The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACUTUS MED INC COM 005111109 9,031 2,648,386 SH   DFND 1 2,648,386 0 0
ADAPTHEALTH CORP COMMON STOCK 00653Q102 250,114 10,225,445 SH   DFND 1 10,225,445 0 0
AERIE PHARMACEUTICALS INC NOTE 1.500%10/0 00771VAB4 130,154 157,390,000 PRN   DFND 1 157,390,000 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 32,959 4,695,020 SH   DFND 1 4,695,020 0 0
ALECTOR INC COM 014442107 21,790 1,055,192 SH   DFND 1 1,055,192 0 0
ALPHATEC HLDGS INC COM NEW 02081G201 41,089 3,594,829 SH   DFND 1 3,594,829 0 0
AMERICAN WELL CORP CL A 03044L105 5,986 991,115 SH   DFND 1 991,115 0 0
ANNEXON INC COM 03589W102 6,709 583,913 SH   DFND 1 583,913 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 16,227 343,213 SH   DFND 1 343,213 0 0
APELLIS PHARMACEUTICALS INC NOTE 3.500% 9/1 03753UAB2 43,542 28,825,000 PRN   DFND 1 28,825,000 0 0
APOLLO ENDOSURGERY INC COM 03767D108 14,753 1,750,000 SH   DFND 1 1,750,000 0 0
APRIA INC COM 03836A101 53,979 1,655,795 SH   DFND 1 1,655,795 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 19,714 2,449,000 SH   DFND 1 2,449,000 0 0
BENEFITFOCUS INC NOTE 1.250%12/1 08180DAB2 6,229 6,500,000 SH   DFND 1 6,500,000 0 0
BIOATLA INC COM 09077B104 5,673 289,002 SH   DFND 1 289,002 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 23,353 1,686,140 SH   DFND 1 1,686,140 0 0
BIODELIVERY SCIENCES INTL IN COM 09060J106 91 29,204 SH   DFND 1 29,204 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 11,782 110,000 SH   DFND 1 110,000 0 0
BRIDGEBIO PHARMA INC COM 10806X102 16,680 1,000,000 SH Call DFND 1 1,000,000 0 0
BRIDGEBIO PHARMA INC NOTE 2.500% 3/1 10806XAB8 58,890 80,000,000 PRN   DFND 1 80,000,000 0 0
BROOKDALE SR LIVING INC COM 112463104 22,058 4,274,808 SH   DFND 1 4,274,808 0 0
BUTTERFLY NETWORK INC *W EXP 02/12/202 124155110 931 733,333 SH   DFND 1 733,333 0 0
CABALETTA BIO INC COM 12674W109 1,760 464,252 SH   DFND 1 464,252 0 0
CAREMAX INC COM CL A 14171W103 128,861 16,778,750 SH   DFND 1 16,778,750 0 0
CAREMAX INC *W EXP 06/08/202 14171W111 941 672,000 SH   DFND 1 672,000 0 0
CENTENE CORP DEL COM 15135B101 82,713 1,003,800 SH   DFND 1 1,003,800 0 0
COGENT BIOSCIENCES INC COM 19240Q201 13,737 1,601,000 SH   DFND 1 1,601,000 0 0
CULLINAN ONCOLOGY INC COM 230031106 10,364 671,690 SH   DFND 1 671,690 0 0
CYTOKINETICS INC COM NEW 23282W605 36,874 809,000 SH   DFND 1 809,000 0 0
DA32 LIFE SCNCE TEC ACQSTN C CLASS A COM 23312M106 15,696 1,600,000 SH   DFND 1 1,600,000 0 0
DAY ONE BIOPHARMACEUTICALS I COM 23954D109 37,113 2,202,533 SH   DFND 1 2,202,533 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 54,521 5,580,456 SH   DFND 1 5,580,456 0 0
DEFINITIVE HEALTHCARE CORP CLASS A COM 24477E103 6,833 250,000 SH   DFND 1 250,000 0 0
DELCATH SYS INC COM NEW 24661P807 3,875 500,000 SH   DFND 1 500,000 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105 60,098 3,933,137 SH   DFND 1 3,933,137 0 0
ENVISTA HOLDINGS CORPORATION NOTE 2.375% 6/0 29415FAB0 116,547 52,500,000 PRN   DFND 1 52,500,000 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 25,000 5,000,000 SH   DFND 1 5,000,000 0 0
EUCRATES BIOMEDICAL ACQU COR *W EXP 10/23/202 G3141W122 193 333,333 SH   DFND 1 333,333 0 0
EUCRATES BIOMEDICAL ACQU COR SHS G3141W106 9,760 999,999 SH   DFND 1 999,999 0 0
FIGS INC CL A 30260D103 22,867 829,707 SH   DFND 1 829,707 0 0
GLAUKOS CORP NOTE 2.750% 6/1 377322AB8 242,436 204,700,000 PRN   DFND 1 204,700,000 0 0
GLAUKOS CORP COM 377322102 51,613 1,161,414 SH   DFND 1 1,161,414 0 0
GLAUKOS CORP COM 377322102 2,009 45,200 SH Call DFND 1 45,200 0 0
GRAYBUG VISION INC COM SHS 38942Q103 9,666 5,281,713 SH   DFND 1 5,281,713 0 0
GUARDANT HEALTH INC NOTE 11/1 40131MAB5 8,053 8,000,000 PRN   DFND 1 8,000,000 0 0
HEALTH CATALYST INC NOTE 2.500% 4/1 42225TAB3 21,789 15,000,000 PRN   DFND 1 15,000,000 0 0
HYPERFINE INC COM CL A 44916K106 7,250 1,000,000 SH   DFND 1 1,000,000 0 0
IGNYTE ACQUISITION CORP *W EXP 01/05/202 45175H114 279 362,500 SH   DFND 1 362,500 0 0
IGNYTE ACQUISITION CORP COM 45175H106 7,062 725,000 SH   DFND 1 725,000 0 0
INOZYME PHARMA INC COM 45790W108 15,991 2,344,786 SH   DFND 1 2,344,786 0 0
INSMED INC NOTE 1.750% 1/1 457669AA7 51,321 50,000,000 PRN   DFND 1 50,000,000 0 0
INSULET CORP NOTE 0.375% 9/0 45784PAK7 76,356 57,581,000 PRN   DFND 1 57,581,000 0 0
INTERCEPT PHARMACEUTICALS IN NOTE 3.250% 7/0 45845PAA6 54,417 57,791,000 PRN   DFND 1 57,791,000 0 0
INVITAE CORP NOTE 2.000% 9/0 46185LAB9 153,337 163,385,000 PRN   DFND 1 163,385,000 0 0
IVERIC BIO INC COM 46583P102 79,606 4,761,138 SH   DFND 1 4,761,138 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 15,547 1,175,131 SH   DFND 1 1,175,131 0 0
KINNATE BIOPHARMA INC COM 49705R105 17,464 985,568 SH   DFND 1 985,568 0 0
KURA ONCOLOGY INC COM 50127T109 49,193 3,513,756 SH   DFND 1 3,513,756 0 0
LARIMAR THERAPEUTICS INC COM 517125100 62,908 5,830,249 SH   DFND 1 5,830,249 0 0
LIANBIO SPONSORED ADS 53000N108 10,982 1,782,747 SH   DFND 1 1,782,747 0 0
MEDAVAIL HOLDINGS INC COM 58406B103 1,600 1,142,552 SH   DFND 1 1,142,552 0 0
MEDTECH ACQUISITION CORP COM CL A 58507N105 9,880 999,999 SH   DFND 1 999,999 0 0
MEDTECH ACQUISITION CORP *W EXP 12/22/202 58507N113 174 333,333 SH   DFND 1 333,333 0 0
MERIDIAN BIOSCIENCE INC COM 589584101 22,952 1,125,083 SH   DFND 1 1,125,083 0 0
MERUS N V COM N5749R100 13,897 437,000 SH   DFND 1 437,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 12,909 88,000 SH   DFND 1 88,000 0 0
MIRUM PHARMACEUTICALS INC COM 604749101 52,362 3,282,912 SH   DFND 1 3,282,912 0 0
MOLINA HEALTHCARE INC COM 60855R100 42,937 134,989 SH   DFND 1 134,989 0 0
NATERA INC NOTE 2.250% 5/0 632307AB0 115,754 45,000,000 PRN   DFND 1 45,000,000 0 0
NEOGENOMICS INC NOTE 0.250% 1/1 64049MAB6 2,132 2,500,000 PRN   DFND 1 2,500,000 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 117,360 1,377,945 SH   DFND 1 1,377,945 0 0
NEVRO CORP NOTE 2.750% 4/0 64157FAC7 68,194 61,000,000 PRN   DFND 1 61,000,000 0 0
NEVRO CORP COM 64157F103 17,511 216,000 SH   DFND 1 216,000 0 0
NOVAVAX INC NOTE 3.750% 2/0 670002AB0 34,424 25,000,000 PRN   DFND 1 25,000,000 0 0
NUVALENT INC COM 670703107 368,253 19,341,024 SH   DFND 1 19,341,024 0 0
NUVASIVE INC NOTE 0.375% 3/1 670704AJ4 74,729 77,859,000 PRN   DFND 1 77,859,000 0 0
NUVASIVE INC NOTE 1.000% 6/0 670704AL9 96,617 96,966,000 PRN   DFND 1 96,966,000 0 0
NUVATION BIO INC COM CL A 67080N101 30,406 3,577,233 SH   DFND 1 3,577,233 0 0
NUVATION BIO INC *W EXP 07/07/202 67080N119 315 166,666 SH   DFND 1 166,666 0 0
NYXOAH S A SHS B6S7WD106 10,471 455,262 SH   DFND 1 455,262 0 0
ONCORUS INC COM 68236R103 16,595 3,148,977 SH   DFND 1 3,148,977 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 9,173 6,949,416 SH   DFND 1 6,949,416 0 0
ORGANOGENESIS HLDGS INC COM 68621F102 78,142 8,456,876 SH   DFND 1 8,456,876 0 0
ORION ACQUISITION CORP *W EXP 02/19/202 68626A116 81 125,000 SH   DFND 1 125,000 0 0
ORION ACQUISITION CORP COM CL A 68626A108 4,890 500,000 SH   DFND 1 500,000 0 0
OUTSET MED INC COM 690145107 18,465 400,622 SH   DFND 1 400,622 0 0
PACIRA BIOSCIENCES INC COM 695127100 35,882 596,338 SH   DFND 1 596,338 0 0
PACIRA BIOSCIENCES INC NOTE 0.750% 8/0 695127AF7 90,486 81,600,000 PRN   DFND 1 81,600,000 0 0
PHARVARIS N V COM N69605108 22,755 1,581,331 SH   DFND 1 1,581,331 0 0
PMV PHARMACEUTICALS INC COM 69353Y103 12,058 522,000 SH   DFND 1 522,000 0 0
PRIVIA HEALTH GROUP INC COM 74276R102 7,761 300,000 SH   DFND 1 300,000 0 0
PROFOUND MED CORP COM NEW 74319B502 19,246 1,713,797 SH   DFND 1 1,713,797 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 40,115 1,172,943 SH   DFND 1 1,172,943 0 0
PTC THERAPEUTICS INC NOTE 3.000% 8/1 69366JAB7 15,326 14,527,000 PRN   DFND 1 14,527,000 0 0
PULMONX CORP COM 745848101 75,905 2,366,867 SH   DFND 1 2,366,867 0 0
PYXIS ONCOLOGY INC COMMON STOCK 747324101 3,420 311,754 SH   DFND 1 311,754 0 0
QUANTUM SI INC COM CL A 74765K105 11,018 1,400,000 SH   DFND 1 1,400,000 0 0
QUANTUM SI INC *W EXP 06/10/202 74765K113 600 333,333 SH   DFND 1 333,333 0 0
REVOLUTION HEALTHCAR AQ CORP CLASS A COM 76155Y108 9,740 1,000,000 SH   DFND 1 1,000,000 0 0
REVOLUTION HEALTHCAR AQ CORP *W EXP 12/31/202 76155Y116 150 200,000 SH   DFND 1 200,000 0 0
REVOLUTION MEDICINES INC COM 76155X100 22,441 891,587 SH   DFND 1 891,587 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 18,637 1,867,467 SH   DFND 1 1,867,467 0 0
ROIVANT SCIENCES LTD *W EXP 09/30/202 G76279119 2,047 1,000,000 SH   DFND 1 1,000,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 12,697 141,000 SH   DFND 1 141,000 0 0
SARISSA CAPITAL ACQUISITN CO CL A G7823W102 9,790 999,999 SH   DFND 1 999,999 0 0
SEMA4 HOLDINGS CORP COM CL A 81663L101 62,292 13,966,824 SH   DFND 1 13,966,824 0 0
SENIOR CONNECT ACQUISITN COR *W EXP 12/31/202 81723H116 263 500,000 SH   DFND 1 500,000 0 0
SENIOR CONNECT ACQUISITN COR COM CL A 81723H108 9,740 1,000,000 SH   DFND 1 1,000,000 0 0
SILK RD MED INC COM 82710M100 64,647 1,517,181 SH   DFND 1 1,517,181 0 0
SINGULAR GENOMICS SYSTEMS IN COM 82933R100 105,335 9,112,019 SH   DFND 1 9,112,019 0 0
SOMALOGIC INC *W EXP 08/31/202 83444K113 401 120,000 SH   DFND 1 120,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 28,015 452,000 SH   DFND 1 452,000 0 0
SURROZEN INC *W EXP 08/01/203 86889P117 192 166,666 SH   DFND 1 166,666 0 0
TABULA RASA HEALTHCARE INC NOTE 1.750% 2/1 873379AA9 80,473 97,816,000 PRN   DFND 1 97,816,000 0 0
TERNS PHARMACEUTICALS INC COM 880881107 16,586 2,345,959 SH   DFND 1 2,345,959 0 0
THE ONCOLOGY INSTITUTE INC *W EXP 11/15/202 68236X118 863 1,250,000 SH   DFND 1 1,250,000 0 0
THE ONCOLOGY INSTITUTE INC COM 68236X100 32,137 3,296,107 SH   DFND 1 3,296,107 0 0
TURMERIC ACQUISITION CORP *W EXP 10/08/202 G9127T124 170 250,000 SH   DFND 1 250,000 0 0
TURMERIC ACQUISITION CORP CL A G9127T108 7,365 750,000 SH   DFND 1 750,000 0 0
VIATRIS INC COM 92556V106 281,072 20,774,000 SH   DFND 1 20,774,000 0 0
VINCERX PHARMA INC COM NEW 92731L106 14,055 1,379,310 SH   DFND 1 1,379,310 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 1,735 552,690 SH   DFND 1 552,690 0 0
WEAVE COMMUNICATIONS INC COM 94724R108 8,418 554,519 SH   DFND 1 554,519 0 0
WEREWOLF THERAPEUTICS INC COM 95075A107 11,411 958,125 SH   DFND 1 958,125 0 0
WINDTREE THERAPEUTICS INC COM 97382D303 32 20,148 SH   DFND 1 20,148 0 0
XERIS BIOPHARMA HOLDINGS INC NOTE 5.000% 7/1 98422LAA5 21,577 18,000,000 PRN   DFND 1 18,000,000 0 0
XILIO THERAPEUTICS INC COM 98422T100 33,739 2,154,061 SH   DFND 1 2,154,061 0 0