The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
1LIFE HEALTHCARE INC COM 68269G107 6,556 836,190 SH   DFND 2 836,190 0 0
10X GENOMICS INC CL A COM 88025U109 11,737 259,371 SH   DFND 2 259,371 0 0
ABBOTT LABS COM 002824100 170,994 1,573,807 SH   DFND 2 1,573,807 0 0
ABBVIE INC COM 00287Y109 124 808 SH   DFND 2 808 0 0
ABIOMED INC COM 003654100 41,955 169,509 SH   DFND 2 169,509 0 0
ACCOLADE INC COM 00437E102 5,095 688,479 SH   DFND 2 688,479 0 0
ACCOLADE INC COM 00437E102 21,803 2,946,407 SH   DFND 3 2,946,407 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 28,631 3,539,055 SH   DFND 3 3,539,055 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 709 32,000 SH   DFND 2 32,000 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 89,363 4,030,792 SH   DFND 1,2 4,030,792 0 0
ALIGN TECHNOLOGY INC COM 016255101 32,007 135,240 SH   DFND 2 135,240 0 0
ALKERMES PLC SHS G01767105 3,193 107,200 SH   DFND 2 107,200 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 4,267 29,257 SH   DFND 2 29,257 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 150,069 1,028,929 SH   DFND 1,2 1,028,929 0 0
ALPHABET INC CAP STK CL C 02079K107 656 300 SH   DFND 2 300 0 0
AMEDISYS INC COM 023436108 8,023 76,322 SH   DFND 2 76,322 0 0
AMEDISYS INC COM 023436108 53,488 508,832 SH   DFND 3 508,832 0 0
AMERICAN WELL CORP CL A 03044L105 7,645 1,769,703 SH   DFND 2 1,769,703 0 0
AMERISOURCEBERGEN CORP COM 03073E105 1,839 13,000 SH   DFND 2 13,000 0 0
AMGEN INC COM 031162100 12,398 50,959 SH   DFND 2 50,959 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 1,379 30,500 SH   DFND 2 30,500 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 53,175 1,175,922 SH   DFND 3 1,175,922 0 0
ARCTURUS THERAPEUTICS HLDGS COM 03969T109 623 39,550 SH   DFND 2 39,550 0 0
ARCUS BIOSCIENCES INC COM 03969F109 2,283 90,100 SH   DFND 2 90,100 0 0
ARGENX SE SPONSORED ADR 04016X101 11,859 31,300 SH   DFND 2 31,300 0 0
ARGENX SE SPONSORED ADR 04016X101 337,782 902,503 SH   DFND 1,2 902,503 0 0
ARVINAS INC COM 04335A105 2,494 59,250 SH   DFND 2 59,250 0 0
ARVINAS INC COM 04335A105 86,917 2,065,026 SH   DFND 1,2 2,065,026 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 5,748 87,000 SH   DFND 2 87,000 0 0
ATRICURE INC COM 04963C209 26,228 641,896 SH   DFND 3 641,896 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 26,848 2,671,413 SH   DFND 3 2,671,413 0 0
AVALARA INC COM 05338G106 92 1,300 SH   DFND 2 1,300 0 0
AVANTOR INC COM 05352A100 15,644 503,007 SH   DFND 2 503,007 0 0
AXONICS INC COM 05465P101 64,720 1,142,056 SH   DFND 2 1,142,056 0 0
AXONICS INC COM 05465P101 66,406 1,171,796 SH   DFND 3 1,171,796 0 0
AXSOME THERAPEUTICS INC COM 05464T104 31,297 817,141 SH   DFND 3 817,141 0 0
BAXTER INTL INC COM 071813109 29,406 457,819 SH   DFND 2 457,819 0 0
BEAM THERAPEUTICS INC COM 07373V105 174 4,500 SH   DFND 2 4,500 0 0
BEAM THERAPEUTICS INC COM 07373V105 21,992 568,121 SH   DFND 1,2 568,121 0 0
BECTON DICKINSON & CO COM 075887109 84,555 342,982 SH   DFND 2 342,982 0 0
BERKELEY LTS INC COM 084310101 1,914 385,014 SH   DFND 2 385,014 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108 1,416 84,400 SH   DFND 2 84,400 0 0
BIOGEN INC COM 09062X103 4,456 21,850 SH   DFND 2 21,850 0 0
BIONTECH SE SPONSORED ADS 09075V102 22,544 151,200 SH   DFND 2 151,200 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 6,112 73,753 SH   DFND 2 73,753 0 0
BIO RAD LABS INC CL A 090572207 45,125 91,161 SH   DFND 3 91,161 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 57 23,000 SH   DFND 2 23,000 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 11,548 4,694,113 SH   DFND 1,2 4,694,113 0 0
BOSTON SCIENTIFIC CORP COM 101137107 143,496 3,850,171 SH   DFND 2 3,850,171 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 1,918 24,907 SH   DFND 2 24,907 0 0
CAREDX INC COM 14167L103 54,506 2,537,524 SH   DFND 3 2,537,524 0 0
CARIBOU BIOSCIENCES INC COM 142038108 382 70,300 SH   DFND 2 70,300 0 0
CASTLE BIOSCIENCES INC COM 14843C105 20,656 941,059 SH   DFND 3 941,059 0 0
CELLDEX THERAPEUTICS COM NEW 15117B202 24,938 925,000 SH   DFND 1,2 925,000 0 0
CENTENE CORP DEL COM 15135B101 46,189 545,903 SH   DFND 2 545,903 0 0
CHARLES RIV LABS INTL INC COM 159864107 49,442 231,069 SH   DFND 3 231,069 0 0
CIGNA CORP NEW COM 125523100 51,032 193,657 SH   DFND 2 193,657 0 0
COOPER COS INC COM NEW 216648402 25,513 81,479 SH   DFND 2 81,479 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 2,030 33,400 SH   DFND 2 33,400 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 54,001 888,605 SH   DFND 1,2 888,605 0 0
CVS HEALTH CORP COM 126650100 21,233 229,153 SH   DFND 2 229,153 0 0
CYTOKINETICS INC COM NEW 23282W605 2,609 66,400 SH   DFND 2 66,400 0 0
DANAHER CORPORATION COM 235851102 92,290 364,036 SH   DFND 2 364,036 0 0
DEXCOM INC COM 252131107 69,202 928,508 SH   DFND 2 928,508 0 0
DOLBY LABORATORIES INC COM CL A 25659T107 114 1,600 SH   DFND 2 1,600 0 0
DOXIMITY INC CL A 26622P107 4,747 136,322 SH   DFND 2 136,322 0 0
DR REDDYS LABS LTD ADR 256135203 687 12,400 SH   DFND 2 12,400 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 96,101 1,010,627 SH   DFND 2 1,010,627 0 0
ELEVANCE HEALTH INC COM 036752103 52,174 108,114 SH   DFND 2 108,114 0 0
ELEVANCE HEALTH INC COM 036752103 48,444 100,386 SH   DFND 3 100,386 0 0
ENVISTA HOLDINGS CORPORATION COM 29415F104 19 484 SH   DFND 2 484 0 0
EQUINIX INC COM 29444U700 26 40 SH   DFND 2 40 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 262 41,200 SH   DFND 2 41,200 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 26,674 4,194,064 SH   DFND 1,2 4,194,064 0 0
ESSA PHARMA INC COM NEW 29668H708 60 19,000 SH   DFND 2 19,000 0 0
ESSA PHARMA INC COM NEW 29668H708 15,721 4,990,714 SH   DFND 1,2 4,990,714 0 0
EVERTEC INC COM 30040P103 27 739 SH   DFND 2 739 0 0
EVOLENT HEALTH INC CL A 30050B101 25,404 827,214 SH   DFND 2 827,214 0 0
EVOLENT HEALTH INC CL A 30050B101 36,585 1,191,307 SH   DFND 3 1,191,307 0 0
EXACT SCIENCES CORP COM 30063P105 29,859 758,023 SH   DFND 3 758,023 0 0
EXELIXIS INC COM 30161Q104 500 24,000 SH   DFND 2 24,000 0 0
EXELIXIS INC COM 30161Q104 55,267 2,654,500 SH   DFND 1,2 2,654,500 0 0
FATE THERAPEUTICS INC COM 31189P102 2,269 91,550 SH   DFND 2 91,550 0 0
FATE THERAPEUTICS INC COM 31189P102 85,703 3,458,536 SH   DFND 1,2 3,458,536 0 0
GENERATION BIO CO COM 37148K100 125 19,000 SH   DFND 2 19,000 0 0
GENERATION BIO CO COM 37148K100 23,670 3,608,280 SH   DFND 1,2 3,608,280 0 0
GILEAD SCIENCES INC COM 375558103 4,662 75,426 SH   DFND 2 75,426 0 0
GLOBUS MED INC CL A 379577208 36,866 656,681 SH   DFND 2 656,681 0 0
GRUPO AEROPORTUARIO DEL SURE SPON ADR SER B 40051E202 27 135 SH   DFND 2 135 0 0
GUARDANT HEALTH INC COM 40131M109 2,847 70,580 SH   DFND 2 70,580 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 42,737 971,300 SH   DFND 2 971,300 0 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104 34,240 702,068 SH   DFND 2 702,068 0 0
HCA HEALTHCARE INC COM 40412C101 49,203 292,771 SH   DFND 2 292,771 0 0
HEALTH CATALYST INC COM 42225T107 6,153 424,611 SH   DFND 2 424,611 0 0
HOLOGIC INC COM 436440101 18,768 270,825 SH   DFND 2 270,825 0 0
HOMOLOGY MEDICINES INC COM 438083107 3,196 1,622,522 SH   DFND 1,2 1,622,522 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 26,914 337,434 SH   DFND 2 337,434 0 0
HUMANA INC COM 444859102 68,015 145,309 SH   DFND 2 145,309 0 0
HUTCHMED CHINA LTD SPONSORED ADS 44842L103 21,359 1,756,307 SH   DFND 3 1,756,307 0 0
IDEXX LABS INC COM 45168D104 40,605 115,773 SH   DFND 2 115,773 0 0
ILLUMINA INC COM 452327109 16,015 86,867 SH   DFND 2 86,867 0 0
INCYTE CORP COM 45337C102 6,252 82,300 SH   DFND 2 82,300 0 0
INCYTE CORP COM 45337C102 204,441 2,691,077 SH   DFND 1,2 2,691,077 0 0
INFOSYS LTD SPONSORED ADR 456788108 21 1,130 SH   DFND 2 1,130 0 0
INHIBRX INC COM 45720L107 869 76,600 SH   DFND 2 76,600 0 0
INSMED INC COM PAR $.01 457669307 71,417 3,621,562 SH   DFND 3 3,621,562 0 0
INSPIRE MED SYS INC COM 457730109 74,357 407,057 SH   DFND 2 407,057 0 0
INSULET CORP COM 45784P101 84,198 386,335 SH   DFND 2 386,335 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 817 15,794 SH   DFND 2 15,794 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101 3,305 57,900 SH   DFND 2 57,900 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101 187,878 3,291,479 SH   DFND 1,2 3,291,479 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 151,575 755,192 SH   DFND 2 755,192 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 30,941 154,156 SH   DFND 3 154,156 0 0
IONIS PHARMACEUTICALS INC COM 462222100 8,718 235,500 SH   DFND 2 235,500 0 0
IONIS PHARMACEUTICALS INC COM 462222100 353,209 9,541,028 SH   DFND 1,2 9,541,028 0 0
IPG PHOTONICS CORP COM 44980X109 99 1,050 SH   DFND 2 1,050 0 0
IQVIA HLDGS INC COM 46266C105 36,584 168,598 SH   DFND 2 168,598 0 0
ISHARES TR MSCI CHINA ETF 46429B671 229 4,100 SH   DFND 2 4,100 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 41,882 268,456 SH   DFND 2 268,456 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 101,321 649,451 SH   DFND 3 649,451 0 0
JOHNSON & JOHNSON COM 478160104 5,133 28,914 SH   DFND 2 28,914 0 0
JUMIA TECHNOLOGIES AG SPONSORED ADS 48138M105 109 18,000 SH   DFND 2 18,000 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 289 35,000 SH   DFND 2 35,000 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 24,810 3,000,000 SH   DFND 1,2 3,000,000 0 0
KOSMOS ENERGY LTD COM 500688106 1,970 318,300 SH   DFND 2 318,300 0 0
KRYSTAL BIOTECH INC COM 501147102 880 13,400 SH   DFND 2 13,400 0 0
KURA ONCOLOGY INC COM 50127T109 1,168 63,700 SH   DFND 2 63,700 0 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409 996 4,250 SH   DFND 2 4,250 0 0
LAUDER ESTEE COS INC CL A 518439104 343 1,348 SH   DFND 2 1,348 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102 34,674 630,439 SH   DFND 2 630,439 0 0
LILLY ELI & CO COM 532457108 314 969 SH   DFND 2 969 0 0
MACROGENICS INC COM 556099109 147 49,950 SH   DFND 2 49,950 0 0
MACROGENICS INC COM 556099109 21,463 7,275,564 SH   DFND 1,2 7,275,564 0 0
MARKETAXESS HLDGS INC COM 57060D108 169 662 SH   DFND 2 662 0 0
MCKESSON CORP COM 58155Q103 828 2,537 SH   DFND 2 2,537 0 0
MEDTRONIC PLC SHS G5960L103 57,934 645,506 SH   DFND 2 645,506 0 0
MERCADOLIBRE INC COM 58733R102 108 170 SH   DFND 2 170 0 0
MERCK & CO. INC COM 58933Y105 88 964 SH   DFND 2 964 0 0
MERSANA THERAPEUTICS INC COM 59045L106 134 29,000 SH   DFND 2 29,000 0 0
MERSANA THERAPEUTICS INC COM 59045L106 17,862 3,866,200 SH   DFND 1,2 3,866,200 0 0
MODERNA INC COM 60770K107 6,485 45,400 SH   DFND 2 45,400 0 0
MODERNA INC COM 60770K107 218,839 1,531,951 SH   DFND 1,2 1,531,951 0 0
MOLECULAR TEMPLATES INC COM 608550109 78 86,000 SH   DFND 2 86,000 0 0
MOLECULAR TEMPLATES INC COM 608550109 10,203 11,192,003 SH   DFND 1,2 11,192,003 0 0
MOLINA HEALTHCARE INC COM 60855R100 69,431 248,313 SH   DFND 2 248,313 0 0
MYOVANT SCIENCES LTD COM G637AM102 584 47,000 SH   DFND 2 47,000 0 0
MYOVANT SCIENCES LTD COM G637AM102 72,997 5,872,639 SH   DFND 1,2 5,872,639 0 0
NEKTAR THERAPEUTICS COM 640268108 109 28,800 SH   DFND 2 28,800 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 4,471 45,868 SH   DFND 2 45,868 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 272,792 2,798,437 SH   DFND 1,2 2,798,437 0 0
NEUROPACE INC COM 641288105 2,514 507,930 SH   DFND 2 507,930 0 0
NEVRO CORP COM 64157F103 11,630 265,339 SH   DFND 2 265,339 0 0
NOVOCURE LTD ORD SHS G6674U108 1,758 25,300 SH   DFND 2 25,300 0 0
OLINK HLDG AB SPONSORED ADS 680710100 3,576 235,273 SH   DFND 2 235,273 0 0
OMNICELL COM COM 68213N109 48,437 425,823 SH   DFND 2 425,823 0 0
OPTHEA LTD SPONSORED ADS 68386J208 296 47,000 SH   DFND 2 47,000 0 0
OPTION CARE HEALTH INC COM NEW 68404L201 80,237 2,887,259 SH   DFND 3 2,887,259 0 0
OUTSET MED INC COM 690145107 10,558 710,480 SH   DFND 2 710,480 0 0
OUTSET MED INC COM 690145107 24,017 1,616,238 SH   DFND 3 1,616,238 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108 7,049 1,594,774 SH   DFND 2 1,594,774 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108 19,300 4,366,455 SH   DFND 3 4,366,455 0 0
PACIRA BIOSCIENCES INC COM 695127100 3,028 51,936 SH   DFND 2 51,936 0 0
PENUMBRA INC COM 70975L107 23,981 192,588 SH   DFND 2 192,588 0 0
PFIZER INC COM 717081103 43,815 835,684 SH   DFND 2 835,684 0 0
PHREESIA INC COM 71944F106 17,011 680,153 SH   DFND 2 680,153 0 0
PRIVIA HEALTH GROUP INC COM 74276R102 15,139 519,876 SH   DFND 2 519,876 0 0
PROCEPT BIOROBOTICS CORP COM 74276L105 19,463 595,380 SH   DFND 2 595,380 0 0
PULMONX CORP COM 745848101 2,552 173,336 SH   DFND 2 173,336 0 0
RADIUS HEALTH INC COM NEW 750469207 653 63,000 SH   DFND 2 63,000 0 0
RADIUS HEALTH INC COM NEW 750469207 90,567 8,733,538 SH   DFND 1,2 8,733,538 0 0
REGENERON PHARMACEUTICALS COM 75886F107 10,479 17,727 SH   DFND 2 17,727 0 0
RELAY THERAPEUTICS INC COM 75943R102 913 54,500 SH   DFND 2 54,500 0 0
RELAY THERAPEUTICS INC COM 75943R102 66,628 3,977,762 SH   DFND 1,2 3,977,762 0 0
RELMADA THERAPEUTICS INC COM 75955J402 665 35,000 SH   DFND 2 35,000 0 0
RESMED INC COM 761152107 17,790 84,865 SH   DFND 2 84,865 0 0
REVOLUTION MEDICINES INC COM 76155X100 1,573 80,700 SH   DFND 2 80,700 0 0
REVOLUTION MEDICINES INC COM 76155X100 64,367 3,302,562 SH   DFND 1,2 3,302,562 0 0
SAGE THERAPEUTICS INC COM 78667J108 740 22,900 SH   DFND 2 22,900 0 0
SAGE THERAPEUTICS INC COM 78667J108 95,294 2,950,278 SH   DFND 1,2 2,950,278 0 0
SANOFI SPONSORED ADR 80105N105 2,116 42,300 SH   DFND 2 42,300 0 0
SAREPTA THERAPEUTICS INC COM 803607100 31 409 SH   DFND 2 409 0 0
SAREPTA THERAPEUTICS INC COM 803607100 85,383 1,139,046 SH   DFND 3 1,139,046 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 106 19,300 SH   DFND 2 19,300 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 11,709 2,132,725 SH   DFND 1,2 2,132,725 0 0
SEAGEN INC COM 81181C104 8,737 49,376 SH   DFND 2 49,376 0 0
SEER INC COM CL A 81578P106 1,218 136,133 SH   DFND 2 136,133 0 0
SHOCKWAVE MED INC COM 82489T104 70,867 370,699 SH   DFND 2 370,699 0 0
SIGHT SCIENCES INC COM 82657M105 2,649 294,606 SH   DFND 2 294,606 0 0
SILENCE THERAPEUTICS PLC ADS 82686Q101 361 30,483 SH   DFND 2 30,483 0 0
SILK RD MED INC COM 82710M100 38,111 1,047,286 SH   DFND 3 1,047,286 0 0
SKYWORKS SOLUTIONS INC COM 83088M102 195 2,100 SH   DFND 2 2,100 0 0
STRYKER CORPORATION COM 863667101 95,016 477,634 SH   DFND 2 477,634 0 0
SUPERNUS PHARMACEUTICALS INC COM 868459108 2,383 82,400 SH   DFND 2 82,400 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 33,267 562,030 SH   DFND 2 562,030 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 44,620 753,843 SH   DFND 3 753,843 0 0
TELADOC HEALTH INC COM 87918A105 13,819 416,112 SH   DFND 2 416,112 0 0
TELEFLEX INCORPORATED COM 879369106 23,598 95,984 SH   DFND 2 95,984 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 39,017 71,818 SH   DFND 2 71,818 0 0
TRANSMEDICS GROUP INC COM 89377M109 18,237 579,887 SH   DFND 2 579,887 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 1,849 31,000 SH   DFND 2 31,000 0 0
UNITEDHEALTH GROUP INC COM 91324P102 85,820 167,086 SH   DFND 2 167,086 0 0
UNITEDHEALTH GROUP INC COM 91324P102 69,318 134,958 SH   DFND 3 134,958 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 45 193 SH   DFND 2 193 0 0
VANECK ETF TRUST GOLD MINERS ETF 92189F106 367 13,400 SH   DFND 2 13,400 0 0
VANECK ETF TRUST JUNIOR GOLD MINE 92189F791 160 5,000 SH   DFND 2 5,000 0 0
VEEVA SYS INC CL A COM 922475108 33,424 168,776 SH   DFND 2 168,776 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 24,327 86,332 SH   DFND 2 86,332 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 39,248 139,281 SH   DFND 3 139,281 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 267,848 950,523 SH   DFND 1,2 950,523 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104 567 49,000 SH   DFND 2 49,000 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 14,607 4,494,458 SH   DFND 1,2 4,494,458 0 0
XENCOR INC COM 98401F105 725 26,500 SH   DFND 2 26,500 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 27,955 266,087 SH   DFND 2 266,087 0 0
ZOETIS INC CL A 98978V103 86 503 SH   DFND 2 503 0 0