The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
1LIFE HEALTHCARE INC COM 68269G107 9,265 836,190 SH   DFND 2 836,190 0 0
10X GENOMICS INC CL A COM 88025U109 19,235 252,859 SH   DFND 2 252,859 0 0
ABBOTT LABS COM 002824100 192,090 1,622,927 SH   DFND 2 1,622,927 0 0
ABBVIE INC COM 00287Y109 50,497 311,500 SH   DFND 2 311,500 0 0
ABIOMED INC COM 003654100 49,745 150,178 SH   DFND 2 150,178 0 0
ACCOLADE INC COM 00437E102 12,090 688,479 SH   DFND 2 688,479 0 0
ACCOLADE INC COM 00437E102 47,290 2,693,028 SH   DFND 3 2,693,028 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 43,657 3,145,293 SH   DFND 3 3,145,293 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 1,077 37,000 SH   DFND 2 37,000 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 119,127 4,092,292 SH   DFND 1,2 4,092,292 0 0
ALIGN TECHNOLOGY INC COM 016255101 61,629 141,351 SH   DFND 2 141,351 0 0
ALKERMES PLC SHS G01767105 1,973 75,000 SH   DFND 2 75,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 8,189 50,150 SH   DFND 2 50,150 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 171,455 1,050,000 SH   DFND 1,2 1,050,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 21,132 129,413 SH   DFND 3 129,413 0 0
ALPHABET INC CAP STK CL C 02079K107 377 135 SH   DFND 2 135 0 0
AMEDISYS INC COM 023436108 13,381 77,668 SH   DFND 2 77,668 0 0
AMEDISYS INC COM 023436108 85,880 498,463 SH   DFND 3 498,463 0 0
AMERICAN WELL CORP CL A 03044L105 7,450 1,769,703 SH   DFND 2 1,769,703 0 0
AMERISOURCEBERGEN CORP COM 03073E105 2,011 13,000 SH   DFND 2 13,000 0 0
AMGEN INC COM 031162100 13,010 53,800 SH   DFND 2 53,800 0 0
ANTHEM INC COM 036752103 128,970 262,550 SH   DFND 2 262,550 0 0
ANTHEM INC COM 036752103 73,235 149,087 SH   DFND 3 149,087 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 2,398 47,200 SH   DFND 2 47,200 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 53,427 1,051,512 SH   DFND 3 1,051,512 0 0
ARCTURUS THERAPEUTICS HLDGS COM 03969T109 1,103 40,900 SH   DFND 2 40,900 0 0
ARCUS BIOSCIENCES INC COM 03969F109 3,525 111,700 SH   DFND 2 111,700 0 0
ARGENX SE SPONSORED ADR 04016X101 10,311 32,700 SH   DFND 2 32,700 0 0
ARGENX SE SPONSORED ADR 04016X101 290,255 920,538 SH   DFND 1,2 920,538 0 0
ARVINAS INC COM 04335A105 4,869 72,350 SH   DFND 2 72,350 0 0
ARVINAS INC COM 04335A105 141,795 2,106,903 SH   DFND 1,2 2,106,903 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 5,944 89,600 SH   DFND 2 89,600 0 0
ATRICURE INC COM 04963C209 39,310 598,605 SH   DFND 3 598,605 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 29,784 2,405,825 SH   DFND 3 2,405,825 0 0
AVALARA INC COM 05338G106 129 1,300 SH   DFND 2 1,300 0 0
AVANTOR INC COM 05352A100 17,323 512,216 SH   DFND 2 512,216 0 0
AXONICS INC COM 05465P101 64,309 1,027,299 SH   DFND 2 1,027,299 0 0
AXONICS INC COM 05465P101 63,971 1,021,906 SH   DFND 3 1,021,906 0 0
AXSOME THERAPEUTICS INC COM 05464T104 29,779 719,482 SH   DFND 3 719,482 0 0
BAXTER INTL INC COM 071813109 37,985 489,880 SH   DFND 2 489,880 0 0
BEAM THERAPEUTICS INC COM 07373V105 344 6,000 SH   DFND 2 6,000 0 0
BEAM THERAPEUTICS INC COM 07373V105 33,052 576,821 SH   DFND 1,2 576,821 0 0
BECTON DICKINSON & CO COM 075887109 105,444 396,405 SH   DFND 2 396,405 0 0
BERKELEY LTS INC COM 084310101 2,737 385,014 SH   DFND 2 385,014 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108 1,602 36,500 SH   DFND 2 36,500 0 0
BILIBILI INC SPONS ADS REP Z 090040106 19 744 SH   DFND 2 744 0 0
BIOGEN INC COM 09062X103 4,707 22,350 SH   DFND 2 22,350 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 4,649 39,207 SH   DFND 2 39,207 0 0
BIONTECH SE SPONSORED ADS 09075V102 19,063 111,766 SH   DFND 2 111,766 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 5,752 74,600 SH   DFND 2 74,600 0 0
BIO RAD LABS INC CL A 090572207 40,558 72,009 SH   DFND 3 72,009 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 64 23,000 SH   DFND 2 23,000 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 9,058 3,270,000 SH   DFND 1,2 3,270,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 1,661 26,000 SH   DFND 2 26,000 0 0
BOSTON SCIENTIFIC CORP COM 101137107 173,349 3,913,947 SH   DFND 2 3,913,947 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 2,447 33,500 SH   DFND 2 33,500 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 43,426 594,628 SH   DFND 3 594,628 0 0
BURNING ROCK BIOTECH LTD SPONSORED ADS 12233L107 4,077 438,869 SH   DFND 2 438,869 0 0
C4 THERAPEUTICS INC COM STK 12529R107 1,322 54,500 SH   DFND 2 54,500 0 0
CAREDX INC COM 14167L103 85,490 2,311,176 SH   DFND 3 2,311,176 0 0
CASTLE BIOSCIENCES INC COM 14843C105 27,258 607,614 SH   DFND 3 607,614 0 0
CENTENE CORP DEL COM 15135B101 55,619 660,635 SH   DFND 2 660,635 0 0
CHARLES RIV LABS INTL INC COM 159864107 35,896 126,406 SH   DFND 3 126,406 0 0
CIGNA CORP NEW COM 125523100 62,094 259,146 SH   DFND 2 259,146 0 0
COOPER COS INC COM NEW 216648402 34,750 83,216 SH   DFND 2 83,216 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 1,557 24,800 SH   DFND 2 24,800 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 56,625 902,105 SH   DFND 1,2 902,105 0 0
CVS HEALTH CORP COM 126650100 23,517 232,355 SH   DFND 2 232,355 0 0
CYTOKINETICS INC COM NEW 23282W605 2,540 69,000 SH   DFND 2 69,000 0 0
DANAHER CORPORATION COM 235851102 104,737 357,062 SH   DFND 2 357,062 0 0
DENTSPLY SIRONA INC COM 24906P109 7,832 159,129 SH   DFND 2 159,129 0 0
DEXCOM INC COM 252131107 120,175 234,900 SH   DFND 2 234,900 0 0
DOLBY LABORATORIES INC COM CL A 25659T107 125 1,600 SH   DFND 2 1,600 0 0
DOXIMITY INC CL A 26622P107 4,316 82,860 SH   DFND 2 82,860 0 0
DR REDDYS LABS LTD ADR 256135203 474 8,500 SH   DFND 2 8,500 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 107,453 912,785 SH   DFND 2 912,785 0 0
EQUINIX INC COM 29444U700 30 40 SH   DFND 2 40 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 191 41,200 SH   DFND 2 41,200 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 19,757 4,257,964 SH   DFND 1,2 4,257,964 0 0
ESSA PHARMA INC COM NEW 29668H708 117 19,000 SH   DFND 2 19,000 0 0
ESSA PHARMA INC COM NEW 29668H708 30,998 5,015,814 SH   DFND 1,2 5,015,814 0 0
EVERTEC INC COM 30040P103 30 739 SH   DFND 2 739 0 0
EVOLENT HEALTH INC CL A 30050B101 26,696 826,495 SH   DFND 2 826,495 0 0
EVOLENT HEALTH INC CL A 30050B101 57,680 1,785,768 SH   DFND 3 1,785,768 0 0
EXACT SCIENCES CORP COM 30063P105 50,294 719,303 SH   DFND 3 719,303 0 0
EXELIXIS INC COM 30161Q104 544 24,000 SH   DFND 2 24,000 0 0
EXELIXIS INC COM 30161Q104 61,096 2,695,000 SH   DFND 1,2 2,695,000 0 0
FATE THERAPEUTICS INC COM 31189P102 2,526 65,150 SH   DFND 2 65,150 0 0
FATE THERAPEUTICS INC COM 31189P102 136,134 3,511,336 SH   DFND 1,2 3,511,336 0 0
GENERATION BIO CO COM 37148K100 139 19,000 SH   DFND 2 19,000 0 0
GENERATION BIO CO COM 37148K100 26,888 3,663,180 SH   DFND 1,2 3,663,180 0 0
GENETRON HLDGS LTD ADS 37186H100 1,173 535,822 SH   DFND 2 535,822 0 0
GILEAD SCIENCES INC COM 375558103 4,961 83,450 SH   DFND 2 83,450 0 0
GLOBUS MED INC CL A 379577208 54,985 745,254 SH   DFND 2 745,254 0 0
GRUPO AEROPORTUARIO DEL SURE SPON ADR SER B 40051E202 30 135 SH   DFND 2 135 0 0
GUARDANT HEALTH INC COM 40131M109 13,891 209,712 SH   DFND 2 209,712 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 40,845 1,024,200 SH   DFND 2 1,024,200 0 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104 6,079 124,961 SH   DFND 2 124,961 0 0
HCA HEALTHCARE INC COM 40412C101 75,235 300,197 SH   DFND 2 300,197 0 0
HEALTH CATALYST INC COM 42225T107 11,095 424,611 SH   DFND 2 424,611 0 0
HOLOGIC INC COM 436440101 21,186 275,783 SH   DFND 2 275,783 0 0
HOMOLOGY MEDICINES INC COM 438083107 5,007 1,647,122 SH   DFND 1,2 1,647,122 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 36,308 345,100 SH   DFND 2 345,100 0 0
HUMANA INC COM 444859102 64,162 147,442 SH   DFND 2 147,442 0 0
HUTCHMED CHINA LTD SPONSORED ADS 44842L103 33,123 1,750,690 SH   DFND 3 1,750,690 0 0
IDEAYA BIOSCIENCES INC COM 45166A102 517 46,200 SH   DFND 2 46,200 0 0
IDEXX LABS INC COM 45168D104 64,449 117,810 SH   DFND 2 117,810 0 0
ILLUMINA INC COM 452327109 27,561 78,881 SH   DFND 2 78,881 0 0
INCYTE CORP COM 45337C102 7,259 91,400 SH   DFND 2 91,400 0 0
INCYTE CORP COM 45337C102 218,882 2,756,000 SH   DFND 1,2 2,756,000 0 0
INFOSYS LTD SPONSORED ADR 456788108 28 1,130 SH   DFND 2 1,130 0 0
INHIBRX INC COM 45720L107 1,107 49,700 SH   DFND 2 49,700 0 0
INSMED INC COM PAR $.01 457669307 83,467 3,551,776 SH   DFND 3 3,551,776 0 0
INSPIRE MED SYS INC COM 457730109 102,036 397,506 SH   DFND 2 397,506 0 0
INSULET CORP COM 45784P101 106,074 398,189 SH   DFND 2 398,189 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 1,184 16,294 SH   DFND 2 16,294 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101 4,357 71,200 SH   DFND 2 71,200 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101 205,502 3,358,419 SH   DFND 1,2 3,358,419 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 187,062 620,068 SH   DFND 2 620,068 0 0
IONIS PHARMACEUTICALS INC COM 462222100 6,856 185,100 SH   DFND 2 185,100 0 0
IONIS PHARMACEUTICALS INC COM 462222100 360,509 9,732,973 SH   DFND 1,2 9,732,973 0 0
IPG PHOTONICS CORP COM 44980X109 115 1,050 SH   DFND 2 1,050 0 0
IQVIA HLDGS INC COM 46266C105 36,790 159,120 SH   DFND 2 159,120 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 3,755 24,122 SH   DFND 2 24,122 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 113,773 730,859 SH   DFND 3 730,859 0 0
JOHNSON & JOHNSON COM 478160104 4,909 27,700 SH   DFND 2 27,700 0 0
JUMIA TECHNOLOGIES AG SPONSORED ADS 48138M105 172 18,000 SH   DFND 2 18,000 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 77,585 4,668,148 SH   DFND 1,2 4,668,148 0 0
KOSMOS ENERGY LTD COM 500688106 2,962 412,000 SH   DFND 2 412,000 0 0
KRYSTAL BIOTECH INC COM 501147102 918 13,800 SH   DFND 2 13,800 0 0
KURA ONCOLOGY INC COM 50127T109 1,061 65,980 SH   DFND 2 65,980 0 0
KYMERA THERAPEUTICS INC COM 501575104 2,218 52,400 SH   DFND 2 52,400 0 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409 1,121 4,250 SH   DFND 2 4,250 0 0
LAUDER ESTEE COS INC CL A 518439104 367 1,348 SH   DFND 2 1,348 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102 23,987 660,069 SH   DFND 2 660,069 0 0
MACROGENICS INC COM 556099109 440 49,950 SH   DFND 2 49,950 0 0
MACROGENICS INC COM 556099109 64,098 7,275,564 SH   DFND 1,2 7,275,564 0 0
MARKETAXESS HLDGS INC COM 57060D108 225 662 SH   DFND 2 662 0 0
MCKESSON CORP COM 58155Q103 696 2,274 SH   DFND 2 2,274 0 0
MEDTRONIC PLC SHS G5960L103 72,787 656,030 SH   DFND 2 656,030 0 0
MERCADOLIBRE INC COM 58733R102 202 170 SH   DFND 2 170 0 0
MERSANA THERAPEUTICS INC COM 59045L106 116 29,000 SH   DFND 2 29,000 0 0
MERSANA THERAPEUTICS INC COM 59045L106 15,661 3,925,000 SH   DFND 1,2 3,925,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 1,217 14,800 SH   DFND 2 14,800 0 0
MODERNA INC COM 60770K107 9,647 56,000 SH   DFND 2 56,000 0 0
MODERNA INC COM 60770K107 272,748 1,583,349 SH   DFND 1,2 1,583,349 0 0
MOLECULAR TEMPLATES INC COM 608550109 297 86,000 SH   DFND 2 86,000 0 0
MOLECULAR TEMPLATES INC COM 608550109 37,922 10,992,003 SH   DFND 1,2 10,992,003 0 0
MOLINA HEALTHCARE INC COM 60855R100 101,010 302,797 SH   DFND 2 302,797 0 0
MYOVANT SCIENCES LTD COM G637AM102 626 47,000 SH   DFND 2 47,000 0 0
MYOVANT SCIENCES LTD COM G637AM102 77,416 5,812,039 SH   DFND 1,2 5,812,039 0 0
NEKTAR THERAPEUTICS COM 640268108 155 28,800 SH   DFND 2 28,800 0 0
NEKTAR THERAPEUTICS COM 640268108 15,958 2,960,676 SH   DFND 1,2 2,960,676 0 0
NEKTAR THERAPEUTICS COM 640268108 9,804 1,818,925 SH   DFND 3 1,818,925 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 14,817 158,051 SH   DFND 2 158,051 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 268,631 2,865,400 SH   DFND 1,2 2,865,400 0 0
NEUROPACE INC COM 641288105 4,170 507,930 SH   DFND 2 507,930 0 0
NEVRO CORP COM 64157F103 17,203 237,841 SH   DFND 2 237,841 0 0
NIO INC SPON ADS 62914V106 23 1,093 SH   DFND 2 1,093 0 0
NOVOCURE LTD ORD SHS G6674U108 704 8,500 SH   DFND 2 8,500 0 0
OLINK HLDG AB SPONSORED ADS 680710100 4,155 235,273 SH   DFND 2 235,273 0 0
OMNICELL COM COM 68213N109 46,918 362,332 SH   DFND 2 362,332 0 0
OPTHEA LTD SPONSORED ADS 68386J208 313 48,000 SH   DFND 2 48,000 0 0
OPTION CARE HEALTH INC COM NEW 68404L201 92,328 3,232,787 SH   DFND 3 3,232,787 0 0
OUTSET MED INC COM 690145107 29,694 654,060 SH   DFND 2 654,060 0 0
OUTSET MED INC COM 690145107 61,885 1,363,099 SH   DFND 3 1,363,099 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108 14,133 1,553,023 SH   DFND 2 1,553,023 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108 30,291 3,328,729 SH   DFND 3 3,328,729 0 0
PACIRA BIOSCIENCES INC COM 695127100 1,613 21,136 SH   DFND 2 21,136 0 0
PENUMBRA INC COM 70975L107 43,016 193,654 SH   DFND 2 193,654 0 0
PFIZER INC COM 717081103 2,407 46,500 SH   DFND 2 46,500 0 0
PHREESIA INC COM 71944F106 15,302 580,498 SH   DFND 2 580,498 0 0
PINDUODUO INC SPONSORED ADS 722304102 19 466 SH   DFND 2 466 0 0
PRIVIA HEALTH GROUP INC COM 74276R102 14,033 525,000 SH   DFND 2 525,000 0 0
PROCEPT BIOROBOTICS CORP COM 74276L105 10,010 286,075 SH   DFND 2 286,075 0 0
PULMONX CORP COM 745848101 4,379 176,510 SH   DFND 2 176,510 0 0
QUANTERIX CORP COM 74766Q101 1,042 35,704 SH   DFND 2 35,704 0 0
RADIUS HEALTH INC COM NEW 750469207 556 63,000 SH   DFND 2 63,000 0 0
RADIUS HEALTH INC COM NEW 750469207 72,898 8,255,714 SH   DFND 1,2 8,255,714 0 0
REGENERON PHARMACEUTICALS COM 75886F107 63,053 90,280 SH   DFND 2 90,280 0 0
RELAY THERAPEUTICS INC COM 75943R102 988 33,000 SH   DFND 2 33,000 0 0
RELAY THERAPEUTICS INC COM 75943R102 116,307 3,885,962 SH   DFND 1,2 3,885,962 0 0
RELMADA THERAPEUTICS INC COM 75955J402 432 16,000 SH   DFND 2 16,000 0 0
RESMED INC COM 761152107 20,940 86,349 SH   DFND 2 86,349 0 0
REVOLUTION MEDICINES INC COM 76155X100 1,510 59,200 SH   DFND 2 59,200 0 0
REVOLUTION MEDICINES INC COM 76155X100 82,945 3,251,462 SH   DFND 1,2 3,251,462 0 0
SAGE THERAPEUTICS INC COM 78667J108 1,400 42,300 SH   DFND 2 42,300 0 0
SAGE THERAPEUTICS INC COM 78667J108 99,634 3,010,104 SH   DFND 1,2 3,010,104 0 0
SANOFI SPONSORED ADR 80105N105 2,238 43,600 SH   DFND 2 43,600 0 0
SAREPTA THERAPEUTICS INC COM 803607100 89,929 1,151,159 SH   DFND 3 1,151,159 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 249 19,300 SH   DFND 2 19,300 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 27,908 2,165,125 SH   DFND 1,2 2,165,125 0 0
SEAGEN INC COM 81181C104 7,260 50,400 SH   DFND 2 50,400 0 0
SEER INC COM CL A 81578P106 2,075 136,133 SH   DFND 2 136,133 0 0
SHOCKWAVE MED INC COM 82489T104 82,649 398,577 SH   DFND 2 398,577 0 0
SIGHT SCIENCES INC COM 82657M105 3,468 300,000 SH   DFND 2 300,000 0 0
SILENCE THERAPEUTICS PLC ADS 82686Q101 887 46,666 SH   DFND 2 46,666 0 0
SILK RD MED INC COM 82710M100 43,171 1,045,567 SH   DFND 3 1,045,567 0 0
SKYWORKS SOLUTIONS INC COM 83088M102 280 2,100 SH   DFND 2 2,100 0 0
STRYKER CORPORATION COM 863667101 117,694 440,225 SH   DFND 2 440,225 0 0
SUPERNUS PHARMACEUTICALS INC COM 868459108 1,907 59,000 SH   DFND 2 59,000 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 65 619 SH   DFND 2 619 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 64,580 555,334 SH   DFND 2 555,334 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 65,259 561,174 SH   DFND 3 561,174 0 0
TELADOC HEALTH INC COM 87918A105 26,199 363,216 SH   DFND 2 363,216 0 0
TELEFLEX INCORPORATED COM 879369106 34,672 97,714 SH   DFND 2 97,714 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 42,901 72,633 SH   DFND 2 72,633 0 0
TRANSMEDICS GROUP INC COM 89377M109 15,653 581,029 SH   DFND 2 581,029 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 1,866 25,700 SH   DFND 2 25,700 0 0
UNITED MICROELECTRONICS CORP SPON ADR NEW 910873405 25 2,698 SH   DFND 2 2,698 0 0
UNITEDHEALTH GROUP INC COM 91324P102 99,114 194,353 SH   DFND 2 194,353 0 0
UNITEDHEALTH GROUP INC COM 91324P102 56,784 111,348 SH   DFND 3 111,348 0 0
VANECK ETF TRUST GOLD MINERS ETF 92189F106 514 13,400 SH   DFND 2 13,400 0 0
VEEVA SYS INC CL A COM 922475108 34,121 160,601 SH   DFND 2 160,601 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 72,424 277,520 SH   DFND 2 277,520 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 58,127 222,733 SH   DFND 3 222,733 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 255,751 980,000 SH   DFND 1,2 980,000 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 9,126 4,562,858 SH   DFND 1,2 4,562,858 0 0
XENCOR INC COM 98401F105 1,110 41,600 SH   DFND 2 41,600 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 34,627 270,734 SH   DFND 2 270,734 0 0