The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACLARIS THERAPEUTICS INC COM 00461U105 4,747 275,333 SH   SOLE   275,333 0 0
ALIGOS THERAPEUTICS INC COM 01626L105 23 10,659 SH   SOLE   10,659 0 0
AMRYT PHARMA PLC SPONSORED ADS 03217L106 1,268 153,267 SH   SOLE   153,267 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101 386 30,000 SH   SOLE   30,000 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 5,354 105,368 SH   SOLE   105,368 0 0
APOLLO ENDOSURGERY INC COM 03767D108 6,077 1,004,399 SH   SOLE   1,004,399 0 0
APTINYX INC COM 03836N103 458 201,600 SH Put SOLE   201,600 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 1,428 25,000 SH   SOLE   25,000 0 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 1,592 500,000 SH   SOLE   500,000 0 0
ATHIRA PHARMA INC COM 04746L104 26,964 10,000 SH   SOLE   10,000 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 177 1,235,784 SH   SOLE   1,235,784 0 0
BENITEC BIOPHARMA INC COM 08205P100 57 492,880 SH   SOLE   492,880 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 197 102,425 SH   SOLE   102,425 0 0
BIOGEN INC COM 09062X103 230 10,248 SH   SOLE   10,248 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 4,359 102,497 SH   SOLE   102,497 0 0
CALITHERA BIOSCIENCES INC COM 13089P101 74 221,809 SH   SOLE   221,809 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 256 45,538 SH   SOLE   45,538 0 0
CERUS CORP COM 157085101 7,677 1,398,400 SH   SOLE   1,398,400 0 0
CODEXIS INC COM 192005106 1,670 81,000 SH   SOLE   81,000 0 0
COGENT BIOSCIENCES INC COM 19240Q201 4,297 573,699 SH   SOLE   573,699 0 0
COMPUGEN LTD ORD M25722105 865 268,596 SH   SOLE   268,596 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 2,502 114,004 SH   SOLE   114,004 0 0
CTI BIOPHARMA CORP COM 12648L601 10,508 2,250,000 SH   SOLE   2,250,000 0 0
CYCLACEL PHARMACEUTICALS INC COM 23254L603 1,411 462,659 SH   SOLE   462,659 0 0
ELIEM THERAPEUTICS INC COM 28658R106 741 88,279 SH   SOLE   88,279 0 0
ELOXX PHARMACEUTICALS INC COM 29014R103 1,092 1,950,949 SH   SOLE   1,950,949 0 0
EVOGENE LTD SHS M4119S104 384 295,746 SH   SOLE   295,746 0 0
EYEPOINT PHARMACEUTICALS INC COM NEW 30233G209 2,256 185,666 SH   SOLE   185,666 0 0
FORMA THERAPEUTICS HLDGS INC SHS 34633R104 1,625 174,768 SH   SOLE   174,768 0 0
GALAPAGOS NV SPON ADR 36315X101 2,543 41,002 SH   SOLE   41,002 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 7,096 67,442 SH   SOLE   67,442 0 0
IMMATICS N.V SHS N44445109 3,558 445,334 SH   SOLE   445,334 0 0
IMMUNIC INC COM 4525EP101 774 68,475 SH   SOLE   68,475 0 0
IMMUNOGEN INC COM 45253H101 1,428 300,000 SH Call SOLE   300,000 0 0
IMMUNOGEN INC COM 45253H101 3,070 645,000 SH   SOLE   645,000 0 0
INSMED INC COM PAR $.01 457669307 2,399 102,067 SH   SOLE   102,067 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101 18,897 308,819 SH   SOLE   308,819 0 0
ITEOS THERAPEUTICS INC COM 46565G104 4,468 138,843 SH   SOLE   138,843 0 0
IVERIC BIO INC COM 46583P102 1,592 94,600 SH Put SOLE   94,600 0 0
JOUNCE THERAPEUTICS INC COM 481116101 1,686 248,347 SH   SOLE   248,347 0 0
KRYSTAL BIOTECH INC COM 501147102 3,093 46,489 SH   SOLE   46,489 0 0
LEAP THERAPEUTICS INC COM 52187K101 1,806 1,032,163 SH   SOLE   1,032,163 0 0
LUCIRA HEALTH INC COM 54948U105 1,109 310,734 SH   SOLE   310,734 0 0
MEDICUS SCIENCES ACQUISITION CL A SHS G5960S108 1,283 131,151 SH   SOLE   131,151 0 0
MEDICUS SCIENCES ACQUISITION *W EXP 02/12/202 G5960S124 21 49,990 SH   SOLE   49,990 0 0
MEREO BIOPHARMA GROUP PLC ADS 589492107 264 235,515 SH   SOLE   235,515 0 0
MERUS N V COM N5749R100 8,586 324,719 SH   SOLE   324,719 0 0
MIRATI THERAPEUTICS INC COM 60468T105 3,792 46,122 SH   SOLE   46,122 0 0
MORPHIC HLDG INC COM 61775R105 2,759 68,709 SH   SOLE   68,709 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 1,920 20,482 SH   SOLE   20,482 0 0
NEXTCURE INC COM 65343E108 953 196,187 SH   SOLE   196,187 0 0
NGM BIOPHARMACEUTICALS INC COM 62921N105 3,058 200,494 SH   SOLE   200,494 0 0
OTONOMY INC COM 68906L105 2,898 1,207,385 SH   SOLE   1,207,385 0 0
POINT BIOPHARMA GLOBAL INC COM 730541109 1,631 204,679 SH   SOLE   204,679 0 0
POLYPID LTD SHS M8001Q118 1,191 218,175 SH   SOLE   218,175 0 0
POSEIDA THERAPEUTICS INC COM 73730P108 1,074 239,696 SH   SOLE   239,696 0 0
RENOVACOR INC *W EXP 99/99/999 75989E114 33 104,828 SH   SOLE   104,828 0 0
SEAGEN INC COM 81181C104 1,578 10,956 SH   SOLE   10,956 0 0
SERES THERAPEUTICS INC COM 81750R102 2,327 326,872 SH   SOLE   326,872 0 0
SIERRA ONCOLOGY INC COM NEW 82640U404 14,210 443,381 SH   SOLE   443,381 0 0
SPDR SER TR S&P BIOTECH 78464A870 26,964 300,000 SH Call SOLE   300,000 0 0
STEREOTAXIS INC COM NEW 85916J409 1,292 346,405 SH   SOLE   346,405 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 1,763 101,447 SH   SOLE   101,447 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 2,662 14,836 SH   SOLE   14,836 0 0
VERACYTE INC COM 92337F107 11,733 425,554 SH   SOLE   425,554 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 1,993 7,638 SH   SOLE   7,638 0 0
VIEWRAY INC COM 92672L107 1,709 436,096 SH   SOLE   436,096 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104 2,332 126,136 SH   SOLE   126,136 0 0
XENON PHARMACEUTICALS INC COM 98420N105 1,428 101,081 SH   SOLE   101,081 0 0