The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CL A COM 88025U109 109,408 734,481 SH   SOLE 1,2,3 734,481 0 0
5 01 ACQUISITION CORP COM CL A 33836P105 3,861 392,000 SH   SOLE 1,2,3 392,000 0 0
908 DEVICES INC COM 65443P102 1,035 40,000 SH   SOLE 1,2,3 40,000 0 0
AADI BIOSCIENCES INC COM 00032Q104 18,468 764,701 SH   SOLE 1,2,3 764,701 0 0
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 61 12,229 SH   SOLE 1,2,3 12,229 0 0
ADICET BIO INC COM 007002108 52,885 3,023,744 SH   SOLE 1,2,3 3,023,744 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 13,296 7,554,817 SH   SOLE 1,2,3 7,554,817 0 0
AGENUS INC COM NEW 00847G705 18,896 5,868,315 SH   SOLE 1,2,3 5,868,315 0 0
AKOYA BIOSCIENCES INC COM 00974H104 1,531 100,000 SH   SOLE 1,2,3 100,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 335,070 1,975,879 SH   SOLE 1,2,3 1,975,879 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 94,106 1,990,404 SH   SOLE 1,2,3 1,990,404 0 0
APOLLO ENDOSURGERY INC COM 03767D108 2,175 258,064 SH   SOLE 1,2,3 258,064 0 0
APYX MEDICAL CORPORATION COM 03837C106 43,566 3,398,279 SH   SOLE 1,2,3 3,398,279 0 0
ARBUTUS BIOPHARMA CORP COM 03879J100 9,742 2,504,493 SH   SOLE 1,2,3 2,504,493 0 0
ARGENX SE SPONSORED ADR 04016X101 111,167 317,447 SH   SOLE 1,2,3 317,447 0 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100 22,996 346,842 SH   SOLE 1,2,3 346,842 0 0
ARYA SCIENCES ACQU CORP IV CL A G31659108 4,958 500,000 SH   SOLE 1,2,3 500,000 0 0
ARYA SCIENCES ACQUISITN CORP CLASS A ORD SHS G31658100 4,850 500,000 SH   SOLE 1,2,3 500,000 0 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 3,640 3,250,000 SH   SOLE 1,2,3 3,250,000 0 0
ATHIRA PHARMA INC COM 04746L104 24,842 1,906,557 SH   SOLE 1,2,3 1,906,557 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 46,395 5,741,939 SH   SOLE 1,2,3 5,741,939 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 113,977 4,795,000 SH   SOLE 1,2,3 4,795,000 0 0
AVITA MEDICAL INC COM 05380C102 1,278 106,667 SH   SOLE 1,2,3 106,667 0 0
AXONICS INC COM 05465P101 108,856 1,943,864 SH   SOLE 1,2,3 1,943,864 0 0
AXSOME THERAPEUTICS INC COM 05464T104 61,159 1,618,819 SH   SOLE 1,2,3 1,618,819 0 0
BCLS ACQUISITION CORP COM CL A G0904B105 6,003 612,500 SH   SOLE 1,2,3 612,500 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 48,043 5,968,017 SH   SOLE 1,2,3 5,968,017 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108 52,913 869,271 SH   SOLE 1,2,3 869,271 0 0
BIOMEA FUSION INC COM 09077A106 4,424 593,846 SH   SOLE 1,2,3 593,846 0 0
BOLT BIOTHERAPEUTICS INC COM 097702104 619 126,365 SH   SOLE 1,2,3 126,365 0 0
BRAINSWAY LTD SPONSORED ADS 10501L106 12,338 1,602,381 SH   SOLE 1,2,3 1,602,381 0 0
C4 THERAPEUTICS INC COM STK 12529R107 80,338 2,494,965 SH   SOLE 1,2,3 2,494,965 0 0
CASTLE BIOSCIENCES INC COM 14843C105 25,680 599,009 SH   SOLE 1,2,3 599,009 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 151,530 3,921,579 SH   SOLE 1,2,3 3,921,579 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128 21,613 666,666 SH   SOLE 1,2,3 666,666 0 0
CLEARSIDE BIOMEDICAL INC COM 185063104 10,467 3,806,018 SH   SOLE 1,2,3 3,806,018 0 0
CODEX DNA INC COM 192003101 2,160 200,000 SH   SOLE 1,2,3 200,000 0 0
CONNECT BIOPHARMA HLDGS LTD ADS 207523101 2,318 450,000 SH   SOLE 1,2,3 450,000 0 0
CUTERA INC COM 232109108 57,727 1,397,063 SH   SOLE 1,2,3 1,397,063 0 0
CYTOKINETICS INC COM NEW 23282W605 116,739 2,561,182 SH   SOLE 1,2,3 2,561,182 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 26,109 6,029,700 SH   SOLE 1,2,3 6,029,700 0 0
DERMTECH INC COM 24984K105 49,275 3,118,666 SH   SOLE 1,2,3 3,118,666 0 0
ESSA PHARMA INC COM NEW 29668H708 37,448 2,637,192 SH   SOLE 1,2,3 2,637,192 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108 156,751 2,319,138 SH   SOLE 1,2,3 2,319,138 0 0
EXAGEN INC COM 30068X103 9,553 821,414 SH   SOLE 1,2,3 821,414 0 0
FULCRUM THERAPEUTICS INC COM 359616109 68,405 3,866,872 SH   SOLE 1,2,3 3,866,872 0 0
GENETRON HLDGS LTD ADS 37186H100 8,674 1,421,894 SH   SOLE 1,2,3 1,421,894 0 0
GH RESEARCH PLC ORDINARY SHARES G3855L106 50,602 2,168,957 SH   SOLE 1,2,3 2,168,957 0 0
GLOBUS MED INC CL A 379577208 120,633 1,670,811 SH   SOLE 1,2,3 1,670,811 0 0
GUARDANT HEALTH INC COM 40131M109 81,350 813,342 SH   SOLE 1,2,3 813,342 0 0
IDEAYA BIOSCIENCES INC COM 45166A102 59,575 2,520,076 SH   SOLE 1,2,3 2,520,076 0 0
ILLUMINA INC COM 452327109 186,567 490,399 SH   SOLE 1,2,3 490,399 0 0
IMMATICS N.V SHS N44445109 4,704 350,000 SH   SOLE 1,2,3 350,000 0 0
IMMUNIC INC COM 4525EP101 16,417 1,715,470 SH   SOLE 1,2,3 1,715,470 0 0
IMMUNOCORE HLDGS PLC ADS 45258D105 42,647 1,245,532 SH   SOLE 1,2,3 1,245,532 0 0
ISOPLEXIS CORP COM 465005106 3,354 365,000 SH   SOLE 1,2,3 365,000 0 0
ITEOS THERAPEUTICS INC COM 46565G104 109,556 2,353,015 SH   SOLE 1,2,3 2,353,015 0 0
IVERIC BIO INC COM 46583P102 112,402 6,722,624 SH   SOLE 1,2,3 6,722,624 0 0
JOHNSON & JOHNSON COM 478160104 21,405 125,127 SH   SOLE 1,2,3 125,127 0 0
JOUNCE THERAPEUTICS INC COM 481116101 23,908 2,863,198 SH   SOLE 1,2,3 2,863,198 0 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 10,825 2,327,903 SH   SOLE 1,2,3 2,327,903 0 0
LANDOS BIOPHARMA INC COM 515069102 20,523 4,275,722 SH   SOLE 1,2,3 4,275,722 0 0
MACROGENICS INC COM 556099109 63,808 3,975,554 SH   SOLE 1,2,3 3,975,554 0 0
MASIMO CORP COM 574795100 248,855 849,971 SH   SOLE 1,2,3 849,971 0 0
MAXCYTE INC COM 57777K106 2,802 275,000 SH   SOLE 1,2,3 275,000 0 0
MEDICUS SCIENCES ACQUISITION *W EXP 02/12/202 G5960S124 24 33,331 SH   SOLE 1,2,3 33,331 0 0
MEDICUS SCIENCES ACQUISITION CL A SHS G5960S108 2,907 300,000 SH   SOLE 1,2,3 300,000 0 0
MERUS N V COM N5749R100 6,240 196,231 SH   SOLE 1,2,3 196,231 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 28,264 4,315,102 SH   SOLE 1,2,3 4,315,102 0 0
MIMEDX GROUP INC COM 602496101 1,786 295,748 SH   SOLE 1,2,3 295,748 0 0
MINERVA SURGICAL INC COM 60343F106 853 166,000 SH   SOLE 1,2,3 166,000 0 0
MINK THERAPEUTICS INC COM 603693102 1,858 416,666 SH   SOLE 1,2,3 416,666 0 0
MIRATI THERAPEUTICS INC COM 60468T105 229,056 1,561,497 SH   SOLE 1,2,3 1,561,497 0 0
MIROMATRIX MED INC COM 60471P108 1,313 280,000 SH   SOLE 1,2,3 280,000 0 0
MONTE ROSA THERAPEUTICS INC COM 61225M102 24,802 1,214,572 SH   SOLE 1,2,3 1,214,572 0 0
NANOSTRING TECHNOLOGIES INC COM 63009R109 25,508 604,029 SH   SOLE 1,2,3 604,029 0 0
NATERA INC COM 632307104 173,914 1,862,234 SH   SOLE 1,2,3 1,862,234 0 0
NAUTILUS BIOTECHNOLOGY INC COM 63909J108 5,698 1,100,000 SH   SOLE 1,2,3 1,100,000 0 0
NEOGENOMICS INC COM NEW 64049M209 10,615 311,111 SH   SOLE 1,2,3 311,111 0 0
NYXOAH S A SHS B6S7WD106 7,933 344,911 SH   SOLE 1,2,3 344,911 0 0
OLINK HLDG AB SPONSORED ADS 680710100 18,531 1,018,188 SH   SOLE 1,2,3 1,018,188 0 0
ORASURE TECHNOLOGIES INC COM 68554V108 10,032 1,154,380 SH   SOLE 1,2,3 1,154,380 0 0
OUTSET MED INC COM 690145107 41,235 894,652 SH   SOLE 1,2,3 894,652 0 0
OYSTER PT PHARMA INC COM 69242L106 37,588 2,058,504 SH   SOLE 1,2,3 2,058,504 0 0
PENUMBRA INC COM 70975L107 178,389 620,871 SH   SOLE 1,2,3 620,871 0 0
PMV PHARMACEUTICALS INC COM 69353Y103 68,860 2,980,960 SH   SOLE 1,2,3 2,980,960 0 0
POINT BIOPHARMA GLOBAL INC COM 730541109 2,744 490,000 SH   SOLE 1,2,3 490,000 0 0
PROCEPT BIOROBOTICS CORP COM 74276L105 4,855 194,136 SH   SOLE 1,2,3 194,136 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108 129,060 3,264,031 SH   SOLE 1,2,3 3,264,031 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 56,292 7,027,725 SH   SOLE 1,2,3 7,027,725 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 88,914 2,599,822 SH   SOLE 1,2,3 2,599,822 0 0
PTC THERAPEUTICS INC COM 69366J200 210,859 5,293,966 SH   SOLE 1,2,3 5,293,966 0 0
PULMONX CORP COM 745848101 37,349 1,164,600 SH   SOLE 1,2,3 1,164,600 0 0
PYXIS ONCOLOGY INC COMMON STOCK 747324101 23,265 2,120,760 SH   SOLE 1,2,3 2,120,760 0 0
QUANTERIX CORP COM 74766Q101 29,106 686,470 SH   SOLE 1,2,3 686,470 0 0
REGENXBIO INC COM 75901B107 60,343 1,845,366 SH   SOLE 1,2,3 1,845,366 0 0
RELMADA THERAPEUTICS INC COM 75955J402 49,258 2,186,324 SH   SOLE 1,2,3 2,186,324 0 0
RENOVACOR INC *W EXP 99/99/999 75989E114 200 350,000 SH   SOLE 1,2,3 350,000 0 0
RENOVACOR INC COM 75989E106 20,386 2,647,540 SH   SOLE 1,2,3 2,647,540 0 0
RESEARCH ALLIANCE CORP II COM CL A 760873109 6,192 637,000 SH   SOLE 1,2,3 637,000 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 344,975 15,802,802 SH   SOLE 1,2,3 15,802,802 0 0
ROIVANT SCIENCES LTD SHS G76279101 8,091 802,717 SH   SOLE 1,2,3 802,717 0 0
RXSIGHT INC COM 78349D107 1,688 150,000 SH   SOLE 1,2,3 150,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 52,433 582,265 SH   SOLE 1,2,3 582,265 0 0
SCIENCE 37 HOLDINGS INC COM 808644108 49,568 3,975,000 SH   SOLE 1,2,3 3,975,000 0 0
SEMA4 HOLDINGS CORP COM CL A 81663L101 1,784 400,000 SH   SOLE 1,2,3 400,000 0 0
SIGHT SCIENCES INC COM 82657M105 20,801 1,183,871 SH   SOLE 1,2,3 1,183,871 0 0
SINGULAR GENOMICS SYSTEMS IN COM 82933R100 1,156 100,000 SH   SOLE 1,2,3 100,000 0 0
SOPHIA GENETICS SA ORDINARY SHARES H82027105 4,230 300,000 SH   SOLE 1,2,3 300,000 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 422,590 889,739 SH   SOLE 1,2,3 889,739 0 0
STOKE THERAPEUTICS INC COM 86150R107 87,426 3,644,248 SH   SOLE 1,2,3 3,644,248 0 0
SUMMIT HEALTHCRE ACQUISTN CO UNIT 06/03/2026 G8566R128 4,975 500,000 SH   SOLE 1,2,3 500,000 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 174,714 1,160,734 SH   SOLE 1,2,3 1,160,734 0 0
TANGO THERAPEUTICS INC COM 87583X109 1,978 180,819 SH   SOLE 1,2,3 180,819 0 0
TARSUS PHARMACEUTICALS INC COM 87650L103 45,306 2,013,601 SH   SOLE 1,2,3 2,013,601 0 0
TELA BIO INC COM 872381108 17,916 1,399,686 SH   SOLE 1,2,3 1,399,686 0 0
TENAYA THERAPEUTICS INC COM 87990A106 46,593 2,458,750 SH   SOLE 1,2,3 2,458,750 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 290,583 435,500 SH   SOLE 1,2,3 435,500 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 115,479 1,373,284 SH   SOLE 1,2,3 1,373,284 0 0
UROGEN PHARMA LTD COM M96088105 8,154 857,464 SH   SOLE 1,2,3 857,464 0 0
VENTYX BIOSCIENCES INC COM 92332V107 30,818 1,551,778 SH   SOLE 1,2,3 1,551,778 0 0
VERICEL CORP COM 92346J108 177,541 4,517,570 SH   SOLE 1,2,3 4,517,570 0 0
VINCERX PHARMA INC COM NEW 92731L106 7,553 741,236 SH   SOLE 1,2,3 741,236 0 0
ZYMERGEN INC COM 98985X100 468 70,000 SH   SOLE 1,2,3 70,000 0 0