The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X Genomics Inc Class A CL A COM 88025U109 154,642 2,032,893 SH   DFND 1 2,032,893 0 0
10X Genomics Inc Class A CL A COM 88025U109 164,140 2,157,753 SH   DFND 2 1,996,826 0 160,927
10X Genomics Inc Class A CL A COM 88025U109 80,540 1,058,765 SH   DFND 3 899,293 0 159,472
10X Genomics Inc Class A CL A COM 88025U109 160,230 2,106,353 SH   SOLE 0 2,106,353 0 0
1Life Healthcare COM 68269G107 5 445 SH   DFND 3 445 0 0
2U COM 90214J101 4 319 SH   DFND 3 319 0 0
2seventy bio COM 901384107 5 286 SH   DFND 3 286 0 0
8x8 Inc COM 282914100 26 2,045 SH   DFND 3 2,045 0 0
908 Devices COM 65443P102 5 249 SH   DFND 3 249 0 0
ACM Research COM 00108J109 14 660 SH   DFND 3 660 0 0
AJ Gallagher & Co COM 363576109 189,590 1,085,855 SH   DFND 1 1,085,855 0 0
AJ Gallagher & Co COM 363576109 539,255 3,088,518 SH   DFND 2 2,805,435 0 283,083
AJ Gallagher & Co COM 363576109 105,097 601,931 SH   DFND 3 363,817 0 238,114
AJ Gallagher & Co COM 363576109 461,343 2,642,285 SH   SOLE 0 1,722,484 0 919,801
Abcellera Biologics Inc COM 00288U106 37,826 3,879,638 SH   DFND 1 3,879,638 0 0
Abcellera Biologics Inc COM 00288U106 24,628 2,525,958 SH   DFND 2 1,149,556 0 1,376,402
Abcellera Biologics Inc COM 00288U106 33,601 3,446,224 SH   DFND 3 2,871,546 0 574,678
Abcellera Biologics Inc COM 00288U106 11,670 1,196,945 SH   SOLE 0 1,196,945 0 0
Abiomed COM 003654100 365,238 1,102,640 SH   DFND 1 1,102,640 0 0
Abiomed COM 003654100 508,676 1,535,673 SH   DFND 2 1,407,479 0 128,194
Abiomed COM 003654100 161,839 488,585 SH   DFND 3 380,729 0 107,856
Abiomed COM 003654100 192,898 582,352 SH   SOLE 0 427,480 0 154,872
Acadia Pharmaceuticals Inc COM 004225108 13 544 SH   DFND 3 544 0 0
Accelerate Diagnostics COM 00430H102 1 418 SH   DFND 3 418 0 0
Accenture 'A' COM G1151C101 16 48 SH   DFND 3 48 0 0
Acutus Medical COM 005111109 1 424 SH   DFND 3 424 0 0
Adaptimmune Therapeutics ADR SPONDS ADR 00653A107 12,477 6,056,564 SH   DFND 1 6,056,564 0 0
Adaptimmune Therapeutics ADR SPONDS ADR 00653A107 7,003 3,399,534 SH   DFND 2 976,474 0 2,423,060
Adaptimmune Therapeutics ADR SPONDS ADR 00653A107 3,306 1,604,961 SH   DFND 3 1,604,961 0 0
Adaptimmune Therapeutics ADR SPONDS ADR 00653A107 8,898 4,319,479 SH   SOLE 0 4,319,479 0 0
Adicet Bio Inc COM 007002108 1,866 93,449 SH   DFND 1 93,449 0 0
Adicet Bio Inc COM 007002108 1,761 88,177 SH   SOLE 0 88,177 0 0
Adobe Systems COM 00724F101 33,560 73,658 SH   DFND 1 73,658 0 0
Adobe Systems COM 00724F101 103,800 227,821 SH   DFND 2 194,873 0 32,948
Adobe Systems COM 00724F101 20,272 44,493 SH   DFND 3 26,053 0 18,440
Adobe Systems COM 00724F101 97,167 213,264 SH   SOLE 0 141,795 0 71,469
Advanced Micro Devices Inc COM 007903107 13 118 SH   DFND 3 118 0 0
Aerovironment COM 008073108 25,062 266,217 SH   DFND 1 266,217 0 0
Aerovironment COM 008073108 21,255 225,784 SH   DFND 2 66,040 0 159,744
Aerovironment COM 008073108 10,637 112,990 SH   DFND 3 112,990 0 0
Aerovironment COM 008073108 20,764 220,567 SH   SOLE 0 220,567 0 0
Affirm Holdings Inc Class A COM CL A 00827B106 158,466 3,424,074 SH   DFND 1 3,424,074 0 0
Affirm Holdings Inc Class A COM CL A 00827B106 417,570 9,022,692 SH   DFND 2 5,540,549 0 3,482,143
Affirm Holdings Inc Class A COM CL A 00827B106 40,765 880,826 SH   DFND 3 754,028 0 126,798
Affirm Holdings Inc Class A COM CL A 00827B106 216,159 4,670,688 SH   SOLE 0 3,903,891 0 766,797
Affirm Holdings Inc Class B - converted at IPO COM CL A 00827B106 114,986 2,484,575 SH   SOLE 0 2,484,575 0 0
Agios Pharmaceuticals Inc COM 00847X104 5 186 SH   DFND 3 186 0 0
Agnico Eagle Mines COM 008474108 208 3,400 SH   DFND 1 3,400 0 0
Agora Inc ADR ADS 00851L103 4,864 489,288 SH   DFND 1 489,288 0 0
Agora Inc ADR ADS 00851L103 2,535 255,012 SH   SOLE 0 255,012 0 0
Albemarle Corp COM 012653101 159,509 721,269 SH   DFND 1 721,269 0 0
Albemarle Corp COM 012653101 389,797 1,762,592 SH   DFND 2 1,594,780 0 167,812
Albemarle Corp COM 012653101 64,840 293,196 SH   DFND 3 182,771 0 110,425
Albemarle Corp COM 012653101 287,211 1,298,714 SH   SOLE 0 1,014,270 0 284,444
Alector Inc COM 014442107 975 68,420 SH   DFND 1 68,420 0 0
Alector Inc COM 014442107 1,874 131,492 SH   DFND 2 131,492 0 0
Alector Inc COM 014442107 2,742 192,439 SH   DFND 3 192,439 0 0
Alibaba Group Holding Sponsored ADR SPONSORED ADS 01609W102 187,668 1,724,888 SH   DFND 2 1,338,487 0 386,401
Alibaba Group Holding Sponsored ADR SPONSORED ADS 01609W102 2,533 23,282 SH   DFND 3 0 0 23,282
Align Technology Inc COM 016255101 10,739 24,631 SH   DFND 2 24,631 0 0
Allbirds Inc COM CL A 01675A109 4,096 681,466 SH   DFND 2 242,231 0 439,235
Allbirds Inc COM CL A 01675A109 4,127 686,619 SH   SOLE 0 686,619 0 0
Allscripts Healthcare Solution COM 01988P108 17 744 SH   DFND 3 744 0 0
Alnylam Pharmaceuticals COM 02043Q107 453,709 2,778,549 SH   DFND 1 2,778,549 0 0
Alnylam Pharmaceuticals COM 02043Q107 634,991 3,888,734 SH   DFND 2 3,225,021 0 663,713
Alnylam Pharmaceuticals COM 02043Q107 220,520 1,350,482 SH   DFND 3 1,082,176 0 268,306
Alnylam Pharmaceuticals COM 02043Q107 346,496 2,121,964 SH   SOLE 0 1,574,983 0 546,981
Alphabet Inc Class A CAP STK CL A 02079K305 6,750 2,427 SH   DFND 1 2,427 0 0
Alphabet Inc Class A CAP STK CL A 02079K305 33,768 12,141 SH   DFND 2 11,462 0 679
Alphabet Inc Class A CAP STK CL A 02079K305 3,026 1,088 SH   DFND 3 753 0 335
Alphabet Inc Class A CAP STK CL A 02079K305 103,157 37,089 SH   SOLE 0 37,089 0 0
Alphabet Inc Class C CAP STK CL C 02079K107 235,876 84,453 SH   DFND 1 84,453 0 0
Alphabet Inc Class C CAP STK CL C 02079K107 780,132 279,318 SH   DFND 2 253,877 0 25,441
Alphabet Inc Class C CAP STK CL C 02079K107 144,252 51,648 SH   DFND 3 30,210 0 21,438
Alphabet Inc Class C CAP STK CL C 02079K107 539,159 193,040 SH   SOLE 0 110,625 0 82,415
Alteryx Inc COM 02156B103 24 336 SH   DFND 3 336 0 0
Amazon.Com COM 023135106 901,503 276,539 SH   DFND 1 276,539 0 0
Amazon.Com COM 023135106 3,398,964 1,042,643 SH   DFND 2 588,315 0 454,328
Amazon.Com COM 023135106 423,203 129,819 SH   DFND 3 101,531 0 28,288
Amazon.Com COM 023135106 1,838,335 563,915 SH   SOLE 0 412,211 0 151,704
Ambarella SHS G037AX101 29,388 280,100 SH   DFND 1 280,100 0 0
Ambarella SHS G037AX101 12,890 122,858 SH   DFND 2 34,859 0 87,999
Ambarella SHS G037AX101 6,758 64,411 SH   DFND 3 64,411 0 0
Ambarella SHS G037AX101 10,241 97,605 SH   SOLE 0 97,605 0 0
Amdocs COM G02602103 30 365 SH   DFND 3 365 0 0
Ameren COM 023608102 1,212 12,931 SH   DFND 1 12,931 0 0
American Superconductor Corp COM 030111207 5,505 723,370 SH   DFND 1 723,370 0 0
American Superconductor Corp COM 030111207 5,844 768,000 SH   SOLE 0 768,000 0 0
American Tower Corp REIT COM 03027X100 772 3,072 SH   DFND 1 3,072 0 0
American Well Corp Class A COM 03044L105 411 97,542 SH   DFND 1 97,542 0 0
American Well Corp Class A COM 03044L105 851 202,062 SH   DFND 2 202,062 0 0
American Well Corp Class A COM 03044L105 1,684 399,957 SH   DFND 3 399,957 0 0
Amicus Therapeutics Inc COM 03152W109 5 538 SH   DFND 3 538 0 0
Amkor Technology COM 031652100 38 1,765 SH   DFND 3 1,765 0 0
Amneal Pharmaceuticals Inc COM 03168L105 4 853 SH   DFND 3 853 0 0
Analog Devices COM 032654105 78,523 475,380 SH   DFND 1 475,380 0 0
Analog Devices COM 032654105 126,466 765,628 SH   DFND 2 691,041 0 74,587
Analog Devices COM 032654105 31,113 188,360 SH   DFND 3 126,353 0 62,007
Analog Devices COM 032654105 138,386 837,788 SH   SOLE 0 599,086 0 238,702
Anaplan Inc Common COM 03272L108 20 306 SH   DFND 3 306 0 0
Anterix COM 03676C100 9 162 SH   DFND 3 162 0 0
Anthem Inc COM 036752103 270,117 549,890 SH   DFND 1 549,890 0 0
Anthem Inc COM 036752103 869,963 1,771,026 SH   DFND 2 1,606,462 0 164,564
Anthem Inc COM 036752103 165,292 336,492 SH   DFND 3 196,825 0 139,667
Anthem Inc COM 036752103 744,190 1,514,984 SH   SOLE 0 975,372 0 539,612
AppFolio COM 03783C100 24 212 SH   DFND 3 212 0 0
Appian Corp CL A 03782L101 131,776 2,166,655 SH   DFND 1 2,166,655 0 0
Appian Corp CL A 03782L101 169,285 2,783,371 SH   DFND 2 2,439,163 0 344,208
Appian Corp CL A 03782L101 17,042 280,199 SH   DFND 3 280,199 0 0
Appian Corp CL A 03782L101 39,052 642,084 SH   SOLE 0 642,084 0 0
Apple COM 037833100 48,410 277,248 SH   DFND 1 277,248 0 0
Apple COM 037833100 668 3,827 SH   DFND 2 0 0 3,827
Apple COM 037833100 7,881 45,133 SH   DFND 3 45,133 0 0
Apple COM 037833100 33,222 190,262 SH   SOLE 0 190,262 0 0
Ares Capital Corp COM 04010L103 65,863 3,143,800 SH   DFND 1 3,143,800 0 0
Ares Capital Corp COM 04010L103 224 10,700 SH   DFND 2 10,700 0 0
Ares Capital Corp COM 04010L103 6,081 290,270 SH   DFND 3 290,270 0 0
Argan COM 04010E109 4 103 SH   DFND 3 103 0 0
Ascendis Pharma ADR 1:1 SPON ADR 04351P101 1,953 16,638 SH   DFND 1 16,638 0 0
Ascendis Pharma ADR 1:1 SPON ADR 04351P101 3,729 31,777 SH   DFND 2 31,777 0 0
Ascendis Pharma ADR 1:1 SPON ADR 04351P101 5,426 46,236 SH   DFND 3 46,236 0 0
Asensus Surgical Inc COM 04367G103 3 5,338 SH   DFND 3 5,338 0 0
AstraZeneca ADR COM 046353108 27 400 SH   DFND 3 400 0 0
Atlassian Corp Plc CL A G06242104 139,327 474,176 SH   DFND 1 474,176 0 0
Atlassian Corp Plc CL A G06242104 1,089,562 3,708,138 SH   DFND 2 1,253,449 0 2,454,689
Atlassian Corp Plc CL A G06242104 141,347 481,050 SH   DFND 3 403,409 0 77,641
Atlassian Corp Plc CL A G06242104 303,433 1,032,681 SH   SOLE 0 476,601 0 556,080
Aurora Innovation Class A Common COM CL A 051774107 83,850 15,000,000 SH   SOLE 0 15,000,000 0 0
Avalara Inc COM 05338G106 38 381 SH   DFND 2 381 0 0
Avalara Inc COM 05338G106 457 4,588 SH   DFND 3 4,588 0 0
Avangrid COM 05351W103 109,796 2,349,072 SH   DFND 1 2,349,072 0 0
Avangrid COM 05351W103 296 6,328 SH   DFND 2 6,328 0 0
Avangrid COM 05351W103 6,901 147,645 SH   DFND 3 147,645 0 0
Avery Dennison Corporation COM 053611109 17 100 SH   DFND 3 100 0 0
Axogen Inc COM 05463X106 4 444 SH   DFND 3 444 0 0
Axon Enterprise Inc COM 05464C101 102,236 742,294 SH   DFND 1 742,294 0 0
Axon Enterprise Inc COM 05464C101 223,248 1,620,910 SH   DFND 2 1,338,272 0 282,638
Axon Enterprise Inc COM 05464C101 52,039 377,837 SH   DFND 3 265,076 0 112,761
Axon Enterprise Inc COM 05464C101 189,265 1,374,172 SH   SOLE 0 925,750 0 448,422
Axonics Modulation Technologies COM 05465P101 12 198 SH   DFND 3 198 0 0
Baidu.com Sponsored ADR SPON ADR REP A 056752108 6,543 49,456 SH   DFND 1 49,456 0 0
Baidu.com Sponsored ADR SPON ADR REP A 056752108 464,048 3,507,540 SH   DFND 2 3,114,085 0 393,455
Baidu.com Sponsored ADR SPON ADR REP A 056752108 24,102 182,176 SH   DFND 3 20,196 0 161,980
Baidu.com Sponsored ADR SPON ADR REP A 056752108 1,026 7,754 SH   DFND 4 7,754 0 0
Banco Bradesco Pn ADR SP ADR PFD NEW 059460303 25,770 5,553,831 SH   DFND 1 5,553,831 0 0
Banco Bradesco Pn ADR SP ADR PFD NEW 059460303 200,150 43,135,790 SH   DFND 2 23,855,429 0 19,280,361
Banco Bradesco Pn ADR SP ADR PFD NEW 059460303 7,278 1,568,558 SH   DFND 3 1,568,558 0 0
Bandwidth COM 05988J103 31 971 SH   DFND 2 971 0 0
Bandwidth COM 05988J103 371 11,463 SH   DFND 3 11,463 0 0
Baozun Spn Adr 1:1 SPONSORED ADR 06684L103 5,083 592,408 SH   DFND 1 592,408 0 0
Baozun Spn Adr 1:1 SPONSORED ADR 06684L103 3,502 408,111 SH   DFND 2 117,916 0 290,195
Baozun Spn Adr 1:1 SPONSORED ADR 06684L103 1,583 184,540 SH   DFND 3 184,540 0 0
Baozun Spn Adr 1:1 SPONSORED ADR 06684L103 2,523 294,100 SH   SOLE 0 294,100 0 0
Beam Therapeutics COM 07373V105 23 398 SH   DFND 3 398 0 0
Beam Therapeutics COM 07373V105 589 10,275 SH   SOLE 0 10,275 0 0
BeiGene Ltd SPONSORED ADR 07725L102 70,967 376,282 SH   DFND 1 376,282 0 0
BeiGene Ltd SPONSORED ADR 07725L102 531,595 2,818,638 SH   DFND 2 1,149,775 0 1,668,863
BeiGene Ltd SPONSORED ADR 07725L102 54,777 290,442 SH   DFND 3 243,798 0 46,644
BeiGene Ltd SPONSORED ADR 07725L102 116,480 617,606 SH   SOLE 0 285,271 0 332,335
Benefitfocus Inc COM 08180D106 3,867 306,448 SH   DFND 1 306,448 0 0
Benefitfocus Inc COM 08180D106 3,615 286,429 SH   DFND 2 78,748 0 207,681
Benefitfocus Inc COM 08180D106 2,193 173,762 SH   DFND 3 173,762 0 0
Benefitfocus Inc COM 08180D106 2,857 226,368 SH   SOLE 0 226,368 0 0
Berkeley Lights Inc COM 084310101 9,439 1,327,518 SH   DFND 1 1,327,518 0 0
Berkeley Lights Inc COM 084310101 4,640 652,600 SH   DFND 2 504,334 0 148,266
Berkeley Lights Inc COM 084310101 8,767 1,233,098 SH   DFND 3 1,072,228 0 160,870
Berkeley Lights Inc COM 084310101 2,323 326,690 SH   SOLE 0 326,690 0 0
Beyond Meat Inc COM 08862E109 59,150 1,224,383 SH   DFND 1 1,224,383 0 0
Beyond Meat Inc COM 08862E109 231,616 4,794,379 SH   DFND 2 1,700,160 0 3,094,219
Beyond Meat Inc COM 08862E109 59,558 1,232,838 SH   DFND 3 1,011,410 0 221,428
Beyond Meat Inc COM 08862E109 63,421 1,312,794 SH   SOLE 0 636,500 0 676,294
Bilibili Inc ADR SPONSORED ADR 090040106 3,579 139,895 SH   DFND 2 0 0 139,895
Bilibili Inc ADR SPONSORED ADR 090040106 666 26,051 SH   DFND 3 0 0 26,051
BioCryst Pharmaceuticals COM 09058V103 27 1,687 SH   DFND 3 1,687 0 0
BioNTech ADR SPONS ADS 09075V102 87,865 515,155 SH   DFND 1 515,155 0 0
BioNTech ADR SPONS ADS 09075V102 786,114 4,609,017 SH   DFND 2 1,820,172 0 2,788,845
BioNTech ADR SPONS ADS 09075V102 85,076 498,803 SH   DFND 3 434,650 0 64,153
BioNTech ADR SPONS ADS 09075V102 191,321 1,121,722 SH   SOLE 0 518,333 0 603,389
Biomarin Pharmaceutical Inc COM 09061G101 6 82 SH   DFND 3 82 0 0
Blackline COM 09239B109 41,995 573,542 SH   DFND 1 573,542 0 0
Blackline COM 09239B109 22,969 313,694 SH   DFND 2 91,120 0 222,574
Blackline COM 09239B109 11,289 154,176 SH   DFND 3 154,176 0 0
Blackline COM 09239B109 20,544 280,576 SH   SOLE 0 280,576 0 0
Blackrock Inc COM 09247X101 15 19 SH   DFND 3 19 0 0
Blink Charging COM 09354A100 11 400 SH   DFND 3 400 0 0
Blue Apron Holdings Inc CL A 09523Q101 601 148,506 SH   DFND 1 148,506 0 0
Bluebird Bio Inc COM 09609G100 4 860 SH   DFND 3 860 0 0
Blueprint Medicines Corp COM 09627Y109 20 315 SH   DFND 3 315 0 0
Booking Holdings Inc COM 09857L108 111,319 47,401 SH   DFND 1 47,401 0 0
Booking Holdings Inc COM 09857L108 300,421 127,923 SH   DFND 2 115,463 0 12,460
Booking Holdings Inc COM 09857L108 61,616 26,237 SH   DFND 3 15,638 0 10,599
Booking Holdings Inc COM 09857L108 263,271 112,104 SH   SOLE 0 71,888 0 40,216
Boston Omaha COM 101044105 13 529 SH   DFND 3 529 0 0
Box Inc COM 10316T104 28 979 SH   DFND 3 979 0 0
Brady Corp COM 104674106 9 200 SH   DFND 3 200 0 0
BridgeBio Pharma Inc COM 10806X102 931 91,704 SH   DFND 1 91,704 0 0
BridgeBio Pharma Inc COM 10806X102 1,880 185,242 SH   DFND 2 185,242 0 0
BridgeBio Pharma Inc COM 10806X102 2,689 264,945 SH   DFND 3 264,945 0 0
Bristol Myers Squibb COM 110122108 34 463 SH   DFND 3 463 0 0
Broadridge Finl.Sltn. COM 11133T103 77,431 497,279 SH   DFND 1 497,279 0 0
Broadridge Finl.Sltn. COM 11133T103 255,115 1,638,397 SH   DFND 2 1,491,994 0 146,403
Broadridge Finl.Sltn. COM 11133T103 46,955 301,556 SH   DFND 3 174,458 0 127,098
Broadridge Finl.Sltn. COM 11133T103 206,606 1,326,866 SH   SOLE 0 845,625 0 481,241
Brookfield Renewable COM 11284V105 77,835 1,777,047 SH   DFND 1 1,777,047 0 0
Brookfield Renewable COM 11284V105 186 4,252 SH   DFND 2 4,252 0 0
Brookfield Renewable COM 11284V105 4,339 99,073 SH   DFND 3 99,073 0 0
Bumble Inc COM CL A 12047B105 11,592 400,000 SH   SOLE 0 400,000 0 0
Burford Capital ORD SHS G17977110 4,578 501,035 SH   DFND 2 501,035 0 0
Burford Capital ORD SHS G17977110 10,224 1,118,922 SH   DFND 1 1,118,922 0 0
Burning Rock Biotech Ltd ADR SPON ADS 12233L107 20,076 2,161,037 SH   DFND 1 2,161,037 0 0
Burning Rock Biotech Ltd ADR SPON ADS 12233L107 59,469 6,401,378 SH   DFND 2 4,175,729 0 2,225,649
Burning Rock Biotech Ltd ADR SPON ADS 12233L107 2,017 217,063 SH   DFND 3 39,351 0 177,712
Burning Rock Biotech Ltd ADR SPON ADS 12233L107 1,224 131,772 SH   SOLE 0 131,772 0 0
Butterfly Network Inc COM CL A 124155102 1,258 264,363 SH   DFND 1 264,363 0 0
Butterfly Network Inc COM CL A 124155102 1,788 375,532 SH   DFND 2 375,532 0 0
Butterfly Network Inc COM CL A 124155102 3,635 763,585 SH   DFND 3 763,585 0 0
Butterfly Network Inc COM CL A 124155102 3,866 812,150 SH   SOLE 0 812,150 0 0
C3.ai CL A 12468P104 3 117 SH   DFND 3 117 0 0
CEVA Inc COM 157210105 7,263 178,680 SH   DFND 1 178,680 0 0
CEVA Inc COM 157210105 5,939 146,102 SH   DFND 2 40,581 0 105,521
CEVA Inc COM 157210105 3,080 75,778 SH   DFND 3 75,778 0 0
CEVA Inc COM 157210105 3,354 82,500 SH   SOLE 0 82,500 0 0
CH Robinson Worldwide COM NEW 12541W209 30,185 280,242 SH   DFND 1 280,242 0 0
CH Robinson Worldwide COM NEW 12541W209 430 3,994 SH   DFND 2 0 0 3,994
CH Robinson Worldwide COM NEW 12541W209 4,910 45,582 SH   DFND 3 45,582 0 0
CH Robinson Worldwide COM NEW 12541W209 21,260 197,381 SH   SOLE 0 197,381 0 0
CS Disco Inc COM 126327105 55 1,628 SH   DFND 2 1,628 0 0
CS Disco Inc COM 126327105 663 19,527 SH   DFND 3 19,527 0 0
Calavo Growers Inc COM 128246105 4 113 SH   DFND 3 113 0 0
Calix Inc COM 13100M509 36 836 SH   DFND 2 836 0 0
Calix Inc COM 13100M509 420 9,794 SH   DFND 3 9,794 0 0
Cardlytics Inc COM 14161W105 21,658 393,924 SH   DFND 1 393,924 0 0
Cardlytics Inc COM 14161W105 14,593 265,427 SH   DFND 2 76,503 0 188,924
Cardlytics Inc COM 14161W105 7,276 132,333 SH   DFND 3 132,333 0 0
Cardlytics Inc COM 14161W105 14,544 264,524 SH   SOLE 0 264,524 0 0
Cargurus Inc COM 141788109 104 2,460 SH   DFND 2 2,460 0 0
Cargurus Inc COM 141788109 1,269 29,876 SH   DFND 3 29,876 0 0
Carvana COM 146869102 167,830 1,406,906 SH   DFND 1 1,406,906 0 0
Carvana COM 146869102 598,119 5,013,995 SH   DFND 2 2,829,813 0 2,184,182
Carvana COM 146869102 68,627 575,294 SH   DFND 3 460,126 0 115,168
Carvana COM 146869102 296,637 2,486,688 SH   SOLE 0 1,829,842 0 656,846
Castle Biosciences COM 14843C105 10 225 SH   DFND 3 225 0 0
Cbre Group Inc CL A 12504L109 134,627 1,471,013 SH   DFND 1 1,471,013 0 0
Cbre Group Inc CL A 12504L109 394,991 4,315,903 SH   DFND 2 3,927,616 0 388,287
Cbre Group Inc CL A 12504L109 75,402 823,882 SH   DFND 3 489,343 0 334,539
Cbre Group Inc CL A 12504L109 325,217 3,553,505 SH   SOLE 0 2,286,236 0 1,267,269
Cellectis ADR SPONS ADS 15117K103 3,299 726,605 SH   DFND 1 726,605 0 0
Cellectis ADR SPONS ADS 15117K103 794 174,990 SH   DFND 2 174,990 0 0
Cellectis ADR SPONS ADS 15117K103 819 180,500 SH   SOLE 0 180,500 0 0
Celsius Holdings COM 15118V207 14 260 SH   DFND 3 260 0 0
Cemex ADR SPON ADR NEW 151290889 33,585 6,348,848 SH   DFND 1 6,348,848 0 0
Cemex ADR SPON ADR NEW 151290889 209,596 39,621,123 SH   DFND 2 11,412,651 0 28,208,472
Cemex ADR SPON ADR NEW 151290889 83,656 15,813,921 SH   DFND 3 1,543,885 0 14,270,036
Cemex ADR SPON ADR NEW 151290889 2,915 551,029 SH   DFND 4 551,029 0 0
Certara COM 15687V109 32,156 1,497,040 SH   DFND 1 1,497,040 0 0
Certara COM 15687V109 101,321 4,716,971 SH   DFND 2 4,256,804 0 460,167
Certara COM 15687V109 19,882 925,612 SH   DFND 3 534,031 0 391,581
Certara COM 15687V109 92,099 4,287,660 SH   SOLE 0 2,798,915 0 1,488,745
Cerus COM 157085101 6 1,143 SH   DFND 3 1,143 0 0
ChargePoint Holdings Inc COM CL A 15961R105 130 6,540 SH   DFND 1 6,540 0 0
ChargePoint Holdings Inc COM CL A 15961R105 90,950 4,574,933 SH   SOLE 0 4,574,933 0 0
Charles Schwab COM 808513105 77,867 923,575 SH   DFND 1 923,575 0 0
Charles Schwab COM 808513105 248,182 2,943,679 SH   DFND 2 2,668,676 0 275,003
Charles Schwab COM 808513105 47,040 557,938 SH   DFND 3 330,088 0 227,850
Charles Schwab COM 808513105 214,794 2,547,671 SH   SOLE 0 1,654,967 0 892,704
Chegg COM 163092109 211,270 5,823,308 SH   DFND 1 5,823,308 0 0
Chegg COM 163092109 295,702 8,150,548 SH   DFND 2 7,121,373 0 1,029,175
Chegg COM 163092109 44,485 1,226,151 SH   DFND 3 989,350 0 236,801
Chegg COM 163092109 125,432 3,457,330 SH   SOLE 0 2,814,746 0 642,584
Chewy Inc CL A 16679L109 140,208 3,438,153 SH   DFND 1 3,438,153 0 0
Chewy Inc CL A 16679L109 255,281 6,259,960 SH   DFND 2 5,998,682 0 261,278
Chewy Inc CL A 16679L109 23,849 584,813 SH   DFND 3 412,991 0 171,822
Chewy Inc CL A 16679L109 97,279 2,385,470 SH   SOLE 0 1,737,335 0 648,135
Chinook Therapeutics COM 16961L106 6,482 396,187 SH   DFND 1 396,187 0 0
Chinook Therapeutics COM 16961L106 3,396 207,590 SH   DFND 2 61,527 0 146,063
Chinook Therapeutics COM 16961L106 1,473 90,044 SH   DFND 3 90,044 0 0
Chinook Therapeutics COM 16961L106 1,915 117,058 SH   SOLE 0 117,058 0 0
Church & Dwight Co Inc COM 171340102 18 179 SH   DFND 3 179 0 0
Cisco Systems COM 17275R102 24,311 435,997 SH   DFND 1 435,997 0 0
Cisco Systems COM 17275R102 339 6,084 SH   DFND 2 0 0 6,084
Cisco Systems COM 17275R102 4,027 72,223 SH   DFND 3 72,223 0 0
Cisco Systems COM 17275R102 16,750 300,399 SH   SOLE 0 300,399 0 0
Clear Secure Inc COM 18467V109 26,880 1,000,000 SH   SOLE 0 1,000,000 0 0
Cloudflare Inc CL A COM 18915M107 527,803 4,409,378 SH   DFND 1 4,409,378 0 0
Cloudflare Inc CL A COM 18915M107 1,856,698 15,511,261 SH   DFND 2 9,177,777 0 6,333,484
Cloudflare Inc CL A COM 18915M107 213,221 1,781,293 SH   DFND 3 1,411,565 0 369,728
Cloudflare Inc CL A COM 18915M107 650,198 5,431,896 SH   SOLE 0 3,194,143 0 2,237,753
Clover Health Investments Corp COM CL A 18914F103 27,646 7,787,680 SH   SOLE 0 7,787,680 0 0
CoStar Group COM 22160N109 233,496 3,505,413 SH   DFND 1 3,505,413 0 0
CoStar Group COM 22160N109 436,508 6,553,189 SH   DFND 2 6,262,267 0 290,922
CoStar Group COM 22160N109 42,041 631,144 SH   DFND 3 430,890 0 200,254
CoStar Group COM 22160N109 181,392 2,723,201 SH   SOLE 0 1,965,503 0 757,698
Coca Cola COM 191216100 27,295 440,250 SH   DFND 1 440,250 0 0
Coca Cola COM 191216100 550 8,874 SH   DFND 2 0 0 8,874
Coca Cola COM 191216100 1,017 16,408 SH   DFND 3 16,408 0 0
Coca Cola COM 191216100 27,343 441,022 SH   SOLE 0 441,022 0 0
Codexis COM 192005106 54,987 2,666,691 SH   DFND 1 2,666,691 0 0
Codexis COM 192005106 41,588 2,016,891 SH   DFND 2 614,600 0 1,402,291
Codexis COM 192005106 22,154 1,074,383 SH   DFND 3 996,578 0 77,805
Codexis COM 192005106 33,583 1,628,663 SH   SOLE 0 1,628,663 0 0
Cognyte Software ORD SHS M25133105 4 369 SH   DFND 3 369 0 0
Cohen & Steers Inc COM 19247A100 26 301 SH   DFND 3 301 0 0
Coherus BioSciences COM 19249H103 18 1,431 SH   DFND 3 1,431 0 0
Cohu COM 192576106 21 700 SH   DFND 3 700 0 0
Columbia Sportswear Co COM 198516106 9 95 SH   DFND 3 95 0 0
Commscope Holding Co Inc COM 20337X109 11 1,442 SH   DFND 3 1,442 0 0
Consensus Cloud Solutions COM 20848V105 1 24 SH   DFND 3 24 0 0
Consolidated Edison COM 209115104 142,369 1,503,689 SH   DFND 1 1,503,689 0 0
Consolidated Edison COM 209115104 392 4,135 SH   DFND 2 4,135 0 0
Consolidated Edison COM 209115104 9,039 95,470 SH   DFND 3 95,470 0 0
Cooper Cos Inc/The COM 216648402 13,101 31,373 SH   DFND 2 31,373 0 0
Copa Holdings S A CL A P31076105 34,611 413,810 SH   DFND 1 413,810 0 0
Copa Holdings S A CL A P31076105 297,759 3,560,004 SH   DFND 2 2,304,915 0 1,255,089
Copa Holdings S A CL A P31076105 62,647 749,002 SH   DFND 3 88,804 0 660,198
Copa Holdings S A CL A P31076105 2,612 31,229 SH   DFND 4 31,229 0 0
Corning COM 219350105 24 653 SH   DFND 3 653 0 0
Costco Wholesale Corporation COM 22160K105 36 63 SH   DFND 3 63 0 0
Coupa Software Inc COM 22266L106 33 325 SH   DFND 3 325 0 0
Coupang CL A 22266T109 154,302 8,727,502 SH   DFND 1 8,727,502 0 0
Coupang CL A 22266T109 1,431,809 80,984,664 SH   DFND 2 50,588,632 0 30,396,032
Coupang CL A 22266T109 114,904 6,499,112 SH   DFND 3 4,229,409 0 2,269,703
Coupang CL A 22266T109 328 18,547 SH   DFND 4 18,547 0 0
Coupang CL A 22266T109 249,945 14,137,177 SH   SOLE 0 7,625,325 0 6,511,852
Coursera Inc COM 22266M104 150,368 6,526,389 SH   DFND 1 6,526,389 0 0
Coursera Inc COM 22266M104 163,168 7,081,929 SH   DFND 2 6,554,645 0 527,284
Coursera Inc COM 22266M104 60,993 2,647,262 SH   DFND 3 2,177,491 0 469,771
Coursera Inc COM 22266M104 26,860 1,165,800 SH   SOLE 0 1,165,800 0 0
Credicorp COM G2519Y108 28,366 165,041 SH   DFND 1 165,041 0 0
Credicorp COM G2519Y108 141,232 821,736 SH   DFND 2 328,484 0 493,252
Credicorp COM G2519Y108 48,852 284,239 SH   DFND 3 38,520 0 245,719
Credicorp COM G2519Y108 2,253 13,108 SH   DFND 4 13,108 0 0
CrowdStrike Holdings COM 22788C105 26 114 SH   DFND 3 114 0 0
Cullen/Frost Bankers COM 229899109 21,567 155,820 SH   DFND 1 155,820 0 0
Cullen/Frost Bankers COM 229899109 304 2,195 SH   DFND 2 0 0 2,195
Cullen/Frost Bankers COM 229899109 3,624 26,180 SH   DFND 3 26,180 0 0
Cullen/Frost Bankers COM 229899109 15,035 108,625 SH   SOLE 0 108,625 0 0
Curevac N.V. COM N2451R105 76,702 3,911,347 SH   DFND 2 3,424,925 0 486,422
CyberArk Software Ltd SHS M2682V108 16,810 99,616 SH   DFND 1 99,616 0 0
CyberArk Software Ltd SHS M2682V108 33,726 199,858 SH   DFND 2 57,963 0 141,895
CyberArk Software Ltd SHS M2682V108 16,639 98,600 SH   DFND 3 98,600 0 0
CyberArk Software Ltd SHS M2682V108 19,426 115,118 SH   SOLE 0 115,118 0 0
Dada Nexus Ltd ADR ADS 23344D108 28,984 3,174,568 SH   DFND 1 3,174,568 0 0
Dada Nexus Ltd ADR ADS 23344D108 34,722 3,803,066 SH   DFND 2 2,598,229 0 1,204,837
Dada Nexus Ltd ADR ADS 23344D108 511 55,932 SH   DFND 3 55,932 0 0
Dada Nexus Ltd ADR ADS 23344D108 7,146 782,705 SH   SOLE 0 782,705 0 0
Darden Restaurants COM 237194105 11 82 SH   DFND 3 82 0 0
Datadog COM 23804L103 234,011 1,544,933 SH   DFND 1 1,544,933 0 0
Datadog COM 23804L103 455,224 3,005,373 SH   DFND 2 2,852,818 0 152,555
Datadog COM 23804L103 49,337 325,719 SH   DFND 3 216,138 0 109,581
Datadog COM 23804L103 200,956 1,326,706 SH   SOLE 0 909,710 0 416,996
Deere & Co COM 244199105 188,227 453,058 SH   DFND 1 453,058 0 0
Deere & Co COM 244199105 85,219 205,120 SH   DFND 2 124,109 0 81,011
Deere & Co COM 244199105 192,397 463,095 SH   DFND 3 373,193 0 89,902
Deere & Co COM 244199105 17,021 40,968 SH   SOLE 0 40,968 0 0
Denali Therapeutics COM 24823R105 93,799 2,915,723 SH   DFND 1 2,915,723 0 0
Denali Therapeutics COM 24823R105 140,029 4,352,772 SH   DFND 2 4,207,446 0 145,326
Denali Therapeutics COM 24823R105 14,896 463,042 SH   DFND 3 424,422 0 38,620
Denali Therapeutics COM 24823R105 233,197 7,248,895 SH   SOLE 0 7,248,895 0 0
DermTech COM 24984K105 4 286 SH   DFND 3 286 0 0
Dexcom Inc COM 252131107 360,884 705,402 SH   DFND 1 705,402 0 0
Dexcom Inc COM 252131107 1,251,725 2,446,687 SH   DFND 2 891,984 0 1,554,703
Dexcom Inc COM 252131107 375,915 734,784 SH   DFND 3 605,352 0 129,432
Dexcom Inc COM 252131107 341,452 667,420 SH   SOLE 0 328,371 0 339,049
Digimarc COM 25381B101 6,921 262,445 SH   DFND 1 262,445 0 0
Digimarc COM 25381B101 7,246 274,790 SH   DFND 2 79,917 0 194,873
Digimarc COM 25381B101 3,678 139,458 SH   DFND 3 139,458 0 0
Digimarc COM 25381B101 4,080 154,711 SH   SOLE 0 154,711 0 0
Digital Realty Trust REIT COM 253868103 456 3,215 SH   DFND 1 3,215 0 0
Docebo COM 25609L105 7,217 139,497 SH   DFND 2 139,497 0 0
Docebo COM 25609L105 14 267 SH   DFND 3 267 0 0
Dolby Laboratories 'A' COM 25659T107 15,861 202,778 SH   DFND 1 202,778 0 0
Dolby Laboratories 'A' COM 25659T107 224 2,867 SH   DFND 2 0 0 2,867
Dolby Laboratories 'A' COM 25659T107 2,614 33,422 SH   DFND 3 33,422 0 0
Dolby Laboratories 'A' COM 25659T107 11,119 142,145 SH   SOLE 0 142,145 0 0
Domo COM 257554105 16 321 SH   DFND 3 321 0 0
Donaldson COM 257651109 23 436 SH   DFND 3 436 0 0
Doordash Inc COM 25809K105 182,710 1,559,089 SH   DFND 1 1,559,089 0 0
Doordash Inc COM 25809K105 369,134 3,149,879 SH   DFND 2 2,970,510 0 179,369
Doordash Inc COM 25809K105 45,146 385,237 SH   DFND 3 249,530 0 135,707
Doordash Inc COM 25809K105 304,569 2,598,931 SH   SOLE 0 2,085,502 0 513,429
Dropbox CL A 26210C104 20 881 SH   DFND 3 881 0 0
Duck Creek Technologies SHS 264120106 8 355 SH   DFND 3 355 0 0
Duke Realty Corporation REIT COM 264411505 131,532 2,265,450 SH   DFND 1 2,265,450 0 0
Duke Realty Corporation REIT COM 264411505 394 6,782 SH   DFND 2 6,782 0 0
Duke Realty Corporation REIT COM 264411505 8,620 148,468 SH   DFND 3 148,468 0 0
Duolingo Inc CL A COM 26603R106 73,963 777,655 SH   DFND 1 777,655 0 0
Duolingo Inc CL A COM 26603R106 74,449 782,771 SH   DFND 2 713,172 0 69,599
Duolingo Inc CL A COM 26603R106 33,787 355,238 SH   DFND 3 290,190 0 65,048
Duolingo Inc CL A COM 26603R106 12,786 134,437 SH   SOLE 0 134,437 0 0
EHang Holdings Ltd ADR ADS 26853E102 35 2,950 SH   DFND 1 2,950 0 0
Eargo COM 270087109 1 263 SH   DFND 3 263 0 0
Ecolab COM 278865100 68,824 389,806 SH   DFND 1 389,806 0 0
Ecolab COM 278865100 39,531 223,894 SH   DFND 2 154,637 0 69,257
Ecolab COM 278865100 69,669 394,590 SH   DFND 3 316,963 0 77,627
Ecolab COM 278865100 5,661 32,065 SH   SOLE 0 32,065 0 0
Edwards Lifesciences Corp COM 28176E108 5,875 49,904 SH   DFND 1 49,904 0 0
Edwards Lifesciences Corp COM 28176E108 27,649 234,867 SH   DFND 2 234,867 0 0
Edwards Lifesciences Corp COM 28176E108 16,534 140,454 SH   DFND 3 140,454 0 0
Electronic Arts, Inc. COM 285512109 21 164 SH   DFND 3 164 0 0
Emergent Biosolutions Inc COM 29089Q105 16 385 SH   DFND 3 385 0 0
Enanta Pharmaceuticals COM 29251M106 23 318 SH   DFND 3 318 0 0
Enphase Energy Inc COM 29355A107 195 964 SH   DFND 1 964 0 0
Estee Lauder 'A' COM 518439104 97,796 359,122 SH   DFND 1 359,122 0 0
Estee Lauder 'A' COM 518439104 338,674 1,243,662 SH   DFND 2 1,136,223 0 107,439
Estee Lauder 'A' COM 518439104 60,591 222,500 SH   DFND 3 130,359 0 92,141
Estee Lauder 'A' COM 518439104 268,849 987,254 SH   SOLE 0 638,056 0 349,198
EverQuote Inc COM CL A 30041R108 11,633 718,967 SH   DFND 1 718,967 0 0
EverQuote Inc COM CL A 30041R108 4,216 260,555 SH   DFND 2 75,433 0 185,122
EverQuote Inc COM CL A 30041R108 2,605 161,032 SH   DFND 3 161,032 0 0
EverQuote Inc COM CL A 30041R108 3,746 231,550 SH   SOLE 0 231,550 0 0
Everbridge Inc COM 29978A104 14,436 330,786 SH   DFND 1 330,786 0 0
Everbridge Inc COM 29978A104 8,657 198,371 SH   DFND 2 57,495 0 140,876
Everbridge Inc COM 29978A104 4,424 101,381 SH   DFND 3 101,381 0 0
Everbridge Inc COM 29978A104 6,478 148,446 SH   SOLE 0 148,446 0 0
Eversource Energy COM 30040W108 124,452 1,411,182 SH   DFND 1 1,411,182 0 0
Eversource Energy COM 30040W108 302 3,428 SH   DFND 2 3,428 0 0
Eversource Energy COM 30040W108 7,025 79,654 SH   DFND 3 79,654 0 0
Exact Sciences COM 30063P105 78,894 1,128,346 SH   DFND 1 1,128,346 0 0
Exact Sciences COM 30063P105 106,507 1,523,265 SH   DFND 2 1,145,723 0 377,542
Exact Sciences COM 30063P105 35,039 501,125 SH   DFND 3 393,177 0 107,948
Exact Sciences COM 30063P105 84,322 1,205,984 SH   SOLE 0 862,095 0 343,889
Exelixis COM 30161Q104 27 1,200 SH   DFND 3 1,200 0 0
Exelon Corporation COM 30161N101 1,355 28,452 SH   DFND 1 28,452 0 0
Expedia Group Inc COM 30212P303 32 165 SH   DFND 3 165 0 0
Expeditors Intl COM 302130109 13 126 SH   DFND 3 126 0 0
Expensify Inc COM CL A 30219Q106 12,242 697,160 SH   DFND 1 697,160 0 0
Expensify Inc COM CL A 30219Q106 42 2,371 SH   DFND 2 2,371 0 0
Expensify Inc COM CL A 30219Q106 495 28,200 SH   DFND 3 28,200 0 0
Expensify Inc COM CL A 30219Q106 6,307 359,144 SH   SOLE 0 359,144 0 0
Exponent COM 30214U102 26 242 SH   DFND 3 242 0 0
Exscientia Ltd ADR ADS 30223G102 13,128 911,680 SH   DFND 1 911,680 0 0
Exscientia Ltd ADR ADS 30223G102 22,542 1,565,418 SH   DFND 2 201,323 0 1,364,095
Exscientia Ltd ADR ADS 30223G102 3,163 219,626 SH   DFND 3 219,626 0 0
Exscientia Ltd ADR ADS 30223G102 18,988 1,318,611 SH   SOLE 0 761,305 0 557,306
Factset Research Systems COM 303075105 26 61 SH   DFND 3 61 0 0
Farfetch ORD SHS CL A 30744W107 61,045 4,037,339 SH   DFND 1 4,037,339 0 0
Farfetch ORD SHS CL A 30744W107 218,660 14,461,618 SH   DFND 2 11,958,576 0 2,503,042
Farfetch ORD SHS CL A 30744W107 28,272 1,869,874 SH   DFND 3 1,213,910 0 655,964
Farfetch ORD SHS CL A 30744W107 154,552 10,221,700 SH   SOLE 0 6,478,602 0 3,743,098
Fastenal COM 311900104 74,849 1,260,090 SH   DFND 1 1,260,090 0 0
Fastenal COM 311900104 18,645 313,885 SH   DFND 2 241,917 0 71,968
Fastenal COM 311900104 15,453 260,146 SH   DFND 3 231,870 0 28,276
Fastenal COM 311900104 44,545 749,922 SH   SOLE 0 749,922 0 0
Fastly CL A 31188V100 4 205 SH   DFND 3 205 0 0
Ferrari NV COM N3167Y103 1,906,940 8,625,424 SH   DFND 2 6,870,497 0 1,754,927
Ferrari NV COM N3167Y103 300,656 1,359,921 SH   SOLE 0 1,359,921 0 0
Fibrogen Inc COM 31572Q808 6 467 SH   DFND 3 467 0 0
First Industrial REIT COM 32054K103 103,155 1,666,203 SH   DFND 1 1,666,203 0 0
First Industrial REIT COM 32054K103 300 4,853 SH   DFND 2 4,853 0 0
First Industrial REIT COM 32054K103 6,585 106,362 SH   DFND 3 106,362 0 0
First Majestic Silver COM 32076V103 107 8,100 SH   DFND 2 8,100 0 0
First Republic Bank COM 33616C100 157,581 972,121 SH   DFND 1 972,121 0 0
First Republic Bank COM 33616C100 245,497 1,514,476 SH   DFND 2 1,465,763 0 48,713
First Republic Bank COM 33616C100 15,441 95,259 SH   DFND 3 81,395 0 13,864
First Republic Bank COM 33616C100 29,477 181,846 SH   SOLE 0 181,846 0 0
FirstCash Holdings Inc COM 33768G107 11,986 170,398 SH   DFND 1 170,398 0 0
FirstCash Holdings Inc COM 33768G107 1,294 18,391 SH   DFND 3 18,391 0 0
Fiverr Intl ORD SHS M4R82T106 5 61 SH   DFND 3 61 0 0
Fortis COM 349553107 1,678 33,889 SH   DFND 1 33,889 0 0
Fortive Corp COM 34959J108 5,960 97,814 SH   DFND 2 97,814 0 0
Fox COM 35137L105 14 359 SH   DFND 3 359 0 0
Freshpet Inc COM 358039105 66 641 SH   DFND 2 641 0 0
Freshpet Inc COM 358039105 784 7,643 SH   DFND 3 7,643 0 0
Full Truck Alliance Co Ltd ADR SPONS ADS 35969L108 107,583 16,129,360 SH   DFND 2 15,675,467 0 453,893
Full Truck Alliance Co Ltd ADR SPONS ADS 35969L108 41,748 6,259,050 SH   SOLE 0 6,259,050 0 0
Futu Hdgs ADR SPON ADR CL A 36118L106 34,514 1,060,019 SH   DFND 2 822,190 0 237,829
GAN COM G3728V109 3 572 SH   DFND 3 572 0 0
Gentex Corp COM 371901109 15 516 SH   DFND 3 516 0 0
Ginkgo Bioworks Holdings Inc CL A COM 37611X100 74,068 18,379,088 SH   DFND 1 18,379,088 0 0
Ginkgo Bioworks Holdings Inc CL A COM 37611X100 177,793 44,117,424 SH   DFND 2 28,497,743 0 15,619,681
Ginkgo Bioworks Holdings Inc CL A COM 37611X100 15,335 3,805,213 SH   DFND 3 3,329,731 0 475,482
Ginkgo Bioworks Holdings Inc CL A COM 37611X100 408,847 101,450,955 SH   SOLE 0 98,047,509 0 3,403,446
Glaukos Corp COM 377322102 14 234 SH   DFND 3 234 0 0
Global Blood Therapeutics Inc COM 37890U108 29 835 SH   DFND 3 835 0 0
Golub Capital BDC Inc COM 38173M102 41,864 2,752,375 SH   DFND 1 2,752,375 0 0
Golub Capital BDC Inc COM 38173M102 130 8,560 SH   DFND 2 8,560 0 0
Golub Capital BDC Inc COM 38173M102 3,305 217,300 SH   DFND 3 217,300 0 0
Goodyear Tire & Rubber Co/The COM 382550101 20 1,400 SH   DFND 3 1,400 0 0
Graco COM 384109104 25 363 SH   DFND 3 363 0 0
Grainger, WW COM 384802104 30 59 SH   DFND 3 59 0 0
HDFC Bank ADR ADR REPS 3 SHS 40415F101 4,988 81,323 SH   DFND 1 81,323 0 0
HDFC Bank ADR ADR REPS 3 SHS 40415F101 66,565 1,085,356 SH   DFND 2 940,991 0 144,365
HDFC Bank ADR ADR REPS 3 SHS 40415F101 12,413 202,394 SH   DFND 3 139,025 0 63,369
HDFC Bank ADR ADR REPS 3 SHS 40415F101 101,860 1,660,853 SH   SOLE 0 1,218,181 0 442,672
HUYA ADR ADS REP SHS A 44852D108 5,116 1,144,570 SH   DFND 1 1,144,570 0 0
HUYA ADR ADS REP SHS A 44852D108 1,645 368,029 SH   DFND 3 0 0 368,029
HUYA ADR ADS REP SHS A 44852D108 2,777 621,141 SH   SOLE 0 621,141 0 0
Halozyme Therapeutics COM 40637H109 31 779 SH   DFND 3 779 0 0
Harris Corp COM 502431109 15 61 SH   DFND 3 61 0 0
Hashicorp Inc COM CL A 418100103 70,387 1,303,468 SH   DFND 1 1,303,468 0 0
Hashicorp Inc COM CL A 418100103 93,134 1,724,711 SH   DFND 2 1,695,504 0 29,207
Hashicorp Inc COM CL A 418100103 4,173 77,269 SH   DFND 3 77,269 0 0
Hashicorp Inc COM CL A 418100103 14,123 261,535 SH   SOLE 0 261,535 0 0
Health Catalyst Inc COM 42225T107 1,972 75,476 SH   DFND 1 75,476 0 0
Health Catalyst Inc COM 42225T107 3,952 151,258 SH   DFND 2 151,258 0 0
Health Catalyst Inc COM 42225T107 5,577 213,433 SH   DFND 3 213,433 0 0
Healthcare Services Group Inc COM 421906108 3 157 SH   DFND 3 157 0 0
Hecla Mining Co COM 422704106 110 16,700 SH   DFND 2 16,700 0 0
Heron Therapeutics Inc COM 427746102 2 308 SH   DFND 3 308 0 0
Hillenbrand COM 431571108 8 170 SH   DFND 3 170 0 0
Home Depot COM 437076102 17 56 SH   DFND 3 56 0 0
Homology Medicines COM 438083107 1 481 SH   DFND 3 481 0 0
Howard Hughes COM 44267D107 58,109 560,843 SH   DFND 1 560,843 0 0
Howard Hughes COM 44267D107 128,572 1,240,927 SH   DFND 2 1,122,643 0 118,284
Howard Hughes COM 44267D107 28,016 270,396 SH   DFND 3 166,685 0 103,711
Howard Hughes COM 44267D107 114,350 1,103,661 SH   SOLE 0 710,495 0 393,166
Hubbell COM 443510607 16 87 SH   DFND 3 87 0 0
Hubspot Inc COM 443573100 63 132 SH   DFND 3 132 0 0
Humana COM 444859102 24 56 SH   DFND 3 56 0 0
Hutchison China Meditech SPONSORED ADR 44842L103 2,292 121,150 SH   DFND 1 121,150 0 0
Hutchison China Meditech SPONSORED ADR 44842L103 1,154 60,971 SH   DFND 2 291 0 60,680
Hutchison China Meditech SPONSORED ADR 44842L103 3,475 183,671 SH   DFND 3 82 0 183,589
ICICI Bank ADR ADR 45104G104 77,338 4,083,324 SH   DFND 1 4,083,324 0 0
ICICI Bank ADR ADR 45104G104 64,786 3,420,589 SH   DFND 2 3,420,589 0 0
ICICI Bank ADR ADR 45104G104 14,182 748,772 SH   DFND 3 748,772 0 0
ICICI Bank ADR ADR 45104G104 4,160 219,620 SH   DFND 4 219,620 0 0
IPG Photonics Corp COM 44980X109 13,253 120,747 SH   DFND 1 120,747 0 0
IPG Photonics Corp COM 44980X109 11,802 107,525 SH   DFND 2 31,257 0 76,268
IPG Photonics Corp COM 44980X109 5,874 53,521 SH   DFND 3 53,521 0 0
IPG Photonics Corp COM 44980X109 9,915 90,336 SH   SOLE 0 90,336 0 0
Iac/Interactivecorp COM 44891N208 21,955 218,935 SH   DFND 1 218,935 0 0
Iac/Interactivecorp COM 44891N208 67,348 671,595 SH   DFND 2 608,613 0 62,982
Iac/Interactivecorp COM 44891N208 13,719 136,804 SH   DFND 3 80,234 0 56,570
Iac/Interactivecorp COM 44891N208 60,509 603,400 SH   SOLE 0 382,220 0 221,180
Ii-Vi Inc COM 902104108 34 475 SH   DFND 3 475 0 0
Illumina COM 452327109 742,248 2,124,350 SH   DFND 1 2,124,350 0 0
Illumina COM 452327109 3,953,506 11,315,130 SH   DFND 2 7,978,723 0 3,336,407
Illumina COM 452327109 450,262 1,288,671 SH   DFND 3 1,040,229 0 248,442
Illumina COM 452327109 2,158,910 6,178,907 SH   SOLE 0 5,300,177 0 878,730
InMode SHS M5425M103 19 526 SH   DFND 3 526 0 0
Incyte Corp COM 45337C102 13 165 SH   DFND 3 165 0 0
Infinera COM 45667G103 25 2,941 SH   DFND 3 2,941 0 0
Infosys Ltd ADR SPONSORED ADR 456788108 29,017 1,165,809 SH   DFND 1 1,165,809 0 0
Infosys Ltd ADR SPONSORED ADR 456788108 24,905 1,000,585 SH   DFND 2 100,142 0 900,443
Infosys Ltd ADR SPONSORED ADR 456788108 34,772 1,397,031 SH   DFND 3 558,695 0 838,336
Infosys Ltd ADR SPONSORED ADR 456788108 4,070 163,530 SH   DFND 4 163,530 0 0
Inogen Inc COM 45780L104 5 141 SH   DFND 3 141 0 0
Insmed Inc COM 457669307 17 707 SH   DFND 3 707 0 0
Inspire Medical Systems COM 457730109 40 154 SH   DFND 3 154 0 0
Intercept Pharmaceuticals Inc COM 45845P108 2 101 SH   DFND 3 101 0 0
International Game Technology SHS G4863A108 25 1,024 SH   DFND 3 1,024 0 0
Intersect ENT COM 46071F103 12 440 SH   DFND 3 440 0 0
Intuit COM 461202103 23 47 SH   DFND 3 47 0 0
Intuitive Surgical COM NEW 46120E602 110,786 367,229 SH   DFND 1 367,229 0 0
Intuitive Surgical COM NEW 46120E602 863,233 2,861,420 SH   DFND 2 968,253 0 1,893,167
Intuitive Surgical COM NEW 46120E602 110,240 365,421 SH   DFND 3 305,430 0 59,991
Intuitive Surgical COM NEW 46120E602 240,520 797,270 SH   SOLE 0 368,014 0 429,256
Invitae COM 46185L103 6 800 SH   DFND 3 800 0 0
Ionis Pharmaceuticals COM 462222100 2,228 60,157 SH   DFND 1 60,157 0 0
Ionis Pharmaceuticals COM 462222100 4,342 117,222 SH   DFND 2 117,222 0 0
Ionis Pharmaceuticals COM 462222100 6,352 171,484 SH   DFND 3 171,484 0 0
Itau Unibanco Holding SA-ADR SPON ADR REP PFD 465562106 13,767 2,410,946 SH   DFND 1 2,410,946 0 0
Itau Unibanco Holding SA-ADR SPON ADR REP PFD 465562106 39,148 6,856,003 SH   DFND 2 485,582 0 6,370,421
Itau Unibanco Holding SA-ADR SPON ADR REP PFD 465562106 51,160 8,959,743 SH   DFND 3 882,990 0 8,076,753
Itau Unibanco Holding SA-ADR SPON ADR REP PFD 465562106 2,200 385,212 SH   DFND 4 385,212 0 0
Itron Inc COM 465741106 9 173 SH   DFND 3 173 0 0
Ivanhoe Mines COM CL A 46579R104 13 1,400 SH   DFND 2 1,400 0 0
J&J Snack Foods Corp COM 466032109 13 83 SH   DFND 3 83 0 0
JD.Com Inc - ADR SPON ADR CL A 47215P106 3,957 68,377 SH   DFND 2 68,377 0 0
JDS Uniphase Corporation COM 925550105 18 1,142 SH   DFND 3 1,142 0 0
JFrog Ltd ORD SHS M6191J100 16,303 604,939 SH   DFND 1 604,939 0 0
JFrog Ltd ORD SHS M6191J100 11,267 418,087 SH   DFND 2 121,155 0 296,932
JFrog Ltd ORD SHS M6191J100 5,810 215,575 SH   DFND 3 215,575 0 0
JFrog Ltd ORD SHS M6191J100 11,159 414,081 SH   SOLE 0 414,081 0 0
Jack Henry & Associates COM 426281101 14 71 SH   DFND 3 71 0 0
Jazz Pharmaceuticals SHS G50871105 26 165 SH   DFND 3 165 0 0
Joby Aviation Inc COM G65163100 50,823 7,677,200 SH   SOLE 0 7,677,200 0 0
Johnson & Johnson COM 478160104 16 89 SH   DFND 3 89 0 0
Jumia Technologies Ag ADR SPONSORED ADS 48138M105 91,541 9,555,480 SH   DFND 2 8,914,907 0 640,573
Jumia Technologies Ag ADR SPONSORED ADS 48138M105 4,158 434,078 SH   DFND 3 374 0 433,704
KE Holdings ADR ADR 482497104 27,156 2,195,349 SH   DFND 1 2,195,349 0 0
KE Holdings ADR ADR 482497104 124,760 10,085,661 SH   DFND 2 4,443,952 0 5,641,709
KE Holdings ADR ADR 482497104 14,033 1,134,436 SH   DFND 3 879,272 0 255,164
KE Holdings ADR ADR 482497104 59,704 4,826,543 SH   SOLE 0 3,519,152 0 1,307,391
KFORCE INC. COM 493732101 22 295 SH   DFND 3 295 0 0
Kaleido Biosciences Inc COM 483347100 608 368,288 SH   DFND 1 368,288 0 0
Kaleido Biosciences Inc COM 483347100 10 6,004 SH   DFND 2 6,004 0 0
Kaleido Biosciences Inc COM 483347100 116 70,130 SH   DFND 3 70,130 0 0
Kaleido Biosciences Inc COM 483347100 477 289,103 SH   SOLE 0 289,103 0 0
Kingsoft Cloud Holdings Ltd ADR SPON ADR 49639K101 10,800 1,779,200 SH   DFND 1 1,779,200 0 0
Kingsoft Cloud Holdings Ltd ADR SPON ADR 49639K101 5,340 879,750 SH   DFND 2 879,750 0 0
Kingsoft Cloud Holdings Ltd ADR SPON ADR 49639K101 1,866 307,429 SH   DFND 3 23,560 0 283,869
Kingsoft Cloud Holdings Ltd ADR SPON ADR 49639K101 2,386 393,153 SH   SOLE 0 393,153 0 0
Knowles Corp COM 49926D109 26 1,200 SH   DFND 3 1,200 0 0
Kulicke & Soffa Industries Inc COM 501242101 28 491 SH   DFND 3 491 0 0
Lemonade Inc COM 52567D107 42,932 1,628,048 SH   DFND 1 1,628,048 0 0
Lemonade Inc COM 52567D107 64,577 2,448,867 SH   DFND 2 2,410,191 0 38,676
Lemonade Inc COM 52567D107 2,463 93,391 SH   DFND 3 93,391 0 0
Lemonade Inc COM 52567D107 25,468 965,782 SH   SOLE 0 965,782 0 0
LendingTree COM 52603B107 27,126 226,675 SH   DFND 1 226,675 0 0
LendingTree COM 52603B107 24,917 208,212 SH   DFND 2 62,772 0 145,440
LendingTree COM 52603B107 12,894 107,750 SH   DFND 3 101,917 0 5,833
LendingTree COM 52603B107 14,237 118,966 SH   SOLE 0 118,966 0 0
Li Auto ADR SPONS ADS 50202M102 45,316 1,755,764 SH   DFND 1 1,755,764 0 0
Li Auto ADR SPONS ADS 50202M102 141,089 5,466,444 SH   DFND 2 4,936,328 0 530,116
Li Auto ADR SPONS ADS 50202M102 27,808 1,077,418 SH   DFND 3 617,544 0 459,874
Li Auto ADR SPONS ADS 50202M102 127,195 4,928,144 SH   SOLE 0 3,193,505 0 1,734,639
Liberty Broadband Corp COM 530307305 9 70 SH   DFND 3 70 0 0
Lightspeed POS COM 53227R106 9 310 SH   DFND 3 310 0 0
Lilium N.V. CL A COM N52586109 35 8,720 SH   DFND 1 8,720 0 0
Lilium N.V. CL A COM N52586109 2,181 547,944 SH   DFND 2 547,944 0 0
Lilium N.V. CL A COM N52586109 70,444 17,699,615 SH   SOLE 0 17,699,615 0 0
LivePerson Inc COM 538146101 12,022 492,291 SH   DFND 1 492,291 0 0
LivePerson Inc COM 538146101 8,652 354,293 SH   DFND 2 101,633 0 252,660
LivePerson Inc COM 538146101 3,847 157,554 SH   DFND 3 157,554 0 0
LivePerson Inc COM 538146101 6,053 247,880 SH   SOLE 0 247,880 0 0
Liveramp Holdings Inc COM 53815P108 23,010 615,401 SH   DFND 1 615,401 0 0
Liveramp Holdings Inc COM 53815P108 11,545 308,781 SH   DFND 2 91,535 0 217,246
Liveramp Holdings Inc COM 53815P108 6,426 171,857 SH   DFND 3 171,857 0 0
Liveramp Holdings Inc COM 53815P108 11,033 295,075 SH   SOLE 0 295,075 0 0
Logitech International SA SHS H50430232 17 235 SH   DFND 3 235 0 0
Lowes Cos COM 548661107 14 69 SH   DFND 3 69 0 0
Lufax Holding Ltd COM 54975P102 42,959 7,712,615 SH   DFND 1 7,712,615 0 0
Lufax Holding Ltd COM 54975P102 97,875 17,571,896 SH   DFND 2 9,972,189 0 7,599,707
Lufax Holding Ltd COM 54975P102 919 164,971 SH   DFND 3 164,971 0 0
Lumentum Hdgs COM 55024U109 14 141 SH   DFND 3 141 0 0
Lyell Immunopharma Inc COM 55083R104 658 130,375 SH   DFND 1 130,375 0 0
Lyell Immunopharma Inc COM 55083R104 1,405 278,187 SH   DFND 2 278,187 0 0
Lyell Immunopharma Inc COM 55083R104 1,900 376,179 SH   DFND 3 376,179 0 0
Lyft Inc Class A Common CL A COM 55087P104 4,161 108,361 SH   DFND 1 108,361 0 0
Lyft Inc Class A Common CL A COM 55087P104 475 12,360 SH   DFND 3 12,360 0 0
MELI Kaszek Pioneer CL A COM G5S74L106 20,560 2,000,000 SH   DFND 2 2,000,000 0 0
MP Materials COM CL A 553368101 109,519 1,910,000 SH   DFND 1 1,910,000 0 0
MP Materials COM CL A 553368101 247 4,300 SH   DFND 2 4,300 0 0
MP Materials COM CL A 553368101 6,112 106,600 SH   DFND 3 106,600 0 0
MakeMyTrip SHS V5633W109 67,201 2,504,679 SH   DFND 2 1,856,714 0 647,965
Marathon Digital Holdings COM 565788106 10 343 SH   DFND 3 343 0 0
Markel Corp COM 570535104 75,302 51,044 SH   DFND 1 51,044 0 0
Markel Corp COM 570535104 236,000 159,974 SH   DFND 2 144,769 0 15,205
Markel Corp COM 570535104 45,390 30,768 SH   DFND 3 18,152 0 12,616
Markel Corp COM 570535104 212,345 143,939 SH   SOLE 0 93,900 0 50,039
MarketAxess Holdings COM 57060D108 167,292 491,745 SH   DFND 1 491,745 0 0
MarketAxess Holdings COM 57060D108 236,197 694,290 SH   DFND 2 554,679 0 139,611
MarketAxess Holdings COM 57060D108 38,416 112,923 SH   DFND 3 103,816 0 9,107
MarketAxess Holdings COM 57060D108 60,337 177,358 SH   SOLE 0 177,358 0 0
Martin Marietta Materials COM 573284106 218,898 568,728 SH   DFND 1 568,728 0 0
Martin Marietta Materials COM 573284106 674,076 1,751,347 SH   DFND 2 1,586,094 0 165,253
Martin Marietta Materials COM 573284106 110,707 287,633 SH   DFND 3 168,632 0 119,001
Martin Marietta Materials COM 573284106 495,080 1,286,290 SH   SOLE 0 922,301 0 363,989
Masimo Corp COM 574795100 2,509 17,236 SH   DFND 1 17,236 0 0
Masimo Corp COM 574795100 4,916 33,780 SH   DFND 2 33,780 0 0
Masimo Corp COM 574795100 7,154 49,158 SH   DFND 3 49,158 0 0
Mastercard Inc-Class A CL A 57636Q104 143,228 400,772 SH   DFND 1 400,772 0 0
Mastercard Inc-Class A CL A 57636Q104 458,873 1,283,991 SH   DFND 2 1,163,803 0 120,188
Mastercard Inc-Class A CL A 57636Q104 86,051 240,783 SH   DFND 3 141,903 0 98,880
Mastercard Inc-Class A CL A 57636Q104 366,608 1,025,822 SH   SOLE 0 657,713 0 368,109
Materialise Nv ADR SPONSORED ADS 57667T100 5,186 268,000 SH   DFND 2 268,000 0 0
Maxlinear Inc COM 57776J100 23 400 SH   DFND 3 400 0 0
McDonald's COM 580135101 21,326 86,242 SH   DFND 1 86,242 0 0
McDonald's COM 580135101 435 1,759 SH   DFND 2 0 0 1,759
McDonald's COM 580135101 820 3,318 SH   DFND 3 3,318 0 0
McDonald's COM 580135101 21,187 85,680 SH   SOLE 0 85,680 0 0
Medifast Inc COM 58470H101 20 120 SH   DFND 3 120 0 0
Medtronic COM G5960L103 21,789 196,385 SH   DFND 1 196,385 0 0
Medtronic COM G5960L103 324 2,920 SH   DFND 2 0 0 2,920
Medtronic COM G5960L103 3,343 30,129 SH   DFND 3 30,129 0 0
Medtronic COM G5960L103 15,527 139,946 SH   SOLE 0 139,946 0 0
MercadoLibre COM 58733R102 360,146 302,776 SH   DFND 1 302,776 0 0
MercadoLibre COM 58733R102 4,913,952 4,131,177 SH   DFND 2 3,333,979 0 797,198
MercadoLibre COM 58733R102 212,405 178,570 SH   DFND 3 149,839 0 28,731
MercadoLibre COM 58733R102 8,612 7,240 SH   DFND 4 7,240 0 0
MercadoLibre COM 58733R102 494,300 415,560 SH   SOLE 0 415,560 0 0
Meta Platforms Inc CL A 30303M102 166,906 750,612 SH   DFND 1 750,612 0 0
Meta Platforms Inc CL A 30303M102 943,878 4,244,819 SH   DFND 2 2,063,077 0 2,181,742
Meta Platforms Inc CL A 30303M102 136,638 614,492 SH   DFND 3 461,404 0 153,088
Meta Platforms Inc CL A 30303M102 408,577 1,837,456 SH   SOLE 0 1,029,711 0 807,745
Mettler-Toledo COM 592688105 118,994 86,655 SH   DFND 1 86,655 0 0
Mettler-Toledo COM 592688105 533,429 388,460 SH   DFND 2 285,595 0 102,865
Mettler-Toledo COM 592688105 4,978 3,625 SH   DFND 3 3,625 0 0
Mettler-Toledo COM 592688105 33,757 24,583 SH   SOLE 0 24,583 0 0
Microsoft COM 594918104 304,588 987,929 SH   DFND 1 987,929 0 0
Microsoft COM 594918104 815,223 2,644,168 SH   DFND 2 2,409,945 0 234,223
Microsoft COM 594918104 156,483 507,552 SH   DFND 3 311,264 0 196,288
Microsoft COM 594918104 681,617 2,210,818 SH   SOLE 0 1,461,288 0 749,530
Mobile Telesystems ADR SPONSORED ADR 607409109 0 42,174 SH   DFND 1 42,174 0 0
Moderna Inc COM 60770K107 835,247 4,848,756 SH   DFND 1 4,848,756 0 0
Moderna Inc COM 60770K107 4,312,297 25,033,655 SH   DFND 2 19,226,725 0 5,806,930
Moderna Inc COM 60770K107 438,384 2,544,897 SH   DFND 3 2,056,347 0 488,550
Moderna Inc COM 60770K107 2,274,162 13,201,918 SH   SOLE 0 11,655,716 0 1,546,202
Momentive Global Inc COM 78489X103 18 1,095 SH   DFND 3 1,095 0 0
MongoDB Inc COM 60937P106 96 216 SH   DFND 3 216 0 0
Monolithic Power Systems Inc COM 609839105 31 63 SH   DFND 3 63 0 0
Moody's Corp COM 615369105 222,475 659,361 SH   DFND 1 659,361 0 0
Moody's Corp COM 615369105 713,085 2,113,409 SH   DFND 2 1,915,116 0 198,293
Moody's Corp COM 615369105 135,066 400,302 SH   DFND 3 233,188 0 167,114
Moody's Corp COM 615369105 592,987 1,757,468 SH   SOLE 0 1,113,603 0 643,865
NIO Inc ADR SPON ADS 62914V106 40,467 1,922,423 SH   DFND 1 1,922,423 0 0
NIO Inc ADR SPON ADS 62914V106 1,223,980 58,146,319 SH   DFND 2 44,791,584 0 13,354,735
NIO Inc ADR SPON ADS 62914V106 41,698 1,980,898 SH   DFND 3 1,660,308 0 320,590
NIO Inc ADR SPON ADS 62914V106 562,056 26,700,981 SH   SOLE 0 24,410,834 0 2,290,147
NV5 Global COM 62945V109 18 138 SH   DFND 3 138 0 0
NVIDIA COM 67066G104 547,922 2,008,069 SH   DFND 1 2,008,069 0 0
NVIDIA COM 67066G104 2,437,898 8,934,611 SH   DFND 2 4,187,169 0 4,747,442
NVIDIA COM 67066G104 274,548 1,006,187 SH   DFND 3 846,807 0 159,380
NVIDIA COM 67066G104 1,342,839 4,921,348 SH   SOLE 0 3,904,325 0 1,017,023
Nano Dimension ADR SPONS ADS 63008G203 6 1,600 SH   DFND 3 1,600 0 0
Nanobiotix ADR COM 63009J107 6,381 850,841 SH   DFND 1 850,841 0 0
Nanobiotix ADR COM 63009J107 4,119 549,159 SH   SOLE 0 549,159 0 0
National Instruments Corp COM 636518102 26,994 665,036 SH   DFND 1 665,036 0 0
National Instruments Corp COM 636518102 383 9,442 SH   DFND 2 0 0 9,442
National Instruments Corp COM 636518102 4,455 109,766 SH   DFND 3 109,766 0 0
National Instruments Corp COM 636518102 18,682 460,267 SH   SOLE 0 460,267 0 0
Nektar Therapeutics COM 640268108 7 1,376 SH   DFND 3 1,376 0 0
NetEase.com ADR SPONSORED ADR 64110W102 14,293 159,358 SH   DFND 1 159,358 0 0
NetEase.com ADR SPONSORED ADR 64110W102 9,313 103,840 SH   DFND 2 500 0 103,340
NetEase.com ADR SPONSORED ADR 64110W102 14 154 SH   DFND 3 154 0 0
Netflix Inc COM 64110L106 445,555 1,189,448 SH   DFND 1 1,189,448 0 0
Netflix Inc COM 64110L106 1,491,319 3,981,203 SH   DFND 2 2,254,636 0 1,726,567
Netflix Inc COM 64110L106 169,449 452,359 SH   DFND 3 365,093 0 87,266
Netflix Inc COM 64110L106 780,004 2,082,288 SH   SOLE 0 1,597,745 0 484,543
Nevro Corp COM 64157F103 11 154 SH   DFND 3 154 0 0
New Relic COM 64829B100 49 733 SH   DFND 3 733 0 0
Newmont Mining COM 651639106 1,603 20,172 SH   DFND 1 20,172 0 0
Newmont Mining COM 651639106 270 3,400 SH   DFND 2 3,400 0 0
NextEra Energy COM 65339F101 53,647 633,299 SH   DFND 1 633,299 0 0
NextEra Energy COM 65339F101 180 2,130 SH   DFND 2 2,130 0 0
NextEra Energy COM 65339F101 4,200 49,579 SH   DFND 3 49,579 0 0
Nike COM 654106103 12 90 SH   DFND 3 90 0 0
Novanta Inc COM 67000B104 87 614 SH   DFND 2 614 0 0
Novanta Inc COM 67000B104 1,042 7,322 SH   DFND 3 7,322 0 0
Novavax Inc COM NEW 670002401 10 130 SH   DFND 3 130 0 0
Novocure Ltd ORD SHS G6674U108 214,543 2,589,535 SH   DFND 1 2,589,535 0 0
Novocure Ltd ORD SHS G6674U108 344,048 4,152,657 SH   DFND 2 3,654,465 0 498,192
Novocure Ltd ORD SHS G6674U108 56,620 683,400 SH   DFND 3 568,030 0 115,370
Novocure Ltd ORD SHS G6674U108 158,679 1,915,253 SH   SOLE 0 1,479,306 0 435,947
Nu Holdings Ltd. ORD SHS CL A G6683N103 46,707 6,050,078 SH   DFND 1 6,050,078 0 0
Nu Holdings Ltd. ORD SHS CL A G6683N103 118,052 15,291,660 SH   DFND 2 13,488,938 0 1,802,722
Nu Holdings Ltd. ORD SHS CL A G6683N103 47,366 6,135,526 SH   DFND 3 4,937,946 0 1,197,580
Nu Holdings Ltd. ORD SHS CL A G6683N103 4,442 575,423 SH   SOLE 0 575,423 0 0
Nucana Plc ADR SPONSORED ADR 67022C106 2,418 2,420,041 SH   DFND 1 2,420,041 0 0
Nucana Plc ADR SPONSORED ADR 67022C106 1,238 1,238,989 SH   SOLE 0 1,238,989 0 0
Nutanix Inc COM 67059N108 15 563 SH   DFND 3 563 0 0
Oatly Inc. SPONS ADS 67421J108 115,751 23,103,983 SH   DFND 2 19,026,878 0 4,077,105
Oatly Inc. SPONS ADS 67421J108 5,320 1,061,969 SH   SOLE 0 1,061,969 0 0
On Semiconductor Corp COM 682189105 31 500 SH   DFND 3 500 0 0
OneConnect Financial Technology ADR COM 68248T105 931 659,993 SH   DFND 1 659,993 0 0
Opko Health Inc COM 68375N103 23 6,635 SH   DFND 3 6,635 0 0
Oscar Health Inc COM 687793109 28,276 2,836,131 SH   DFND 1 2,836,131 0 0
Oscar Health Inc COM 687793109 84,052 8,430,442 SH   DFND 2 7,635,077 0 795,365
Oscar Health Inc COM 687793109 18,647 1,870,333 SH   DFND 3 1,151,007 0 719,326
Oscar Health Inc COM 687793109 82,203 8,244,998 SH   SOLE 0 5,656,835 0 2,588,163
Outset Medical COM 690145107 16 346 SH   DFND 3 346 0 0
Oxford Industries Inc COM 691497309 7 73 SH   DFND 3 73 0 0
Ozon Holdings COM 69269L104 0 333,970 SH   DFND 1 333,970 0 0
Ozon Holdings COM 69269L104 0 2,478,153 SH   DFND 2 1,319,308 0 1,158,845
Ozon Holdings COM 69269L104 0 19,278 SH   DFND 3 19,278 0 0
PROCEPT BioRobotics COM 74276L105 13 376 SH   DFND 3 376 0 0
Pacific Biosciences of California COM 69404D108 5 561 SH   DFND 3 561 0 0
Pacira BioSciences COM 695127100 67,743 887,616 SH   DFND 1 887,616 0 0
Pacira BioSciences COM 695127100 42,826 561,143 SH   DFND 2 185,194 0 375,949
Pacira BioSciences COM 695127100 25,707 336,836 SH   DFND 3 292,649 0 44,187
Pacira BioSciences COM 695127100 25,491 334,005 SH   SOLE 0 334,005 0 0
PagerDuty COM 69553P100 19 565 SH   DFND 3 565 0 0
Pagseguro Digital Ltd COM CL A G68707101 3 148 SH   DFND 2 148 0 0
Pan American Silver Corp COM 697900108 123 4,500 SH   DFND 2 4,500 0 0
Paychex COM 704326107 16 116 SH   DFND 3 116 0 0
Peloton Interactive Inc CL A COM 70614W100 143,814 5,443,379 SH   DFND 1 5,443,379 0 0
Peloton Interactive Inc CL A COM 70614W100 499,823 18,918,339 SH   DFND 2 9,779,337 0 9,139,002
Peloton Interactive Inc CL A COM 70614W100 79,110 2,994,324 SH   DFND 3 2,397,562 0 596,762
Peloton Interactive Inc CL A COM 70614W100 154,177 5,835,629 SH   SOLE 0 3,239,418 0 2,596,211
Penumbra Inc COM 70975L107 106,226 478,215 SH   DFND 1 478,215 0 0
Penumbra Inc COM 70975L107 153,387 690,529 SH   DFND 2 679,496 0 11,033
Penumbra Inc COM 70975L107 6,377 28,708 SH   DFND 3 28,708 0 0
Penumbra Inc COM 70975L107 22,547 101,505 SH   SOLE 0 101,505 0 0
Pepsico COM 713448108 48,552 290,071 SH   DFND 1 290,071 0 0
Pepsico COM 713448108 673 4,018 SH   DFND 2 0 0 4,018
Pepsico COM 713448108 7,831 46,785 SH   DFND 3 46,785 0 0
Pepsico COM 713448108 33,663 201,118 SH   SOLE 0 201,118 0 0
Petrobras Common ADR SPONSORED ADR 71654V408 253,155 17,105,088 SH   DFND 1 17,105,088 0 0
Petrobras Common ADR SPONSORED ADR 71654V408 749,090 50,614,174 SH   DFND 2 25,671,925 0 24,942,249
Petrobras Common ADR SPONSORED ADR 71654V408 33,672 2,275,157 SH   DFND 3 2,275,157 0 0
Petrobras Common ADR SPONSORED ADR 71654V408 11,453 773,864 SH   DFND 4 773,864 0 0
Petrobras Common ADR SPONSORED ADR 71654V408 15,287 1,032,931 SH   SOLE 0 1,032,931 0 0
Petrobras Pref ADR SP ADR NON VTG 71654V101 22,481 1,608,059 SH   DFND 1 1,608,059 0 0
Petrobras Pref ADR SP ADR NON VTG 71654V101 130,656 9,345,934 SH   DFND 2 6,907,271 0 2,438,663
Petrobras Pref ADR SP ADR NON VTG 71654V101 1,135 81,219 SH   DFND 3 81,219 0 0
Pfizer COM 717081103 26 500 SH   DFND 3 500 0 0
Piedmont Lithium Inc COM 72016P105 15 212 SH   DFND 3 212 0 0
Pinduoduo Inc ADR SPONSORED ADS 722304102 71,754 1,788,927 SH   DFND 1 1,788,927 0 0
Pinduoduo Inc ADR SPONSORED ADS 722304102 693,224 17,283,075 SH   DFND 2 8,237,066 0 9,046,009
Pinduoduo Inc ADR SPONSORED ADS 722304102 67,840 1,691,337 SH   DFND 3 1,416,729 0 274,608
Pinduoduo Inc ADR SPONSORED ADS 722304102 333,882 8,324,153 SH   SOLE 0 6,352,428 0 1,971,725
Pinterest COM 72352L106 56,047 2,277,401 SH   DFND 1 2,277,401 0 0
Pinterest COM 72352L106 87,089 3,538,772 SH   DFND 2 3,484,277 0 54,495
Pinterest COM 72352L106 3,315 134,692 SH   DFND 3 134,692 0 0
Pinterest COM 72352L106 12,761 518,530 SH   SOLE 0 518,530 0 0
Plantronics Inc COM 727493108 10 254 SH   DFND 3 254 0 0
Precision BioSciences Inc COM 74019P108 15 4,887 SH   DFND 2 4,887 0 0
Precision BioSciences Inc COM 74019P108 175 56,678 SH   DFND 3 56,678 0 0
Procter & Gamble COM 742718109 57,801 378,278 SH   DFND 1 378,278 0 0
Procter & Gamble COM 742718109 799 5,230 SH   DFND 2 0 0 5,230
Procter & Gamble COM 742718109 9,315 60,961 SH   DFND 3 60,961 0 0
Procter & Gamble COM 742718109 40,408 264,451 SH   SOLE 0 264,451 0 0
Progyny COM 74340E103 27,753 539,946 SH   DFND 1 539,946 0 0
Progyny COM 74340E103 18,688 363,573 SH   DFND 2 116,603 0 246,970
Progyny COM 74340E103 10,712 208,408 SH   DFND 3 185,015 0 23,393
Progyny COM 74340E103 11,579 225,281 SH   SOLE 0 225,281 0 0
Prologis Inc REIT COM 74340W103 106,111 657,115 SH   DFND 1 657,115 0 0
Prologis Inc REIT COM 74340W103 314 1,947 SH   DFND 2 1,947 0 0
Prologis Inc REIT COM 74340W103 6,890 42,665 SH   DFND 3 42,665 0 0
Proterra Inc COM 74374T109 82 10,898 SH   DFND 1 10,898 0 0
Ptc Therapeutics Inc COM 69366J200 9 246 SH   DFND 3 246 0 0
Pure Storage Inc COM 74624M102 47 1,335 SH   DFND 3 1,335 0 0
Q2 Holdings Inc COM 74736L109 19,626 318,346 SH   DFND 1 318,346 0 0
Q2 Holdings Inc COM 74736L109 11,093 179,932 SH   DFND 2 52,985 0 126,947
Q2 Holdings Inc COM 74736L109 5,942 96,375 SH   DFND 3 96,375 0 0
Q2 Holdings Inc COM 74736L109 7,536 122,235 SH   SOLE 0 122,235 0 0
Quaker Chemical Corp COM 747316107 15 86 SH   DFND 3 86 0 0
Qualcomm COM 747525103 28 181 SH   DFND 3 181 0 0
Quanterix Corp COM 74766Q101 11,417 391,135 SH   DFND 1 391,135 0 0
Quanterix Corp COM 74766Q101 71 2,423 SH   DFND 2 2,423 0 0
Quanterix Corp COM 74766Q101 847 29,013 SH   DFND 3 29,013 0 0
Quanterix Corp COM 74766Q101 6,120 209,677 SH   SOLE 0 209,677 0 0
QuantumScape Corp COM CL A 74767V109 60 3,002 SH   DFND 1 3,002 0 0
QuantumScape Corp COM CL A 74767V109 18,256 913,279 SH   SOLE 0 913,279 0 0
Quest Diagnostics COM 74834L100 20 145 SH   DFND 3 145 0 0
Quidel Corp COM 74838J101 14 128 SH   DFND 3 128 0 0
REGENXBIO COM 75901B107 25 752 SH   DFND 3 752 0 0
Rambus Inc COM 750917106 20 630 SH   DFND 3 630 0 0
Recursion Pharmaceuticals Inc CL A 75629V104 20,381 2,846,499 SH   DFND 1 2,846,499 0 0
Recursion Pharmaceuticals Inc CL A 75629V104 28,488 3,978,800 SH   DFND 2 3,916,615 0 62,185
Recursion Pharmaceuticals Inc CL A 75629V104 4,227 590,320 SH   DFND 3 590,320 0 0
Recursion Pharmaceuticals Inc CL A 75629V104 104,292 14,565,985 SH   SOLE 0 14,565,985 0 0
Redfin COM 75737F108 71,431 3,959,592 SH   DFND 1 3,959,592 0 0
Redfin COM 75737F108 95,624 5,300,639 SH   DFND 2 5,136,188 0 164,451
Redfin COM 75737F108 6,544 362,762 SH   DFND 3 321,165 0 41,597
Redfin COM 75737F108 13,297 737,083 SH   SOLE 0 737,083 0 0
Regeneron Pharmaceuticals COM 75886F107 32 46 SH   DFND 3 46 0 0
Relay Therapeutics Inc COM 75943R102 1,280 42,777 SH   DFND 1 42,777 0 0
Relay Therapeutics Inc COM 75943R102 2,476 82,714 SH   DFND 2 82,714 0 0
Relay Therapeutics Inc COM 75943R102 3,555 118,786 SH   DFND 3 118,786 0 0
ResMed COM 761152107 3,377 13,927 SH   DFND 1 13,927 0 0
ResMed COM 761152107 6,683 27,556 SH   DFND 2 27,556 0 0
ResMed COM 761152107 9,505 39,196 SH   DFND 3 39,196 0 0
Research in Motion COM 09228F103 20 2,731 SH   DFND 3 2,731 0 0
Rexford Industrial Realty REIT COM 76169C100 129,812 1,740,339 SH   DFND 1 1,740,339 0 0
Rexford Industrial Realty REIT COM 76169C100 384 5,146 SH   DFND 2 5,146 0 0
Rexford Industrial Realty REIT COM 76169C100 8,416 112,824 SH   DFND 3 112,824 0 0
Ringcentral Inc COM 76680R206 42 356 SH   DFND 3 356 0 0
Ritchie Bros Auctioneers (USA) COM 767744105 96,681 1,637,820 SH   DFND 2 1,494,109 0 143,711
Ritchie Bros. Auctioneers COM 767744105 65,383 1,105,995 SH   DFND 2 650,294 0 455,701
Rivian Automotive Inc COM CL A 76954A103 65,178 1,297,331 SH   DFND 1 1,297,331 0 0
Rivian Automotive Inc COM CL A 76954A103 93,696 1,864,964 SH   DFND 2 1,835,200 0 29,764
Rivian Automotive Inc COM CL A 76954A103 3,949 78,608 SH   DFND 3 78,608 0 0
Rivian Automotive Inc COM CL A 76954A103 14,928 297,127 SH   SOLE 0 297,127 0 0
Robert Half International Inc COM 770323103 15 131 SH   DFND 3 131 0 0
Roblox CL A 771049103 30,373 656,849 SH   DFND 1 656,849 0 0
Roblox CL A 771049103 235,670 5,096,679 SH   DFND 2 1,727,409 0 3,369,270
Roblox CL A 771049103 30,707 664,088 SH   DFND 3 557,241 0 106,847
Roblox CL A 771049103 65,848 1,424,053 SH   SOLE 0 658,628 0 765,425
Roku COM CL A 77543R102 159,294 1,271,608 SH   DFND 1 1,271,608 0 0
Roku COM CL A 77543R102 242,778 1,938,041 SH   DFND 2 1,907,596 0 30,445
Roku COM CL A 77543R102 9,507 75,889 SH   DFND 3 75,889 0 0
Roku COM CL A 77543R102 34,106 272,260 SH   SOLE 0 272,260 0 0
Rollins Inc COM 775711104 20 562 SH   DFND 3 562 0 0
Royal Caribbean Cruises COM V7780T103 12,920 154,209 SH   DFND 1 154,209 0 0
Royal Caribbean Cruises COM V7780T103 1,421 16,960 SH   DFND 3 16,960 0 0
Royalty Pharma SHS CLASS A G7709Q104 5,962 153,037 SH   DFND 1 153,037 0 0
Royalty Pharma SHS CLASS A G7709Q104 18,431 473,067 SH   DFND 2 404,652 0 68,415
Royalty Pharma SHS CLASS A G7709Q104 3,648 93,636 SH   DFND 3 55,142 0 38,494
Royalty Pharma SHS CLASS A G7709Q104 15,868 407,291 SH   SOLE 0 258,439 0 148,852
Rubius Therapeutics Inc COM 78116T103 4,887 887,000 SH   DFND 1 887,000 0 0
Rubius Therapeutics Inc COM 78116T103 1,555 282,190 SH   DFND 2 80,564 0 201,626
Rubius Therapeutics Inc COM 78116T103 841 152,722 SH   DFND 3 152,722 0 0
Rubius Therapeutics Inc COM 78116T103 19,756 3,585,559 SH   SOLE 0 3,585,559 0 0
Ryanair ADR SPONSORED ADR NE 783513203 33,358 382,894 SH   DFND 1 382,894 0 0
Ryanair ADR SPONSORED ADR NE 783513203 756,239 8,680,427 SH   DFND 2 7,561,378 0 1,119,049
Ryanair ADR SPONSORED ADR NE 783513203 4,315 49,528 SH   DFND 3 49,528 0 0
Ryanair ADR SPONSORED ADR NE 783513203 13,541 155,430 SH   SOLE 0 149,132 0 6,298
S&P Global Inc COM 78409V104 93,146 227,085 SH   DFND 1 227,085 0 0
S&P Global Inc COM 78409V104 304,276 741,811 SH   DFND 2 674,293 0 67,518
S&P Global Inc COM 78409V104 57,197 139,444 SH   DFND 3 81,812 0 57,632
S&P Global Inc COM 78409V104 251,888 614,092 SH   SOLE 0 394,499 0 219,593
SCP Pool Corporation COM 73278L105 30 70 SH   DFND 3 70 0 0
SEA Ltd ADR ADR 81141R100 313,109 2,613,814 SH   DFND 1 2,613,814 0 0
SEA Ltd ADR ADR 81141R100 1,306,629 10,907,667 SH   DFND 2 8,026,256 0 2,881,411
SEA Ltd ADR ADR 81141R100 96,722 807,432 SH   DFND 3 569,333 0 238,099
SEA Ltd ADR ADR 81141R100 1,743 14,549 SH   DFND 4 14,549 0 0
SEA Ltd ADR ADR 81141R100 353,326 2,949,542 SH   SOLE 0 1,884,989 0 1,064,553
SKYWORKS SOLUTIONS, INC. COM 83088M102 18 136 SH   DFND 3 136 0 0
Sage Therapeutics Inc COM 78667J108 539 16,276 SH   DFND 1 16,276 0 0
Sage Therapeutics Inc COM 78667J108 1,122 33,912 SH   DFND 2 33,912 0 0
Sage Therapeutics Inc COM 78667J108 1,608 48,578 SH   DFND 3 48,578 0 0
Sailpoint Technologies Holding COM 78781P105 20 388 SH   DFND 3 388 0 0
Salesforce.com COM 79466L302 61,058 287,577 SH   DFND 1 287,577 0 0
Salesforce.com COM 79466L302 489,016 2,303,205 SH   DFND 2 828,355 0 1,474,850
Salesforce.com COM 79466L302 60,757 286,160 SH   DFND 3 239,286 0 46,874
Salesforce.com COM 79466L302 132,227 622,773 SH   SOLE 0 288,222 0 334,551
Sana Biotechnology Inc COM 799566104 16,584 2,007,781 SH   DFND 1 2,007,781 0 0
Sana Biotechnology Inc COM 799566104 23,476 2,842,131 SH   DFND 2 2,842,131 0 0
Sana Biotechnology Inc COM 799566104 1,766 213,787 SH   DFND 3 213,787 0 0
Sana Biotechnology Inc COM 799566104 49,743 6,022,162 SH   SOLE 0 6,022,162 0 0
Sarepta Therapeutics Inc COM 803607100 14 177 SH   DFND 3 177 0 0
Schrodinger COM 80810D103 11,347 332,569 SH   DFND 1 332,569 0 0
Schrodinger COM 80810D103 14,049 411,756 SH   DFND 2 118,189 0 293,567
Schrodinger COM 80810D103 6,745 197,686 SH   DFND 3 197,686 0 0
Schrodinger COM 80810D103 10,947 320,840 SH   SOLE 0 320,840 0 0
Schweitzer-Maudit Int. COM 808541106 7 265 SH   DFND 3 265 0 0
Seagen Inc COM 81181C104 18 128 SH   DFND 3 128 0 0
Seer COM CL A 81578P106 3 223 SH   DFND 3 223 0 0
Sei Investments Co COM 784117103 26 438 SH   DFND 3 438 0 0
Service Corp.Intl. COM 817565104 144,710 2,198,572 SH   DFND 1 2,198,572 0 0
Service Corp.Intl. COM 817565104 465,414 7,071,009 SH   DFND 2 6,420,375 0 650,634
Service Corp.Intl. COM 817565104 88,839 1,349,725 SH   DFND 3 788,191 0 561,534
Service Corp.Intl. COM 817565104 397,325 6,036,540 SH   SOLE 0 3,914,611 0 2,121,929
Sherwin-Williams Co COM 824348106 11,096 44,453 SH   DFND 2 44,453 0 0
ShockWave Medical Inc COM 82489T104 27,734 133,748 SH   DFND 1 133,748 0 0
ShockWave Medical Inc COM 82489T104 41,334 199,336 SH   DFND 2 116,032 0 83,304
ShockWave Medical Inc COM 82489T104 36,847 177,698 SH   DFND 3 177,698 0 0
ShockWave Medical Inc COM 82489T104 17,811 85,892 SH   SOLE 0 85,892 0 0
Shopify 'A' CL A 82509L107 725,496 1,073,283 SH   DFND 1 1,073,283 0 0
Shopify 'A' CL A 82509L107 1,968,270 2,911,814 SH   DFND 2 1,993,188 0 918,626
Shopify 'A' CL A 82509L107 236,022 349,166 SH   DFND 3 275,026 0 74,140
Shopify 'A' CL A 82509L107 695,435 1,028,811 SH   SOLE 0 763,083 0 265,728
Shopify Inc COM 82509L107 6,567 9,702 SH   DFND 2 9,702 0 0
Shopify Inc COM 82509L107 126 186 SH   DFND 3 186 0 0
Silicon Motion Technology ADR COM 82706C108 28,128 420,954 SH   DFND 1 420,954 0 0
Silicon Motion Technology ADR COM 82706C108 323 4,839 SH   DFND 2 0 0 4,839
Silicon Motion Technology ADR COM 82706C108 4,498 67,320 SH   DFND 3 67,320 0 0
Silicon Motion Technology ADR COM 82706C108 19,764 295,784 SH   SOLE 0 295,784 0 0
Silk Road Medical COM 82710M100 10 235 SH   DFND 3 235 0 0
SiteOne Landscape Supply COM 82982L103 70,616 436,739 SH   DFND 1 436,739 0 0
SiteOne Landscape Supply COM 82982L103 219,048 1,354,738 SH   DFND 2 1,226,633 0 128,105
SiteOne Landscape Supply COM 82982L103 42,574 263,305 SH   DFND 3 154,104 0 109,201
SiteOne Landscape Supply COM 82982L103 188,884 1,168,184 SH   SOLE 0 748,126 0 420,058
Six Flags Entertainment Corp COM 83001A102 13,751 316,104 SH   DFND 1 316,104 0 0
Six Flags Entertainment Corp COM 83001A102 1,509 34,700 SH   DFND 3 34,700 0 0
Sixth Street Specialty Lending COM 83012A109 22,240 954,900 SH   DFND 1 954,900 0 0
Sixth Street Specialty Lending COM 83012A109 140 6,000 SH   DFND 2 6,000 0 0
Sixth Street Specialty Lending COM 83012A109 3,582 153,800 SH   DFND 3 153,800 0 0
Smartsheet COM 83200N103 17 311 SH   DFND 3 311 0 0
Snap Inc CL A 83304A106 150,256 4,174,931 SH   DFND 1 4,174,931 0 0
Snap Inc CL A 83304A106 220,308 6,121,354 SH   DFND 2 6,023,314 0 98,040
Snap Inc CL A 83304A106 8,956 248,850 SH   DFND 3 248,850 0 0
Snap Inc CL A 83304A106 34,428 956,596 SH   SOLE 0 956,596 0 0
Snap On COM 833034101 18 86 SH   DFND 3 86 0 0
Snowflake Inc COM 833445109 215,628 941,074 SH   DFND 1 941,074 0 0
Snowflake Inc COM 833445109 392,689 1,713,827 SH   DFND 2 1,637,671 0 76,156
Snowflake Inc COM 833445109 38,259 166,975 SH   DFND 3 114,760 0 52,215
Snowflake Inc COM 833445109 377,244 1,646,417 SH   SOLE 0 1,448,370 0 198,047
Sohu.com COM 83410S108 3,366 200,140 SH   DFND 3 0 0 200,140
Solaredge Technologies Inc COM 83417M104 436 1,353 SH   DFND 1 1,353 0 0
Solaredge Technologies Inc COM 83417M104 54 167 SH   DFND 3 167 0 0
Sorrento Therapeutics COM 83587F202 10 4,314 SH   DFND 3 4,314 0 0
Spire Global Inc COM CL A 848560108 1,819 866,045 SH   SOLE 0 866,045 0 0
Splunk Inc COM 848637104 11,077 74,540 SH   DFND 1 74,540 0 0
Splunk Inc COM 848637104 19,560 131,619 SH   DFND 2 37,456 0 94,163
Splunk Inc COM 848637104 8,571 57,674 SH   DFND 3 57,674 0 0
Splunk Inc COM 848637104 10,980 73,884 SH   SOLE 0 73,884 0 0
Spotify Technology SA SHS L8681T102 188,721 1,249,642 SH   DFND 1 1,249,642 0 0
Spotify Technology SA SHS L8681T102 2,768,883 18,334,543 SH   DFND 2 13,706,520 0 4,628,023
Spotify Technology SA SHS L8681T102 79,450 526,088 SH   DFND 3 418,928 0 107,160
Spotify Technology SA SHS L8681T102 470,926 3,118,301 SH   SOLE 0 2,529,651 0 588,650
Sprout Social COM 85209W109 25,725 321,078 SH   DFND 1 321,078 0 0
Sprout Social COM 85209W109 13,759 171,732 SH   DFND 2 49,604 0 122,128
Sprout Social COM 85209W109 7,698 96,076 SH   DFND 3 96,076 0 0
Sprout Social COM 85209W109 19,699 245,870 SH   SOLE 0 245,870 0 0
Staar Surgical COM PAR $0.01 852312305 118,533 1,483,337 SH   DFND 1 1,483,337 0 0
Staar Surgical COM PAR $0.01 852312305 138,204 1,729,492 SH   DFND 2 1,191,718 0 537,774
Staar Surgical COM PAR $0.01 852312305 44,271 554,006 SH   DFND 3 433,785 0 120,221
Staar Surgical COM PAR $0.01 852312305 118,254 1,479,839 SH   SOLE 0 1,139,744 0 340,095
Starbucks Corp COM 855244109 16,697 183,549 SH   DFND 1 183,549 0 0
Starbucks Corp COM 855244109 227 2,499 SH   DFND 2 0 0 2,499
Starbucks Corp COM 855244109 3,076 33,810 SH   DFND 3 33,810 0 0
Starbucks Corp COM 855244109 12,600 138,502 SH   SOLE 0 138,502 0 0
Stitch Fix COM CL A 860897107 27 2,668 SH   DFND 2 2,668 0 0
Stitch Fix COM CL A 860897107 325 32,301 SH   DFND 3 32,301 0 0
StoneCo COM CL A G85158106 1,877 160,397 SH   DFND 1 160,397 0 0
StoneCo COM CL A G85158106 15,509 1,325,566 SH   DFND 2 761,765 0 563,801
StoneCo COM CL A G85158106 107 9,131 SH   DFND 3 9,131 0 0
Stratasys SHS M85548101 5,746 226,300 SH   DFND 1 226,300 0 0
Stratasys SHS M85548101 8,637 340,181 SH   DFND 2 93,131 0 247,050
Stratasys SHS M85548101 4,176 164,468 SH   DFND 3 164,468 0 0
Stratasys SHS M85548101 3,671 144,600 SH   SOLE 0 144,600 0 0
Stryker COM 863667101 14 54 SH   DFND 3 54 0 0
Summit Therapeutics New Listing COM 86627T108 526 214,617 SH   DFND 1 214,617 0 0
Summit Therapeutics New Listing COM 86627T108 544 221,895 SH   SOLE 0 221,895 0 0
Sumo Logic COM 86646P103 8 726 SH   DFND 3 726 0 0
Sunpower Corp COM 867652406 25 1,171 SH   DFND 3 1,171 0 0
Sutro Biopharma COM 869367102 8,569 1,042,428 SH   DFND 1 1,042,428 0 0
Sutro Biopharma COM 869367102 48 5,815 SH   DFND 2 5,815 0 0
Sutro Biopharma COM 869367102 572 69,532 SH   DFND 3 69,532 0 0
Sutro Biopharma COM 869367102 6,171 750,726 SH   SOLE 0 750,726 0 0
T. Rowe Price COM 74144T108 18,473 122,185 SH   DFND 1 122,185 0 0
T. Rowe Price COM 74144T108 267 1,765 SH   DFND 2 0 0 1,765
T. Rowe Price COM 74144T108 3,090 20,438 SH   DFND 3 20,438 0 0
T. Rowe Price COM 74144T108 13,619 90,076 SH   SOLE 0 90,076 0 0
TJX Companies COM 872540109 6,508 107,431 SH   DFND 2 107,431 0 0
TSMC ADR SPONSORED ADR 874039100 727,616 6,978,858 SH   DFND 2 5,315,129 0 1,663,729
TSMC ADR SPONSORED ADR 874039100 1,678 16,093 SH   DFND 3 16,093 0 0
TSMC ADR SPONSORED ADR 874039100 94,524 906,617 SH   SOLE 0 734,543 0 172,074
Tabula Rasa HealthCare Inc COM 873379101 3,232 561,175 SH   DFND 1 561,175 0 0
Tabula Rasa HealthCare Inc COM 873379101 14 2,492 SH   DFND 2 2,492 0 0
Tabula Rasa HealthCare Inc COM 873379101 170 29,449 SH   DFND 3 29,449 0 0
Tabula Rasa HealthCare Inc COM 873379101 1,374 238,574 SH   SOLE 0 238,574 0 0
Tandem Diabetes Care COM NEW 875372203 20,210 173,792 SH   DFND 1 173,792 0 0
Tandem Diabetes Care COM NEW 875372203 103 882 SH   DFND 2 882 0 0
Tandem Diabetes Care COM NEW 875372203 1,250 10,750 SH   DFND 3 10,750 0 0
Tandem Diabetes Care COM NEW 875372203 17,255 148,377 SH   SOLE 0 148,377 0 0
Target Corp COM 87612E106 22 105 SH   DFND 3 105 0 0
Tata Motors Ltd ADR COM 876568502 68,329 2,444,687 SH   DFND 1 2,444,687 0 0
Tata Motors Ltd ADR COM 876568502 30,872 1,104,545 SH   DFND 2 1,104,545 0 0
Tata Motors Ltd ADR COM 876568502 901 32,237 SH   DFND 3 32,237 0 0
Tata Motors Ltd ADR COM 876568502 15,772 564,300 SH   SOLE 0 564,300 0 0
Teladoc COM 87918A105 233,155 3,232,425 SH   DFND 1 3,232,425 0 0
Teladoc COM 87918A105 293,595 4,070,354 SH   DFND 2 3,448,302 0 622,052
Teladoc COM 87918A105 118,312 1,640,256 SH   DFND 3 1,335,011 0 305,245
Teladoc COM 87918A105 128,757 1,785,064 SH   SOLE 0 1,367,288 0 417,776
Telus Corp COM 87971M103 10 397 SH   DFND 3 397 0 0
Tenable Holdings COM 88025T102 18 315 SH   DFND 3 315 0 0
Tencent Music Entertainment ADR SPONSORED ADS 88034P109 21,179 4,348,812 SH   DFND 1 4,348,812 0 0
Tencent Music Entertainment ADR SPONSORED ADS 88034P109 180,482 37,059,992 SH   DFND 2 27,196,899 0 9,863,093
Tencent Music Entertainment ADR SPONSORED ADS 88034P109 8,269 1,698,049 SH   DFND 3 1,047,600 0 650,449
Tencent Music Entertainment ADR SPONSORED ADS 88034P109 34,011 6,983,725 SH   SOLE 0 4,401,477 0 2,582,248
Teradyne COM 880770102 95,618 808,749 SH   DFND 1 808,749 0 0
Teradyne COM 880770102 293,460 2,482,113 SH   DFND 2 2,243,495 0 238,618
Teradyne COM 880770102 57,864 489,423 SH   DFND 3 288,723 0 200,700
Teradyne COM 880770102 252,522 2,135,853 SH   SOLE 0 1,363,672 0 772,181
Tesla Inc COM 88160R101 1,332,914 1,236,928 SH   DFND 1 1,236,928 0 0
Tesla Inc COM 88160R101 5,917,058 5,490,960 SH   DFND 2 3,850,075 0 1,640,885
Tesla Inc COM 88160R101 669,206 621,015 SH   DFND 3 503,208 0 117,807
Tesla Inc COM 88160R101 2,654,506 2,463,350 SH   SOLE 0 2,025,601 0 437,749
Texas Roadhouse Inc COM 882681109 11 131 SH   DFND 3 131 0 0
The Trade Desk COM CL A 88339J105 783,132 11,308,762 SH   DFND 1 11,308,762 0 0
The Trade Desk COM CL A 88339J105 1,956,771 28,256,615 SH   DFND 2 19,973,917 0 8,282,698
The Trade Desk COM CL A 88339J105 211,305 3,051,339 SH   DFND 3 2,367,551 0 683,788
The Trade Desk COM CL A 88339J105 631,290 9,116,098 SH   SOLE 0 5,860,443 0 3,255,655
Thermo Fisher Scientific COM 883556102 107,771 182,462 SH   DFND 1 182,462 0 0
Thermo Fisher Scientific COM 883556102 352,133 596,179 SH   DFND 2 543,531 0 52,648
Thermo Fisher Scientific COM 883556102 64,599 109,369 SH   DFND 3 63,514 0 45,855
Thermo Fisher Scientific COM 883556102 290,192 491,310 SH   SOLE 0 320,914 0 170,396
Thor Industries Inc COM 885160101 10 133 SH   DFND 3 133 0 0
Toro Co COM 891092108 21 245 SH   DFND 3 245 0 0
Tractor Supply Co COM 892356106 32 136 SH   DFND 3 136 0 0
TransMedics Group COM 89377M109 72 2,677 SH   DFND 2 2,677 0 0
TransMedics Group COM 89377M109 876 32,502 SH   DFND 3 32,502 0 0
Trip.com Group Sponsored ADR AMERICAN DEP SHS 89677Q107 76,540 3,310,561 SH   DFND 2 2,453,378 0 857,183
Trupanion COM 898202106 17,610 197,600 SH   DFND 1 197,600 0 0
Trupanion COM 898202106 29,177 327,385 SH   DFND 2 93,264 0 234,121
Trupanion COM 898202106 14,127 158,513 SH   DFND 3 158,513 0 0
Trupanion COM 898202106 33,967 381,138 SH   SOLE 0 381,138 0 0
TuSimple Hdgs CL A 90089L108 4 349 SH   DFND 3 349 0 0
Twilio Inc CL A 90138F102 275,360 1,670,775 SH   DFND 1 1,670,775 0 0
Twilio Inc CL A 90138F102 493,903 2,996,801 SH   DFND 2 2,842,267 0 154,534
Twilio Inc CL A 90138F102 52,511 318,616 SH   DFND 3 220,720 0 97,896
Twilio Inc CL A 90138F102 198,253 1,202,918 SH   SOLE 0 868,480 0 334,438
Ultragenyx COM 90400D108 8 115 SH   DFND 3 115 0 0
United Parcel Service CL B 911312106 70,733 329,817 SH   DFND 1 329,817 0 0
United Parcel Service CL B 911312106 1,001 4,666 SH   DFND 2 0 0 4,666
United Parcel Service CL B 911312106 10,992 51,256 SH   DFND 3 51,256 0 0
United Parcel Service CL B 911312106 50,749 236,637 SH   SOLE 0 236,637 0 0
UnitedHealth COM 91324P102 34 67 SH   DFND 3 67 0 0
Unity Biotechnology Inc COM 91381U101 278 248,000 SH   DFND 1 248,000 0 0
Unity Biotechnology Inc COM 91381U101 382 341,111 SH   SOLE 0 341,111 0 0
Upwork Inc COM 91688F104 59,576 2,563,524 SH   DFND 1 2,563,524 0 0
Upwork Inc COM 91688F104 38,085 1,638,750 SH   DFND 2 513,571 0 1,125,179
Upwork Inc COM 91688F104 20,922 900,271 SH   DFND 3 820,107 0 80,164
Upwork Inc COM 91688F104 30,933 1,331,003 SH   SOLE 0 1,331,003 0 0
Uxin ADR ADS 91818X108 753 738,636 SH   DFND 1 738,636 0 0
Uxin ADR ADS 91818X108 351 344,229 SH   SOLE 0 344,229 0 0
Vale SA ADR ADR 91912E105 31,525 1,577,061 SH   DFND 1 1,577,061 0 0
Vale SA ADR ADR 91912E105 181,015 9,055,283 SH   DFND 2 6,623,038 0 2,432,245
Vale SA ADR ADR 91912E105 1,568 78,455 SH   DFND 3 78,455 0 0
Varonis Systems Inc COM 922280102 81 1,708 SH   DFND 2 1,708 0 0
Varonis Systems Inc COM 922280102 996 20,943 SH   DFND 3 20,943 0 0
Veeco Instruments COM 922417100 8,082 297,254 SH   DFND 1 297,254 0 0
Veeco Instruments COM 922417100 13,292 488,864 SH   DFND 2 143,284 0 345,580
Veeco Instruments COM 922417100 6,671 245,365 SH   DFND 3 245,365 0 0
Veeva Systems Inc Class A COM 922475108 1,640 7,718 SH   DFND 1 7,718 0 0
Veeva Systems Inc Class A COM 922475108 3,248 15,287 SH   DFND 2 15,287 0 0
Veeva Systems Inc Class A COM 922475108 4,600 21,650 SH   DFND 3 21,650 0 0
Veoneer Inc COM 92336X109 26 700 SH   DFND 3 700 0 0
Verint Systems Inc COM 92343X100 20 395 SH   DFND 3 395 0 0
Verisk Analytics COM 92345Y106 10,838 50,495 SH   DFND 2 50,495 0 0
Veritone COM 92347M100 12 649 SH   DFND 3 649 0 0
ViewRay COM 92672L107 4 911 SH   DFND 3 911 0 0
Vimeo Inc. COM 92719V100 11,818 994,740 SH   DFND 1 994,740 0 0
Vimeo Inc. COM 92719V100 36,078 3,036,844 SH   DFND 2 2,741,901 0 294,943
Vimeo Inc. COM 92719V100 7,171 603,633 SH   DFND 3 352,620 0 251,013
Vimeo Inc. COM 92719V100 31,672 2,665,979 SH   SOLE 0 1,712,458 0 953,521
Vir Biotechnology Inc COM 92764N102 827 32,165 SH   DFND 1 32,165 0 0
Vir Biotechnology Inc COM 92764N102 1,630 63,371 SH   DFND 2 63,371 0 0
Vir Biotechnology Inc COM 92764N102 2,430 94,468 SH   DFND 3 94,468 0 0
Vir Biotechnology Inc COM 92764N102 96,634 3,757,156 SH   SOLE 0 3,757,156 0 0
Visa Inc-Class A Shares COM CL A 92826C839 11,618 52,389 SH   DFND 2 52,389 0 0
Visa Inc-Class A Shares COM CL A 92826C839 24 110 SH   DFND 3 110 0 0
Visteon Corp COM 92839U206 25 230 SH   DFND 3 230 0 0
Vuzix COM 92921W300 6 924 SH   DFND 3 924 0 0
Vyne Therapeutics Inc COM 92941V209 32 48,706 SH   DFND 1 48,706 0 0
Vyne Therapeutics Inc COM 92941V209 33 50,056 SH   SOLE 0 50,056 0 0
WD-40 Co COM 929236107 11 58 SH   DFND 3 58 0 0
WEC Energy Group COM 92939U106 1,896 18,996 SH   DFND 1 18,996 0 0
Wal-Mart Stores COM 931142103 15 101 SH   DFND 3 101 0 0
Warby Parker Inc CL A COM 93403J106 5,787 171,156 SH   DFND 1 171,156 0 0
Warby Parker Inc CL A COM 93403J106 18,441 545,421 SH   DFND 2 215,881 0 329,540
Warby Parker Inc CL A COM 93403J106 2,498 73,869 SH   DFND 3 50,200 0 23,669
Warby Parker Inc CL A COM 93403J106 185,033 5,472,724 SH   SOLE 0 5,472,724 0 0
Waters COM 941848103 8,071 26,003 SH   DFND 1 26,003 0 0
Waters COM 941848103 10,843 34,934 SH   DFND 2 27,723 0 7,211
Waters COM 941848103 3,526 11,359 SH   DFND 3 7,820 0 3,539
Waters COM 941848103 340 1,094 SH   SOLE 0 1,094 0 0
Watsco Inc COM 942622200 240,667 790,003 SH   DFND 1 790,003 0 0
Watsco Inc COM 942622200 297,151 975,416 SH   DFND 2 947,179 0 28,237
Watsco Inc COM 942622200 23,700 77,796 SH   DFND 3 71,840 0 5,956
Watsco Inc COM 942622200 68,921 226,238 SH   SOLE 0 226,238 0 0
Wayfair Inc Class A CL A 94419L101 261,386 2,359,503 SH   DFND 1 2,359,503 0 0
Wayfair Inc Class A CL A 94419L101 422,993 3,818,313 SH   DFND 2 3,576,503 0 241,810
Wayfair Inc Class A CL A 94419L101 42,548 384,075 SH   DFND 3 296,203 0 87,872
Wayfair Inc Class A CL A 94419L101 292,870 2,643,706 SH   SOLE 0 2,351,160 0 292,546
Wheaton Precious Metals COM 962879102 971 20,416 SH   DFND 1 20,416 0 0
Williams-Sonoma Inc COM 969904101 9 63 SH   DFND 3 63 0 0
Wix Com SHS M98068105 395,332 3,784,531 SH   DFND 2 2,427,066 0 1,357,465
Wix Com SHS M98068105 41 395 SH   DFND 3 395 0 0
Workday Inc CL A 98138H101 320,814 1,339,741 SH   DFND 1 1,339,741 0 0
Workday Inc CL A 98138H101 1,139,316 4,757,856 SH   DFND 2 2,454,733 0 2,303,123
Workday Inc CL A 98138H101 122,805 512,840 SH   DFND 3 429,835 0 83,005
Workday Inc CL A 98138H101 273,298 1,141,310 SH   SOLE 0 628,968 0 512,342
XP CL A G98239109 2,058 68,387 SH   DFND 1 68,387 0 0
XP CL A G98239109 4,944 164,256 SH   DFND 2 12,129 0 152,127
XP CL A G98239109 6,284 208,760 SH   DFND 3 22,286 0 186,474
XP CL A G98239109 268 8,893 SH   DFND 4 8,893 0 0
XPEL COM 98379L100 16 295 SH   DFND 3 295 0 0
Xencor Inc COM 98401F105 65 2,434 SH   DFND 2 2,434 0 0
Xencor Inc COM 98401F105 790 29,603 SH   DFND 3 29,603 0 0
Xperi Holding Corp COM 98390M103 27 1,549 SH   DFND 3 1,549 0 0
Xylem COM 98419M100 87,636 1,027,868 SH   DFND 1 1,027,868 0 0
Xylem COM 98419M100 39,379 461,869 SH   DFND 2 278,043 0 183,826
Xylem COM 98419M100 89,243 1,046,711 SH   DFND 3 839,013 0 207,698
Xylem COM 98419M100 7,901 92,673 SH   SOLE 0 92,673 0 0
Yatsen Holding Ltd ADR COM 985194109 551 802,289 SH   DFND 1 802,289 0 0
Yatsen Holding Ltd ADR COM 985194109 5,107 7,439,172 SH   DFND 2 6,943,609 0 495,563
Yatsen Holding Ltd ADR COM 985194109 0 626 SH   DFND 3 626 0 0
Yelp COM 985817105 9 262 SH   DFND 3 262 0 0
Zai Lab ADR ADR 98887Q104 32,822 746,286 SH   DFND 1 746,286 0 0
Zai Lab ADR ADR 98887Q104 67,772 1,540,982 SH   DFND 2 622,878 0 918,104
Zai Lab ADR ADR 98887Q104 14,931 339,500 SH   DFND 3 27,927 0 311,573
Zai Lab ADR ADR 98887Q104 289 6,577 SH   DFND 4 6,577 0 0
Zai Lab ADR ADR 98887Q104 4,128 93,865 SH   SOLE 0 93,865 0 0
Ziff Davis Inc COM 48123V102 5 53 SH   DFND 3 53 0 0
Zillow Group Inc Class A CL A 98954M101 1,495 30,990 SH   DFND 1 30,990 0 0
Zillow Group Inc Class A CL A 98954M101 7,545 156,432 SH   DFND 2 44,835 0 111,597
Zillow Group Inc Class A CL A 98954M101 3,333 69,099 SH   DFND 3 69,099 0 0
Zillow Group Inc Class A CL A 98954M101 4,381 90,840 SH   SOLE 0 90,840 0 0
Zillow Group Inc Class C CL C CAP STK 98954M200 49,706 1,008,449 SH   DFND 1 1,008,449 0 0
Zillow Group Inc Class C CL C CAP STK 98954M200 33,543 680,533 SH   DFND 2 192,451 0 488,082
Zillow Group Inc Class C CL C CAP STK 98954M200 14,559 295,366 SH   DFND 3 295,366 0 0
Zillow Group Inc Class C CL C CAP STK 98954M200 28,764 583,573 SH   SOLE 0 583,573 0 0
Zoom Video Communications Inc CL A 98980L101 171,625 1,464,005 SH   DFND 1 1,464,005 0 0
Zoom Video Communications Inc CL A 98980L101 471,338 4,020,630 SH   DFND 2 2,433,870 0 1,586,760
Zoom Video Communications Inc CL A 98980L101 46,275 394,736 SH   DFND 3 337,761 0 56,975
Zoom Video Communications Inc CL A 98980L101 225,546 1,923,965 SH   SOLE 0 1,573,109 0 350,856
Zuora Inc Class A COM CL A 98983V106 30,113 2,010,224 SH   DFND 1 2,010,224 0 0
Zuora Inc Class A COM CL A 98983V106 16,346 1,091,187 SH   DFND 2 314,101 0 777,086
Zuora Inc Class A COM CL A 98983V106 8,515 568,414 SH   DFND 3 568,414 0 0
Zuora Inc Class A COM CL A 98983V106 11,706 781,436 SH   SOLE 0 781,436 0 0
Zymergen Inc COM 98985X100 8,155 2,821,956 SH   SOLE 0 2,821,956 0 0
Zynex COM 98986M103 3 481 SH   DFND 3 481 0 0
Zynga Inc COM 98986T108 30 3,223 SH   DFND 3 3,223 0 0
dLocal CL A G29018101 7,698 246,272 SH   DFND 3 0 0 246,272
dLocal CL A G29018101 4 142 SH   DFND 2 142 0 0
dLocal CL A G29018101 17,310 553,728 SH   DFND 1 553,728 0 0
iRobot COM 462726100 8,349 131,693 SH   SOLE 0 131,693 0 0
iRobot COM 462726100 8,564 135,084 SH   DFND 3 124,296 0 10,788
iRobot COM 462726100 15,128 238,615 SH   DFND 2 74,366 0 164,249
iRobot COM 462726100 13,559 213,872 SH   DFND 1 213,872 0 0
iShares Physical Silver ETC (c) COM 46428Q109 3,023 126,100 SH   DFND 3 126,100 0 0
iShares Physical Silver ETC (c) COM 46428Q109 18,190 758,716 SH   DFND 1 758,716 0 0
nLIGHT COM 65487K100 8 468 SH   DFND 3 468 0 0