The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
1LIFE HEALTHCARE INC COM 68269G107 14,692 836,190 SH   DFND 2 836,190 0 0
10X GENOMICS INC CL A COM 88025U109 34,659 232,672 SH   DFND 2 232,672 0 0
ABBOTT LABS COM 002824100 245,704 1,745,801 SH   DFND 2 1,745,801 0 0
ABBVIE INC COM 00287Y109 41,554 306,900 SH   DFND 2 306,900 0 0
ABIOMED INC COM 003654100 53,939 150,178 SH   DFND 2 150,178 0 0
ACCOLADE INC COM 00437E102 18,148 688,479 SH   DFND 2 688,479 0 0
ACCOLADE INC COM 00437E102 53,587 2,032,896 SH   DFND 3 2,032,896 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 55,234 1,968,431 SH   DFND 3 1,968,431 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 160 1,000 SH   DFND 2 1,000 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 1,216 37,000 SH   DFND 2 37,000 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 141,745 4,312,292 SH   DFND 1,2 4,312,292 0 0
ALIGN TECHNOLOGY INC COM 016255101 96,319 146,564 SH   DFND 2 146,564 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 8,564 50,500 SH   DFND 2 50,500 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 188,234 1,110,000 SH   DFND 1,2 1,110,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 29,615 174,640 SH   DFND 3 174,640 0 0
AMEDISYS INC COM 023436108 12,590 77,773 SH   DFND 2 77,773 0 0
AMEDISYS INC COM 023436108 66,733 412,239 SH   DFND 3 412,239 0 0
AMERICAN EXPRESS CO COM 025816109 245 1,500 SH   DFND 2 1,500 0 0
AMERICAN WELL CORP CL A 03044L105 12,852 2,127,838 SH   DFND 2 2,127,838 0 0
AMGEN INC COM 031162100 13,082 58,150 SH   DFND 2 58,150 0 0
ANTHEM INC COM 036752103 126,413 272,713 SH   DFND 2 272,713 0 0
ANTHEM INC COM 036752103 84,634 182,581 SH   DFND 3 182,581 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 2,269 48,000 SH   DFND 2 48,000 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 28,491 602,591 SH   DFND 3 602,591 0 0
ARCTURUS THERAPEUTICS HLDGS COM 03969T109 1,540 41,600 SH   DFND 2 41,600 0 0
ARCUS BIOSCIENCES INC COM 03969F109 3,541 87,500 SH   DFND 2 87,500 0 0
ARGENX SE SPONSORED ADR 04016X101 9,280 26,500 SH   DFND 2 26,500 0 0
ARGENX SE SPONSORED ADR 04016X101 339,873 970,538 SH   DFND 1,2 970,538 0 0
ARVINAS INC COM 04335A105 4,641 56,500 SH   DFND 2 56,500 0 0
ARVINAS INC COM 04335A105 178,811 2,176,903 SH   DFND 1,2 2,176,903 0 0
ASPEN TECHNOLOGY INC COM 045327103 285 1,874 SH   DFND 2 1,874 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 3,437 59,000 SH   DFND 2 59,000 0 0
ATRICURE INC COM 04963C209 34,665 498,556 SH   DFND 3 498,556 0 0
AVALARA INC COM 05338G106 168 1,300 SH   DFND 2 1,300 0 0
AVANTOR INC COM 05352A100 21,585 512,216 SH   DFND 2 512,216 0 0
AXONICS INC COM 05465P101 55,876 997,790 SH   DFND 2 997,790 0 0
AXONICS INC COM 05465P101 48,957 874,224 SH   DFND 3 874,224 0 0
AXSOME THERAPEUTICS INC COM 05464T104 24,630 651,937 SH   DFND 3 651,937 0 0
BAXTER INTL INC COM 071813109 38,615 449,849 SH   DFND 2 449,849 0 0
BEAM THERAPEUTICS INC COM 07373V105 478 6,000 SH   DFND 2 6,000 0 0
BEAM THERAPEUTICS INC COM 07373V105 48,358 606,821 SH   DFND 1,2 606,821 0 0
BECTON DICKINSON & CO COM 075887109 114,527 455,412 SH   DFND 2 455,412 0 0
BEIGENE LTD SPONSORED ADR 07725L102 6,231 23,000 SH   DFND 2 23,000 0 0
BERKELEY LTS INC COM 084310101 7,000 385,014 SH   DFND 2 385,014 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108 3,269 53,700 SH   DFND 2 53,700 0 0
BIOGEN INC COM 09062X103 5,998 25,000 SH   DFND 2 25,000 0 0
BIOGEN INC COM 09062X103 119,960 500,000 SH   DFND 1,2 500,000 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 5,238 38,007 SH   DFND 2 38,007 0 0
BIONTECH SE SPONSORED ADS 09075V102 29,252 113,466 SH   DFND 2 113,466 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 6,308 71,400 SH   DFND 2 71,400 0 0
BIO RAD LABS INC CL A 090572207 29,983 39,683 SH   DFND 3 39,683 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 123 23,000 SH   DFND 2 23,000 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 18,335 3,440,000 SH   DFND 1,2 3,440,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 2,731 25,500 SH   DFND 2 25,500 0 0
BOSTON SCIENTIFIC CORP COM 101137107 125,912 2,964,031 SH   DFND 2 2,964,031 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 66,050 1,059,347 SH   DFND 3 1,059,347 0 0
BURNING ROCK BIOTECH LTD SPONSORED ADS 12233L107 4,669 489,890 SH   DFND 2 489,890 0 0
C4 THERAPEUTICS INC COM STK 12529R107 1,520 47,200 SH   DFND 2 47,200 0 0
CAREDX INC COM 14167L103 66,699 1,466,552 SH   DFND 3 1,466,552 0 0
CATALENT INC COM 148806102 2,957 23,100 SH   DFND 2 23,100 0 0
CELLECTIS S A SPON ADS 15117K103 670 82,500 SH   DFND 2 82,500 0 0
CENTENE CORP DEL COM 15135B101 54,385 660,010 SH   DFND 2 660,010 0 0
CHARLES RIV LABS INTL INC COM 159864107 24,834 65,911 SH   DFND 3 65,911 0 0
CIGNA CORP NEW COM 125523100 56,299 245,174 SH   DFND 2 245,174 0 0
CLOROX CO DEL COM 189054109 209 1,200 SH   DFND 2 1,200 0 0
COOPER COS INC COM NEW 216648402 34,906 83,319 SH   DFND 2 83,319 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 1,902 25,100 SH   DFND 2 25,100 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 71,959 949,584 SH   DFND 1,2 949,584 0 0
CVS HEALTH CORP COM 126650100 23,603 228,798 SH   DFND 2 228,798 0 0
CYBERARK SOFTWARE LTD SHS M2682V108 364 2,100 SH   DFND 2 2,100 0 0
DANAHER CORPORATION COM 235851102 194,708 591,800 SH   DFND 2 591,800 0 0
DENTSPLY SIRONA INC COM 24906P109 8,878 159,129 SH   DFND 2 159,129 0 0
DEXCOM INC COM 252131107 126,265 235,153 SH   DFND 2 235,153 0 0
DOLBY LABORATORIES INC COM CL A 25659T107 343 3,600 SH   DFND 2 3,600 0 0
DR REDDYS LABS LTD ADR 256135203 556 8,500 SH   DFND 2 8,500 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 119,340 921,185 SH   DFND 2 921,185 0 0
ELECTRONIC ARTS INC COM 285512109 299 2,270 SH   DFND 2 2,270 0 0
ENTEGRIS INC COM 29362U104 416 3,000 SH   DFND 2 3,000 0 0
EQUINIX INC COM 29444U700 34 40 SH   DFND 2 40 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 206 41,200 SH   DFND 2 41,200 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 22,390 4,477,964 SH   DFND 1,2 4,477,964 0 0
ESSA PHARMA INC COM NEW 29668H708 270 19,000 SH   DFND 2 19,000 0 0
ESSA PHARMA INC COM NEW 29668H708 71,225 5,015,814 SH   DFND 1,2 5,015,814 0 0
EVERTEC INC COM 30040P103 37 739 SH   DFND 2 739 0 0
EVOLENT HEALTH INC CL A 30050B101 31,372 1,133,786 SH   DFND 2 1,133,786 0 0
EVOLENT HEALTH INC CL A 30050B101 40,827 1,475,507 SH   DFND 3 1,475,507 0 0
EXACT SCIENCES CORP COM 30063P105 50,012 642,582 SH   DFND 3 642,582 0 0
EXELIXIS INC COM 30161Q104 439 24,000 SH   DFND 2 24,000 0 0
EXELIXIS INC COM 30161Q104 51,824 2,835,000 SH   DFND 1,2 2,835,000 0 0
FATE THERAPEUTICS INC COM 31189P102 4,353 74,400 SH   DFND 2 74,400 0 0
FATE THERAPEUTICS INC COM 31189P102 216,565 3,701,336 SH   DFND 1,2 3,701,336 0 0
FORTINET INC COM 34959E109 289 803 SH   DFND 2 803 0 0
GENERATION BIO CO COM 37148K100 135 19,000 SH   DFND 2 19,000 0 0
GENERATION BIO CO COM 37148K100 27,281 3,853,180 SH   DFND 1,2 3,853,180 0 0
GENETRON HLDGS LTD ADS 37186H100 4,411 723,137 SH   DFND 2 723,137 0 0
GILEAD SCIENCES INC COM 375558103 11,400 157,000 SH   DFND 2 157,000 0 0
GLOBUS MED INC CL A 379577208 54,689 757,464 SH   DFND 2 757,464 0 0
GRACO INC COM 384109104 363 4,500 SH   DFND 2 4,500 0 0
GRUPO AEROPORTUARIO DEL SURE SPON ADR SER B 40051E202 28 135 SH   DFND 2 135 0 0
GUARDANT HEALTH INC COM 40131M109 29,367 293,612 SH   DFND 2 293,612 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 42,924 1,067,500 SH   DFND 2 1,067,500 0 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104 5,166 121,161 SH   DFND 2 121,161 0 0
HCA HEALTHCARE INC COM 40412C101 75,646 294,434 SH   DFND 2 294,434 0 0
HEALTH CATALYST INC COM 42225T107 27,443 692,666 SH   DFND 2 692,666 0 0
HOLOGIC INC COM 436440101 34,888 455,701 SH   DFND 2 455,701 0 0
HOLOGIC INC COM 436440101 9,472 123,723 SH   DFND 3 123,723 0 0
HOMOLOGY MEDICINES INC COM 438083107 6,323 1,737,122 SH   DFND 1,2 1,737,122 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 39,720 368,600 SH   DFND 2 368,600 0 0
HUMANA INC COM 444859102 63,508 136,912 SH   DFND 2 136,912 0 0
HUMANA INC COM 444859102 77,365 166,785 SH   DFND 3 166,785 0 0
HUTCHMED CHINA LTD SPONSORED ADS 44842L103 37,777 1,076,870 SH   DFND 3 1,076,870 0 0
IDEAYA BIOSCIENCES INC COM 45166A102 1,111 47,000 SH   DFND 2 47,000 0 0
IDEXX LABS INC COM 45168D104 77,684 117,979 SH   DFND 2 117,979 0 0
ILLUMINA INC COM 452327109 28,582 75,130 SH   DFND 2 75,130 0 0
I MAB SPONSORED ADS 44975P103 6,870 144,957 SH   DFND 2 144,957 0 0
INCYTE CORP COM 45337C102 4,404 60,000 SH   DFND 2 60,000 0 0
INCYTE CORP COM 45337C102 212,640 2,897,000 SH   DFND 1,2 2,897,000 0 0
INFOSYS LTD SPONSORED ADR 456788108 29 1,130 SH   DFND 2 1,130 0 0
INHIBRX INC COM 45720L107 2,205 50,500 SH   DFND 2 50,500 0 0
INSMED INC COM PAR $.01 457669307 95,908 3,520,861 SH   DFND 3 3,520,861 0 0
INSPIRE MED SYS INC COM 457730109 96,805 420,780 SH   DFND 2 420,780 0 0
INSULET CORP COM 45784P101 101,831 382,723 SH   DFND 2 382,723 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 1,962 16,594 SH   DFND 2 16,594 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101 4,737 90,500 SH   DFND 2 90,500 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101 185,201 3,538,419 SH   DFND 1,2 3,538,419 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 209,998 584,463 SH   DFND 2 584,463 0 0
IONIS PHARMACEUTICALS INC COM 462222100 3,717 122,150 SH   DFND 2 122,150 0 0
IONIS PHARMACEUTICALS INC COM 462222100 311,389 10,232,973 SH   DFND 1,2 10,232,973 0 0
IPG PHOTONICS CORP COM 44980X109 181 1,050 SH   DFND 2 1,050 0 0
IQVIA HLDGS INC COM 46266C105 46,136 163,520 SH   DFND 2 163,520 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 112,985 886,854 SH   DFND 3 886,854 0 0
JD.COM INC SPON ADR CL A 47215P106 252 3,600 SH   DFND 2 3,600 0 0
JOHNSON & JOHNSON COM 478160104 3,456 20,200 SH   DFND 2 20,200 0 0
JUMIA TECHNOLOGIES AG SPONSORED ADS 48138M105 205 18,000 SH   DFND 2 18,000 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 82,231 4,918,148 SH   DFND 1,2 4,918,148 0 0
KOSMOS ENERGY LTD COM 500688106 1,010 292,000 SH   DFND 2 292,000 0 0
KRYSTAL BIOTECH INC COM 501147102 979 14,000 SH   DFND 2 14,000 0 0
KYMERA THERAPEUTICS INC COM 501575104 3,111 49,000 SH   DFND 2 49,000 0 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409 2,655 8,450 SH   DFND 2 8,450 0 0
LAUDER ESTEE COS INC CL A 518439104 499 1,348 SH   DFND 2 1,348 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102 30,653 657,656 SH   DFND 2 657,656 0 0
LILLY ELI & CO COM 532457108 2,086 7,552 SH   DFND 2 7,552 0 0
LIVE NATION ENTERTAINMENT IN COM 538034109 563 4,700 SH   DFND 2 4,700 0 0
MACROGENICS INC COM 556099109 802 49,950 SH   DFND 2 49,950 0 0
MACROGENICS INC COM 556099109 116,773 7,275,564 SH   DFND 1,2 7,275,564 0 0
MACROGENICS INC COM 556099109 19,821 1,234,948 SH   DFND 3 1,234,948 0 0
MARKEL CORP COM 570535104 370 300 SH   DFND 2 300 0 0
MARKETAXESS HLDGS INC COM 57060D108 272 662 SH   DFND 2 662 0 0
MASIMO CORP COM 574795100 38,464 131,376 SH   DFND 2 131,376 0 0
MCKESSON CORP COM 58155Q103 586 2,359 SH   DFND 2 2,359 0 0
MEDTRONIC PLC SHS G5960L103 69,043 667,408 SH   DFND 2 667,408 0 0
MERCADOLIBRE INC COM 58733R102 229 170 SH   DFND 2 170 0 0
MERSANA THERAPEUTICS INC COM 59045L106 180 29,000 SH   DFND 2 29,000 0 0
MERSANA THERAPEUTICS INC COM 59045L106 25,720 4,135,000 SH   DFND 1,2 4,135,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 3,169 21,600 SH   DFND 2 21,600 0 0
MODERNA INC COM 60770K107 11,658 45,900 SH   DFND 2 45,900 0 0
MODERNA INC COM 60770K107 422,457 1,663,349 SH   DFND 1,2 1,663,349 0 0
MOLECULAR TEMPLATES INC COM 608550109 337 86,000 SH   DFND 2 86,000 0 0
MOLECULAR TEMPLATES INC COM 608550109 42,305 10,792,003 SH   DFND 1,2 10,792,003 0 0
MOLINA HEALTHCARE INC COM 60855R100 100,062 314,582 SH   DFND 2 314,582 0 0
MYOVANT SCIENCES LTD COM G637AM102 732 47,000 SH   DFND 2 47,000 0 0
MYOVANT SCIENCES LTD COM G637AM102 95,320 6,122,039 SH   DFND 1,2 6,122,039 0 0
NEKTAR THERAPEUTICS COM 640268108 389 28,800 SH   DFND 2 28,800 0 0
NEKTAR THERAPEUTICS COM 640268108 35,405 2,620,676 SH   DFND 1,2 2,620,676 0 0
NEKTAR THERAPEUTICS COM 640268108 24,348 1,802,217 SH   DFND 3 1,802,217 0 0
NEOGENOMICS INC COM NEW 64049M209 16,026 469,695 SH   DFND 3 469,695 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 14,066 165,151 SH   DFND 2 165,151 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 256,822 3,015,400 SH   DFND 1,2 3,015,400 0 0
NEUROPACE INC COM 641288105 5,120 507,930 SH   DFND 2 507,930 0 0
NEVRO CORP COM 64157F103 19,282 237,841 SH   DFND 2 237,841 0 0
NEW YORK TIMES CO CL A 650111107 362 7,500 SH   DFND 2 7,500 0 0
NIO INC SPON ADS 62914V106 25 780 SH   DFND 2 780 0 0
NOVAVAX INC COM NEW 670002401 1,488 10,400 SH   DFND 2 10,400 0 0
OLINK HLDG AB SPONSORED ADS 680710100 4,282 235,273 SH   DFND 2 235,273 0 0
OMNICELL INC COM 68213N109 65,379 362,332 SH   DFND 2 362,332 0 0
OPTHEA LTD SPONSORED ADS 68386J208 368 49,000 SH   DFND 2 49,000 0 0
OPTION CARE HEALTH INC COM NEW 68404L201 83,160 2,924,043 SH   DFND 3 2,924,043 0 0
OSCAR HEALTH INC CL A 687793109 5,338 679,952 SH   DFND 2 679,952 0 0
OUTSET MED INC COM 690145107 25,838 560,606 SH   DFND 2 560,606 0 0
PACIFIC BIOSIENCES CALIF IN COM 69404D108 31,775 1,553,023 SH   DFND 2 1,553,023 0 0
PENUMBRA INC COM 70975L107 55,664 193,734 SH   DFND 2 193,734 0 0
PFIZER INC COM 717081103 6,673 113,000 SH   DFND 2 113,000 0 0
PHREESIA INC COM 71944F106 24,676 592,327 SH   DFND 2 592,327 0 0
PRIVIA HEALTH GROUP INC COM 74276R102 13,582 525,000 SH   DFND 2 525,000 0 0
PROCEPT BIOROBOTICS CORP COM 74276L105 4,343 173,649 SH   DFND 2 173,649 0 0
PULMONX CORP COM 745848101 5,661 176,510 SH   DFND 2 176,510 0 0
QUANTERIX CORP COM 74766Q101 16,852 397,464 SH   DFND 2 397,464 0 0
QUEST DIAGNOSTICS INC COM 74834L100 2,638 15,250 SH   DFND 2 15,250 0 0
RADIUS HEALTH INC COM NEW 750469207 436 63,000 SH   DFND 2 63,000 0 0
RADIUS HEALTH INC COM NEW 750469207 53,324 7,705,714 SH   DFND 1,2 7,705,714 0 0
REGENERON PHARMACEUTICALS COM 75886F107 58,769 93,060 SH   DFND 2 93,060 0 0
RELAY THERAPEUTICS INC COM 75943R102 614 20,000 SH   DFND 2 20,000 0 0
RELAY THERAPEUTICS INC COM 75943R102 125,480 4,085,962 SH   DFND 1,2 4,085,962 0 0
RESMED INC COM 761152107 22,529 86,490 SH   DFND 2 86,490 0 0
REVOLUTION MEDICINES INC COM 76155X100 1,226 48,700 SH   DFND 2 48,700 0 0
REVOLUTION MEDICINES INC COM 76155X100 86,118 3,421,462 SH   DFND 1,2 3,421,462 0 0
SAGE THERAPEUTICS INC COM 78667J108 2,463 57,900 SH   DFND 2 57,900 0 0
SAGE THERAPEUTICS INC COM 78667J108 134,856 3,170,104 SH   DFND 1,2 3,170,104 0 0
SAREPTA THERAPEUTICS INC COM 803607100 74,448 826,741 SH   DFND 3 826,741 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 479 19,300 SH   DFND 2 19,300 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 56,514 2,275,125 SH   DFND 1,2 2,275,125 0 0
SEAGEN INC COM 81181C104 7,112 46,000 SH   DFND 2 46,000 0 0
SEER INC COM CL A 81578P106 3,105 136,133 SH   DFND 2 136,133 0 0
SHOCKWAVE MED INC COM 82489T104 76,077 426,610 SH   DFND 2 426,610 0 0
SIGHT SCIENCES INC COM 82657M105 5,271 300,000 SH   DFND 2 300,000 0 0
SILENCE THERAPEUTICS PLC ADS 82686Q101 1,092 46,666 SH   DFND 2 46,666 0 0
SILK RD MED INC COM 82710M100 40,583 952,433 SH   DFND 3 952,433 0 0
SKYWORKS SOLUTIONS INC COM 83088M102 326 2,100 SH   DFND 2 2,100 0 0
SPOTIFY TECHNOLOGY SA SHS L8681T102 257 1,100 SH   DFND 2 1,100 0 0
STONECO LTD COM CL A G85158106 72 4,300 SH   DFND 2 4,300 0 0
STRYKER CORPORATION COM 863667101 112,820 421,884 SH   DFND 2 421,884 0 0
SYNEOS HEALTH INC CL A 87166B102 2,208 21,500 SH   DFND 2 21,500 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 42 346 SH   DFND 2 346 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 80,323 533,640 SH   DFND 2 533,640 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 62,559 415,617 SH   DFND 3 415,617 0 0
TELADOC HEALTH INC COM 87918A105 33,350 363,216 SH   DFND 2 363,216 0 0
TELEFLEX INCORPORATED COM 879369106 32,116 97,771 SH   DFND 2 97,771 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 65,608 98,328 SH   DFND 2 98,328 0 0
TRANSMEDICS GROUP INC COM 89377M109 11,133 581,029 SH   DFND 2 581,029 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 1,766 21,000 SH   DFND 2 21,000 0 0
UNITED MICROELECTRONICS CORP SPON ADR NEW 910873405 32 2,698 SH   DFND 2 2,698 0 0
UNITEDHEALTH GROUP INC COM 91324P102 100,963 201,066 SH   DFND 2 201,066 0 0
UNITEDHEALTH GROUP INC COM 91324P102 55,846 111,215 SH   DFND 3 111,215 0 0
UNIVERSAL DISPLAY CORP COM 91347P105 225 1,365 SH   DFND 2 1,365 0 0
VEEVA SYS INC CL A COM 922475108 42,143 164,955 SH   DFND 2 164,955 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 60,917 277,400 SH   DFND 2 277,400 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 106,366 484,361 SH   DFND 3 484,361 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 226,188 1,030,000 SH   DFND 1,2 1,030,000 0 0
VOCERA COMMUNICATONS INC COM 92857F107 33,518 516,939 SH   DFND 2 516,939 0 0
VOCERA COMMUNICATONS INC COM 92857F107 41,736 643,674 SH   DFND 3 643,674 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 14,453 4,602,858 SH   DFND 1,2 4,602,858 0 0
XENCOR INC COM 98401F105 2,090 52,100 SH   DFND 2 52,100 0 0
ZAI LAB LTD ADR 98887Q104 7,957 126,600 SH   DFND 2 126,600 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 34,452 271,190 SH   DFND 2 271,190 0 0
ZOETIS INC CL A 98978V103 1,733 7,100 SH   DFND 2 7,100 0 0