EX-99.1 2 nstg-20228kex991.htm EX-99.1 Document


Exhibit 99.1
nstg-logoa06.jpg
NanoString Technologies Releases Operating Results for Second Quarter of 2022
Generated Orders for ~ 50 Spatial Biology Instruments, Representing 65% Growth Year-over-Year,
Including Orders for More than 25 CosMx Spatial Molecular Imagers
SEATTLE - August 4, 2022 - NanoString Technologies, Inc. (NASDAQ:NSTG), a leading provider of life science tools for discovery and translational research, today reported financial results for the second quarter ended June 30, 2022.
Second Quarter Financial Highlights
•Product and service revenue of $32.0 million
•GeoMx® Digital Spatial Profiler (DSP) revenue of $10.9 million. GeoMx DSP revenue includes:
◦Instrument revenue of $5.2 million
◦Consumables revenue of $5.7 million, annualized pull-through of approximately $77,000 per installed system
•nCounter® revenue, inclusive of all service revenue, of $21.1 million. nCounter revenue includes:
◦Instrument revenue of $4.3 million
◦Consumables revenue of $12.2 million, annualized pull-through of approximately $45,000 per installed system
◦Service revenue of $4.6 million
•Cash, cash equivalents and short-term investments balance of $272.3 million
“NanoString had an excellent second quarter, as our commercial execution continued to improve, and laboratories adopting our solutions drove a 65% year-on-year increase in orders for new spatial biology instruments. Orders for our CosMx Spatial Molecular Imager are ahead of our expectations, and are helping us build a large revenue backlog that we expect will set us up for significant growth in 2023,” said Brad Gray, president & CEO of NanoString. “With complementary instrument platforms, our new AtoMx Spatial Informatics Platform, and blue-chip partnerships, we believe we are ideally positioned to win the spatial biology land-grab currently underway.”
Operational Highlights
Spatial Biology
•CosMx Orders: Secured customer orders for more than 25 CosMx™ Spatial Molecular Imager (SMI) systems, bringing total orders to date to more than 60 systems
•Commercial Status: First CosMx beta instrument was shipped to a customer during the first week of August, with two additional beta instruments scheduled for shipments to customers later in August
•Advances in Genome Biology and Technology (AGBT) Conference: Unveiled the AtoMx Spatial Informatics Platform and showcased data from 20 spatial biology studies, including 15 for CosMx SMI
•Introduced Integrated Informatics Platform for GeoMx Using NGS: Began offering a streamlined end-to-end solution to fully integrate GeoMx with Illumina NextSeq sequencers
•GeoMx Installed Base: Grew installed base to approximately 315 GeoMx DSP Systems at June 30, 2022, representing 66% growth over the prior year
•Publications: Continued growth of peer-reviewed publications utilizing GeoMx DSP technology, with approximately 20 new publications in the second quarter, bringing the cumulative total to approximately 130 peer-reviewed publications as of June 30, 2022
nCounter
•nCounter Installed Base: Grew installed base to approximately 1,085 nCounter Analysis Systems at June 30, 2022, representing 7% growth over the prior year
•Publications: Surpassed 5,800 cumulative peer-reviewed publications utilizing nCounter technology at June 30, 2022
2022 Outlook
The company updated its 2022 outlook, with results expected as follows:
•Orders for about 200 spatial biology systems, consistent with previous guidance, with an expected mix now comprised of approximately 50% GeoMx system orders and approximately 50% CosMx system orders
•Cumulative orders for approximately 120 CosMx systems expected by the end of 2022, providing a revenue backlog valued at approximately $30 million
•Total product and service revenue of $140 to $150 million, as compared to previous guidance of $150 to $160 million, reflecting an order mix that is weighted more heavily to CosMx, with material CosMx revenue recognition expected to begin in 2023
•nCounter revenue, inclusive of all service revenue, of $90 to $95 million, consistent with previous guidance
•Adjusted EBITDA loss of $75 to $85 million, as compared to previous guidance of $65 to $75 million
Financial Results
We have elected to present selected non-GAAP, or adjusted, financial measures, including Adjusted EBITDA. These adjusted financial measures are calculated excluding certain items that may make it more challenging to compare our GAAP operating results across periods. Such items may include collaboration revenue, stock-based compensation, depreciation and amortization, or one-time charges such as transaction related fees and expenses or restructuring charges and severance costs. A reconciliation of adjusted financial measures to the nearest comparable GAAP financial measure can be found in the tables at the end of this press release.
(dollars in thousands)Three Months Ended June 30,
GAAPNon-GAAP Adjusted
2022202120222021
Product and service revenue$31,998 $33,632 $31,998 $33,632 
Collaboration revenue221 231 — — 
Total revenue32,219 33,863 31,998 33,632 
Cost of product and service revenue15,852 15,481 14,756 14,735 
Gross Margin50 %54 %54 %56 %
Research and development17,346 17,162 14,474 14,469 
Selling, general and administrative36,112 26,855 30,224 21,717 
Adjusted EBITDAN / AN / A$(27,456)$(17,289)
Non-operating expense, net(2,148)(1,385)(2,148)(1,385)
Net loss$(39,239)$(27,020)$(29,604)$(18,674)
Six Months Ended June 30,
GAAPNon-GAAP Adjusted
2022202120222021
Product and service revenue$62,839 $65,026 $62,839 $65,026 
Collaboration revenue460 454 — — 
Total revenue63,299 65,480 62,839 65,026 
Cost of product and service revenue30,630 31,104 28,545 29,762 
Gross Margin51 %52 %55 %54 %
Research and development34,763 32,225 29,430 27,042 
Selling, general and administrative72,467 53,654 59,621 42,675 
Adjusted EBITDAN / AN / A$(54,757)$(34,453)
Non-operating expense, net(4,178)(3,229)(4,178)(3,229)
Net loss$(78,739)$(54,732)$(58,935)$(37,682)
Supplemental Information
As a supplement to the table above, we have posted to the investor relations section of our website, at www.nanostring.com/Investor Relations/Financials/Quarterly Results, supplemental financial data that include our adjusted financial measures as compared to the nearest comparable GAAP financial measures, for the second quarter and the six months ended June 30, 2022 and for each quarter of and the full year of 2021.
Conference Call
Management will host a conference call today beginning at 1:30 pm PT / 4:30 pm ET to discuss these results and answer questions. Investors and other interested parties can register for the call in advance by visiting https://ige.netroadshow.com/registration/q4inc/11218/nanostring-second-quarter-operating-results/. After registering, an email confirmation will be sent including dial-in details and unique conference call codes for entry. Registration is open throughout the call, but to ensure connection for the full call, registration in advance is recommended. The link to the webcast and audio replay will be made available at the Investor Relations website: www.nanostring.com. A replay of the call will be available beginning August 4, 2022 at 7:30pm ET through midnight ET on August 11, 2022. To access the replay, dial (866) 813-9403 or (929) 458-6194 and reference Conference ID: 426771. The webcast will also be available on our website for one year following the completion of the call.
Non-GAAP, or Adjusted, Financial Information
We believe that the presentation of non-GAAP, or adjusted, financial information provides important supplemental information to management and investors regarding financial and business trends relating to our financial condition and results of operations. Reconciliation of adjusted financial measures to the most directly comparable financial result as determined in accordance with GAAP are included at the end of this press release following the accompanying financial data. A reconciliation of adjusted guidance measures to corresponding GAAP measures is not available on a forward-looking basis without unreasonable effort due to the uncertainty regarding certain expenses that may be incurred in the future. For further information regarding why we believe that these adjusted measures provide useful information to investors, the specific manner in which management uses these measures and some of the limitations associated with the use of these measures, please refer to “Notes Regarding Non-GAAP Financial Information” at the end of this press release.
About NanoString Technologies, Inc.
NanoString Technologies is a leading provider of life science tools for discovery and translational research. The company provides three platforms that allow researchers to map the universe of biology. The nCounter® Analysis System, cited in more than 5,800 peer-reviewed publications, offers a way to easily profile the expression of hundreds of genes, proteins, miRNAs, or copy number variations, simultaneously with high sensitivity and precision. NanoString’s GeoMx® Digital Spatial Profiler enables highly multiplexed spatial profiling of RNA and protein targets in various sample types, including FFPE tissue sections, and has been cited in approximately 130 peer-reviewed publications. The CosMx™ Spatial Molecular Imager, with commercial availability expected in 2022, enables highly sensitive, high-resolution imaging of hundreds to thousands of RNAs or proteins directly from single cells within morphologically intact whole tissue sections. For more information, visit www.nanostring.com.
Forward-Looking Statements
This news release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934 and the Private Securities Litigation Reform Act of 1995. These forward-looking statements include statements regarding expectations for demand for our products and growth in our business, future revenue growth, the impact of the COVID-19 pandemic on our operations and future financial performance, the impact of new products and expansion into new markets, the growth trajectory of our nCounter, GeoMx and CosMx franchises, the anticipated launch of new products and technology and our estimated 2022 operating results and our anticipated GAAP and non-GAAP operating results. Such statements are based on current assumptions that involve risks and uncertainties that could cause actual outcomes and results to differ materially. These risks and uncertainties, many of which are beyond our control, include market acceptance of our products; delays or denials of regulatory approvals or clearances for products or applications; the extent and duration of the impact of the COVID-19 pandemic and adverse conditions in the general domestic and global economic markets; the effects of ongoing litigation; the impact of competition; the impact of expanded sales, marketing, product development and clinical activities on operating expenses; delays or other unforeseen problems with respect to manufacturing and product development; as well as the other risks set forth in our filings with the Securities and Exchange Commission. These forward-looking statements speak only as of the date hereof. NanoString Technologies disclaims any obligation to update these forward-looking statements.
The NanoString logo, NanoString, NanoString Technologies, GeoMx, CosMx, and nCounter are trademarks or registered trademarks of NanoString Technologies, Inc., in the United States and/or other countries.
Contact    
Doug Farrell
Vice President, Investor Relations & Corporate Communications
dfarrell@nanostring.com
Phone: 206-602-1768



NANOSTRING TECHNOLOGIES, INC.
CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS
(In thousands, except per share amounts)
(Unaudited)
Three Months Ended
June 30,		Six Months Ended
June 30,
 2022202120222021
Revenue:
Instruments$9,538 $11,816 $18,641 $23,561 
Consumables17,847 17,981 35,315 33,944 
Services4,613 3,835 8,883 7,521 
Total product and service revenue31,998 33,632 62,839 65,026 
Collaboration221 231 460 454 
Total revenue32,219 33,863 63,299 65,480 
Costs and expenses:
Cost of product and service revenue15,852 15,481 30,630 31,104 
Research and development17,346 17,162 34,763 32,225 
Selling, general and administrative36,112 26,855 72,467 53,654 
Total costs and expenses (a) (b)69,310 59,498 137,860 116,983 
Loss from operations(37,091)(25,635)(74,561)(51,503)
Other income (expense):
Interest income406 231 557 349 
Interest expense(1,880)(1,868)(3,763)(3,738)
Other income expense, net(490)334 (707)302 
Total other expense, net(1,964)(1,303)(3,913)(3,087)
Net loss before provision for income taxes(39,055)(26,938)(78,474)(54,590)
Provision for income taxes(184)(82)(265)(142)
Net loss$(39,239)$(27,020)$(78,739)$(54,732)
Net loss per share, basic and diluted$(0.85)$(0.60)$(1.70)$(1.22)
Weighted average shares used in computing basic and diluted net loss per share46,427 45,274 46,201 44,973 
(a) Includes $6.5 million and $8.0 million of stock-based compensation expense for the three months ended June 30, 2022 and 2021, respectively, and $14.1 million and $15.4 million for the six months ended June 30, 2022 and 2021, respectively.
(b) Includes $2.0 million and $1.4 million of depreciation and amortization expense for the three months ended June 30, 2022 and 2021, respectively, and $3.5 million and $2.9 million for the six months ended June 30, 2022 and 2021, respectively.



NANOSTRING TECHNOLOGIES, INC.
CONDENSED CONSOLIDATED BALANCE SHEETS
(In thousands)
(Unaudited)
June 30, 2022December 31, 2021
Assets
Current assets:
Cash and cash equivalents$126,027 $107,068 
Short-term investments146,315 241,821 
Accounts receivable, net31,404 40,130 
Inventory, net41,524 31,486 
Prepaid expenses and other9,427 7,115 
Total current assets354,697 427,620 
Property and equipment, net35,414 27,043 
Operating lease right-of-use assets17,645 19,226 
Other assets5,623 5,592 
Total assets$413,379 $479,481 
Liabilities and Stockholders’ Equity
Current liabilities:
Accounts payable$16,292 $14,283 
Accrued liabilities6,999 6,765 
Accrued compensation and other employee benefits13,729 17,466 
Customer deposits1,588 1,278 
Deferred revenue and other liabilities, current portion7,987 7,474 
Operating lease liabilities, current portion5,249 4,889 
Total current liabilities51,844 52,155 
Deferred revenue and other liabilities, net of current portion3,857 3,527 
Long-term debt, net225,877 225,144 
Operating lease liabilities, net of current portion19,136 21,693 
Total liabilities300,714 302,519 
Total stockholders’ equity112,665 176,962 
Total liabilities and stockholders’ equity$413,379 $479,481 




Notes Regarding Non-GAAP Financial Information. In addition to our results reported in accordance with U.S. generally accepted accounting principles (“GAAP”), we believe certain non-GAAP, or adjusted, measures are useful in evaluating our operating performance. We use adjusted financial measures to evaluate our ongoing operations and for internal planning and forecasting purposes. We believe that adjusted financial measures, when taken collectively, may be helpful to investors because it provides consistency and comparability with past financial performance. However, adjusted financial information has limitations as an analytical tool and should not be considered in isolation or as a substitute for financial information presented in accordance with U.S. GAAP. In particular, other companies, including companies in our industry, may calculate similarly titled non-GAAP or adjusted measures differently or may use other measures to evaluate their performance, all of which could reduce the usefulness of our adjusted financial measures as tools for comparison. A reconciliation is provided below for adjusted financial measures to the most directly comparable financial measure stated in accordance with U.S. GAAP. Investors are cautioned that there are a number of limitations associated with the use of non-GAAP, or adjusted, financial measures as analytical tools. Investors are encouraged to review the related U.S. GAAP financial measures and the reconciliation of these adjusted financial measures to their most directly comparable U.S. GAAP financial measure, and not to rely on any single financial measure to evaluate our business.
Expenses excluded from non-GAAP, or adjusted, cost of product and service revenue, research and development expense and selling, general and administrative expense and net loss. We exclude stock-based compensation expense and depreciation and amortization expense, which are non-cash expenses, from certain of our adjusted financial measures because we believe that excluding such items provides meaningful supplemental information regarding operational performance. We exclude certain expenses related to collaborations, recoveries of certain previously remitted state and local taxes, cloud computing arrangement implementation expenses, litigation expenses, and other business development expenses from certain of our adjusted financial measures because such expenses have no direct correlation to the continuing operation of our business as such expenses are non-recurring or non-operating in nature, and therefore we believe excluding these items provides meaningful supplemental information regarding operational performance.
Adjusted EBITDA. Adjusted EBITDA is a non-GAAP financial measure defined as GAAP net loss adjusted for collaboration revenue, stock-based compensation expense, depreciation and amortization, net interest expense, other non-operating expense or income, provision for income tax and other special items as determined by management, including certain expenses related to collaborations, recoveries of certain previously remitted state and local taxes, cloud computing arrangement implementation expenses, litigation expenses, and other business development expenses.



The following tables reflect the reconciliation between GAAP and non-GAAP measures (in thousands).
Three Months Ended June 30,Six Months Ended June 30,
2022202120222021
Net loss - GAAP$(39,239)$(27,020)$(78,739)$(54,732)
Collaboration revenue(221)(231)(460)(454)
Stock-based compensation6,458 7,989 14,125 15,405 
Depreciation and amortization1,961 1,439 3,504 2,880 
Interest expense, net1,474 1,637 3,206 3,389 
Other (income) expense, net490 (334)707 (302)
Provision for income taxes184 82 265 142 
Other business development expenses44 45 393 115 
Litigation expenses1,237 — 1,930 — 
Recovery of certain previously remitted state and local taxes— (896)— (896)
Cloud computing arrangement implementation expenses156 — 312 — 
Adjusted EBITDA - non-GAAP(27,456)(17,289)(54,757)(34,453)
Non-operating expense, net(2,148)(1,385)(4,178)(3,229)
Net loss - non-GAAP$(29,604)$(18,674)$(58,935)$(37,682)
Three Months Ended June 30,Six Months Ended June 30,
2022202120222021
GAAP Total revenue$32,219 $33,863 $63,299 $65,480 
 Collaboration revenue(221)(231)(460)(454)
Non-GAAP Total revenue$31,998 $33,632 $62,839 $65,026 
GAAP Cost of product and service revenue$15,852 $15,481 $30,630 $31,104 
Stock-based compensation(699)(585)(1,275)(1,025)
Depreciation and amortization(397)(161)(810)(317)
Non-GAAP Cost of product and service revenue$14,756 $14,735 $28,545 $29,762 
GAAP Gross Margin50%54%51%52%
Non-GAAP Gross Margin54%56%55%54%
GAAP Research and development$17,346 $17,162 $34,763 $32,225 
Stock-based compensation(1,818)(1,658)(3,561)(3,041)
Depreciation and amortization(1,054)(990)(1,772)(2,027)
Other business development activities— (45)— (115)
Non-GAAP Research and development$14,474 $14,469 $29,430 $27,042 
GAAP Selling, general and administrative$36,112 $26,855 $72,467 $53,654 
Stock-based compensation(3,941)(5,746)(9,289)(11,339)
Depreciation and amortization(510)(288)(922)(536)
Other business development activities(44)— (393)— 
Litigation expenses(1,237)— (1,930)— 
Recovery of certain previously remitted state and local taxes— 896 — 896 
Cloud computing arrangements implementation expense(156)— (312)— 
Non-GAAP Selling, general and administrative$30,224 $21,717 $59,621 $42,675