The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ADOBE SYSTEMS INCORPORATED COM 00724F101 323,841 710,770 SH   DFND 2 371,420 0 339,350
ADOBE SYSTEMS INCORPORATED COM 00724F101 24,653 54,108 SH   DFND 1 54,108 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 10,521 1,156,142 SH   DFND 2 1,156,142 0 0
ALIGN TECHNOLOGY INC COM 016255101 27,655 63,428 SH   DFND 2 63,428 0 0
ALLEGION PLC ORD SHS G0176J109 4,488 40,884 SH   DFND 2 9,269 0 31,615
ALPHABET INC CAP STK CL C 02079K107 981,152 351,291 SH   DFND 2 183,043 0 168,248
ALPHABET INC CAP STK CL C 02079K107 73,718 26,394 SH   DFND 1 26,394 0 0
ALPHABET INC CAP STK CL A 02079K305 2,417 869 SH   DFND 2 0 0 869
AMAZON INC COM 023135106 680,400 208,715 SH   DFND 2 107,748 0 100,967
AMAZON INC COM 023135106 51,357 15,754 SH   DFND 1 15,754 0 0
AMDOCS LTD SHS G02602103 157 1,910 SH   DFND 2 1,910 0 0
AMDOCS LTD SHS G02602103 459 5,578 SH   DFND 1 5,578 0 0
AMERICAN TOWER CORP NEW COM 03027X100 26,943 107,247 SH   DFND 1 107,247 0 0
AMERICAN TOWER CORP NEW COM 03027X100 347,127 1,381,763 SH   DFND 2 704,254 0 677,509
ANTHEM INC COM 036752103 34,877 71,000 SH   DFND 2 71,000 0 0
AUTOMATIC DATA PROCESSING IN COM 053015103 493 2,168 SH   DFND 1 2,168 0 0
AUTOMATIC DATA PROCESSING IN COM 053015103 171 752 SH   DFND 2 752 0 0
AXONICS MODULATION TECHNOLOG COM 05465P101 23,813 380,400 SH   DFND 2 380,400 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 20,453 172,498 SH   DFND 2 172,498 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 16,488 213,851 SH   DFND 2 213,851 0 0
BROOKFIELD RENEWABLE CORP CL A SUB VTG 11284V105 674 15,389 SH   DFND 2 15,389 0 0
BROOKFIELD RENEWABLE CORP CL A SUB VTG 11284V105 2,009 45,867 SH   DFND 1 45,867 0 0
CARA THERAPEUTICS INC COM 140755109 7,089 583,460 SH   DFND 2 583,460 0 0
CENTENE CORP DEL COM 15135B101 28,183 334,756 SH   DFND 2 334,756 0 0
COGNEX CORP COM 192422103 4,878 63,222 SH   DFND 2 14,310 0 48,912
COHERUS BIOSCIENCES INC COM 19249H103 11,986 928,464 SH   DFND 2 928,464 0 0
COOPER COS INC COM NEW 216648402 7,385 17,684 SH   DFND 2 4,005 0 13,679
DEX INC COM 252131107 29,673 58,000 SH   DFND 2 58,000 0 0
DOLLAR GEN CORP NEW COM 256677105 359 1,611 SH   DFND 2 1,611 0 0
DOLLAR GEN CORP NEW COM 256677105 1,023 4,595 SH   DFND 1 4,595 0 0
DROPBOX INC CL A 26210C104 6,475 278,516 SH   DFND 2 63,091 0 215,425
ECOLAB INC COM 278865100 286,906 1,624,976 SH   DFND 2 843,437 0 781,539
ECOLAB INC COM 278865100 21,692 122,857 SH   DFND 1 122,857 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 38,897 330,416 SH   DFND 2 285,401 0 45,015
ELECTRONIC ARTS INC COM 285512109 5,231 41,351 SH   DFND 2 12,970 0 28,381
ELECTRONIC ARTS INC COM 285512109 1,545 12,212 SH   DFND 1 12,212 0 0
EXACT SCIENCES CORP COM 30063P105 23,787 340,205 SH   DFND 2 281,734 0 58,471
FIRST REP BK SAN FRANCISCO C COM 33616C100 323,560 1,996,053 SH   DFND 2 1,046,436 0 949,617
FIRST REP BK SAN FRANCISCO C COM 33616C100 25,115 154,933 SH   DFND 1 154,933 0 0
FISERV INC COM 337738108 19,630 193,594 SH   DFND 1 193,594 0 0
FISERV INC COM 337738108 243,447 2,400,857 SH   DFND 2 1,287,013 0 1,113,844
GENPACT LIMITED SHS G3922B107 881 20,241 SH   DFND 1 20,241 0 0
GENPACT LIMITED SHS G3922B107 309 7,104 SH   DFND 2 7,104 0 0
GLAUKOS CORP COM 377322102 11,403 197,212 SH   DFND 2 197,212 0 0
GLOBAL PMTS INC COM 37940X102 4,733 34,589 SH   DFND 2 7,840 0 26,749
GLOBANT S A COM L44385109 374 1,428 SH   DFND 1 1,428 0 0
GLOBANT S A COM L44385109 550 2,100 SH   DFND 2 2,100 0 0
HDFC BANK LTD SPONSORED ADS 40415F101 195,008 3,179,657 SH   DFND 2 1,552,985 0 1,626,672
HDFC BANK LTD SPONSORED ADS 40415F101 18,129 295,604 SH   DFND 1 295,604 0 0
HERON THERAPEUTICS INC COM 427746102 6,876 1,202,069 SH   DFND 2 1,202,069 0 0
HOME DEPOT INC COM 437076102 624,807 2,087,352 SH   DFND 2 1,081,443 0 1,005,909
HOME DEPOT INC COM 437076102 47,987 160,314 SH   DFND 1 160,314 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 32,778 311,544 SH   DFND 2 311,544 0 0
HUMANA INC COM 444859102 22,829 52,459 SH   DFND 2 52,459 0 0
ICICI BANK LIMITED ADR 45104G104 8,311 438,793 SH   DFND 1 438,793 0 0
ICICI BANK LIMITED ADR 45104G104 124,886 6,593,762 SH   DFND 2 2,181,221 0 4,412,541
ILLUMINA INC COM 452327109 20,258 57,978 SH   DFND 2 57,978 0 0
INFOSYS LTD SPONSORED ADR 456788108 521 20,950 SH   DFND 1 20,950 0 0
INFOSYS LTD SPONSORED ADR 456788108 15,639 628,322 SH   DFND 2 386,211 0 242,111
INSMED INC COM PAR $.01 457669307 8,063 343,110 SH   DFND 2 343,110 0 0
INSULET CORP COM 45784P101 16,758 62,908 SH   DFND 2 62,908 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 577 4,364 SH   DFND 2 4,364 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 1,393 10,542 SH   DFND 1 10,542 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 33,429 110,811 SH   DFND 2 110,811 0 0
IRHYTHM TECHNOLOGIES INC COM 450056106 12,598 80,000 SH   DFND 2 80,000 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 11,055 1,500,000 SH   DFND 2 1,500,000 0 0
KRYSTAL BIOTECH INC COM 501147102 15,025 225,809 SH   DFND 2 225,809 0 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409 1,525 5,783 SH   DFND 1 5,783 0 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409 605 2,295 SH   DFND 2 2,295 0 0
MASTERCARD INCORPORATED CL A 57636Q104 399 1,117 SH   DFND 2 1,117 0 0
MASTERCARD INCORPORATED CL A 57636Q104 1,103 3,087 SH   DFND 1 3,087 0 0
MERCADOLIBRE INC COM 58733R102 5,550 4,666 SH   DFND 2 1,499 0 3,167
MERCADOLIBRE INC COM 58733R102 454 382 SH   DFND 1 382 0 0
MICROSOFT CORP COM 594918104 57,015 184,927 SH   DFND 1 184,927 0 0
MICROSOFT CORP COM 594918104 787,890 2,555,511 SH   DFND 2 1,326,249 0 1,229,262
MSCI INC COM 55354G100 4,378 8,706 SH   DFND 2 1,974 0 6,732
NEXTERA ENERGY INC COM 65339F101 30,959 365,468 SH   DFND 1 365,468 0 0
NEXTERA ENERGY INC COM 65339F101 403,522 4,763,572 SH   DFND 2 2,281,536 0 2,482,036
NOMAD FOODS LTD USD ORD SHS G6564A105 431 19,070 SH   DFND 2 19,070 0 0
NOMAD FOODS LTD USD ORD SHS G6564A105 1,248 55,284 SH   DFND 1 55,284 0 0
NOVOCURE LTD ORD SHS G6674U108 24,589 296,784 SH   DFND 2 296,784 0 0
OAK STR HEALTH INC COM 67181A107 18,949 704,933 SH   DFND 2 704,933 0 0
OSISKO GOLD ROYALTIES LTD COM 68827L101 741 56,193 SH   DFND 2 56,193 0 0
OSISKO GOLD ROYALTIES LTD COM 68827L101 2,056 155,898 SH   DFND 1 155,898 0 0
PROCTER AND GAMBLE CO COM 742718109 31,142 203,806 SH   DFND 1 203,806 0 0
PROCTER AND GAMBLE CO COM 742718109 431,807 2,825,964 SH   DFND 2 1,501,607 0 1,324,357
PTC INC COM 69370C100 4,501 41,786 SH   DFND 2 9,463 0 32,323
QUIDEL CORP COM 74838J101 11,246 100,000 SH   DFND 2 100,000 0 0
REPUBLIC SVCS INC COM 760759100 465 3,506 SH   DFND 1 3,506 0 0
REPUBLIC SVCS INC COM 760759100 159 1,201 SH   DFND 2 1,201 0 0
RESMED INC COM 761152107 6,035 24,884 SH   DFND 2 5,637 0 19,247
S&P GLOBAL INC COM 78409V104 387,782 945,395 SH   DFND 2 489,478 0 455,917
S&P GLOBAL INC COM 78409V104 30,201 73,629 SH   DFND 1 73,629 0 0
SAREPTA THERAPEUTICS INC COM 803607100 9,400 120,329 SH   DFND 2 120,329 0 0
SEA LTD SPONSORD ADS 81141R100 4,253 35,504 SH   DFND 1 35,504 0 0
SEA LTD SPONSORD ADS 81141R100 60,640 506,218 SH   DFND 2 155,486 0 350,732
SERVICE CORP INTL COM 817565104 9,080 137,945 SH   DFND 2 37,540 0 100,405
SERVICE CORP INTL COM 817565104 1,606 24,393 SH   DFND 1 24,393 0 0
SMITH A O CORP COM 831865209 6,292 98,479 SH   DFND 2 22,321 0 76,158
SYNOPSYS INC COM 871607107 8,412 25,241 SH   DFND 2 5,723 0 19,518
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 51,420 493,192 SH   DFND 2 400,806 0 92,386
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 35,511 340,598 SH   DFND 1 340,598 0 0
TELADOC HEALTH INC COM 87918A105 12,118 168,000 SH   DFND 2 168,000 0 0
TELEFLEX INCORPORATED COM 879369106 20,580 58,000 SH   DFND 2 58,000 0 0
THERAPEUTICSMD INC COM 88338N107 2,352 6,189,834 SH   DFND 2 6,189,834 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 848,736 1,436,952 SH   DFND 2 785,243 0 651,709
THERMO FISHER SCIENTIFIC INC COM 883556102 61,629 104,341 SH   DFND 1 104,341 0 0
TJX COS INC NEW COM 872540109 166 2,745 SH   DFND 2 2,745 0 0
TJX COS INC NEW COM 872540109 474 7,828 SH   DFND 1 7,828 0 0
TRANSUNION COM 89400J107 6,598 63,844 SH   DFND 2 14,440 0 49,404
TRIP COM GROUP LTD ADS 89677Q107 39,261 1,698,155 SH   DFND 2 527,470 0 1,170,685
TRIP COM GROUP LTD ADS 89677Q107 2,688 116,281 SH   DFND 1 116,281 0 0
TYLER TECHNOLOGIES INC COM 902252105 3,327 7,478 SH   DFND 2 1,692 0 5,786
VERISK ANALYTICS INC COM 92345Y106 5,279 24,596 SH   DFND 2 5,564 0 19,032
VERTEX PHARMACEUTICALS INC COM 92532F100 28,330 108,557 SH   DFND 2 108,557 0 0
VISA INC COM CL A 92826C839 673,973 3,039,062 SH   DFND 2 1,592,471 0 1,446,591
VISA INC COM CL A 92826C839 53,088 239,385 SH   DFND 1 239,385 0 0
WASTE MGMT INC DEL COM 94106L109 736 4,642 SH   DFND 1 4,642 0 0
WASTE MGMT INC DEL COM 94106L109 244 1,542 SH   DFND 2 1,542 0 0
WATERS CORP COM 941848103 7,445 23,986 SH   DFND 2 5,437 0 18,549
XYLEM INC COM 98419M100 3,139 36,821 SH   DFND 2 8,333 0 28,488