The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
1LIFE HEALTHCARE INC COM 68269G107 11,684 665,000 SH   DFND 2 665,000 0 0
ADOBE SYSTEMS INCORPORATED COM 00724F101 414,312 730,631 SH   DFND 2 367,323 0 363,308
ADOBE SYSTEMS INCORPORATED COM 00724F101 31,273 55,150 SH   DFND 1 55,150 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 8,116 1,156,142 SH   DFND 2 1,156,142 0 0
ALIGN TECHNOLOGY INC COM 016255101 39,055 59,428 SH   DFND 2 59,428 0 0
ALLEGION PLC ORD SHS G0176J109 4,840 36,544 SH   DFND 2 4,929 0 31,615
ALPHABET INC CAP STK CL C 02079K107 1,045,746 361,401 SH   DFND 2 181,141 0 180,260
ALPHABET INC CAP STK CL C 02079K107 77,612 26,822 SH   DFND 1 26,822 0 0
ALPHABET INC CAP STK CL A 02079K305 2,518 869 SH   DFND 2 0 0 869
ALTUS POWER INC COM CL A ADDED 02217A102 532 50,916 SH   DFND 2 50,916 0 0
ALTUS POWER INC COM CL A ADDED 02217A102 1,808 172,974 SH   DFND 1 172,974 0 0
AMAZON INC COM 023135106 715,296 214,524 SH   DFND 2 106,624 0 107,900
AMAZON INC COM 023135106 53,640 16,087 SH   DFND 1 16,087 0 0
AMDOCS LTD SHS G02602103 840 11,219 SH   DFND 1 11,219 0 0
AMDOCS LTD SHS G02602103 327 4,370 SH   DFND 2 4,370 0 0
AMERICAN TOWER CORP NEW COM 03027X100 415,948 1,422,046 SH   DFND 2 699,345 0 722,701
AMERICAN TOWER CORP NEW COM 03027X100 32,015 109,452 SH   DFND 1 109,452 0 0
ANTHEM INC COM 036752103 42,182 91,000 SH   DFND 2 91,000 0 0
AUTOMATIC DATA PROCESSING IN COM 053015103 535 2,168 SH   DFND 1 2,168 0 0
AUTOMATIC DATA PROCESSING IN COM 053015103 185 752 SH   DFND 2 752 0 0
AXONICS INC COM 05465P101 21,302 380,400 SH   DFND 2 380,400 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 29,284 212,498 SH   DFND 2 212,498 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 18,894 213,851 SH   DFND 2 213,851 0 0
BROOKFIELD RENEWABLE CORP CL A SUB VTG 11284V105 383 10,405 SH   DFND 2 10,405 0 0
BROOKFIELD RENEWABLE CORP CL A SUB VTG 11284V105 1,689 45,867 SH   DFND 1 45,867 0 0
CARA THERAPEUTICS INC COM 140755109 7,107 583,460 SH   DFND 2 583,460 0 0
CENTENE CORP DEL COM 15135B101 27,584 334,756 SH   DFND 2 334,756 0 0
COGNEX CORP COM 192422103 4,395 56,521 SH   DFND 2 7,609 0 48,912
COHERUS BIOSCIENCES INC COM 19249H103 14,818 928,464 SH   DFND 2 928,464 0 0
COOPER COS INC COM NEW 216648402 6,623 15,809 SH   DFND 2 2,130 0 13,679
DEX INC COM 252131107 28,458 53,000 SH   DFND 2 53,000 0 0
DLOCAL LTD CLASS A COM G29018101 350 9,800 SH   DFND 1 9,800 0 0
DLOCAL LTD CLASS A COM G29018101 421 11,800 SH   DFND 2 11,800 0 0
DOLLAR GEN CORP NEW COM 256677105 580 2,460 SH   DFND 2 2,460 0 0
DOLLAR GEN CORP NEW COM 256677105 1,809 7,669 SH   DFND 1 7,669 0 0
DROPBOX INC CL A 26210C104 6,110 248,973 SH   DFND 2 33,548 0 215,425
ECOLAB INC COM 278865100 392,481 1,673,052 SH   DFND 2 838,236 0 834,816
ECOLAB INC COM 278865100 29,437 125,481 SH   DFND 1 125,481 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 43,364 334,729 SH   DFND 2 280,659 0 54,070
ELECTRONIC ARTS INC COM 285512109 1,611 12,212 SH   DFND 1 12,212 0 0
ELECTRONIC ARTS INC COM 285512109 4,941 37,458 SH   DFND 2 9,077 0 28,381
EXACT SCIENCES CORP COM 30063P105 25,866 332,341 SH   DFND 2 273,870 0 58,471
FIRST REP BK SAN FRANCISCO C COM 33616C100 424,123 2,053,767 SH   DFND 2 1,039,131 0 1,014,636
FIRST REP BK SAN FRANCISCO C COM 33616C100 32,694 158,319 SH   DFND 1 158,319 0 0
FISERV INC COM 337738108 256,779 2,474,028 SH   DFND 2 1,283,731 0 1,190,297
FISERV INC COM 337738108 20,558 198,070 SH   DFND 1 198,070 0 0
GLAUKOS CORP COM 377322102 8,764 197,212 SH   DFND 2 197,212 0 0
GLOBAL PMTS INC COM 37940X102 4,179 30,918 SH   DFND 2 4,169 0 26,749
GLOBANT S A COM L44385109 660 2,100 SH   DFND 2 2,100 0 0
GLOBANT S A COM L44385109 691 2,200 SH   DFND 1 2,200 0 0
HDFC BANK LTD SPONSORED ADS 40415F101 208,284 3,200,919 SH   DFND 2 1,527,106 0 1,673,813
HDFC BANK LTD SPONSORED ADS 40415F101 20,318 312,249 SH   DFND 1 312,249 0 0
HEADHUNTER GROUP PLC SPONSORED ADS 42207L106 320 6,260 SH   DFND 1 6,260 0 0
HEADHUNTER GROUP PLC SPONSORED ADS 42207L106 382 7,482 SH   DFND 2 7,482 0 0
HERON THERAPEUTICS INC COM 427746102 10,975 1,202,069 SH   DFND 2 1,202,069 0 0
HOME DEPOT INC COM 437076102 890,154 2,144,897 SH   DFND 2 1,070,445 0 1,074,452
HOME DEPOT INC COM 437076102 67,827 163,434 SH   DFND 1 163,434 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 29,262 271,544 SH   DFND 2 271,544 0 0
HUMANA INC COM 444859102 31,292 67,459 SH   DFND 2 67,459 0 0
ICICI BANK LIMITED ADR 45104G104 132,277 6,684,032 SH   DFND 2 2,261,356 0 4,422,676
ICICI BANK LIMITED ADR 45104G104 9,696 489,967 SH   DFND 1 489,967 0 0
ILLUMINA INC COM 452327109 22,057 57,978 SH   DFND 2 57,978 0 0
INFOSYS LTD SPONSORED ADR 456788108 530 20,950 SH   DFND 1 20,950 0 0
INFOSYS LTD SPONSORED ADR 456788108 16,439 649,514 SH   DFND 2 388,950 0 260,564
INSMED INC COM PAR $.01 457669307 9,346 343,110 SH   DFND 2 343,110 0 0
INSULET CORP COM 45784P101 16,738 62,908 SH   DFND 2 62,908 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 1,442 10,542 SH   DFND 1 10,542 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 373 2,727 SH   DFND 2 2,727 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 39,814 110,811 SH   DFND 2 110,811 0 0
IRHYTHM TECHNOLOGIES INC COM 450056106 9,415 80,000 SH   DFND 2 80,000 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 9,645 1,500,000 SH   DFND 2 1,500,000 0 0
KRYSTAL BIOTECH INC COM 501147102 12,997 185,809 SH   DFND 2 185,809 0 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409 1,817 5,783 SH   DFND 1 5,783 0 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409 615 1,956 SH   DFND 2 1,956 0 0
LHC GROUP INC COM 50187A107 15,185 110,657 SH   DFND 2 110,657 0 0
MASTERCARD INCORPORATED CL A 57636Q104 1,109 3,087 SH   DFND 1 3,087 0 0
MASTERCARD INCORPORATED CL A 57636Q104 401 1,117 SH   DFND 2 1,117 0 0
MERCADOLIBRE INC COM 58733R102 4,215 3,126 SH   DFND 2 917 0 2,209
MERCADOLIBRE INC COM 58733R102 646 479 SH   DFND 1 479 0 0
MICROSOFT CORP COM 594918104 884,357 2,629,511 SH   DFND 2 1,311,030 0 1,318,481
MICROSOFT CORP COM 594918104 63,378 188,446 SH   DFND 1 188,446 0 0
MSCI INC COM 55354G100 4,768 7,782 SH   DFND 2 1,050 0 6,732
NEXTERA ENERGY INC COM 65339F101 455,843 4,882,632 SH   DFND 2 2,230,708 0 2,651,924
NEXTERA ENERGY INC COM 65339F101 32,297 345,940 SH   DFND 1 345,940 0 0
NOMAD FOODS LTD USD ORD SHS G6564A105 484 19,070 SH   DFND 2 19,070 0 0
NOMAD FOODS LTD USD ORD SHS G6564A105 1,404 55,284 SH   DFND 1 55,284 0 0
NOVOCURE LTD ORD SHS G6674U108 18,153 241,784 SH   DFND 2 241,784 0 0
OAK STR HEALTH INC COM 67181A107 13,419 404,933 SH   DFND 2 404,933 0 0
OSISKO GOLD ROYALTIES LTD COM 68827L101 324 26,412 SH   DFND 2 26,412 0 0
OSISKO GOLD ROYALTIES LTD COM 68827L101 935 76,307 SH   DFND 1 76,307 0 0
PRIVIA HEALTH GROUP INC COM 74276R102 17,333 670,000 SH   DFND 2 670,000 0 0
PROCTER AND GAMBLE CO COM 742718109 476,921 2,915,519 SH   DFND 2 1,495,930 0 1,419,589
PROCTER AND GAMBLE CO COM 742718109 34,666 211,918 SH   DFND 1 211,918 0 0
PTC INC COM 69370C100 4,526 37,355 SH   DFND 2 5,032 0 32,323
QUIDEL CORP COM 74838J101 13,499 100,000 SH   DFND 2 100,000 0 0
REPUBLIC SVCS INC COM 760759100 970 6,955 SH   DFND 1 6,955 0 0
REPUBLIC SVCS INC COM 760759100 378 2,714 SH   DFND 2 2,714 0 0
RESMED INC COM 761152107 5,794 22,244 SH   DFND 2 2,997 0 19,247
ROBERT HALF INTL INC COM 770323103 168 1,510 SH   DFND 2 1,510 0 0
ROBERT HALF INTL INC COM 770323103 486 4,356 SH   DFND 1 4,356 0 0
S&P GLOBAL INC COM 78409V104 459,119 972,855 SH   DFND 2 486,054 0 486,801
S&P GLOBAL INC COM 78409V104 36,176 76,656 SH   DFND 1 76,656 0 0
SAREPTA THERAPEUTICS INC COM 803607100 10,836 120,329 SH   DFND 2 120,329 0 0
SEA LTD SPONSORD ADS 81141R100 115,219 515,039 SH   DFND 2 164,307 0 350,732
SEA LTD SPONSORD ADS 81141R100 9,271 41,440 SH   DFND 1 41,440 0 0
SERVICE CORP INTL COM 817565104 8,606 121,232 SH   DFND 2 20,827 0 100,405
SERVICE CORP INTL COM 817565104 1,095 15,418 SH   DFND 1 15,418 0 0
SMITH A O CORP COM 831865209 7,557 88,027 SH   DFND 2 11,869 0 76,158
SYNOPSYS INC COM 871607107 8,314 22,561 SH   DFND 2 3,043 0 19,518
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 39,807 330,868 SH   DFND 1 330,868 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 58,340 484,911 SH   DFND 2 392,525 0 92,386
TELADOC HEALTH INC COM 87918A105 8,080 88,000 SH   DFND 2 88,000 0 0
TELEFLEX INCORPORATED COM 879369106 19,052 58,000 SH   DFND 2 58,000 0 0
THERAPEUTICSMD INC COM 88338N107 2,200 6,189,834 SH   DFND 2 6,189,834 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 984,474 1,475,442 SH   DFND 2 778,673 0 696,769
THERMO FISHER SCIENTIFIC INC COM 883556102 71,108 106,571 SH   DFND 1 106,571 0 0
TJX COS INC NEW COM 872540109 650 8,563 SH   DFND 2 8,563 0 0
TJX COS INC NEW COM 872540109 1,796 23,658 SH   DFND 1 23,658 0 0
TRANSUNION COM 89400J107 7,070 59,626 SH   DFND 2 10,222 0 49,404
TRANSUNION COM 89400J107 787 6,637 SH   DFND 1 6,637 0 0
TREACE MED CONCEPTS INC COM 89455T109 93 5,000 SH   DFND 2 5,000 0 0
TRIP COM GROUP LTD ADS 89677Q107 3,194 129,712 SH   DFND 1 129,712 0 0
TRIP COM GROUP LTD ADS 89677Q107 42,180 1,713,241 SH   DFND 2 542,556 0 1,170,685
TYLER TECHNOLOGIES INC COM 902252105 3,597 6,686 SH   DFND 2 900 0 5,786
VERISK ANALYTICS INC COM 92345Y106 3,262 14,260 SH   DFND 2 1,946 0 12,314
VERTEX PHARMACEUTICALS INC COM 92532F100 23,839 108,557 SH   DFND 2 108,557 0 0
VISA INC COM CL A 92826C839 677,271 3,125,239 SH   DFND 2 1,576,527 0 1,548,712
VISA INC COM CL A 92826C839 52,740 243,369 SH   DFND 1 243,369 0 0
VOCERA MUNICATIONS INC COM 92857F107 12,323 190,058 SH   DFND 2 190,058 0 0
WASTE MGMT INC DEL COM 94106L109 399 2,390 SH   DFND 2 2,390 0 0
WASTE MGMT INC DEL COM 94106L109 1,043 6,251 SH   DFND 1 6,251 0 0
WATERS CORP COM 941848103 7,989 21,440 SH   DFND 2 2,891 0 18,549
WILLIS TOWERS WATSON PLC LTD SHS G96629103 380 1,598 SH   DFND 2 1,598 0 0
WILLIS TOWERS WATSON PLC LTD SHS G96629103 1,179 4,963 SH   DFND 1 4,963 0 0
XYLEM INC COM 98419M100 3,956 32,990 SH   DFND 2 4,502 0 28,488