SH   DFND 1 91,735 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 10,958 11,022 SH   DFND 1 11,022 0 0
IONIS PHARMACEUTICALS INC NOTE 0.125%12/1 462222AB6 18,958 20,677,000 SH   DFND 1 20,677,000 0 0
IQIYI INC NOTE 3.750%12/0 46267XAB4 99 100,000 SH   DFND 1 100,000 0 0
IQIYI INC SPONSORED ADS 46267X108 251 31,227 SH   DFND 1 31,227 0 0
ITAU UNIBANCO HLDG S A SPON ADR REP PFD 465562106 5,555 1,054,006 SH   DFND 1 1,054,006 0 0
IVERIC BIO INC COM 46583P102 25,098 1,545,425 SH   DFND 1 1,545,425 0 0
JAMES RIV GROUP LTD COM G5005R107 33,957 900,000 SH   DFND 1 900,000 0 0
JAZZ INVESTMENTS I LTD NOTE 2.000% 6/1 472145AF8 6,956 6,000,000 SH   DFND 1 6,000,000 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 35,808 275,000 SH   DFND 1 275,000 0 0
JD.COM INC SPON ADR CL A 47215P106 985 13,634 SH   DFND 1 13,634 0 0
JOHNSON & JOHNSON COM 478160104 124,048 768,098 SH   DFND 1 768,098 0 0
JPMORGAN CHASE & CO COM 46625H100 36,777 224,675 SH   DFND 1 224,675 0 0
KLA CORP COM NEW 482480100 48,309 144,417 SH   DFND 1 144,417 0 0
KURA ONCOLOGY INC COM 50127T109 6,556 350,000 SH   DFND 1 350,000 0 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409 8,705 30,930 SH   DFND 1,2 30,930 0 0
LANTHEUS HLDGS INC COM 516544103 501 19,504 SH   DFND 1 19,504 0 0
LATTICE SEMICONDUCTOR CORP COM 518415104 146,644 2,268,274 SH   DFND 1 2,268,274 0 0
LIBERTY MEDIA CORP DEL COM SER C FRMLA 531229854 13,099 254,791 SH   DFND 1 254,791 0 0
LILLY ELI & CO COM 532457108 10,869 47,040 SH   DFND 1 47,040 0 0
LINDE PLC SHS G5494J103 215 668 SH   DFND 1 668 0 0
LITTELFUSE INC COM 537008104 36,978 135,317 SH   DFND 1 135,317 0 0
LIVANOVA PLC SHS G5509L101 57,707 728,712 SH   DFND 1 728,712 0 0
LIVE NATION ENTERTAINMENT IN NOTE 2.500% 3/1 538034AQ2 1,448 1,000,000 SH   DFND 1 1,000,000 0 0
LIVEPERSON INC COM 538146101 71,645 1,215,359 SH   DFND 1 1,215,359 0 0
LIVERAMP HLDGS INC COM 53815P108 10,799 228,642 SH   DFND 1 228,642 0 0
LOGITECH INTL S A SHS H50430232 62,882 721,075 SH   DFND 1 721,075 0 0
LUMENTUM HLDGS INC NOTE 0.500%12/1 55024UAD1 6,068 5,500,000 SH   DFND 1 5,500,000 0 0
MARKEL CORP COM 570535104 130,448 109,150 SH   DFND 1 109,150 0 0
MARSH & MCLENNAN COS INC COM 571748102 181,792 1,200,500 SH   DFND 1 1,200,500 0 0
MARVELL TECHNOLOGY INC COM 573874104 252,042 4,179,103 SH   DFND 1 4,179,103 0 0
MASIMO CORP COM 574795100 3,666 13,544 SH   DFND 1 13,544 0 0
MASTERCARD INCORPORATED CL A 57636Q104 67,770 194,922 SH   DFND 1 194,922 0 0
MATCH GROUP INC NEW COM 57667L107 179,897 1,145,916 SH   DFND 1 1,145,916 0 0
MEDTRONIC PLC SHS G5960L103 35,855 286,043 SH   DFND 1 286,043 0 0
MERCADOLIBRE INC COM 58733R102 25,162 14,983 SH   DFND 1 14,983 0 0
MERIDIAN BIOSCIENCE INC COM 589584101 619 32,163 SH   DFND 1 32,163 0 0
MERIT MED SYS INC COM 589889104 49,415 688,231 SH   DFND 1 688,231 0 0
MICRON TECHNOLOGY INC COM 595112103 145,970 2,056,490 SH   DFND 1 2,056,490 0 0
MICROSOFT CORP COM 594918104 1,025,275 3,636,760 SH   DFND 1,2 3,636,760 0 0
MICROSOFT CORP COM 594918104 710,438 2,520,000 SH Call DFND 1 2,520,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 10,719 60,592 SH   DFND 1 60,592 0 0
MKS INSTRS INC COM 55306N104 23,157 153,450 SH   DFND 1 153,450 0 0
MODIVCARE INC COM 60783X104 54,212 298,491 SH   DFND 1 298,491 0 0
MOHAWK INDS INC COM 608190104 10,836 61,084 SH   DFND 1 61,084 0 0
MOLINA HEALTHCARE INC COM 60855R100 77,319 284,983 SH   DFND 1 284,983 0 0
MONOLITHIC PWR SYS INC COM 609839105 70,333 145,113 SH   DFND 1 145,113 0 0
MORGAN STANLEY COM NEW 617446448 10,199 104,806 SH   DFND 1 104,806 0 0
MORPHIC HLDG INC COM 61775R105 14,160 250,000 SH   DFND 1 250,000 0 0
NANOSTRING TECHNOLOGIES INC COM 63009R109 46,850 975,832 SH   DFND 1 975,832 0 0
NATERA INC COM 632307104 13,244 118,840 SH   DFND 1 118,840 0 0
NCINO INC COM 63947U107 12,839 180,752 SH   DFND 1 180,752 0 0
NETEASE INC SPONSORED ADS 64110W102 644 7,540 SH   DFND 1 7,540 0 0
NETFLIX INC COM 64110L106 7,603 12,457 SH   DFND 1 12,457 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 2,860 29,815 SH   DFND 1 29,815 0 0
NEVRO CORP COM 64157F103 4,422 38,000 SH   DFND 1 38,000 0 0
NIO INC SPON ADS 62914V106 203 5,700 SH   DFND 1 5,700 0 0
NVIDIA CORPORATION COM 67066G104 493,376 2,381,620 SH   DFND 1 2,381,620 0 0
NXP SEMICONDUCTORS N V COM N6596X109 304 1,550 SH   DFND 1 1,550 0 0
OAK STR HEALTH INC COM 67181A107 5,868 137,962 SH   DFND 1 137,962 0 0
OCULAR THERAPEUTIX INC COM 67576A100 378 37,790 SH   DFND 1 37,790 0 0
OKTA INC CL A 679295105 29,630 124,841 SH   DFND 1 124,841 0 0
OKTA INC NOTE 0.375% 6/1 679295AF2 13,486 11,000,000 SH   DFND 1 11,000,000 0 0
OMNICELL COM COM 68213N109 874 5,887 SH   DFND 1 5,887 0 0
ON SEMICONDUCTOR CORP COM 682189105 307 6,700 SH   DFND 1 6,700 0 0
ONCOCYTE CORP COM 68235C107 379 106,422 SH   DFND 1 106,422 0 0
OPTIMIZERX CORP COM NEW 68401U204 601 7,028 SH   DFND 1 7,028 0 0
OPTION CARE HEALTH INC COM NEW 68404L201 49,332 2,033,485 SH   DFND 1 2,033,485 0 0
ORACLE CORP COM 68389X105 4,227 48,514 SH   DFND 2 48,514 0 0
OREILLY AUTOMOTIVE INC COM 67103H107 2,872 4,700 SH   DFND 2 4,700 0 0
OWENS & MINOR INC NEW COM 690732102 1,059 33,831 SH   DFND 1 33,831 0 0
PACIFIC PREMIER BANCORP COM 69478X105 7,930 191,366 SH   DFND 1 191,366 0 0
PACIRA BIOSCIENCES INC COM 695127100 973 17,368 SH   DFND 1 17,368 0 0
PACWEST BANCORP DEL COM 695263103 10,552 232,828 SH   DFND 1 232,828 0 0
PAGSEGURO DIGITAL LTD COM CL A G68707101 51,670 999,037 SH   DFND 1 999,037 0 0
PALO ALTO NETWORKS INC NOTE 0.375% 6/0 697435AF2 14,905 9,000,000 SH   DFND 1 9,000,000 0 0
PAR TECHNOLOGY CORP NOTE 1.500%10/1 698884AE3 2,691 2,500,000 SH   DFND 1 2,500,000 0 0
PAYPAL HLDGS INC COM 70450Y103 197,214 757,904 SH   DFND 1 757,904 0 0
PELOTON INTERACTIVE INC CL A COM 70614W100 7,458 85,674 SH   DFND 1 85,674 0 0
PENUMBRA INC COM 70975L107 3,786 14,206 SH   DFND 1 14,206 0 0
PG&E CORP UNIT 99/99/9999 69331C140 95,600 1,000,000 SH   DFND 1 1,000,000 0 0
PHOENIX NEW MEDIA LTD SPONSORED ADS 71910C103 128 99,808 SH   DFND 1 99,808 0 0
PINDUODUO INC SPONSORED ADS 722304102 68,771 758,472 SH   DFND 1 758,472 0 0
PNC FINL SVCS GROUP INC COM 693475105 10,351 52,910 SH   DFND 1 52,910 0 0
POWER INTEGRATIONS INC COM 739276103 86,587 874,707 SH   DFND 1 874,707 0 0
PROASSURANCE CORP COM 74267C106 28,536 1,200,000 SH   DFND 1 1,200,000 0 0
PROGRESSIVE CORP COM 743315103 55,070 609,250 SH   DFND 1 609,250 0 0
PROGYNY INC COM 74340E103 1,018 18,175 SH   DFND 1 18,175 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 3,880 218,936 SH   DFND 1 218,936 0 0
QIAGEN NV SHS NEW N72482123 2,619 46,522 SH   DFND 1 46,522 0 0
QORVO INC COM 74736K101 44,213 264,450 SH   DFND 1 264,450 0 0
QUALCOMM INC COM 747525103 118,929 922,071 SH   DFND 1 922,071 0 0
QUIDEL CORP COM 74838J101 703 4,977 SH   DFND 1 4,977 0 0
QUOTIENT LTD SHS G73268107 21,649 9,251,653 SH   DFND 1 9,251,653 0 0
R1 RCM INC COM 749397105 12,190 553,848 SH   DFND 1 553,848 0 0
RECRO PHARMA INC COM 75629F109 458 222,222 SH   DFND 1 222,222 0 0
REGENERON PHARMACEUTICALS COM 75886F107 102,881 170,000 SH   DFND 1 170,000 0 0
REINSURANCE GRP OF AMERICA I COM NEW 759351604 62,862 565,000 SH   DFND 1 565,000 0 0
RENAISSANCERE HLDGS LTD COM G7496G103 125,391 899,504 SH   DFND 1,2 899,504 0 0
REVANCE THERAPEUTICS INC COM 761330109 48,560 1,742,997 SH   DFND 1 1,742,997 0 0
RLI CORP COM 749607107 27,574 275,000 SH   DFND 1 275,000 0 0
ROBLOX CORP CL A 771049103 67,326 891,139 SH   DFND 1 891,139 0 0
ROCKWELL AUTOMATION INC COM 773903109 16,214 55,142 SH   DFND 1 55,142 0 0
ROYAL CARIBBEAN GROUP NOTE 4.250% 6/1 780153BB7 3,525 2,500,000 SH   DFND 1 2,500,000 0 0
RYAN SPECIALTY GROUP HLDGS I CL A 78351F107 13,548 400,000 SH   DFND 1 400,000 0 0
S&P GLOBAL INC COM 78409V104 20,395 48,001 SH   DFND 1 48,001 0 0
SALESFORCE COM INC COM 79466L302 181,763 670,168 SH   DFND 1 670,168 0 0
SAREPTA THERAPEUTICS INC DBCV 1.500%11/1 803607AB6 4,444 3,000,000 SH   DFND 1 3,000,000 0 0
SEA LTD SPONSORD ADS 81141R100 153,370 481,190 SH   DFND 1 481,190 0 0
SEAGATE TECHNOLOGY HLDNGS PL ORD SHS G7997R103 110,063 1,333,776 SH   DFND 1 1,333,776 0 0
SEAGEN INC COM 81181C104 78,575 462,748 SH   DFND 1 462,748 0 0
SEASPINE HLDGS CORP COM 81255T108 620 39,413 SH   DFND 1 39,413 0 0
SENSATA TECHNOLOGIES HLDG PL SHS G8060N102 21,226 387,896 SH   DFND 2 387,896 0 0
SERVICENOW INC COM 81762P102 239,968 385,633 SH   DFND 1 385,633 0 0
SHIFT TECHNOLOGIES INC CL A 82452T107 9,672 1,393,680 SH   DFND 1 1,393,680 0 0
SHOCKWAVE MED INC COM 82489T104 476 2,310 SH   DFND 1 2,310 0 0
SHOPIFY INC CL A 82509L107 23,778 17,538 SH   DFND 1 17,538 0 0
SIGNATURE BK NEW YORK N Y COM 82669G104 40,542 148,900 SH   DFND 1 148,900 0 0
SILICON LABORATORIES INC NOTE 0.625% 6/1 826919AD4 17,325 13,441,000 SH   DFND 1 13,441,000 0 0
SLR INVESTMENT CORP COM 83413U100 5,265 275,248 SH   DFND 1 275,248 0 0
SMARTSHEET INC COM CL A 83200N103 110,484 1,605,402 SH   DFND 1 1,605,402 0 0
SNAP INC CL A 83304A106 284,159 3,846,745 SH   DFND 1 3,846,745 0 0
SNOWFLAKE INC CL A 833445109 64,105 211,966 SH   DFND 1 211,966 0 0
SOLAREDGE TECHNOLOGIES INC NOTE 9/1 83417MAD6 4,351 3,500,000 SH   DFND 1 3,500,000 0 0
SONOS INC COM 83570H108 9,817 303,357 SH   DFND 1 303,357 0 0
SOUTHWEST AIRLS CO NOTE 1.250% 5/0 844741BG2 2,546 1,700,000 SH   DFND 1 1,700,000 0 0
SPIRIT AIRLS INC NOTE 1.000% 5/1 848577AB8 7,535 8,000,000 SH   DFND 1 8,000,000 0 0
SPOTIFY TECHNOLOGY S A SHS L8681T102 25,128 111,511 SH   DFND 1 111,511 0 0
SQUARE INC CL A 852234103 95,279 397,259 SH   DFND 1 397,259 0 0
SS&C TECHNOLOGIES HLDGS INC COM 78467J100 24,682 355,650 SH   DFND 1 355,650 0 0
SSR MNG INC NOTE 2.500% 4/0 784730AB9 16,119 14,039,000 SH   DFND 1 14,039,000 0 0
STELLANTIS N.V SHS N82405106 25,262 1,210,698 SH   DFND 2 1,210,698 0 0
STEREOTAXIS INC COM NEW 85916J409 342 63,487 SH   DFND 1 63,487 0 0
STERIS PLC SHS USD G8473T100 91,004 445,488 SH   DFND 1 445,488 0 0
STITCH FIX INC COM CL A 860897107 9,426 235,942 SH   DFND 1 235,942 0 0
STONECO LTD COM CL A G85158106 11,178 321,958 SH   DFND 1 321,958 0 0
STRIDE INC NOTE 1.125% 9/0 86333MAA6 1,498 1,500,000 SH   DFND 1 1,500,000 0 0
STRYKER CORPORATION COM 863667101 9,203 34,896 SH   DFND 1 34,896 0 0
SUMMIT THERAPEUTICS INC COM 86627T108 32,076 6,402,409 SH   DFND 1 6,402,409 0 0
SUPERNUS PHARMACEUTICALS NOTE 0.625% 4/0 868459AD0 13,285 13,453,000 SH   DFND 1 13,453,000 0 0
SURGERY PARTNERS INC COM 86881A100 432 10,196 SH   DFND 1 10,196 0 0
SVB FINANCIAL GROUP COM 78486Q101 10,926 16,890 SH   DFND 1 16,890 0 0
SYNEOS HEALTH INC CL A 87166B102 12,809 146,420 SH   DFND 1 146,420 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 14,204 127,215 SH   DFND 2 127,215 0 0
TAKE-TWO INTERACTIVE SOFTWAR COM 874054109 11,866 77,018 SH   DFND 1 77,018 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 1,811 15,173 SH   DFND 1 15,173 0 0
TAYLOR MORRISON HOME CORP COM 87724P106 17,835 691,818 SH   DFND 1 691,818 0 0
TE CONNECTIVITY LTD REG SHS H84989104 105,240 766,944 SH   DFND 1 766,944 0 0
TELEFLEX INCORPORATED COM 879369106 58,903 156,428 SH   DFND 1 156,428 0 0
TENABLE HLDGS INC COM 88025T102 82,984 1,798,530 SH   DFND 1 1,798,530 0 0
TESLA INC COM 88160R101 82,904 106,907 SH   DFND 1 106,907 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 7,628 13,351 SH   DFND 1 13,351 0 0
T-MOBILE US INC COM 872590104 37,481 293,371 SH   DFND 1 293,371 0 0
TORONTO DOMINION BK ONT COM NEW 891160509 15,710 210,023 SH   DFND 1 210,023 0 0
TRAVELERS COMPANIES INC COM 89417E109 106,261 699,038 SH   DFND 1 699,038 0 0
TREVENA INC COM 89532E109 131 106,900 SH   DFND 1 106,900 0 0
TRIPADVISOR INC COM 896945201 108,934 3,218,130 SH   DFND 1 3,218,130 0 0
TWILIO INC CL A 90138F102 112,390 352,265 SH   DFND 1 352,265 0 0
TWITTER INC COM 90184L102 121,413 2,010,490 SH   DFND 1 2,010,490 0 0
UBER TECHNOLOGIES INC COM 90353T100 88,304 1,971,064 SH   DFND 1 1,971,064 0 0
UBS GROUP AG SHS H42097107 12,507 796,060 SH   DFND 1 796,060 0 0
UNIQURE NV SHS N90064101 1,072 33,476 SH   DFND 1 33,476 0 0
UNITED RENTALS INC COM 911363109 36,873 105,072 SH   DFND 1 105,072 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 17,250 93,456 SH   DFND 1 93,456 0 0
UNITEDHEALTH GROUP INC COM 91324P102 71,292 182,455 SH   DFND 1 182,455 0 0
UNITY SOFTWARE INC COM 91332U101 25,875 204,954 SH   DFND 1 204,954 0 0
UPSTART HLDGS INC COM 91680M107 4,852 15,332 SH   DFND 1 15,332 0 0
US BANCORP DEL COM NEW 902973304 9,291 156,313 SH   DFND 1 156,313 0 0
US FOODS HLDG CORP COM 912008109 31,358 904,733 SH   DFND 1 904,733 0 0
VERICEL CORP COM 92346J108 837 17,160 SH   DFND 1 17,160 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 54,417 300,000 SH   DFND 1 300,000 0 0
VIAVI SOLUTIONS INC NOTE 1.000% 3/0 925550AB1 1,630 1,250,000 SH   DFND 1 1,250,000 0 0
VISA INC COM CL A 92826C839 38,315 172,008 SH   DFND 1 172,008 0 0
WEBSTER FINL CORP CONN COM 947890109 13,640 250,456 SH   DFND 1 250,456 0 0
WELLS FARGO CO NEW COM 949746101 28,214 607,920 SH   DFND 1 607,920 0 0
WESTERN ALLIANCE BANCORP COM 957638109 8,408 77,263 SH   DFND 1 77,263 0 0
WESTERN DIGITAL CORP. COM 958102105 76,267 1,351,300 SH   DFND 1 1,351,300 0 0
WORKDAY INC CL A 98138H101 102,655 410,802 SH   DFND 1 410,802 0 0
XOMETRY INC CLASS A COM 98423F109 7,281 126,250 SH   DFND 1 126,250 0 0
XPENG INC ADS 98422D105 256 7,200 SH   DFND 1 7,200 0 0
YANDEX N V SHS CLASS A N97284108 14,147 177,522 SH   DFND 1 177,522 0 0
Y-MABS THERAPEUTICS INC COM 984241109 32,963 1,154,961 SH   DFND 1 1,154,961 0 0
ZAI LAB LTD ADR 98887Q104 8,572 81,337 SH   DFND 1 81,337 0 0
ZENDESK INC COM 98936J101 125,631 1,079,393 SH   DFND 1 1,079,393 0 0
ZENDESK INC NOTE 0.625% 6/1 98936JAD3 1,915 1,500,000 SH   DFND 1 1,500,000 0 0
ZENTALIS PHARMACEUTICALS INC COM 98943L107 34,500 517,712 SH   DFND 1 517,712 0 0
ZILLOW GROUP INC CL C CAP STK 98954M200 65,282 740,665 SH   DFND 1 740,665 0 0
ZOOM VIDEO COMMUNICATIONS IN CL A 98980L101 12,205 46,674 SH   DFND 1 46,674 0 0
ZUORA INC COM CL A 98983V106 22,634 1,365,148 SH   DFND 1 1,365,148 0 0