The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CL A COM 88025U109 55,872 734,481 SH   SOLE 1,2,3 734,481 0 0
2SEVENTY BIO INC COMMON STOCK 901384107 20,975 1,229,508 SH   SOLE 1,2,3 1,229,508 0 0
5 01 ACQUISITION CORP COM CL A 33836P105 3,861 392,000 SH   SOLE 1,2,3 392,000 0 0
908 DEVICES INC COM 65443P102 760 40,000 SH   SOLE 1,2,3 40,000 0 0
AADI BIOSCIENCES INC COM 00032Q104 12,977 764,701 SH   SOLE 1,2,3 764,701 0 0
ADICET BIO INC COM 007002108 59,700 2,989,482 SH   SOLE 1,2,3 2,989,482 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 293 223,725 SH   SOLE 1,2,3 223,725 0 0
AGENUS INC COM NEW 00847G705 8,813 3,582,481 SH   SOLE 1,2,3 3,582,481 0 0
AKOYA BIOSCIENCES INC COM 00974H104 854 77,676 SH   SOLE 1,2,3 77,676 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 274,876 1,683,362 SH   SOLE 1,2,3 1,683,362 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 2,601 51,194 SH   SOLE 1,2,3 51,194 0 0
APOLLO ENDOSURGERY INC COM 03767D108 1,561 258,064 SH   SOLE 1,2,3 258,064 0 0
APYX MEDICAL CORPORATION COM 03837C106 22,191 3,398,279 SH   SOLE 1,2,3 3,398,279 0 0
ARGENX SE SPONSORED ADR 04016X101 106,253 336,978 SH   SOLE 1,2,3 336,978 0 0
ARYA SCIENCES ACQU CORP IV CL A G31659108 4,900 500,000 SH   SOLE 1,2,3 500,000 0 0
ARYA SCIENCES ACQUISITN CORP CLASS A ORD SHS G31658100 4,855 500,000 SH   SOLE 1,2,3 500,000 0 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 2,924 3,250,000 SH   SOLE 1,2,3 3,250,000 0 0
ATHIRA PHARMA INC COM 04746L104 25,739 1,906,557 SH   SOLE 1,2,3 1,906,557 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 39,217 5,741,939 SH   SOLE 1,2,3 5,741,939 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 88,564 4,795,000 SH   SOLE 1,2,3 4,795,000 0 0
AVITA MEDICAL INC COM 05380C102 905 106,667 SH   SOLE 1,2,3 106,667 0 0
AXONICS INC COM 05465P101 109,166 1,743,864 SH   SOLE 1,2,3 1,743,864 0 0
AXSOME THERAPEUTICS INC COM 05464T104 67,003 1,618,819 SH   SOLE 1,2,3 1,618,819 0 0
BCLS ACQUISITION CORP COM CL A G0904B105 6,045 612,500 SH   SOLE 1,2,3 612,500 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108 56,003 1,276,276 SH   SOLE 1,2,3 1,276,276 0 0
BRAINSWAY LTD SPONSORED ADS 10501L106 13,989 1,602,381 SH   SOLE 1,2,3 1,602,381 0 0
C4 THERAPEUTICS INC COM STK 12529R107 109,946 4,531,982 SH   SOLE 1,2,3 4,531,982 0 0
CASTLE BIOSCIENCES INC COM 14843C105 22,281 496,675 SH   SOLE 1,2,3 496,675 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 105,048 3,084,215 SH   SOLE 1,2,3 3,084,215 0 0
CINCOR PHARMA INC COM 17240Y109 24,375 1,389,705 SH   SOLE 1,2,3 1,389,705 0 0
CODEX DNA INC COM 192003101 1,074 200,000 SH   SOLE 1,2,3 200,000 0 0
CONNECT BIOPHARMA HLDGS LTD ADS 207523101 1,349 446,564 SH   SOLE 1,2,3 446,564 0 0
CUTERA INC COM 232109108 105,312 1,526,263 SH   SOLE 1,2,3 1,526,263 0 0
CYTOKINETICS INC COM NEW 23282W605 94,277 2,561,182 SH   SOLE 1,2,3 2,561,182 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 15,432 5,779,700 SH   SOLE 1,2,3 5,779,700 0 0
DERMTECH INC COM 24984K105 45,782 3,118,666 SH   SOLE 1,2,3 3,118,666 0 0
ESSA PHARMA INC COM NEW 29668H708 16,298 2,637,192 SH   SOLE 1,2,3 2,637,192 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108 156,287 2,319,138 SH   SOLE 1,2,3 2,319,138 0 0
EXAGEN INC COM 30068X103 7,951 990,143 SH   SOLE 1,2,3 990,143 0 0
FULCRUM THERAPEUTICS INC COM 359616109 85,405 3,611,194 SH   SOLE 1,2,3 3,611,194 0 0
GENETRON HLDGS LTD ADS 37186H100 2,626 1,198,961 SH   SOLE 1,2,3 1,198,961 0 0
GH RESEARCH PLC ORDINARY SHARES G3855L106 39,670 2,168,957 SH   SOLE 1,2,3 2,168,957 0 0
GLOBUS MED INC CL A 379577208 124,119 1,682,291 SH   SOLE 1,2,3 1,682,291 0 0
GUARDANT HEALTH INC COM 40131M109 45,698 689,887 SH   SOLE 1,2,3 689,887 0 0
ILLUMINA INC COM 452327109 177,976 509,375 SH   SOLE 1,2,3 509,375 0 0
IMMATICS N.V SHS N44445109 2,797 350,000 SH   SOLE 1,2,3 350,000 0 0
IMMUNIC INC COM 4525EP101 30,572 2,705,513 SH   SOLE 1,2,3 2,705,513 0 0
IMMUNOCORE HLDGS PLC ADS 45258D105 55,598 1,859,471 SH   SOLE 1,2,3 1,859,471 0 0
ISOPLEXIS CORP COM 465005106 1,252 365,000 SH   SOLE 1,2,3 365,000 0 0
ITEOS THERAPEUTICS INC COM 46565G104 15,736 489,014 SH   SOLE 1,2,3 489,014 0 0
JOHNSON & JOHNSON COM 478160104 3,213 18,127 SH   SOLE 1,2,3 18,127 0 0
JOUNCE THERAPEUTICS INC COM 481116101 31,780 4,680,412 SH   SOLE 1,2,3 4,680,412 0 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 9,938 2,327,403 SH   SOLE 1,2,3 2,327,403 0 0
LANDOS BIOPHARMA INC COM 515069102 6,307 4,275,722 SH   SOLE 1,2,3 4,275,722 0 0
MACROGENICS INC COM 556099109 35,025 3,975,554 SH   SOLE 1,2,3 3,975,554 0 0
MASIMO CORP COM 574795100 164,110 1,127,593 SH   SOLE 1,2,3 1,127,593 0 0
MAXCYTE INC COM 57777K106 1,395 199,567 SH   SOLE 1,2,3 199,567 0 0
MEDICUS SCIENCES ACQUISITION *W EXP 02/12/202 G5960S124 14 33,331 SH   SOLE 1,2,3 33,331 0 0
MEDICUS SCIENCES ACQUISITION CL A SHS G5960S108 2,934 300,000 SH   SOLE 1,2,3 300,000 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 27,703 4,315,102 SH   SOLE 1,2,3 4,315,102 0 0
MINERVA SURGICAL INC COM 60343F106 747 166,000 SH   SOLE 1,2,3 166,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 128,386 1,561,497 SH   SOLE 1,2,3 1,561,497 0 0
MIROMATRIX MED INC COM 60471P108 1,109 280,000 SH   SOLE 1,2,3 280,000 0 0
MONTE ROSA THERAPEUTICS INC COM 61225M102 17,028 1,214,572 SH   SOLE 1,2,3 1,214,572 0 0
NANOSTRING TECHNOLOGIES INC COM 63009R109 14,040 404,029 SH   SOLE 1,2,3 404,029 0 0
NATERA INC COM 632307104 77,995 1,917,283 SH   SOLE 1,2,3 1,917,283 0 0
NAUTILUS BIOTECHNOLOGY INC COM 63909J108 4,774 1,100,000 SH   SOLE 1,2,3 1,100,000 0 0
NYXOAH S A SHS B6S7WD106 6,602 344,911 SH   SOLE 1,2,3 344,911 0 0
OLINK HLDG AB SPONSORED ADS 680710100 17,981 1,018,188 SH   SOLE 1,2,3 1,018,188 0 0
OUTSET MED INC COM 690145107 40,844 899,652 SH   SOLE 1,2,3 899,652 0 0
OYSTER PT PHARMA INC COM 69242L106 23,961 2,058,504 SH   SOLE 1,2,3 2,058,504 0 0
PENUMBRA INC COM 70975L107 147,910 665,871 SH   SOLE 1,2,3 665,871 0 0
PMV PHARMACEUTICALS INC COM 69353Y103 80,618 3,872,154 SH   SOLE 1,2,3 3,872,154 0 0
POINT BIOPHARMA GLOBAL INC COM 730541109 3,905 490,000 SH   SOLE 1,2,3 490,000 0 0
PROCEPT BIOROBOTICS CORP COM 74276L105 5,638 161,138 SH   SOLE 1,2,3 161,138 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108 104,140 2,757,947 SH   SOLE 1,2,3 2,757,947 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 6,354 7,019,610 SH   SOLE 1,2,3 7,019,610 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 113,534 4,794,499 SH   SOLE 1,2,3 4,794,499 0 0
PTC THERAPEUTICS INC COM 69366J200 194,804 5,221,228 SH   SOLE 1,2,3 5,221,228 0 0
PULMONX CORP COM 745848101 19,805 798,255 SH   SOLE 1,2,3 798,255 0 0
PYXIS ONCOLOGY INC COMMON STOCK 747324101 8,568 2,120,760 SH   SOLE 1,2,3 2,120,760 0 0
QUANTERIX CORP COM 74766Q101 36,444 1,248,517 SH   SOLE 1,2,3 1,248,517 0 0
REGENXBIO INC COM 75901B107 61,248 1,845,366 SH   SOLE 1,2,3 1,845,366 0 0
RELMADA THERAPEUTICS INC COM 75955J402 68,557 2,540,074 SH   SOLE 1,2,3 2,540,074 0 0
RENOVACOR INC *W EXP 99/99/999 75989E114 109 350,000 SH   SOLE 1,2,3 350,000 0 0
RENOVACOR INC COM 75989E106 12,723 3,000,803 SH   SOLE 1,2,3 3,000,803 0 0
RESEARCH ALLIANCE CORP II COM CL A 760873109 6,217 637,000 SH   SOLE 1,2,3 637,000 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 250,632 15,802,802 SH   SOLE 1,2,3 15,802,802 0 0
ROIVANT SCIENCES LTD SHS G76279101 3,965 802,717 SH   SOLE 1,2,3 802,717 0 0
RXSIGHT INC COM 78349D107 1,857 150,000 SH   SOLE 1,2,3 150,000 0 0
SCIENCE 37 HOLDINGS INC COM 808644108 21,610 4,039,341 SH   SOLE 1,2,3 4,039,341 0 0
SIGHT SCIENCES INC COM 82657M105 11,526 997,099 SH   SOLE 1,2,3 997,099 0 0
SINGULAR GENOMICS SYSTEMS IN COM 82933R100 631 100,000 SH   SOLE 1,2,3 100,000 0 0
SOPHIA GENETICS SA ORDINARY SHARES H82027105 1,752 226,589 SH   SOLE 1,2,3 226,589 0 0
STOKE THERAPEUTICS INC COM 86150R107 76,711 3,644,248 SH   SOLE 1,2,3 3,644,248 0 0
SUMMIT HEALTHCRE ACQUISTN CO UNIT 06/03/2026 G8566R128 4,889 500,000 SH   SOLE 1,2,3 500,000 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 116,864 1,004,936 SH   SOLE 1,2,3 1,004,936 0 0
TARSUS PHARMACEUTICALS INC COM 87650L103 33,869 2,013,601 SH   SOLE 1,2,3 2,013,601 0 0
TELA BIO INC COM 872381108 11,834 1,017,546 SH   SOLE 1,2,3 1,017,546 0 0
TENAYA THERAPEUTICS INC COM 87990A106 28,964 2,458,750 SH   SOLE 1,2,3 2,458,750 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 220,312 373,000 SH   SOLE 1,2,3 373,000 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 99,728 1,373,284 SH   SOLE 1,2,3 1,373,284 0 0
UROGEN PHARMA LTD COM M96088105 7,469 857,464 SH   SOLE 1,2,3 857,464 0 0
VENTYX BIOSCIENCES INC COM 92332V107 21,058 1,551,778 SH   SOLE 1,2,3 1,551,778 0 0
VERICEL CORP COM 92346J108 153,552 4,017,570 SH   SOLE 1,2,3 4,017,570 0 0
ZYMERGEN INC COM 98985X100 202 70,000 SH   SOLE 1,2,3 70,000 0 0